检索结果-南通市图书馆

The future of artificial hibernation medicine:protection of nerves and organs after spinal cord injury

Neural Regeneration Research 2024年第1期19卷 22-28页

作者： Caiyun Liu haixin Yu Zhengchao Li Shulian chen Xiaoyin Li Xuyi chen Bo chen School of Acupuncture&Moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjinChina Research Center of Experimental Acupucture Science Tianjin University of Traditional Chinese MedicineTianjinChina Characteristic Medical Center of Chinese People’s Armed Police Force TianjinChina Binhai New Area Hospital of TCM TianjinChina Fourth Teaching Hospital of Tianjin University of TCM TianjinChina

Spinal cord injury is a serious disease of the central nervous system involving irreversible nerve injury and various organ system injuries.At present,no effective clinical treatment exists.As one of the artificial hibernation techniques,mild hypothermia has preliminarily confirmed its clinical effect on spinal cord injury.However,its technical defects and barriers,along with serious clinical side effects,restrict its clinical application for spinal cord injury.Artificial hibernation is a futureoriented disruptive technology for human life support.It involves endogenous hibernation inducers and hibernation-related central neuromodulation that activate particular neurons,reduce the central constant temperature setting point,disrupt the normal constant body temperature,make the body adapt"to the external cold environment,and reduce the physiological resistance to cold stimulation.Thus,studying the artificial hibernation mechanism may help develop new treatment strategies more suitable for clinical use than the cooling method of mild hypothermia technology.This review introduces artificial hibernation technologies,including mild hypothermia technology,hibernation inducers,and hibernation-related central neuromodulation technology.It summarizes the relevant research on hypothermia and hibernation for organ and nerve protection.These studies show that artificial hibernation technologies have therapeutic significance on nerve injury after spinal co rd injury through inflammatory inhibition,immunosuppression,oxidative defense,and possible central protection.It also promotes the repair and protection of res pirato ry and digestive,cardiovascular,locomoto r,urinary,and endocrine systems.This review provides new insights for the clinical treatment of nerve and multiple organ protection after spinal cord injury thanks to artificial hibernation.At present,artificial hibernation technology is not mature,and research fa ces various challenges.Neve rtheless,the effort is wo rthwhile for the future development of medicine.

关键词： artificial hibernation central thermostatic-resista nt regulation hypothermia multi-system protection neuroprotection organ protection spinal cord injury synthetic torpor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Accelerating the evaluation of operational lifetimes of perovskite solar cells and modules

引用

Journal of Energy Chemistry 2024年第7期94卷 1-9页

作者： Fumeng Ren Qian Lu Xin Meng Jing Zhou Rui chen Jianan Wang haixin Wang Sanwan Liu Zonghao Liu Wei chen Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074HubeiChina China-EU Institute for Clean and Renewable Energy Huazhong University of Science and TechnologyWuhan 430073HubeiChina Powerchina Huadong Engineering Corporation Limited Hangzhou 311122ZhejiangChina Optics Valley Laboratory Wuhan 430074HubeiChina

Compared with the power conversion efficicency,the operational stability of perovskite solar cells(PsCs)remains a major challenge hampering its commercialization.However,conducting a light soaking test under 1 sun illumination to get a long lifetime is time-consuming and experimentally inefficient.Here,we report an accelerated stability test protocol by aging PsCs under high-intensity light illumination to accelerate the evaluation of their operation stability.It is found that the efficiency degradation rate of a typical inverted PsC is almost linearly dependent on the light intensity within the range of 1 to 4 suns regardless of the encapsulations.The results prove that it can save the light-soaking time by at least 4 times to predict the operation lifetime on the basis of the equivalent light irradiation dose.

关键词： Perovskite Light-soaking Stability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pressure distribution feature-oriented sampling for statistical analysis of supercritical airfoil aerodynamics

引用

Chinese Journal of Aeronautics 2022年第4期35卷 134-147页

作者： Runze LI Yufei ZHANG haixin chen School of Aerospace Engineering Tsinghua UniversityBeijing 100084China

In the field of supercritical wing design, various principles and rules have been summarized through theoretical and experimental analyses. Compared with black-box relationships between geometry parameters and performances, quantitative physical laws about pressure distributions and performances are clearer and more beneficial to designers. With the advancement of computational fluid dynamics and computational intelligence, discovering new rules through statistical analysis on computers has become increasingly attractive and affordable. This paper proposes a novel sampling method for the statistical study on pressure distribution features and performances, so that new physical laws can be revealed. It utilizes an adaptive sampling algorithm, of which the criteria are developed based on Kullback–Leibler divergence and Euclidean distance.In this paper, the proposed method is employed to generate airfoil samples to study the relationships between the supercritical pressure distribution features and the drag divergence Mach number as well as the drag creep characteristic. Compared with conventional sampling methods, the proposed method can efficiently distribute samples in the pressure distribution feature space rather than directly sampling airfoil geometry parameters. The corresponding geometry parameters are searched and found under constraints, so that supercritical airfoil samples that are well distributed in the pressure distribution space are obtained. These samples allow statistical studies to obtain more reliable and universal aerodynamic rules that can be applied to supercritical airfoil designs.

关键词： Adaptive sampling Output space Statistics Pressure distribution features Supercritical airfoil

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimization design of airfoils under atmospheric icing conditions for UAV

引用

Chinese Journal of Aeronautics 2022年第4期35卷 118-133页

作者： Haoran LI Yufei ZHANG haixin chen School of Aerospace Engineering Tsinghua UniversityBeijing 100084China

Natural ice accretion on the lifting surface of an aircraft is detrimental to its aerodynamic performance, as it changes the effective streamlined body. The main focus of this work considers the optimization design of airfoils under atmospheric icing conditions for the Unmanned Aerial Vehicle(UAV). The ice formation process is simulated by the Eulerian approach and the three-dimensional Myers model. A three-equation turbulence model is implemented to accurately predict the stall performance of the iced airfoil. In recognition of the real atmospheric variability in the icing parameters, the medium volume diameter of supercooled water droplets is treated as an uncertainty with an assumed probability density function. A technique of polynomial chaos expansion is used to propagate the input uncertainty through the deterministic system. The numerical results show that the multipoint/multiobjective optimization strategy can efficiently improve both the ice tolerance and the cruise performance of an airfoil. The reason for the focus on robust optimization is that the ice angle of the optimized airfoil becomes less critical to the incoming flow.The optimized airfoils are applied to a UAV platform, in which the performance improvement and the relevant key flow feature are both preserved.

关键词： Aircraft icing Ice-accretion Ice-tolerant airfoil Optimization design Separated flow UAV

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Transfer learning from two-dimensional supercritical airfoils to three-dimensional transonic swept wings

引用

中国航空学报:英文版 2023年第9期36卷 96-110页

作者： Runze LI Yufei ZHANG haixin chen School of Aerospace Engineering Tsinghua UniversityBeijing 100084China

Machine learning has been widely utilized in flow field modeling and aerodynamic optimization.However,most applications are limited to two-dimensional problems.The dimensionality and the cost per simulation of three-dimensional problems are so high that it is often too expensive to prepare sufficient samples.Therefore,transfer learning has become a promising approach to reuse well-trained two-dimensional models and greatly reduce the need for samples for threedimensional problems.This paper proposes to reuse the baseline models trained on supercritical airfoils to predict finite-span swept supercritical wings,where the simple swept theory is embedded to improve the prediction accuracy.Two baseline models are investigated:one is commonly referred to as the forward problem of predicting the pressure coefficient distribution based on the geometry,and the other is the inverse problem that predicts the geometry based on the pressure coefficient distribution.Two transfer learning strategies are compared for both baseline models.The transferred models are then tested on complete wings.The results show that transfer learning requires only approximately 500 wing samples to achieve good prediction accuracy on different wing planforms and different free stream conditions.Compared to the two baseline models,the transferred models reduce the prediction error by 60%and 80%,respectively.

关键词： Inverse design Pressure distribution Supercritical airfoils Swept wings Transfer learning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimization of multi-element airfoil settings considering ice accretion effect

引用

Chinese Journal of Aeronautics 2023年第2期36卷 41-57页

作者： Jinzhao DAI Haoran LI Yufei ZHANG haixin chen School of Aerospace Engineering Tsinghua UniversityBeijing 100084China Beijing Electro-mechanical Engineering Institute Beijing 100074China

Almost half of all flight accidents caused by inflight icing occur at the approach and landing phases when high-lift devices are deployed.The present study focuses on the optimization of an ice-tolerant multi-element airfoil.Dual-objective optimization is carried out with critical hornshaped ice accumulated during the holding phase.The optimization results show that the present optimization method significantly enhances the iced-state and clean-state performance.The optimal multi-element airfoil has a larger deflection angle and wider gap at the slat and the flap compared with the baseline configuration.The sensitivity of each design parameter is analyzed,which verifies the robustness of the design.The design is further assessed when ice is accreted during the approach and landing phases,which also shows performance improvement.

关键词： Aircraft icing Airliner Ice-tolerant airfoil Multi-element airfoil Optimization design

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aerodynamic optimization of a high-lift system with adaptive dropped hinge flap

引用

Chinese Journal of Aeronautics 2022年第11期35卷 191-208页

作者： Qiang JI Yufei ZHANG haixin chen Junke YE School of Aerospace Engineering Tsinghua UniversityBejing 100084China 63870 PLA Troops Huayin 714200China Shanghai Aircraft Design and Research Institute Shanghai 200236China

The Adaptive Dropped Hinge Flap(ADHF) is a novel trailing edge high-lift device characterized by the integration of downward deflection spoiler and simple hinge flap, with excellent aerodynamic and mechanism performance. In this paper, aerodynamic optimization design of an ADHF high-lift system is conducted considering the mechanism performance. Shape and settings of both takeoff and landing configurations are optimized and analyzed, with considering the kinematic constraints of ADHF mechanism, and the desired optimization results were obtained after optimization. Sensitivity analysis proves the robustness of the optimal design. Comparison shows that the ADHF design has better comprehensive performance of both mechanism and aerodynamics than the conventional Fowler flap and simple hinge flap design.

关键词： Adaptive dropped hinge flap Aerodynamic design High-Lift aerodynamics Multidisciplinary optimization Optimization of aircraft design

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A nanoplatform with oxygen self-supplying and heat-sensitizing capabilities enhances the efficacy of photodynamic therapy in eradicating multidrug-resistant biofilms

引用

Journal of Materials Science & Technology 2024年第2期169卷 209-219页

作者： haixin Zhang Yi Zou Kunyan Lu Yan Wu Yuancheng Lin Jingjing cheng Chunxia Liu Hong chen Yanxia Zhang Qian Yu State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Department of Cardiovascular Surgery of the First Affiliated Hospital and Institute for Cardiovascular Science Suzhou Medical College of Soochow UniversitySoochow UniversitySuzhou 215007China

Bacterial biofilms,especially those caused by multidrug-resistant bacteria,have emerged as one of the greatest dangers to global public health.The acceleration of antimicrobial resistance to conventional an-tibiotics and the severe lack of new drugs necessitates the development of novel agents for biofilm eradication.Photodynamic therapy(PDT)is a promising non-antibiotic method for treating bacterial infections.However,its application in biofilm eradication is hampered by the hypoxic microenvironment of biofilms and the physical protection of extracellular polymeric substances.In this study,we develop a composite nanoplatform with oxygen(O_(2))self-supplying and heat-sensitizing capabilities to improve the PDT efficacy against biofilms.CaO_(2)/ICG@PDA nanoparticles(CIP NPs)are fabricated by combining calcium peroxide(CaO_(2))with the photosensitizer indocyanine green(ICG)via electrostatic interactions,followed by coating with polydopamine(PDA).The CIP NPs can gradually generate O_(2)in response to the acidic microenvironment of the biofilm,thereby alleviating its hypoxic state.Under near-infrared(NIR)irradiation,the nanoplatform converts O_(2)into a significant amount of singlet oxygen(^(1)O_(2))and heat to eradicate biofilm.The generated heat enhances the release of O_(2),accelerates the generation of^(1)O_(2)in PDT,increases cell membrane permeability,and increases bacterial sensitivity to^(1)O_(2).This nanoplatform significantly improves the efficacy of PDT in eradicating biofilm-dwelling bacteria without fostering drug resistance.Experiments on biofilm eradication demonstrate that this nanoplatform can eradicate over 99.9999%of methicillin-resistant Staphylococcus aureus(MRSA)biofilms under 5-min NIR irradiation.Notably,these integrated advantages enable the system to promote the healing of MRSA biofilm-infected wounds with negligible toxicity in vivo,indicating great promise for overcoming the obstacles associated with bacterial biofilm eradication.

关键词： Bacterial biofilm Multidrug-resistant bacteria Photodynamic therapy Oxygen supplying Photothermal therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Real-time Risk-averse Dispatch of an Integrated Electricity and Natural Gas System via Condi-tional Value-at-risk-based Lookup-table Ap-proximate Dynamic Programming

引用

Protection and Control of Modern Power Systems 2024年第2期9卷 47-60页

作者： Jianquan Zhu Guanhai Li Ye Guo Jiajun chen haixin Liu Yuhao Luo Wenhao Liu School of Electric Power Engineering South China University of Tech-nologyGuangzhou 510640China South China University of Technology GuangzhouChina

The real-time risk-averse dispatch problem of an integrated electricity and natural gas system(IEGS)is studied in this paper.It is formulated as a real-time conditional value-at-risk(CVaR)-based risk-averse dis-patch model in the Markov decision process framework.Because of its stochasticity,nonconvexity and nonlinearity,the model is difficult to analyze by traditional algorithms in an acceptable time.To address this non-deterministic polynomial-hard problem,a CVaR-based lookup-table approximate dynamic programming(CVaR-ADP)algo-rithm is proposed,and the risk-averse dispatch problem is decoupled into a series of tractable subproblems.The line pack is used as the state variable to describe the impact of one period’s decision on the future.This facilitates the reduction of load shedding and wind power curtailment.Through the proposed method,real-time decisions can be made according to the current information,while the value functions can be used to overview the whole opti-mization horizon to balance the current cost and future risk loss.Numerical simulations indicate that the pro-posed method can effectively measure and control the risk costs in extreme scenarios.Moreover,the decisions can be made within 10 s,which meets the requirement of the real-time dispatch of an IEGS.Index Terms—Integrated electricity and natural gas system,approximate dynamic programming,real-time dispatch,risk-averse,conditional value-at-risk.

关键词： Integrated electricity and natural gas system approximate dynamic programming real-time dispatch risk-averse conditional value-at-risk

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aeroacoustic prediction based on large-eddy simulation and the Ffowcs Williams-Hawkings equation

引用

Advances in Aerodynamics 2022年第1期4卷 395-412页

作者： Yufei Zhang Yang Xiao Ruihuan Liu haixin chen School of Aerospace Engineering Tsinghua UniversityBeijing100084China

A hybrid noise computation method is presented in this paper.Large-eddy simulation with wall-model equation is proposed to compute the flow field.With a stress-balanced wall-model equation,the near-wall computation cost of large eddy simulation was effectively reduced.The instantaneous flow variables obtained by the large-eddy simulation were used to compute the noise source terms of the Ffowcs Williams-Hawkings equation.The present method was investigated with two test cases:a single cylinder at Re=10,000 and a rod-airfoil at Re=480,000.The flow quantities and aeroacoustic characteristics were compared with the reference data.The mean velocity profiles and spectra of the flow fluctuations were consistent with data from the literature.When compared with the reference data,the noise computation error was less than 3 dB.The computation results demonstrate the present wall-modeled large eddy simulation is efficient for the noise computation of complex vortex shedding flows.

关键词： Aeroacoustic prediction Wall-modeled large-eddy simulation Vortex shedding Vortex interaction noise

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：