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实时拉曼光谱分析技术及其在临床早期癌症检测中的应用

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中国激光 2018年第2期45卷 35-49页

作者：王爽 haishan zeng 西北大学光子学与光子技术研究所陕西西安710069 Imaging Unit-Integrative Oncology Department BC Cancer Agency Research CentreVancouverBritish Columbia VSZ 1L3加拿大 Photomedicine Institute Department of Dermatology and Skin ScienceUniversity of British ColumbiaVancouverBritish Columbia V5Z 4E8加拿大

拉曼光谱分析技术可以在分子水平上研究物质分子结构和生化组成信息,具有快速、准确、无创(或低创)等优点,已成为临床早期癌症检测和组织病理生理分析的重要工具。近年来,激光技术、光纤探测器件和光电检测技术的发展,不仅极大促进了新... 详细信息

拉曼光谱分析技术可以在分子水平上研究物质分子结构和生化组成信息,具有快速、准确、无创(或低创)等优点,已成为临床早期癌症检测和组织病理生理分析的重要工具。近年来,激光技术、光纤探测器件和光电检测技术的发展,不仅极大促进了新型拉曼光谱分析仪器与技术的研发,更进一步扩展了其临床应用的广度和深度,彰显出其独特的科学内涵与应用价值。对临床拉曼光谱分析技术的理论基础进行了阐述,归纳总结了临床快速拉曼光谱分析集成系统设计思路。在此基础上,以作者相关研究工作为例,探讨了拉曼光谱分析技术在临床癌症早期检测与病理分析中的应用特点,为推动相关基础研究及技术创新提供有益参考。

关键词：医用光学拉曼光谱早期癌症诊断临床检测仪器皮肤癌肺癌

RAMAN SPECTROSCOPY FOR IN VIVO TISSUE ANALYSIS AND DIAGNOSIS,FROM INSTRUMENT DEVELOPMENT TO CLINICAL APPLICATIONS

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Journal of Innovative Optical Health Sciences 2008年第1期1卷 95-106页

作者： haishan zeng JIANHUA ZHAO MICHAEL SHORT DAVID I.MCLEAN STEPHEN LAM ANNETTE MCWILLIAMS HARVEY LUI Laboratory for Advanced Medical Photonics(LAMP)Cancer Imaging Department British Columbia Cancer Research Centre 675 West 10th Avenue Vancouver BCV5Z 1L3Canada Photomedicine Institute Department of Dermatology and Skin Science University of British Columbia and Vancouver Coastal Health Research Institute 835 West 10th Avenue VancouverBCV5Z 4E8Canada

Raman spectroscopy is a noninvasive,nondestructive analytical method capable of determining the biochemical constituents based on molecular *** does not require sample preparation or ***,the use of Raman spectroscopy for in vivo clinical applications will depend on the feasibility of measuring Raman spectra in a relatively short time period(a few seconds).In this work,a fast dispersive-type nearinfrared(NIR)Raman spectroscopy system and a skin Raman probe were developed to facilitate real-time,noninvasive,in vivo human skin *** image aberration was corrected by a parabolic-line fiber array,permitting complete CCD vertical binning,thereby yielding a 16-fold improvement in signal-to-noise *** quality in vivo skin NIR Raman spectra free of interference from fiber fluorescence and silica Raman scattering can be acquired within one second,which greatly facilitates practical noninvasive tissue characterization and clinical ***,we are conducting a large clinical study of various skin diseases in order to develop Raman spectroscopy into a useful tool for non-invasive skin cancer *** data analysis results are ***,we have also successfully developed a technically more challenging endoscopic Laser-Raman probe for early lung cancer *** in vivo results from endoscopic lung Raman measurements are discussed.

关键词： Rapid Raman system in vivo skin Raman in vivo lung Raman endoscopic Raman probe early cancer detection

Nonlinear optical microscopy for skin in vivo:Basics,development and applications

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Journal of Innovative Optical Health Sciences 2023年第1期16卷 95-113页

作者： Jianhua Zhao Yuan Zhao Zhenguo Wu Yunxian Tian haishan zeng Integrative Oncology Department–Imaging Unit BC Cancer Research Institute VancouverBCCanada Department of Dermatology and Skin Science University of British Columbia and Vancouver Coastal Health Research Institute VancouverBCCanada

Multi-photon microscopy(MPM)and coherent anti-Stokes Raman scattering(CARS)are two advanced nonlinear optical imaging techniques,which provide complementary information and have great potential in combination for noninvasive in vrito biomedical *** paper provides a detailed discussion of the basics,development and applications of these technologies for in vrivo skin research,covering the following topics:The principle and advantage of MPM and CARS,instrumentation development for in vino applications,MPM and CARS of normal skin,application of MPM and CARS in skin cancer and disease diagnosis;application of MPM in skin disease intervention,ie.,imaging guided two-photon photothermolysis.

关键词： Nonlinear microscopy multiphoton microscopy coherent anti-Stokes Raman scattering microscopy skin skin cancer multiphoton therapy

MICROCOMPUTERIZED MEASUREMENT AND ANALYSIS OF ELECTRON EMISSION PROPERTIES OF THERMIONIC CATHODES

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Journal of Electronics(China) 1989年第3期6卷 272-281页

作者：曾海山杨凌云叶毓林 Institute of Electronics Academia SinicaBeijing

A microcomputerized measurement system is *** system automatically acquiresan I-V characteristic curve in 5 seconds with the accuracy of 0.05％ FSR(full scale range).The Schottkyextrapolation field-free emission,the inflection-point emission,the flection-point emission,the average effec-tive work *** Richardson work function,the work function distribution at the operation tempera-ture and other important information that reflects properties of cathodes are obtained by this *** re-sults of analysing four types of cathodes demonstrate that this system is very suitable for measuring the activi-ty changes of the cathode in the processes of activation,ageing,poisoning and life *** is proved that thissystem can also be used to monitor the actlvity of the cathode in the assembled tube by measuring a gridcontrolled travelling-wave tube.

关键词： Thermionic cathode Measurement of thermionic emission properties Work function distribution Inflection-point emission Flection-point emission Application of microcomputer

PROBE-HOLE FIELD EMISSION MICROSCOPE SYSTEM CONTROLLED BY COMPUTER

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Journal of Electronics(China) 1992年第1期9卷 69-75页

作者：巩运明曾海山张恩虬 Peking University Beijing 100871 Institute of Electronics Academia SinicaBeijing 100080

A probe-hole field emission microscope system,controlled by the Apple Ⅱ computer,has been developed and operated successfully for measuring the work function of a single *** detection screen,the phototube and the amplifier are combined for measuring theprobe-hole *** combination is calibrated and the calibrated data are used in the com-puter *** high voltage on the viewing screen is adjusted by using a D/A *** total current and the probe-hole current are acquired by using an A/D converter.A programin BASIC is used for processing all data and the Fowler-Nordheim plot parameters are *** functions of single crystal planes can then be calculated;as examples,the work functionson the clean W(100)and W(111)planes are measured to be 4.67 eV and 4.45 eV,respectively.

关键词： Probe-hole field emission microscope Computer control Work function of single crystal plane

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具有三种颜色的白癜风皮肤的荧光光谱

光学学报 2007年第1期27卷 124-128页

作者：陈荣曾海山黄宝华黄志伟谢树森福建师范大学医学光电科学与技术教育部重点实验室福州350007 加拿大BC癌研究中心

将荧光光谱方法应用于具有三种颜色的白癜风皮肤特性的研究,在对荧光测量以及皮肤组织病理检查的基础上,建立了三色白癜风皮肤的光学模型,分析了皮肤黑色素的含量与分布,并进行了蒙特卡罗计算,其结果与实测结果基本一致。研究表明:具有... 详细信息

将荧光光谱方法应用于具有三种颜色的白癜风皮肤特性的研究,在对荧光测量以及皮肤组织病理检查的基础上,建立了三色白癜风皮肤的光学模型,分析了皮肤黑色素的含量与分布,并进行了蒙特卡罗计算,其结果与实测结果基本一致。研究表明:具有三种颜色的白癜风皮肤可作为一个较好的皮肤黑色素含量与分布的模型;荧光光谱法可以探测到皮肤较深层(真皮层)的黑色素分布或其他组织光学特性;所建立的白癜风皮肤的光学模型及建模方法,所采用的光谱比率法等可以在皮肤光学的其他研究中应用。

关键词：医用光学与生物技术三色白癜风荧光光谱黑色素含量分布蒙特卡罗模拟

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绿色食品的开发与农村经济可持续发展

中国农业银行武汉管理干部学院学报 2001年第5期 59-62页

作者：张开华曾海姗中南财经政法大学工商管理学院湖北武汉430064

本文对绿色食品开发与农村经济可持续发展，以及加快绿色食品开发的作用与前景作了探讨，部析了现阶段影响我国绿色食品开发的制约因素，在此基础上，提出了相应的对策。

关键词：绿色食品开发思路

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纳米碳管激光热疗治疗小鼠肿瘤的初步观察

中国激光医学杂志 2010年第6期19卷 349-349页

作者：黄乃艳 Hequn Wang Jianhua Zhao Harvey Lui Mladen Korbelik haishan zeng Cancer Imaging Department British Columbia Cancer Research CentreVancouver Laboratory for Advanced Medical Photonics Photomedicine InstituteDepartment of Dermatology and Skin ScienceUniversity of British Columbia&Vancouver Coastal Health Research Institute 解放军总医院激光医学科

目的:观察纳米碳管溶液经激光照射后温度升高的情况,以及纳米碳管激光热疗治疗小鼠肿瘤的效果,为肿瘤的治疗提供一种新的思路。材料与方法:SWNT溶液温升实验方法:单壁纳米碳管(single-walled carbon nanotube,SWNT)溶于双蒸水中,配置成... 详细信息

目的:观察纳米碳管溶液经激光照射后温度升高的情况,以及纳米碳管激光热疗治疗小鼠肿瘤的效果,为肿瘤的治疗提供一种新的思路。材料与方法:SWNT溶液温升实验方法:单壁纳米碳管(single-walled carbon nanotube,SWNT)溶于双蒸水中,配置成最大浓度为1mg/ml的倍比稀释溶液。用波长785nm、功率密度分别为100、200、500mW/cm2的激光照射溶液10min,红外测温仪每分钟记录一

关键词：小鼠肿瘤激光热疗 SWNT 纳米碳管

Synthesis and Characterization of a Silica-Based Drug Delivery System for Spinal Cord Injury Therapy

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Nano-Micro Letters 2019年第2期11卷 61-80页

作者： Guodong Sun Shenghui zeng Xu Liu haishan Shi Renwen Zhang Baocheng Wang Changren Zhou Tao Yu College of Chemistry and Material Sciences Jinan UniversityGuangzhou 510632People’s Republic of China Department of Orthopedics First Affiliated HospitalJinan UniversityGuangzhou 510632People’s Republic of China College of Traditional Chinese Medicine Jinan UniversityGuangzhou 510632People’s Republic of China Tsinghua-Berkeley Shenzhen Institute Tsinghua UniversityShenzhen 518055People’s Republic of China

Acute inflammation is a central component in the progression of spinal cord injury(SCI).Anti-inflammatory drugs used in the clinic are often administered systemically at high doses,which can paradoxically increase inflammation and result in drug toxicity.A cluster-like mesoporous silica/arctigenin/CAQK composite(MSN-FC@ARCG)drug delivery system was designed to avoid systemic side effects of high-dose therapy by enabling site-specific drug delivery to the spinal *** this nanosystem,mesoporous silica was modified with the FITC fluorescent molecule and CAQK peptides that target brain injury and SCI *** size of the nanocarrier was kept at approximately 100 nm to enable penetration of the blood–brain ***,a Chinese herbal medicine,was loaded into the nanosystem to reduce *** in vivo results showed that MSN-FC@ARC-G could attenuate inflammation at the injury *** and morphology experiments suggested that MSN-FC@ARC-G could diminish local microenvironment damage,especially reducing the expression of interleukin-17(IL-17) and IL-17-related inflammatory factors,inhibiting the activation of astrocytes,thus protecting neurons and accelerating the recovery of *** study demonstrated that this novel,silica-based drug delivery system has promising potential for clinical application in SCI therapy.

关键词： Silica Drug delivery Spinal cord injury Arctigenin Astrocytes