检索结果-南通市图书馆

Bioactive Materials 2018年第1期3卷 97-101页

作者： haiyong ao Jiajia Zong Yanjiao Nie Yizao Wan Xiebin Zheng School of Materials Science and Engineering East China Jiaotong UniversityNanchang330013China Key Laboratory of Inorganic Coating Materials Shanghai Institute of CeramicsChinese Academy of ScienceShanghai200050China

Aseptic loosening of implant is one of the main causes of Ti-based implant *** our previous work,a novel stable collagen/hyaluronic acid(Col/HA)multilayer modified titanium coatings(TCs)was developed by layer-by-layer(LBL)covalent immobilization technique,which showed enhanced biological properties compared with TCs that were physically absorbed with Col/HA multilayer in *** this study,a rabbit model with femur condyle defect was employed to compare the osteointegration performance of *** indicated that Col/HA multilayer with favourable stability could better facilitate osteogenesis around implants and bone-implant *** Col/HA multilayer covalentimmobilized TC may reduce aseptic loosening of implant.

关键词： Collagen I Hyaluronic acid LBL covalent immobilization Stability Osteointegration

Cytocompatibility with osteogenic cells and enhanced in vivo anti-infection potential of quaternized chitosan-loaded titania nanotubes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bone Research 2016年第3期4卷 140-153页

作者： Ying Yang haiyong ao Yugang Wang Wentao Lin Shengbing Yang Shuhong Zhang Zhifeng Yu Tingting Tang Shanghai Key Laboratory of Orthopedic Implants Department of Orthopedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong UniversitySchool of Medicine

Infection is one of the major causes of failure of orthopedic implants. Our previous study demonstrated that nanotube modification of the implant surface, together with nanotubes loaded with quaternized chitosan （hydroxypropyltrimethyl ammonium chloride chitosan, HACC）, could effectively inhibit bacterial adherence and biofilm formation in vitro. Therefore, the aim of this study was to further investigate the in vitro cytocompatibility with osteogenic cells and the in vivo anti-infection activity of titanium implants with HACC-loaded nanotubes （NT-H）. The titanium implant （Ti）, nanotubes without polymer loading （NT）, and nanotubes loaded with chitosan （NT-C） were fabricated and served as controls. Firstly, we evaluated the cytocompatibility of these specimens with human bone marrow-derived mesenchymal stem cells in vitro. The observation of cell attachment, proliferation, spreading, and viability in vitro showed that NT-H has improved osteogenic activity compared with Ti and NT-C. A prophylaxis rat model with implantation in the femoral medullary cavity and inoculation with methiciUin-resistant Staphylococcus aureus was established and evaluated by radiographical, microbiological, and histopathological assessments. Our in vivo study demonstrated that NT-H coatings exhibited significant anti-infection capability compared with the Ti and NT-C groups. In conclusion, HACC-loaded nanotubes fabricated on a titanium substrate show good compatibility with osteogenic cells and enhanced anti-infection ability in vivo, providing a good foundation for clinical application to combat orthopedic implant-associated infections.

关键词： NT Cytocompatibility with osteogenic cells and enhanced in vivo anti-infection potential of quaternized chitosan-loaded titania nanotubes HACC

De novo strategy with engineering a multifunctional bacterial cellulose-based dressing for rapid healing of infected wounds

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2022年第7期7卷 212-222页

作者： Chen Zhou Zhifei Yang Xiaowei Xun Le Ma Zejing Chen Xiaoming Hu Xidong Wu Yizao Wan haiyong ao Jiangxi Key Laboratory of Nanobiomaterials&Institute of Advanced Materials East China Jiaotong UniversityNanchang330000China Department of Drug Safety Evaluation Jiangxi Testing Center of Medical DeviceNanchang330000China

The treatment and healing of infected skin lesions is one of the major challenges in *** solve this problem,collagen I(Col-I)and the antibacterial agent hydroxypropyltrimethyl ammonium chloride chitosan(HACC)were composited into the bacterial cellulose(BC)three-dimensional network structure by a novel membrane-liquid interface(MLI)culture,and a Col-I/HACC/BC(CHBC)multifunctional dressing was *** water absorption rate and water vapor transmission rate of the obtained CHBC dressing were 35.78±2.45 g/g and 3084±56 g m^(-2)⋅day^(-1),*** water retention of the CHBC dressing was significantly improved compared with the BC caused by the introduced Col-I and *** vitro results indicated that the combined advantages of HACC and Col-I confer on CHBC dressings not only have outstanding antibacterial properties against Staphylococcus aureus(***)compared with BC and CBC,but also exhibit better cytocompatibility than BC and HBC to promote the proliferation and spread of NIH3T3 cells and *** importantly,the results of in vivo animal tests demonstrated that the CHBC dressings fully promoted wound healing for 8 days and exhibited shorter healing times,especially in the case of wound *** skin regeneration effects and higher expression levels of collagen during infection were also shown in the CHBC *** believe that CHBC composites with favorable multifunctionality have potential applications as wound dressings to treat infected wounds.

关键词： Bacterial cellulose Quaternized chitosan Multifunctional dressing Antibacterial activity Healing promotion

Hemodynamic evaluation of different stent graft schemes in aortic arch covered stent implantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Medicine in Novel Technology and Devices 2022年第1期13卷 79-86页

作者： Jingxin Liu Xinyong Cai Yuliang Zhan Hongmin Zhu haiyong ao Yizao Wan Honglin Luo Zhiwei Yang Quanchao Zhang Jiangxi Key Laboratory of Nanobiomaterials Institute of Advanced MaterialsEast China Jiaotong UniversityNanchang330013China Department of Cardiology Jiangxi Provincial People's Hospital Affiliated to Nanchang UniversityNanchang330006China School of Materials Science and Engineering Tianjin UniversityTianjin300072China

Implantation of the left subclavian artery(LSA)stent graft used in fenestration technique of the thoracic endovascular aortic repair(TEVAR)may interfere with the aortic helical blood flow that is believed to have important protective functions against *** present study investigated four different LSA stent graft implantation schemes for their resulted blood flow patterns in the thoracic aortic with hemodynamic computational simulation methods:the flush branch(FB),the protruding branch(PB),the straight cuff branch(SCB)and the cured cuff branch(CCB).The results showed that the PB scheme could slightly enhance helicity of the swirling flow in the aorta,but the other three schemes had less effect on blood flow *** PB scheme produced lowTAWSS,high-OSI and high-RRT around the LSA root,and the FB scheme had similar TAWSS,OSI and RRT in both value and distribution to those in the aorta without LSA stent graft *** SCB and CCB schemes led to less area of high-OSI and high-RRT values along the walls of the LSA branch *** results also showed that the PB scheme would significantly reduce blood supply to the LSA,on the contrary,the CCB scheme enhanced LSA blood supply and less effect on the total blood supply to the three branches of the thoracic *** summary,all of the four schemes have no significant effect on the aortic swirling flow,however,in the terms of TAWSS,OSI,RRT and blood supply to the LSA,the CCB model might be the best option with less area of low-WSS,high-OSI,high-RRT and well blood supply in the LSA.

关键词： Helical flow Thoracic endovascular aortic repair Fenestration technique Hemodynamic LSA stent Graft

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

形状记忆聚合物表面响应性润湿性研究进展

材料导报 2022年第21期36卷 201-209页

作者：王冕张全超敖海勇万怡灶华东交通大学先进材料研究院江西省纳米生物重点实验室南昌330013 天津大学材料科学与工程学院天津300072

润湿性是固体材料表面的一种重要性质,会影响材料的各种功能。随着人们对材料性能要求的不断提高,具有固定润湿性能的表面已不能满足复杂多变的应用环境,亟需开发各种具有响应性润湿性的表面。在这种背景下,形状记忆聚合物(SMP)基响应... 详细信息

润湿性是固体材料表面的一种重要性质,会影响材料的各种功能。随着人们对材料性能要求的不断提高,具有固定润湿性能的表面已不能满足复杂多变的应用环境,亟需开发各种具有响应性润湿性的表面。在这种背景下,形状记忆聚合物(SMP)基响应性润湿性表面因具有简单方便及良好的可控性等优点,在液滴定向传输、气泡收集和油水分离等领域具有巨大的应用潜力,引起了人们的广泛关注。众所周知,调控SMP表面的微结构及形状记忆编程手段是控制SMP表面响应性润湿性的重要方法。虽然众多文献均对此进行了简单探讨,但是二者到底如何影响SMP表面的响应性润湿性,尚缺乏系统而深入的论述。本文基于SMP材料表面不同的微结构(微柱阵列、多孔结构、纹路结构及二元杂化结构),从垂直热压、倾斜热压、选区热压及热拉等编程手段出发,综述了近年来SMP表面响应性润湿性方面的研究进展,并着重介绍了不同的编程及形状记忆回复参数对材料表面响应性润湿性能的影响。最后,指出了当前SMP响应性润湿性表面存在的问题及可能的发展方向。本文通过梳理表面微结构和编程手段调控SMP表面可控润湿性的最新进展,以期帮助材料领域相关研究人员加深对SMP基响应性润湿性表面的理解,并为智能表面响应性润湿性的研究和开发提供技术及理论指导。

关键词：响应性润湿性形状记忆聚合物微结构编程

双叶机械瓣膜不同植入角度对主动脉血流动力学的影响

在线全文

学校读者我要写书评

暂无评论

医用生物力学 2024年第4期39卷 685-690页

作者：刘晶鑫邓小燕敖海勇张全超北京航空航天大学生物与医学工程学院生物力学与力生物学教育部重点实验室北京100083 华东交通大学材料科学与工程学院南昌330013

目的研究双叶机械瓣膜(bileaflet mechanical heart valve,BMHV)不同植入角度对升主动脉旋动流的影响。方法基于1位健康志愿者主动脉CT图像,采用计算机数值模拟方法,在定常流条件下,比较研究4种不同瓣膜植入角度(0°、45°、90°和135°... 详细信息

目的研究双叶机械瓣膜(bileaflet mechanical heart valve,BMHV)不同植入角度对升主动脉旋动流的影响。方法基于1位健康志愿者主动脉CT图像,采用计算机数值模拟方法,在定常流条件下,比较研究4种不同瓣膜植入角度(0°、45°、90°和135°)对主动脉旋动流的影响。结果BMHV植入会严重干扰主动脉内的旋动流,影响升主动脉处的旋动流结构和旋动流强度分布,在瓣膜下游出现扰流区。135°植入角度对旋动流的破坏最大,产生逆向旋动区域最多;0°和45°角植入对旋动流破坏相对较小。植入角为0°时主动脉低壁面剪切应力(<0.5 Pa)所覆盖面积最小。结论植入角度为0°~45°时,BMHV对升主动脉内旋动流破坏相对较小。因此,对不同患者而言,应根据其主动脉(包括主动脉窦)的空间几何构型进行个性化选择,植入角度可在0°~45°之间确定。

关键词：旋动流机械心脏瓣膜主动脉血流动力学

维普期刊数据库博看期刊

A novel privacy preserving data aggregation scheme with data integrity and fault tolerance for smart grid communications

在线全文

学校读者我要写书评

暂无评论

Frontiers of Computer Science 2021年第5期15卷 217-219页

作者： haiyong Bao Beibei LI Software Engineering Institute East China Normal UniversityShanghai 200062China School of Computer Science and Information Engineering Zhejiang Gongshang UniversityHangzhou 310018China College of Cybersecurity Sichuan UniversityChengdu 610065China

1 Introduction By making the best of the information technology in smart grid,considerable power energy can be effectively saved[1,2].However,frequently collecting userJs power consumption data incurs privacy disclosure ***,data integrity is also critical to make the decisions to be more credible and *** the smart meters for collecting electricity consumptions are prone to communication failures for being deployed in unattended environment commonly.

关键词： smart preserving fault

Numerical investigation on the flow structures in a narrow confined channel with staggered jet array arrangement

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2015年第6期28卷 1616-1628页

作者： Liu haiyong Liu Cunliang Wu Wenming Section of Engine and Energy Xi'an High-Tech Institute School of Power and Engine Northwestern Polytechnical University

A series of numerical analyses have been performed to investigate the flow structures in a narrow confined channel with 12 staggered circular impingement holes and one bigger exit hole. The flow enters the channel through the impingement holes and exits through the far end outlet. The flow fields corresponding to two jet Reynolds numbers （25000 and 65000） and three channel con- figurations with different ratios of the channel height to the impingement hole diameter （Zr 1, 3, 5） are analyzed by solving the Reynolds averaged Navier-Stokes equations with the realizable k-e turbulence model. Detailed flow field information including the secondary flow, the interaction between the jets and the cross flow, and flow distribution along the channel has been obtained. Comparisons between the numerical and experimental results of the flow fields at the four planes along the channel are performed to validate the numerical method. The calculated impingement pattern, high velocity flow distribution, low velocity separation region and vortices are in good agreement with the experimental data, implying the validity and effectiveness of the employed numerical approach for analyzing relevant flow field.

关键词： Confined channel Cross flow Flow structure Impingement coolingTurbulence model

Therapeutic utility of Lung-MAP:ushering into an era of genomic and biomarker-driven clinical trials

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2021年第5期6卷 1393-1395页

作者： Chenyue Zhang haiyong Wang Department of Integrated Therapy Fudan University Shanghai Cancer CenterShanghai Medical CollegeShanghaiChina Department of Internal Medicine Oncology Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinanChina

demonstrated us The Lung Cancer Master Protocol(Lung-MAP;SI400)in a detailed *** authors introduced us screening registrations,assignments,and sub-study registrations *** conventional clinical trials,Lung-MAP study is a biomarker-driven umbrella trial testing the effect of different drugs on different mutations for squamous cell lung cancer(LUSC)(***).It is known that LUSC is intimately associated with tobacco exposure and could possibly amount to a high tumor mutation burden.2 Different subtypes of LUSC have been defined according to comprehensive analyses of genomic alterations.

关键词： Lung clinical alterations

Image Smearing Modeling and Verification for Strapdown Star Sensor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2012年第1期25卷 115-123页

作者： WANG haiyong ZHOU Wenrui CHENG Xuan LIN Haoyu School of Astronautics Beihang UniversityBeijing 100191China School of Instrument Science and Opto-electronics Engineering Beihang UniversityBeijing 100191China

To further extend study on celestial attitude determination with strapdown star sensor from static into dynamic field, one prerequisite is to generate precise dynamic simulating star maps. First a neat analytical solution of the smearing trajectory caused by spacecraft attitude maneuver is deduced successfully, whose parameters cover the geometric size of optics, three-axis angular velocities and CCD integral time. Then for the first time the mathematical law and method are discovered about how to synthesize the two formulae of smearing trajectory and the static Gaussian distribution function （GDF） model, the key of which is a line integral with regard to the static GDF attenuated by a factor 1/Ls （Ls is the arc length of the smearing trajectory） along the smearing trajectory. The dynamic smearing model is then obtained, also in an analytical form. After that, three sets of typical simulating maps and data are simulated from this dynamic model manifesting the expected smearing effects, also compatible with the linear model as its special case of no boresight rotation. Finally, model validity tests on a rate turntable are carried out, which results in a mean correlation coefficient 0.920 0 between the camera images and the corresponding model simulated ones with the same parameters. The sufficient similarity verifies the validity of the dynamic smearing model. This model, after pa- rameter calibration, can serve as a front-end loop of the ground semi-physical simulation system for celestial attitude determination with strapdown star sensor.

关键词： dynamic Gaussian distribution image smearing star sensor star map simulation