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Lycium barbarum glycopeptide(wolfberry extract)slows N-methyl-N-nitrosourea-induced degradation of photoreceptors

Neural Regeneration Research 2024年第10期19卷 2290-2298页

作者： Qihang Kong Xiu Han haiyang cheng Jiayu Liu Huijun Zhang Tangrong Dong Jiansu Chen Kwok-Fai So Xuesong Mi Ying Xu Shibo Tang Department of Ophthalmology Aier Eye HospitalJinan UniversityGuangzhouGuangdong ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Guangdong-Hong Kong-Macao Institute of CNS Regeneration Key Laboratory of CNS Regeneration(Ministry of Education)Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Ophthalmology Guangzhou Panyu Central HospitalGuangzhouGuangdong ProvinceChina School of Stomatology Jinan UniversityGuangzhouGuangdong ProvinceChina Aier Academician Station ChangshaHunan ProvinceChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina State Key Laboratory of Brain and Cognitive Sciences Hong Kong Special Administrative RegionChina

Photoreceptor cell degeneration leads to blindness, for which there is currently no effective treatment. Our previous studies have shown that Lycium barbarum(L. barbarum) polysaccharide(LBP) protects degenerated photoreceptors in rd1, a transgenic mouse model of retinitis pigmentosa. L. barbarum glycopeptide(Lb GP) is an immunoreactive glycoprotein extracted from LBP. In this study, we investigated the potential protective effect of Lb GP on a chemically induced photoreceptor-degenerative mouse model. Wild-type mice received the following: oral administration of Lb GP as a protective pre-treatment on days 1–7;intraperitoneal administration of 40 mg/kg N-methylN-nitrosourea to induce photoreceptor injury on day 7;and continuation of orally administered Lb GP on days 8–14. Treatment with Lb GP increased photoreceptor survival and improved the structure of photoreceptors, retinal photoresponse, and visual behaviors of mice with photoreceptor degeneration. Lb GP was also found to partially inhibit the activation of microglia in N-methyl-N-nitrosourea-injured retinas and significantly decreased the expression of two pro-inflammatory cytokines. In conclusion, Lb GP effectively slowed the rate of photoreceptor degeneration in N-methyl-N-nitrosourea-injured mice, possibly through an anti-inflammatory mechanism, and has potential as a candidate drug for the clinical treatment of photoreceptor degeneration.

关键词： anti-inflammation inherited retinal diseases Lycium barbarum glycopeptide N-methyl-N-nitrosourea opsin photoreceptor reactive gliosis retinal degeneration retinitis pigmentosa rhodopsin

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A Highly Efficient Ni/Al_(2)O_(3)-LaO_(x) Catalyst for the Reductive Amination of Furfural to Furfurylamine:the Promoting Effect of La

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Chemical Research in Chinese Universities 2024年第1期40卷 36-46页

作者： YANG Yinze ZHANG Liyan ZHOU Leilei cheng haiyang ZHAO Fengyu State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022P.R.China School of Applied Chemistry and Engineering University of Science Technology of ChinaHefei 230026P.R.China Jilin Province Key Laboratory of Green Chemistry and Process Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022P.R.China

The reductive amination of furfural to furfurylamine is an important and still challenging topic in the field of biomass conversion. In this work, we prepared a series of Ni/Al_(2)O_(3)-LaO_(x) catalysts by co-precipitation method, the role of La played in promoting the catalytic performances of reductive amination furfural was discussed based on the changes in the electronic state of Ni species, acidity, and Ni particle size. The catalytic activity and the selectivity of furfurylamine are highly dependent on the surface properties and the structure of the catalyst. The addition of La promoted the amount of strong acidic sites and the H2dissociation and spillover on the surface, thus inducing the improvement of the catalytic activity and furfurylamine selectivity. The Ni/Al_(2)O_(3)-0.5LaO_(x)catalyst with suitable acid sites gave a high yield of furfurylamine (94.9%) under mild reaction conditions. Moreover, the catalyst could be recycled five times without significant loss in activity. The Ni/Al_(2)O_(3)-LaO_(x) catalyst is of great promise in the production of amines via reductive amination reaction.

关键词： Reductive amination Furfural Nickel catalyst Furfurylamine Lanthanum

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Catalytic reductive amination of furfural to furfurylamine on robust ultra-small Ni nanoparticles

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Nano Research 2023年第3期16卷 3719-3729页

作者： Yinze Yang Leilei Zhou Xinchao Wang Liyan Zhang haiyang cheng Fengyu Zhao State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Jilin Province Key Laboratory of Green Chemistry and Process Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

The synthesis of primary amines via reductive amination in the presence of NH_(3)and H_(2),as a green and sustainable process,has attracted much attention.In this paper,we prepared series of Ni/SiO_(2)catalysts with deposition-precipitation and impregnation methods,and their catalytic performances on the reductive amination of a biomass derived compound of furfural to produce furfurylamine were studied.The catalytic activity and the yield were correlated to the structure and the surface properties of catalysts largely.The Ni/SiO_(2)is of high Lewis acidity and small Ni particle with numerous large Ni flat step surface showed high activity and selectivity,it afforded a reaction rate of 12.8 h^(−1)and a high yield to furfurylamine around 98%.These results are superior to the most non-noble metal catalysts reported so far.Moreover,the reaction route was examined with the unit control reactions of the intermediate.To produce furfurylamine selectively,the most suitable catalyst should have the moderate but not the highest activity in activation of hydrogen and hydrogenation in the reductive amination of furfural.This work provides some useful information for the catalytic reductive amination of aldehydes both in the design of catalyst and the reaction route.

关键词： Ni nanoparticle reductive amination furfural furfurylamine

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Cyclic oligourea synthesized from CO_(2):Purification,characterization and properties

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Green Energy & Environment 2022年第3期7卷 477-484页

作者： Ruhui Shi haiyang cheng Hongxiang Li Peixuan Wu Chao Zhang Masahiko Arai Fengyu Zhao State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesNo.5625 Renmin Rd.Changchun130022China University of Science and Technology of China No.96 Jinzhai Rd.Hefei230026China Jilin Province Key Laboratory of Green Chemistry and Process Changchun Institute of Applied ChemistryChinese Academy of SciencesNo.5625 Renmin Rd.Changchun130022China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesNo.5625 Renmin Rd.Changchun130022China

Carbon dioxide(CO_(2)) as a sustainable resource instead of toxic reagents has attracted considerable attention in synthesis of chemicals and polymeric materials.Herein,a kind of cyclic oligourea was synthesized via polycondensation of CO_(2) with 4,7,10-trioxa-1,13-tridecanediamine(TTD)followed by effective separation and purification processes.We developed an efficient separation strategy in which the linear oligourea molecules were selectively transformed to macromolecular polyurea molecules by a reaction of the–NH_(2) end group with 4,4’-diphenylmethane diisocyanate(MDI),followed by separation from cyclic oligourea using selected solvents.The structure and physicochemical properties were confirmed by MALDI-TOF mass spectra,NMR,Cryo-EM,thermal analysis and solubility measurement.The well-defined cyclic oligourea was produced with a high purity(99.4%)and the average-number molecular weight(Mn)of 1040 Da.It is semi-crystalline in structure with a melting point of 106℃and glass transition point of-10℃.The cyclic oligourea presented characteristically difference to its linear analogue.This work provides a new member to cyclic polymer family.

关键词： materials separation purity

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Comprehensive analysis on the economy and energy demand of pressure-swing distillation and pervaporation for separating waste liquid containing multiple components

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Chinese Journal of Chemical Engineering 2023年第11期63卷 12-20页

作者： Hongru Zhang Yusen Chen haiyang cheng Yangyang Wang Peizhe Cui Shiqing Zheng Zhaoyou Zhu Yinglong Wang Yanyue Lu Jun Gao College of Chemical Engineering Qingdao University of Science and TechnologyQingdao 266042China School of Chemistry and Chemical Engineering Guangxi University for NationalitiesNanning 530006China College of Chemical and Environmental Engineering Shandong University of Science and TechnologyQingdao 266590China

A large amount of waste liquids containing methanol/acetone/water mixtures are produced in the synthesis of methyl methacrylate(MMA).Under the advocacy of green chemical industry,it is urgent to develop an efficient,economic and energy-saving mixture separation process.Through thermodynamic azeotropic behavior and pressure sensitivity analysis,pressure-swing distillation was determined and the optimal separation pressure of each column in the process was obtained.Due to the composition of waste liquids produced were quite different in MMA production,the pressure-swing distillation separation process was designed to fully achieve the accurate waste liquids treatment.Taking the total annual cost(TAC)as the target,the sequential iteration method was used to optimize the process,and the impact of composition on economy was compared.In order to further realize the energy-saving of the separation process,the pervaporation membrane module was introduced to pretreat the waste liquid in the pressure-swing distillation.The results showed that the TAC of the coupling process was 46% higher than that of the pressure-swing distillation process,and the thermodynamic efficiency was 30% higher.This study provides waste liquid treatment technology for enterprises and analyzes its economic and energy efficiency,which has reference significance for the development of coupled separation technology.

关键词： Distillation Pervaporation Organic compounds Sequential iterative algorithms Economy and energy consumption

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Synthesis of polyurea from 1,6-hexanediamine with CO_2 through a two-step polymerization

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Green Energy & Environment 2017年第4期2卷 370-376页

作者： Shan Jiang Ruhui Shi haiyang cheng Chao Zhang Fengyu Zhao School of Chemical Engineering Changchun University of Technology State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Jilin Province Key Laboratory of Green Chemistry and Process Changchun Institute of Applied Chemistry Chinese Academy of Sciences

Activation and transformation of CO_2 is one of the important issues in the field of green and sustainable chemistry. Herein, CO_2 as a carbonoxygen resource was converted to CO_2-polyurea with 1,6-hexanediamine through a two-step polymerization. The reaction parameters such as temperature, pressure and reaction time were examined; and several kinds of catalysts were screened in the absence and presence of NMP solvent. The formed oligomer and the final polyurea were characterized by FT-IR, VT-DRIFTS, NMR, XRD, AFM and their thermal properties were examined by TGA and DSC. It was confirmed that the final polyurea has a high thermal stability; the melting temperature is 269℃ and the decomposition temperature is above 300℃. It is a brittle polymer with a tensile strength of 18.35 MPa at break length of 1.64%. The polyurea has a stronger solvent resistance due to the ordered hydrogen bond in structure. The average molecular weight should be enhanced in the postpolymerization as the appearance, hydrogen bond intensity, crystallinity, melting point and the thermal stability changed largely compared to the oligomer. The present work provides a new kind of polyurea, it is expected to have a wide application in the field of polymer materials.

关键词： CO2 Polyurea Two-step polymerization Catalysis

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新型旋转减冲装置对桩基局部冲刷防护试验研究

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海洋通报 2024年第2期43卷 220-228,274页

作者：张竞程永舟程海洋郑余伟吕行长沙理工大学水利与环境工程学院湖南长沙410114 水沙科学与水灾害防治湖南省重点实验室湖南长沙410114

为减轻海上风电单桩基础周围局部冲刷对其结构安全的影响,本文提出了一种新型旋转减冲装置。在波流水槽中开展物理模型试验,改变波流条件、装置安装高度、安装距离,记录桩周冲刷发展历时,运用激光地形仪扫描冲刷坑形态,分析各工况下冲... 详细信息

为减轻海上风电单桩基础周围局部冲刷对其结构安全的影响,本文提出了一种新型旋转减冲装置。在波流水槽中开展物理模型试验,改变波流条件、装置安装高度、安装距离,记录桩周冲刷发展历时,运用激光地形仪扫描冲刷坑形态,分析各工况下冲刷坑形态差异,验证装置不同安装距离、安装高度下的冲刷防护效果,提出了不同安装位置下的防护效率公式。结果表明:新型旋转减冲装置具有较好的冲刷防护效果,本试验工况下,桩周最大冲刷深度可减小44%左右。装置安装距离对冲刷防护效果影响较小,波流作用下的冲刷防护效果受装置安装高度影响显著,冲刷防护效果随装置安装高度的增加而减弱。

关键词：波流共同作用冲刷防护桩基础冲刷深度减冲装置

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钢结构在建筑结构设计中存在的问题分析

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工程建设（维泽科技） 2024年第3期7卷 174-176页

作者：程海洋河北建筑设计研究院有限责任公司河北石家庄050000

随着我国经济国民城镇化建设的不断发展,各个城镇的高楼大厦拔地而起,建筑行业越来越蒸蒸日上,随着城镇化的大力发展,直接推动了我国建筑业的整体促进发展,而钢结构在建筑施工应用中起着最广泛以及重要的作用,文中主要对钢结构进行概述... 详细信息

随着我国经济国民城镇化建设的不断发展,各个城镇的高楼大厦拔地而起,建筑行业越来越蒸蒸日上,随着城镇化的大力发展,直接推动了我国建筑业的整体促进发展,而钢结构在建筑施工应用中起着最广泛以及重要的作用,文中主要对钢结构进行概述,并且提出钢结构在建筑结构设计中遇到的问题和改进措施,并且针对钢结构设计提供科学有效的实际建议和进行深入的分析探讨。

关键词：钢结构建筑结构结构设计问题及措施

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复杂高层与超高层建筑结构设计要点探析

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智能城市应用 2024年第3期7卷 68-70页

作者：程海洋河北建筑设计研究院有限责任公司河北石家庄050000

随着城市化进程的不断推进和人口的持续增长,高层建筑作为现代城市的标志性存在,扮演着重要的城市发展和空间利用角色。高层建筑的崛起不仅改变了城市天际线,更是对土地资源的有效利用,提高了城市的居住密度。然而,与日益增加的建筑高... 详细信息

随着城市化进程的不断推进和人口的持续增长,高层建筑作为现代城市的标志性存在,扮演着重要的城市发展和空间利用角色。高层建筑的崛起不仅改变了城市天际线,更是对土地资源的有效利用,提高了城市的居住密度。然而,与日益增加的建筑高度和复杂性相伴而来的是结构设计面临的巨大挑战。在高层建筑中,如何确保结构的安全性、稳定性和舒适性成为工程设计的核心问题。

关键词：高层超高层建筑结构设计

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Reductive amination of 1,6-hexanediol with Ru/Al2O3 catalyst in supercritical ammonia

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Science China Chemistry 2017年第7期60卷 920-926页

作者： Yan Li haiyang cheng Chao Zhang Bin Zhang Tong Liu Qifan Wu Xinluona Su Weiwei Lin Fengyu Zhao State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Laboratory of Green Chemistry and Process Changchun Institute of Applied ChemistryChinese Academy of Sciences Changchun 130022China Department of Environmental Science and Engineering Heilongfiang UniversityHarbin 150080China

Hexamethylenediamine(HMDA) is an important reagent for the synthesis of Nylon-6,6, and it is usually produced by the hydrogenation of adiponitrile using a toxic reagent of hydrocyanic acid. Herein, we developed an environmental friendly route to produce HMDA via catalytic reductive amination of 1,6-hexanediol(HDO) in the presence of hydrogen. The activities of several heterogeneous metal catalysts such as supported Ni, Co, Ru, Pt, Pd catalysts were screened for the present reaction in supercritical ammonia without any additives. Among the catalysts examined, Ru/Al_2O_3 presented a high catalytic activity and highest selectivity for the desired product of HMDA. The high performance of Ru/Al_2O_3 was discussed based on the Ru dispersion and the surface properties like the acid-basicity. In addition, the reaction parameters such as reaction temperature,time, H_2 and NH_3 pressure were examined, and the reaction processes were discussed in detail.

关键词： Ru/Al2O3催化剂还原胺化超临界己二醇胺化反应氨水非金属催化剂反应活性

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