检索结果-南通市图书馆

Study on blood pressure rhythm in hypertensive patients with Yin deficiency syndrome and a random forest model for predicting hypertension with Yin deficiency syndrome

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2024年第3期44卷 564-571页

作者： ZHOU Ying LI Ping luan Jianwei SHEN Rui WU Yinglan XU Qiwen WANG Xinyue ZHU Yao XU Xiangru LIU Zitian JIANG Yuning ZHONG Yong HE Yun JIANG Weimin Department of Cardiology the Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Traditional Chinese MedicineNanjing 210029China Department of Health Management Centre Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002China Emergency Department Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of General Internal Medicine the Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Traditional Chinese MedicineNanjing 210029China

OBJECTIVE: To investigate blood pressure rhythm(BPR)in Yin deficiency syndrome of hypertension(YDSH)patients and develop a random forest model for predicting ***: Our study was consistent with technical processes and specification for developing guidelines of Evidence-based Chinese medicine clinical practice(T/CACM 1032-2017). We enrolled 234 patients who had been diagnosed with primary hypertension without antihypertensive medications prior to the enrollment. All participants were divided into Yin deficiency group(YX, n = 74) and non-Yin deficiency group(NYX, n = 160).Participants were professionally grouped by three experienced chief Traditional Chinese Medicine(TCM)physicians according to four examinations(i.e.,inspection, listening and smelling, inquiry and palpation).We collected data on 24 h ambulatory blood pressure monitoring(ABPM) and YDSH rating scale. We divided 24 h of a day into 12 two-hour periods [Chen-Shi(7:00-9:00), Si-Shi(9:00-11:00), Wu-Shi(11:00-13:00), Wei-Shi(13:00-15:00), Shen-Shi(15:00-17:00), You-Shi(17:00-19:00), Xu-Shi(19:00-21:00), Hai-Shi(21:00-23:00), ZiShi(23:00-1:00), Chou-Shi(1:00-3:00), Yin-Shi(3:00-5:00), Mao-Shi(5:00-7:00)] according to the theory of “midnight-midday ebb flow”. We used random forest to build the diagnostic model of YDSH, with whether it was Yin deficiency syndrome as the outcome. RESULTS: Compared with NYX group, YX group had more female participants with older age, lower waist circumference, body mass index(BMI), diastolic blood pressure(DBP), and smoking and drinking rate(all P < 0.05). The YDSH rating scores of YX group [28.5(21.0-36.0)] were significantly higher than NYX group [13.0(8.0-22.0)](P < 0.001), and the typical symptoms of YX group included vexing heat in the chest, palms and soles, dizziness, dry eyes, string-like and fine pulse, soreness and weakness of lumbus and knees, palpitations, reddened cheeks, and tinnitus(all P < 0.05). The ratio of non-dipper hypertension in YX group was higher t

关键词： hypertension Yin deficiency syndrome random forest blood pressure rhythm blood pressure variability

在线全文

学校读者我要写书评

暂无评论

基于大数据背景的智慧旅游管理模式

山西财经大学学报 2024年第S1期46卷 67-69页

作者：栾玲北京工业职业技术学院北京100042

随着经济的快速发展,人们的精神生活需求不断提高。大数据背景下旅游形态发生改变,形成现代化智慧旅游管理模式。智慧旅游模式可以促进旅游景区经营管理效率的提升。大数据时代旅游业竞争日益激烈,必须实现对传统管理模式的变革,注重信... 详细信息

随着经济的快速发展,人们的精神生活需求不断提高。大数据背景下旅游形态发生改变,形成现代化智慧旅游管理模式。智慧旅游模式可以促进旅游景区经营管理效率的提升。大数据时代旅游业竞争日益激烈,必须实现对传统管理模式的变革,注重信息数据的挖掘整理,开辟智慧旅游良好局面。本文概述了智慧旅游管理内涵,阐明了大数据时代智慧旅游管理的优势,进一步分析了大数据背景下智慧旅游管理存在的问题,提出了基于大数据的智慧旅游管理模式的构建策略。

关键词：大数据智慧旅游管理模式

Toosendanin: upgrade of an old agent in cancer treatment

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2024年第10期22卷 887-899页

作者： LI Shuwei XIONG Qingyi SHEN Yiwen LIN Jiayi ZHANG Lijun WU Ye JIN Jinmei luan Xin Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology Institute of Interdisciplinary Integrative Medicine Research and Shuguang Hospital Shanghai University of Traditional Chinese Medicine

Toosendanin(TSN), a tetracyclic triterpenoid derived from Melia toosendan and M. azedarach, demonstrates broad application prospects in cancer treatment. Although previously employed as a pesticide, recent studies have revealed its potential therapeutic value in treating various types of cancer. TSN exerts an anticancer effect via mechanisms including proliferation inhibition, apoptosis induction, migration suppression, and angiogenesis inhibition. However, TSN's toxicity, particularly its hepatotoxicity, significantly limits its therapeutic application. This review explored the dual nature of TSN, evaluating both its anticancer potential and toxicological risks, emphasizing the importance of balancing these aspects in therapeutic applications. Furthermore, we investigated the incorporation of TSN into novel therapeutic strategies, such as Proteolysis-targeting chimeras(PROTAC) technology and nanotechnology-based drug delivery systems(DDS), which enhance treatment efficacy while mitigating toxicity in normal tissues.

关键词： Cancer therapy Hepatotoxicity Nano-delivery systems PROTAC Toosendanin

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

窗口长度自适应调整的策略迭代最优控制

控制理论与应用 2024年第4期41卷 745-750页

作者：方欣栾小丽刘飞江南大学自动化研究所轻工过程先进控制教育部重点实验室江苏无锡214122

在系统模型参数未知的最优控制问题中,策略迭代能否快速收敛到最优控制策略的关键在于值函数的估计.为了提升值函数的估计精度以及收敛速度,本文提出一种窗口长度自适应调整的策略迭代最优控制算法.充分利用一段时间内的历史样本数据,... 详细信息

在系统模型参数未知的最优控制问题中,策略迭代能否快速收敛到最优控制策略的关键在于值函数的估计.为了提升值函数的估计精度以及收敛速度,本文提出一种窗口长度自适应调整的策略迭代最优控制算法.充分利用一段时间内的历史样本数据,通过影响力函数构建窗口长度与值函数估计性能之间的定量关系,根据数据窗口长度对估计性能影响力的不同,实现窗口长度的自适应调整.最后,将本文所提方法应用到连续发酵过程,结果表明,本文所提方法能够加快最优控制策略的收敛,克服参数变化或外部扰动对控制性能的影响,从而提升控制精度.

关键词：最优控制策略迭代窗口长度自适应调整影响力函数

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

徽学研究兴起往事

中国史研究动态 2024年第2期 32-38页

作者：栾成显中国社会科学院古代史研究所北京100101

1964年8月,我从北京师范大学历史系本科毕业,考取中国科学院哲学社会科学部历史研究所张政烺的研究生,来到历史研究所读研。不过,进所仅一个月,即随本所人员到山东搞“四清”,随后又进行劳动实习锻炼,至1965年底才回到北京。1966年初又... 详细信息

1964年8月,我从北京师范大学历史系本科毕业,考取中国科学院哲学社会科学部历史研究所张政烺的研究生,来到历史研究所读研。不过,进所仅一个月,即随本所人员到山东搞“四清”,随后又进行劳动实习锻炼,至1965年底才回到北京。1966年初又参加京郊门头沟“四清”两个月。而后遇到“文革”,学部成了重灾区,图书馆长期关闭,一直无法正规学习。“文革”结束以后,1964年进所的这批研究生遂转为正式研究人员。1977年,哲学社会科学部从中国科学院分离出来,中国社会科学院正式成立,研究业务逐渐恢复。改革开放之初,社会上掀起了一股科学热、学习潮,在社会科学界,多年积赞的研究热情也进发出来。

关键词：中国科学院中国社会科学院社会科学界研究生徽学研究哲学社会科学张政烺图书馆

Author correction to “Tumor-microenvironment activated duplex genome-editing nanoprodrug for sensitized near-infrared titania phototherapy” [Acta Pharm Sin B (2022) 4224-4234]

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第2期14卷 897-899页

作者： Zekun Li Yongchun Pan Shiyu Du Yayao Li Chao Chen Hongxiu Song Yueyao Wu Xiaowei luan Qin Xu Xiaoxiang Guan Yujun Song Xin Han Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica School of Medicine&Holistic Integrative MedicineJiangsu Joint International Research Laboratory of Chinese Medicine and Regenerative MedicineNanjing University of Chinese MedicineNanjing 210023China College of Engineering and Applied Sciences Jiangsu Key Laboratory of Artificial Functional MaterialsState Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjing 210023China Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

The authors regret that there is an error in the article Fig.5E due to the mistake of copying and pasting in the process of assembling figures and negligence in the *** it does not affect the conclusion,it is an obvio... 详细信息

关键词： journal correction conclusion

Esophageal cancer screening,early detection and treatment:Current insights and future directions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1180-1191页

作者： Hong-Tao Qu Qing Li Liang Hao Yan-Jing Ni Wen-Yu luan Zhe Yang Xiao-Dong Chen Tong-Tong Zhang Yan-Dong Miao Fang Zhang Department of Emergency Yantai Mountain HospitalYantai 264000Shandong ProvinceChina Cancer Center Yantai Affiliated Hospital of Binzhou Medical UniversityThe 2nd Medical College of Binzhou Medical UniversityYantai 264100Shandong ProvinceChina

Esophageal cancer ranks among the most prevalent malignant tumors globally,primarily due to its highly aggressive nature and poor survival *** to the 2020 global cancer statistics,there were approximately 604000 new cases of esophageal cancer,resulting in 544000 *** 5-year survival rate hovers around a mere 15%-25%.Notably,distinct variations exist in the risk factors associated with the two primary histological types,influencing their worldwide incidence and *** cell carcinoma displays a high incidence in specific regions,such as certain areas in China,where it meets the cost-effect-iveness criteria for widespread endoscopy-based early diagnosis within the local ***,adenocarcinoma(EAC)represents the most common histological subtype of esophageal cancer in Europe and the United *** role of early diagnosis in cases of EAC originating from Barrett's esophagus(BE)remains a subject of *** effectiveness of early detection for EAC,particularly those arising from BE,continues to be a debated *** variations in how early-stage esophageal carcinoma is treated in different regions are largely due to the differing rates of early-stage cancer *** areas with higher incidences,such as China and Japan,early diagnosis is more common,which has led to the advancement of endoscopic methods as definitive *** techniques have demonstrated remarkable efficacy with minimal complications while preserving esophageal *** screening,prompt diagnosis,and timely treatment are key strategies that can significantly lower both the occurrence and death rates associated with esophageal cancer.

关键词： Esophageal cancer Screening Early detection Treatment Endoscopic mucosal resection Endoscopic submucosal dissection

Efficacy of Online Learning and Influence on Skin and Eyes Among College Students

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Plant Engineering and Management 2024年第1期29卷 14-27页

作者： luan Mei LI Luyao CHEN Jianan ZHAO Yixin HE qiannan Department of Dermatology the Frist Affiliated Hospital of Xi′an Jiaotong UniversityXi′an 710061China Department of Pathology the First Affiliated Hospital of Xi′an Jiaotong UniversityXi′an 710061China

To evaluate the efficacy of online learning and explore the impact of long-term use of electronic products on facial skin as well as eyes.A cross-sectional survey was conducted to 180 sophomores in Xi′an Jiaotong University by cluster random sampling from September to October *** questionnaire covering study condition,skin lesion and Ocular Surface Disease Index.χ_(2) test was used to compare the facial skin condition among different groups,and spearman correlation test was used to test the correlation of rank *** online education,students′learning pressure is reduced,their autonomy is improved,and the learning efficiency is *** were differences in the incidence of facial itching and papules among different *** of use of electronic products was positively correlated with the facial itching,with an r value of 0.231(P<0.05);the proportion of pigmentation in non-blue light protection groups(12.8%)was higher than that in blue light protection groups(1.7%),the difference was statistically significant(χ_(2)=8.384,P<0.05).The prevalence of dry eye among college students is 66.7%,and the proportion of moderate to severe dry eye is 34.5%.The study autonomy has been improved during online ***-term use of electronic products and no blue light protection have an impact on facial *** should enhance the knowledge of skin-care and eye-care and develop better habits.

关键词： online learning facial skin dry eye college students

“时代新人”精神状态的前提追问、主要内容及优化路径

在线全文

学校读者我要写书评

暂无评论

思想政治教育研究 2024年第4期40卷 133-140页

作者：栾青天津理工大学马克思主义学院天津300380

进入新时代,民族复兴伟业对担当大任的“时代新人”在各项能力和素质上都提出来更高的要求。据此,我们对“时代新人”进行了更加深入地探索,充分认识到其精神状态的重要性。要优化“时代新人”的精神状态就要从历史进程、现实发展以及... 详细信息

进入新时代,民族复兴伟业对担当大任的“时代新人”在各项能力和素质上都提出来更高的要求。据此,我们对“时代新人”进行了更加深入地探索,充分认识到其精神状态的重要性。要优化“时代新人”的精神状态就要从历史进程、现实发展以及理论渊源三个层面追问考察时代新人精神状态的依据,回答“为什么优化”的问题;全面分析其精神状态的主要内容,明确“优化什么”;进而通过深刻认识和发挥理论知识、文化资源、实践锻炼以及人的主观因素在优化人精神状态过程中的作用,帮助“时代新人”最终达成良好的精神状态,解决“如何优化”的问题。

关键词：时代新人精神状态优化路径