Interaction between the gut microbiome and mucosal immune system

作     者：Na Shi Na Li Xinwang Duan Haitao Niu 

作者机构：Institute of Laboratory Animal Sciences Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center Peking Union Medical Collage (PUMC) Key Laboratory of Human Disease Comparative Medicine Ministry of Health Department of Rheumatology the Second Affiliated Hospital of Nanchang University 

出 版 物：《Military Medical Research》 (军事医学研究（英文版）)

年 卷 期：2017年第4卷第3期

页      面：170-177页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金："PUMC"Fellow award from Peking Union Medical Collage(PUMC)CAMS Initiative for Innovative Medicine(2016-I2M-1-006) 

主　　题：Microbiome Immunity Inflammation 

摘      要：The gut microbiota, the largest symbiotic ecosystem with the host, has been shown to play important roles in maintaining intestinal homeostasis. Dysbiosis of the gut microbiome is caused by the imbalance between the commensal and pathogenic microbiomes. The commensal microbiome regulates the maturation of the mucosal immune system, while the pathogenic microbiome causes immunity dysfunction, resulting in disease *** gut mucosal immune system, which consists of lymph nodes, lamina propria and epithelial cells, constitutes a protective barrier for the integrity of the intestinal tract. The composition of the gut microbiota is under the surveillance of the normal mucosal immune system. Inflammation, which is caused by abnormal immune responses,influences the balance of the gut microbiome, resulting in intestinal diseases. In this review, we briefly outlined the interaction between the gut microbiota and the immune system and provided a reference for future studies.