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Construct hepatic analog by cell-matrix controlled assembly technology

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Chinese Science Bulletin 2006年第15期51卷 1830-1835页

作者： LIU haixia yan Yongnian WANG Xiaohong CHENG Jie LIN Feng XIONG Zhuo Wu Rendong Institute of Life Science & Medicine/Center of Organism Manufacturing Department of Mechanical Engineering Tsinghua University Beijing 100084 China

A mixture of hepatic cells and chito- san/gelatin solution was deposited to construct a hepatic analog by way of layer-by-layer deposition technique using a home-made devise. The size and cell concentration of the analogs can be controlled freely. Approximately 90% of the hepatic cells re- mained viable under 0.2 Mpa extrusion pressure. Cultured in vitro 8 weeks before animal test, hepatic cells in structure maintained their phenotype and kept proliferating, and albumin and other secretion of the cells increased. Cords and hepaton-like structures were observed after culture for 20 d. These results indicate that hepatic cells could be assembled di- rectly into a 3D viable structure and expanded to form a hepatic organoid. This accomplishment is consid- ered to be an interesting means for the fabrication of liver replacements.

关键词：肝细胞动物模型壳聚糖凝胶肝类似物

An early screening model of pulse detection technology for hepatic steatosis

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Intelligent Medicine 2023年第4期3卷 280-286页

作者： Wenjie Wu Chunke Zhang Xiaotian Ma Rui Guo Jianjun yan Yiqin Wang haixia yan Yeqing Zhang Department of Basic Medical Science Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Intelligent Perception and Diagnosis School of Mechanical and Power EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Chinese Internal Medicine Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai 200071China

Background The increasing prevalence of hepatic steatosis presents a considerable challenge to public *** is a critical need for the development of novel preventive and screening strategies for this *** evaluated the potential applications of wrist pulse detection technology for the early detection of *** pulse time-domain features of a medical exam population with and without hepatic steatosis wereassessed to develop a screening model for this *** Participants were consecutively recruited from March 2021 to March 2022 in the medical examinationcenters of the Yueyang Hospital of Integrated Traditional Chinese and Western Medicine and the Shanghai Municipal Hospital of Traditional Chinese *** data from 255 participants,including general information(sex,age,and body mass index),and data related to glucose and blood lipids(fasting plasma glucose,triglyceride,total cholesterol,high-density lipoprotein,and low-density lipoprotein levels)were *** pulse signalswere acquired using a pulse detection device,and the pulse time-domain features,including t_(1),t_(4),t_(5),T,w_(1),w_(2),h_(2)/h_(1),h_(3)/h_(1),and h5/h_(1) were *** were assigned to hepatic steatosis and non-hepatic steatosisgroups according to their abdominal ultrasound examination *** clinical data and pulse time-domainfeatures were compared using chi-square and parametric or non-parametric statistical *** datasetswere used to construct screening models for hepatic steatosis based on the random forest *** datasetsfor modeling were defined as Dataset 1,containing blood glucose and lipid data and general information;Dataset2,containing time-domain features and general information;Dataset 3,containing time-domain features,bloodglucose and lipid data,and general *** evaluation metrics,accuracy,precision,recall,F1-score,andareas under the receiver operating characteristic curve(AUC

关键词： Pulse detection technology Time-domain method Hepatic steatosis Early screening Random forest

Attention network function of insomniacs improved by manual acupuncture: Evidence from Attention Network Task

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World Journal of Acupuncture-Moxibustion 2019年第2期29卷 91-96页

作者： Fei-yi ZHAO Hong XU Yu-fang HONG Ying-xia ZHAO haixia yan Qia-yi MA Xing MING Jing HU yan XU Nursing Department Shanghai Sanda University Shanghai 201209 China Shanghai Municipal Hospital of TCM affiliated to Shanghai TCM University Shanghai 200071 China College of Basic Medicine Shanghai University of TCM Shanghai 201203 China Shanghai Tianshan Hospital of TCM Shanghai 200051 China

Objective:To investigate if manual acupuncture can improve the primary insomnia-induced impairments of attention network function and its ***:Totally 64 eligible participants were enrolled in a randomized controlled trial,with 32 cases allocated to the treatment group and 32 cases allocated to the control group,*** participants in the treatment group received real-acupuncture therapy[acupuncture at 'Five Spirits Acupoints' including Shéntíng(神庭 GV 24),Běnshén(本神 GB 13),Sìshéncōng(四神聪 EX-HN 1),Shéndào(神道 GV11)and Shénmén(神门 HT 7)]whereas participants in control group received sham-acupuncture therapy with Streitberger placebo-needle and same *** were offered every two days and three times a week for total 8 *** Pittsburgh sleep quality index(PSQI)and Attention Network Task(ANT)were employed to assess the changes of sleep quality and attention network function at pretreatment and post-treatment,***,adverse effects were monitored and ***:(1)After 8-week treatment,the total score of PSQI in the treatment group decreased from14.22±3.46 to 8.19±3.34(P<0.001),and the total score of PSQI in the control group decreased from12.84±3.90 to 11.41±3.90(P<0.05).The decrease in the treatment group was more significant than that in the control group(P<0.001).(2)After treatment,the alerting efficiency of both groups increased,the treatment group increased from 40.44±5.62 to 56.44±5.37(P<0.001),and the control group increased from 39.50±6.39 to 40.06±6.14(P<0.05).The increase in the treatment group was more significant than that in the control group(P<0.001).The total reaction time of both groups decreased,the treatment group decreased from 574.94±10.1 to 548.34±15.05(P<0.001),and the control group decreased from578.25±13.26 to 576.78±12.15(P<0.05).The decrease in the treatment group was more significant than that in the control group(P<0.001).(3)No obvious change in orienting efficiency was observed in

关键词： Insomnia Attention network function Acupuncture

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采用统一建模的拥挤度驱动三维芯片布局算法

计算机辅助设计与图形学学报 2008年第10期20卷 1271-1275页

作者：闫海霞周强洪先龙清华大学计算机科学与技术系北京100084

三维芯片设计对于提高芯片性能以及减少线长显现了很好的优势,降低连线拥挤度是保证布线成功率和三维芯片实现的关键.为了解决三维芯片布局阶段的拥挤度问题,提出一种拥挤度驱动的三维芯片布局算法.该算法首先对拥挤度单元分布和线长等... 详细信息

三维芯片设计对于提高芯片性能以及减少线长显现了很好的优势,降低连线拥挤度是保证布线成功率和三维芯片实现的关键.为了解决三维芯片布局阶段的拥挤度问题,提出一种拥挤度驱动的三维芯片布局算法.该算法首先对拥挤度单元分布和线长等优化目标进行统一建模,利用二次规划求解单元位置,得到一个单元分布均匀、走线均匀以及线长优化的总体布局;然后利用拥挤度驱动的层分配算法将空间上均匀分布的单元分配到各个芯片层上;最后对各个芯片层进行详细布局,消除重叠,优化拥挤度和线长.实验结果表明,该算法能够改善走线拥挤度约15%,而线长仅有3%的增加.

关键词：三维芯片拥挤度统一建模二次规划布局

Progress and Prospects in Propagation Techniques for Camellia nitidissima

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Agricultural Biotechnology 2017年第6期6卷 13-16页

作者： Changyan HUANG Zhaoyang BU Xiaoguo WANG Jingzhou HE haixia yan Zhugui ZHOU Flower Research Institute Guangxi Academy of Agricultural Sciences Nanning 530007 China

Camellia nitidissima is a species of shrub or small tree whose leaves and leaf buds are used to produce tea. In recent years, C. nitidissima planting area has been increasing, resulting in the growing gap between the supply and demand of C. nitidissima seedlings. At present, C. nitidissima can be propagated through seeding, cutting, grafting, plant tissue culture and air layering. Among them, cutting and tissue culture are the most commonly used methods for rapid propagation of C. nitidissima. Optimal rooting medium, type and concentration of hormones and environmental conditions are critical factors for C. nitidissima propagation by cuttings, while detoxification and optimization of medium composition are important for C. nitidissima propagation by tissue culture. This paper reviews recent pro- gress in propagation techniques for C. nitidissima, and finally puts forward some prospects and suggestions in C. nitidissima propagation.

关键词： Camellia nitidissima Propagation Cutting Tissue culture

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试论发展21世纪马克思主义的三维向度

西安交通大学学报（社会科学版） 2018年第3期38卷 96-103页

作者：温海霞燕连福西安交通大学马克思主义学院陕西西安710049

马克思主义的发展作为一个整体性的过程而存在,发展21世纪马克思主义,需要将其置于过程视角整体把握,从历史、当下、未来三重维度进行理论认识和实践关注。要追溯马克思主义的理论源流和世界科学社会主义的历史演进,从理论逻辑与历史逻... 详细信息

马克思主义的发展作为一个整体性的过程而存在,发展21世纪马克思主义,需要将其置于过程视角整体把握,从历史、当下、未来三重维度进行理论认识和实践关注。要追溯马克思主义的理论源流和世界科学社会主义的历史演进,从理论逻辑与历史逻辑中把握21世纪马克思主义的理论初心及其历史方位,在历史沿承中创新发展;要立足世界社会主义的现实,以中国特色社会主义为核心,在构建当代中国马克思主义的过程中巩固21世纪马克思主义的现实根基;要指向未来,在对人类社会发展重大问题的科学研判和对人类命运共同体的深切关怀中不断推进21世纪马克思主义的发展。

关键词： 21世纪马克思主义世界社会主义中国特色社会主义人类命运共同体

A New Record of Orchidaceae from Guangxi:Galeola nudifolia Lour.

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Asian Agricultural Research 2020年第12期12卷 67-68,76页

作者： Xueqiang CUI Changyan HUANG Jieling DENG Qian SONG haixia yan Xuan TANG Zibin ZHANG Flower Research Institute Guangxi Academy of Agricultural Sciences Nanning 530007 China

This paper reported a new record of Orchidaceae from Guangxi,Galeola nudifolia *** species was previously known from Hainan Province and Yunnan Province of China,India,Myanmar,Vietnam,Thailand,Malaysia,Indonesia and the *** new Orchidaceae record has broken the record of only one species of the genus Galeola *** Guangxi,and it filled the gap in the northern part of the original distribution area,and proved that the species in general is in a continuous distribution *** new Orchidaceae record in Guangxi is of great significance to the study of the distribution pattern and geographical origin of the species.

关键词： Guangxi Zhuang Autonomous Region Orchidaceae New record Galeola nudifolia Lour.

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动态时钟拓扑引导下的布局算法

计算机辅助设计与图形学学报 2013年第5期25卷 745-750,757页

作者：刘大为姬改县闫海霞工程兵学院指挥系徐州221004 北京华大九天软件有限公司北京100102

为了优化时钟线网,提出一种动态时钟拓扑引导下的布局算法.该算法中采用由从上而下的划分和从下而上的结群过程建立时钟的拓扑结构,并在布局过程中能够随着时钟节点分布变化对拓扑进行动态调整;通过对底层时钟子集节点的子群添加伪线网... 详细信息

为了优化时钟线网,提出一种动态时钟拓扑引导下的布局算法.该算法中采用由从上而下的划分和从下而上的结群过程建立时钟的拓扑结构,并在布局过程中能够随着时钟节点分布变化对拓扑进行动态调整;通过对底层时钟子集节点的子群添加伪线网来引导节点的分布,结群和伪线网也可以随节点分布动态调整,使时钟优化与未来的时钟综合过程更加匹配.实验结果表明,文中算法可以有效地减少时钟线长、降低功耗.

关键词： VLSI 时钟线网布局

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次氯酸钠固体淀粉黏合剂的研制

中国粮油学报 2008年第4期23卷 107-110页

作者：仝其根闫海霞北京农学院食品科学系北京102206

氧化淀粉的优化生产工艺条件是:淀粉:NaClO=100∶8、pH=8、温度45℃、时间135 min。固体黏合剂的原料最佳配比为:淀粉:NaOH∶硼砂(NaB4O7.10H2O)∶羧甲基纤维素钠(CMC-Na)∶黄原胶∶明胶与硫酸铝钾混合物(1∶1)=100∶1.5∶2.5∶2∶1∶3.7。

关键词：次氯酸钠玉米淀粉黏合剂