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Applications of Next-generation Sequencing in Systemic Autoimmune Diseases

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Genomics, Proteomics & Bioinformatics 2015年第4期13卷 242-249页

作者： Yiyangzi Ma Na Shi Mengtao Li Fei Chen haitao niu Institute of Laboratory Animal Sciences Chinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical Collage Department of Rheumatology and Clinical Immunology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical Collage CAS Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics Chinese Academy of Sciences

Systemic autoimmune diseases are a genetic and environmental factors. Although group of heterogeneous disorders caused by both numerous causal genes have been identified by genome-wide association studies （GWAS）, these susceptibility genes are correlated to a relatively low disease risk, indicating that environmental factors also play an important role in the pathogen- esis of disease. The intestinal microbiome, as the main symbiotic ecosystem between the host and host-associated microorganisms, has been demonstrated to regulate the development of the body＇s immune system and is likely related to genetic mutations in systemic autoimmune diseases. Next-generation sequencing （NGS） technology, with high-throughput capacity and accuracy, provides a powerful tool to discover genomic mutations, abnormal transcription and intestinal microbiome identification for autoimmune diseases. In this review, we briefly outlined the applications of NGS in systemic autoimmune diseases. This review may provide a reference for future studies in the pathogenesis of systemic autoimmune diseases.

关键词： Next-generation sequencing Intestinal microbiome Susceptibility genes Systemic autoimmune diseases

Interaction between the gut microbiome and mucosal immune system

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Military Medical Research 2017年第3期4卷 170-177页

作者： Na Shi Na Li Xinwang Duan haitao niu Institute of Laboratory Animal Sciences Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center Peking Union Medical Collage (PUMC) Key Laboratory of Human Disease Comparative Medicine Ministry of Health Department of Rheumatology the Second Affiliated Hospital of Nanchang University

The gut microbiota, the largest symbiotic ecosystem with the host, has been shown to play important roles in maintaining intestinal homeostasis. Dysbiosis of the gut microbiome is caused by the imbalance between the commensal and pathogenic microbiomes. The commensal microbiome regulates the maturation of the mucosal immune system, while the pathogenic microbiome causes immunity dysfunction, resulting in disease *** gut mucosal immune system, which consists of lymph nodes, lamina propria and epithelial cells, constitutes a protective barrier for the integrity of the intestinal tract. The composition of the gut microbiota is under the surveillance of the normal mucosal immune system. Inflammation, which is caused by abnormal immune responses,influences the balance of the gut microbiome, resulting in intestinal diseases. In this review, we briefly outlined the interaction between the gut microbiota and the immune system and provided a reference for future studies.

关键词： Microbiome Immunity Inflammation

Recent Advances in Superhydrophobic and Antibacterial Cellulose‑Based Fibers and Fabrics:Bio‑inspiration,Strategies,and Applications

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Advanced Fiber Materials 2023年第5期5卷 1555-1591页

作者： Hua Zhou Qingshuo Li Zhong Zhang Xungai Wang haitao niu College of Textiles and Clothing Qingdao UniversityQingdao 266071China Collaborative Innovation Center for Eco‑Textiles of Shandong Province and the Ministry of Education Collaborative Qingdao UniversityQingdao 266071China JC STEM Lab of Sustainable Fibers and Textiles School of Fashion and TextilesThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

Cellulose-based fabrics are ubiquitous in our daily *** are the preferred choice for bedding materials,active sportswear,and next-to-skin ***,the hydrophilic and polysaccharide characteristics of cellulose materials make them vulnerable to bacterial attack and pathogen *** design of antibacterial cellulose fabrics has been a long-term and on-going *** strategies based on the construction of surface micro-/nanostructure,chemical modification,and the application of antibacterial agents have been extensively investigated by many research groups *** review systematically discusses recent research on super-hydrophobic and antibacterial cellulose fabrics,focusing on morphology construction and surface ***,natural surfaces showing liquid-repellent and antibacterial properties are introduced and the mechanisms behind are ***,the strategies for fabricating super-hydrophobic cellulose fabrics are summarized,and the contribution of the liquid-repellent function to reducing the adhesion of live bacteria and removing dead bacteria is *** studies on cellulose fabrics functionalized with super-hydrophobic and antibacterial properties are discussed in detail,and their potential applications are also ***,the challenges in achieving super-hydrophobic antibacterial cellulose fabrics are discussed,and the future research direction in this area is proposed.

关键词： Cellulose fiber Super-hydrophobic Antibacterial Fabrication strategies Applications

A pilot phase Ⅱ study of neoadjuvant triplet chemotherapy regimen in patients with locally advanced resectable colon cancer

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Chinese Journal of Cancer Research 2016年第6期28卷 598-605页

作者： haitao Zhou Yan Song Jun Jiang haitao niu Hong Zhao Jianwei Liang Hao Su Zheng Wang Zhixiang Zhou Jing Huang Department of Colorectal Surgery National Cancer Center/Cancer HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology National Cancer Center/Cancer HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100021China Department of Imageology National Cancer Center/Cancer HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100021China Department of Abdominal Surgery National Cancer Center/Cancer HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100021China

Objective： This study aims to investigate the feasibility, safety and efficacy of triplet regimen of neoadjuvant chemotherapy in patients with locally advanced resectable colon ***： Patients with clinical stage IIIb colon cancer received a perioperative triple chemotherapy regimen（oxaliplatin 85 mg/m2 and irinotecan 150 mg/m2, combined with folinic acid 200 mg, 5-fluorouracil 500 mg bolus and then 2,400 mg/m2 by 44 h infusion or capecitabine 1 g/m2 or S-1 40–60 mg b.i.d orally d 1–10, repeated at 2-week intervals） for 4 cycles. Complete mesocolic excision was scheduled 2–6 weeks after completion of neoadjuvant treatment and followed by a further 6 cycles of FOLFOXIRI or XELOX. Primary outcome measures of this stage II trial were feasibility, safety, tolerance and efficacy of neoadjuvant ***： All 23 patients received neoadjuvant chemotherapy and underwent surgery. Twenty-one patients（91.3%） had reductions in tumor volume after neoadjuvant treatment, and 13 patients（56.5%） had grade 3–4toxicity. No patients had severe complications from surgery. Preoperative therapy resulted in significant downstaging of T-stage and N-stage compared with the baseline clinical stage including one pathological complete ***： Neoadjuvant triple chemotherapy has high activity and acceptable toxicity and perioperative morbidity, and is feasible, tolerable and effective for locally advanced resectable colon cancer.

关键词： 5-Fluorouracil colon cancer irinotecan oxaliplatin neoadjuvant chemotherapy

The status,limitation and improvement of adoptive cellular immunotherapy in advanced urologic malignancies

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Chinese Journal of Cancer Research 2015年第2期27卷 128-137页

作者： Haoqing Shi Xiangjie Qi Bin Ma Yanwei Cao Lina Wang Lijiang Sun haitao niu Department of Urology Affiliated Hospital of Qingdao University Department of Urology People's Hospital of Linzi District Medical College of Qingdao University

In recent years, immunotherapy has been gradually established as the fourth frequently adopted antitumor therapy, following surgery, chemotherapy and radiotherapy, for advanced urologic malignancies with an improved understanding of theoretical basis, such as molecular biology and immunology. Thereinto, adoptive cellular immunotherapy （ACI） has become one of the hotspots, which comprises a variety of treatment approaches, such as TIL, CIK cell, ~＇~ T cell, CAR-engineered T cell and Allogeneie stem cell transplantation （alloSCT）. Although preclinical efficacy has been demonstrated remarkably, clinical trials could not consistently show the benefit due to multi-factors in complex immnnosuppressive microenvironment in vivo compared to that of in vitro. Here we review some timely aspects of ACI for advanced urologic malignancies, and describe the current status and limitation of immunotherapy from the cellular level. It＇s our expectation to provide prompting consideration of novel combinatorial ACI strategies and a resurgence of interest in ACI for advanced urologic malignancies.

关键词： Adoptive cellular immunotherapy (ACI) limitation improvement urologic malignancies

Protective effect of hydroxychloroquine on rheumatoid arthritis-associated atherosclerosis

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Animal Models and Experimental Medicine 2019年第2期2卷 98-106页

作者： Na Shi Shuangyue Zhang Gregg Silverman Mengtao Li Jun Cai haitao niu NHC Key Laboratory of Human Disease Comparative Medicine (The Institute of Laboratory Animal Sciences CAMS&PUMC) Key Laboratory of Human Diseases Animal Model State Administration of Traditional Chinese Medicine Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases Beijing China Department of Rheumatology Langone Medical Center New York University New York City New York Peking Union Medical College Hospital Beijing China Fuwai Hospital Chinese Academy of Medical Sciences Beijing China

Background: Patients with rheumatoid arthritis (RA) have an increased risk for cardiovascular disease. We examined the effect of gut microbiota in a mouse model of RA that develops atherosclerosis. Methods: We created three groups of K/BxN female mice that were positive for the anti‐glucose‐6‐phosphate isomerase (GPI) antibody: control diet (CD), high fat diet (HFD), and HFD with hydroxychloroquine (HFD + HCQ). Serological tests were used to detect the serum levels of total cholesterol (TCHO), low‐density lipoprotein cholesterol (LDL‐C), triglyceride (TG), high‐density lipoprotein cholesterol (HDL‐C), anti‐ GPI antibody titers, and serum cytokines. Atherosclerotic plaque was determined by histological analysis, and gut microbiota were determined by 16sV4 sequencing. Results: Relative to mice given the CD, those receiving the HFD had increased serum levels of LDL‐C, TCHO, and TG, decreased serum levels of HDL‐C, increased atherosclerotic lesions in the aortic root, and altered gut microbiota. Addition of HCQ to HFD decreased the serum levels of LDL‐C, TCHO, and TG, increased serum levels of HDL‐C, and decreased the atherosclerotic lesions in the aortic root. Mice receiving HFD + HCQ also had the greatest bacterial diversity among the three experimental groups. Moreover, HCQ treatment significantly increased the abundance of Akkermansia and Parabacteroides, and decreased the abundance of Clostridium sensu stricto cluster 1, and therefore may be responsible for the reduced RA‐associated atherosclerosis and dyslipidemia. Conclusion: Our mouse model of RA indicated that HFD increased ankle width and aggravated a therosclerosis a nd d yslipidemia, a nd t hat H CQ a lleviated t he d yslipidemia and atherosclerosis, but had no effect on ankle width.

关键词： atherosclerosis autoimmunity hydroxychloroquine intestinal microbiota rheumatoid arthritis

Mucin-Producing Urothelial-Type Adenocarcinoma of the Prostate (a Case Report and Review of the Literature)

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Chinese Journal of Clinical Oncology 2006年第5期3卷 370-372页

作者： haitao niu Guang Sun Jiwu Chang Yibing Zhang Department of Urology Second Hospital of Tianjin Medical University Institute of Urology Tianjin 300211 China.

OBJECTIVE To report clinical and pathologic findings of one case of mucin-producing urothelial-type adenocarcinoma of the prostate, and to discuss the diagnosis and prognosis of this disease. METHODS The patient was a 60-year-old man who had an 8-month history of urinary frequency and dysuria culminating in an aggravating condition for 10-days. Laboratory results were tPSA 3.0 and fPSA 0.4. An ultrasound and digital rectal exam showed no abnormal findings, so he was diagnosed as having benign prostatic hyperplasia, and underwent a transurethral prostate resection. RESULTS The findings during the operation resembled benign prostatic hyperplasia (BPH), whereas the pathological exam showed that the pro-static construction was deranged in the tumor infiltrating region, with many mucin lakes and signet ring cell in the cancer tissue. Immunohisto-chemical staining revealed that the cancer tissue was negative for prostate-specific antigen (PSA) and postive for carcinoembryonic antigen (CEA). Final diagnosis: mucin-producing urothelial-type adenocarcinoma of the prostate. After 50 Gy radiotherapy, the patient was free of recurrent signs and metastasis up to 8 months after operation. CONCLUSION Mucin-producing urothelial-type adenocarcinoma of the prostate is extremely rare. Its differential diagnosis mainly includes conventional prostatic adenocarcinoma with mucin production and secondary adenocarcinoma. The diagnosis and treatment of this disease should be further investigated.

关键词： mucin-producing urothelial-type adenocarcinoma prostate diagnosis.

Self-crosslinkable chitosan-hyaluronic acid dialdehyde nanoparticles for CD44-targeted siRNA delivery to treat bladder cancer

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Bioactive Materials 2021年第2期6卷 433-446页

作者： Ye Liang Yonghua Wang Liping Wang Zhijuan Liang Dan Li Xiaoyu Xu Yuanbin Chen Xuecheng Yang Hongbo Zhang haitao niu Key Laboratory of Urology and Andrology Medical Research CentreAffiliated Hospital of Qingdao UniversityQingdao266003China Department of Urology Affiliated Hospital of Qingdao UniversityQingdao266003China Pharmaceutical Sciences Laboratory and Turku Bioscience Centre Åbo Akademi UniversityTurku20520Finland

Bladder cancer is one of the concerning malignancies worldwide,which is lacking effective targeted *** therapy is a potential approach for bladder cancer ***,a safe and effective targeted gene delivery system is urgently needed for prompting the bladder cancer treatment in *** this study,we confirmed that the bladder cancer had CD44 overexpression and small interfering RNAs(siRNA)with high interfere to Bcl2 oncogene were designed and *** hyaluronic acid dialdehyde(HAD)was prepared in an ethanol-water mixture and covalently conjugated to the chitosan nanoparticles(CS-HAD NPs)to achieve CD44 targeted siRNA *** in vitro and in vivo evaluations indicated that the siRNA-loaded CS-HAD NPs(siRNA@CS-HAD NPs)were approximately 100 nm in size,with improved stability,high siRNA encapsulation efficiency and low ***-HAD NPs could target to CD44 receptor and deliver the therapeutic siRNA into T24 bladder cancer cells through a ligand-receptor-mediated targeting mechanism and had a specific accumulation capacity in vivo to interfere the targeted oncogene Bcl2 in bladder ***,a CD44 targeted gene delivery system based on natural macromolecules was developed for effective bladder cancer treatment,which could be more conducive to clinical application due to its simple preparation and high biological safety.

关键词： siRNA delivery Chitosan Hyaluronic acid dialdehyde CD44 targeting Bladder cancer

Gut Microbiota Can Promote the Inflammatory Response in The Pathogenesis of Systemic Lupus Erythematosus

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Gut Microbiota Can Promote the Inflammatory Response in The ...