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Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1

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International Journal of Oral Science 2022年第3期14卷 396-409页

作者： Yu Jin Zhen liu Zhenxia li hairui li Cheng Zhu Ruomei li Ting Zhou Bing Fang Department of Orthodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghaiChina

Osteoarthritis(OA)is a prevalent joint disease with no effective treatment *** mechanical stimuli was demonstrated to be an essential factor for OA *** multiple studies have detected potential regulatory mechanisms underlying OA and have concentrated on developing novel treatment strategies,the epigenetic control of OA remains *** demethylase JMJD3 has been reported to mediate multiple physiological and pathological processes,including cell differentiation,proliferation,autophagy,and ***,the regulation of JMJD3 in aberrant force-related OA and its mediatory effect on disease progression are still *** this work,we confirmed the upregulation of JMJD3 in aberrant forceinduced cartilage injury in vitro and in ***,inhibition of JMJD3 by its inhibitor,GSK-J4,or downregulation of JMJD3 by adenovirus infection of sh-JMJD3 could alleviate the aberrant force-induced chondrocyte *** investigation illustrated that aberrant force induces JMJD3 expression and then demethylates H3K27me3 at the NR4A1 promoter to promote its *** experiments indicated that NR4A1 can regulate chondrocyte apoptosis,cartilage degeneration,extracellular matrix degradation,and inflammatory *** vivo,anterior cruciate ligament transection(ACLT)was performed to construct an OA model,and the therapeutic effect of GSK-J4 was *** importantly,we adopted a peptide-si RNA nanoplatform to deliver si-JMJD3 into articular cartilage,and the severity of joint degeneration was remarkably *** together,our findings demonstrated that JMJD3 is flow-responsive and epigenetically regulates OA *** work provides evidences for JMJD3 inhibition as an innovative epigenetic therapy approach for joint diseases by utilizing p5RHH-si RNA nanocomplexes.

关键词： Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1

The research on structural damage identifcation using rough set and integrated neural network

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Frontiers of Mechanical Engineering 2013年第3期8卷 305-310页

作者： Juelong li hairui li Jianchun XING Qiliang YANG Naval-port Airport Barracks Department of Navy Logistics PLA University of Science ＆ Technology

A huge amount of information and identifcation accuracy in large civil engineering structural damage identifcation has not been addressed *** effciently solve this problem,a new damage identifcation method based on rough set and integrated neural network is frst *** brief,rough set was used to reduce attributes so as to decrease spatial dimensions of data and extract effective *** then the reduced attributes will be put into the sub-neural *** sub-neural network can give the preliminary diagnosis from different aspects of *** decision fusion network will give the fnal damage identifcation *** identifcation examples show that this method can simplify the redundant information to reduce the neural network model,making full use of the range of information to effectively improve the accuracy of structural damage identifcation.

关键词： rough set integrated neural network damage identification decision making fusion

Notch fatigue of Cu50Zr50 metallic glasses under cyclic loading:molecular dynamics simulations

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Communications in Theoretical Physics 2021年第6期73卷 119-125页

作者： Yong Yang hairui li Zailin Yang Jin liu Evans Kabutey Kateye Jianwei Zhao College of Aerospace and Civil Engineering Harbin Engineering UniversityHarbin 150001China Key Laboratory of Advanced Material of Ship and Mechanics Ministry of Industry and Information TechnologyHarbin Engineering UniversityHarbin 150001China College of Materials and Textile Engineering Jiaxing UniversityJiaxing 314000China

Molecular dynamics simulation is performed to simulate the tension–compression fatigue of notched metallic glasses(MGs),and the notch effect of MGs is *** notches will accelerate the accumulation of shear transition zones,leading to faster shear banding around the notches’root causing it to undergo severe plastic ***,a qualitative investigation of the notched MGs demonstrates that fatigue life gradually becomes shorter with the increase in sharpness until it reaches a critical *** fatigue performance of blunt notches is stronger than that of sharp *** the notches blunter can improve the fatigue life of MGs.

关键词： metallic glasses notches fatigue life molecular dynamics simulations

The Research on Safety Evaluation of High-pile Wharf Structure

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仪器仪表学报 2013年第S1期34卷 178-184页

作者： li Jue long Xing Jianchun li hairui Yang Qiliang The Center for Coast Defense Engineering Research of Navy Institute of National Defense Engineering PLA University of Science & Technology

Due to a combination of the sea erosion,the ship collision,the change of ground condition,the effect of alternative static and dynamic load and the material deterioration,the structure of high-pile wharf is easily *** the structure of high-pile wharf destroyed,it is bound to be a great threat to the safety of various facilities and personnel in the *** all of that,the multi-level comprehensive evaluation method based on the extension theory is proposed in this *** this method to assess the safety of high-pile wharf structure,the reasonable advice on its maintenance and reinforcement can be given in ***’s more,the method is simple and can give more objective result of the evaluation.

关键词： high-pile wharf safety evaluation extension theory analytical hierarchy process

Intelligent UAV Based Energy Supply for 6G Wireless Powered IoT Networks

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China Communications 2024年第9期21卷 321-337页

作者： Miao Jiansong Chen Haoqiang Wang Pengjie li hairui Zhao Yan Mu Junsheng Yan Shi School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China Beijing Key Laboratory of Network System Architecture and Convergence Beijing University of Posts and TelecommunicationsBeijing 100876China

In this paper,we develop a 6G wireless powered Internet of Things(IoT)system assisted by unmanned aerial vehicles(UAVs)to intelligently supply energy and collect data at the same *** our dual-UAV scheme,UAV-E,with a constant power supply,transmits energy to charge the IoT devices on the ground,whereas UAV-B serves the IoT devices by data collection as a base *** this framework,the system's energy efficiency is maximized,which we define as a ratio of the sum rate of IoT devices to the energy consumption of two UAVs during a fixed working *** the constraints of duration,transmit power,energy,and mobility,a difficult non-convex issue is presented by optimizing the trajectory,time duration allocation,and uplink transmit power of *** tackle the non-convex fractional optimization issue,we deconstruct it into three subproblems and we solve each of them iteratively using the descent method in conjunction with sequential convex approximation(SCA)approaches and the Dinkelbach *** simulation findings indicate that the suggested cooperative design has the potential to greatly increase the energy efficiency of the 6G intelligent UAV-assisted wireless powered IoT system when compared to previous benchmark systems.

关键词： 6G wireless powered network energy efficiency IoT intelligent network UAV communication

Recent progress and clinical applications of advanced biomaterials in cosmetic surgery

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Regenerative Biomaterials 2023年第1期10卷 459-469页

作者： hairui li Xiujuan Xu lina Wu Xi Chen Haris Akhter Yixi Wang Ping Song Xiaoxia liao Zhenyu Zhang Zhengyong li Changchun Zhou Ying Cen Hua Ai and Xingdong Zhang Department of Plastic Reconstructive and Aesthetic Surgery West China Tianfu HospitalSichuan UniversityChengdu 610213China Department of Burn and Plastic Surgery West China School of MedicineWest China HospitalSichuan UniversityChengdu 610041China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China College of Biomedical Engineering Sichuan UniversityChengdu 610064China Department of Orthopedic Surgery West China HospitalWest China School of MedicineSichuan UniversityChengdu 610041China Department of Plastic and Reconstructive Surgery University of Nebraska Medical CenterNebraska 68588USA

Materials of different allogeneic or xenogeneic or autologous origins are widely used as soft-tissue fillers or structural scaffolds in the field of cosmetic surgery,while complications including prosthesis infection,donor site deformity and filler embolization have always been difficult problems for plastic *** application of novel biomaterials may bring in hopeful solutions for these ***,some advanced biomaterials,such as regenerative biomaterials can effectively promote the repair of defective tissues,which have been proven to have good therapeutic as well as cosmetic effects in cosmetic ***,biomaterials with active compounds have drawn significant attention for the tissue regeneration of reconstructive and esthetic *** of these applications have achieved better clinical outcomes than traditional biological *** review summarized recent progress and clinical applications of advanced biomaterials in cosmetic surgery.

关键词： applications biomaterials cosmetic soft tissue scaffolds regenerative mechanism

3D printing of personalized polylactic acid scaffold laden with GelMA/autologous auricle cartilage to promote ear reconstruction

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Bio-Design and Manufacturing 2023年第4期6卷 451-463页

作者： Xingyu Gui Zhiyu Peng Ping Song li Chen Xiujuan Xu hairui li Pei Tang Yixi Wang Zixuan Su Qingquan Kong Zhenyu Zhang Zhengyong li Ying Cen Changchun Zhou Yujiang Fan Xingdong Zhang National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China Department of Thoracic Surgery West China HospitalSichuan UniversityChengdu 610041China Analytical and Testing Center Sichuan UniversityChengdu 610064China College of Biomedical Engineering Sichuan UniversityChengdu 610064China Department of Burn and Plastic Surgery West China HospitalSichuan UniversityChengdu 610041China Department of Orthopedics West China HospitalSichuan UniversityChengdu 610041China

At present,the clinical reconstruction of the auricle usually adopts the strategy of taking autologous costal *** method has great trauma to patients,poor plasticity and inaccurate ***-dimensional(3D)printing technology has made a great breakthrough in the clinical application of orthopedic *** study explored the combination of 3D printing and tissue engineering to precisely reconstruct the ***,a polylactic acid(PLA)polymer scaffold with a precisely customized patient appearance was fabricated,and then auricle cartilage fragments were loaded into the 3D-printed porous PLA scaffold to promote auricle *** vitro,gelatin methacrylamide(GelMA)hydrogels loaded with different sizes of rabbit ear cartilage fragments were studied to assess the regenerative activity of various autologous cartilage *** vivo,rat ear cartilage fragments were placed in an accurately designed porous PLA polymer ear scaffold to promote auricle *** results indicated that the chondrocytes in the cartilage fragments could maintain the morphological phenotype in *** three months of implantation observation,it was conducive to promoting the subsequent regeneration of cartilage in *** autologous cartilage fragments combined with 3D printing technology show promising potential in auricle reconstruction.

关键词： Microtia 3D printing Polylactic acid(PLA)polymer scaffolds Gelatin methacrylamide Cartilage reconstruction

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面向瞬态成像仿真的遮挡目标逆向重构方法

西安电子科技大学学报 2018年第2期45卷 66-70页

作者：李海瑞吴鑫张建奇西安电子科技大学物理与光电工程学院陕西西安710071

由于瞬态成像硬件系统存在结构复杂、价格昂贵以及性能评估困难等问题,提出了一种新的逆向重构算法,并利用软件仿真的方法建立了瞬态成像链路.该方法首先根据仿真场景简化像素累积函数,并引入检测概率的方法获得三维空间中目标体素的采... 详细信息

由于瞬态成像硬件系统存在结构复杂、价格昂贵以及性能评估困难等问题,提出了一种新的逆向重构算法,并利用软件仿真的方法建立了瞬态成像链路.该方法首先根据仿真场景简化像素累积函数,并引入检测概率的方法获得三维空间中目标体素的采样;然后利用射线追踪的方法计算目标的全局检测概率,通过阈值分割得到目标的三维点云信息;最后融合点云进行三维场景渲染.实验结果表明,这种方法能够仿真遮挡目标三维场景的瞬态成像过程,并且逆向重构算法增强了遮挡目标重构的效果.

关键词：瞬态成像计算成像遮挡重构逆向问题

Handedness inversion in preparing chiral 4,4’-biphenylene-silica nanostructures

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Handedness inversion in preparing chiral 4,4’-biphenylene-s...