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Perspective on new cell-free DNA technologies for early cancer detection

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Cancer Biology & Medicine 2024年第2期21卷 139-143页

作者： Jie Li Xun lan Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China MOE Key Laboratory of Bioinformatics Tsinghua UniversityBeijing 100084China Tsinghua-Peking Joint Center for Life Sciences Tsinghua UniversityBeijing 100084China

High cancer heterogeneity and aggressiveness are major factors contributing to the poor prognosis of patients with advanced cancer~(1-5).Early detection of cancer can significantly improve the prognosis of patients with early-stage cancer after standard treatment.Although traditional cancer detection technologies,such as endoscopy for gastrointestinal cancer,mammography for breast cancer。

关键词： prognosis cancer patients

Non-destructive detection of the fruit firmness of Korla fragrant pear based on electrical properties

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International Journal of Agricultural and Biological Engineering 2022年第6期15卷 216-221页

作者： Hong Zhang Yang Liu Yurong Tang haipeng lan Hao Niu Hong Zhang Modern Agricultural Engineering Key Laboratory at Universities of Education Department of Xinjiang Uygur Autonomous Region Tarim UniversityAlaer 843300XinjiangChina College of Water Resources and Architectural Engineering Tarim UniversityAlaer 843300XinjiangChina College of Mechanical and Electrical Engineering Tarim UniversityAlaer 843300XinjiangChina

In order to achieve the non-destructive detection of the firmness of Korla fragrant pear during the ripening period,the characteristic variables integrating the parallel equivalent inductance(Lp),quality factor(Q),parallel equivalent capacitance(Cp),dissipation factor(D),parallel equivalent resistance(Rp)and impedance(Z)were formulated through principal component analysis(PCA).Further,based on the characteristic variables,the models were established for predicting the firmness of Korla fragrant pear by using the generalized regression neural network(GRNN)and back-propagation neural network(BPNN).The results showed that firmness has significant correlations with the six electrical parameters.The first two principal components(PCs)were selected as the characteristic variables of the electrical parameters.GRNN exhibited the best performance in predicting firmness(R2=0.9628,RMSE=0.383).The results could provide important references for non-destructive detection of the quality of Korla fragrant pear.

关键词： Korla fragrant pear firmness electrical properties principal component analysis non-destructive detection

Cognitive impairment in cerebral small vessel disease induced by hypertension

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Neural Regeneration Research 2024年第7期19卷 1454-1462页

作者： Weipeng Wei Denglei Ma Lin Li lan Zhang Department of Pharmacy Xuanwu Hospital of Capital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center Beijing Engineering Research Center for Nervous System DrugsNational Center for Neurological DisordersNational Clinical Research Center for Geriatric DiseasesBeijingChina

Hypertension is a primary risk factor for the progression of cognitive impairment caused by cerebral small vessel disease,the most common cerebrovascular disease.Howeve r,the causal relationship between hypertension and cerebral small vessel disease remains unclear.Hypertension has substantial negative impacts on brain health and is recognized as a risk factor for cerebrovascular disease.Chronic hypertension and lifestyle factors are associated with risks for stro ke and dementia,and cerebral small vessel disease can cause dementia and stroke.Hypertension is the main driver of cerebral small vessel disease,which changes the structure and function of cerebral vessels via various mechanisms and leads to lacunar infarction,leukoaraiosis,white matter lesions,and intracerebral hemorrhage,ultimately res ulting in cognitive decline and demonstrating that the brain is the to rget organ of hypertension.This review updates our understanding of the pathogenesis of hypertensioninduced cerebral small vessel disease and the res ulting changes in brain structure and function and declines in cognitive ability.We also discuss drugs to treat cerebral small vessel disease and cognitive impairment.

关键词： blood-brain barrier cerebral small vessel disease cognitive impairment dementia endothelial dysfunction enlarged perivascular space hypertension lacunar infarction neuroinflammation treatment white matter high signal intensity

Editorial:special topic on advanced energy catalytic materials

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Science China Materials 2024年第6期67卷 1681-1683页

作者： Shaojun Guo Yaqian lan School of Materials Science and Engineering Peking UniversityBeijing 100871China School of Chemistry South China Normal UniversityGuangzhou 510630China

Aiming to lowering the society’s dependence on fossil fuels,energy catalysis stands at the forefront of technological advancement,which promises to revolutionize the way we harness,convert,and utilize renewable energy.The current special topic of our journal,titled"Advanced Energy Catalytic Materials",aims to highlight the latest innovations,challenges,and opportunities in this exciting field.

关键词： field utilize catalysis

A direct electrochemical biosensor for rapid glucose detection based on nitrogen-doped carbon nanocages

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Rare Metals 2024年第5期43卷 2184-2192页

作者： lan-lan Li Yu Zhao Li-Jia Pan Jian-Bin Xu Yi Shi College of Mechanical and Electrical Engineering Henan Agricultural University School of Electronic Science and Engineering Collaborative Innovation Center of Advanced Microstructures Nanjing University Department of Electronic Engineering The Chinese University of Hong Kong

Given the increasing number of diabetic patients,rapid and accurate detection of glucose in body fluids is critical.This study developed a direct electrochemical biosensor for glucose based on nitrogen-doped carbon nanocages （NCNCs）.NCNCs possess a large specific surface area of 1395 m2·g-1,a high N atomic content of 9.37%and good biocompatibility,which is favorable for enzyme loading and electron transfer.The surface average concentration of electroactive glucose oxidase on NCNCs was 2.82×10–10mol·cm-2.The NCNC-based direct electrochemical biosensor exhibited a high sensitivity of 13.7μA·(mmol·L-1)-1·cm-2,rapid response time of 5 s and an impressive electron-transferrate constant （ks） of 1.87 s-1.Furthermore,we investigated an NCNC-based direct electron transfer （DET） biosensor for sweat glucose detection,which demonstrated tremendous promise for non-invasive wearable diabetes diagnosis

关键词： Direct electron transfer (DET) Nitrogen-doped carbon nanocages (NCNCs) Glucose oxidase Biosensor

Normalized Solution for p-Kirchhoff Equation with a L2-supercritical Growth

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 414-429页

作者： Zhi-min REN Yong-yi lan School of Sciences Jimei UniversityXiamen 361005China

In this paper,we investigate the following p-Kirchhoff equation{∫R^(N)|u|^(2)dx=ρ,(a+b)∫RN(|Δu}^(p)+|u|^(p))dx)(-Δpu+|u|^(p-2u)=|u|^(s-2)u+μu,x∈R^(N),where a>0,b≥0,p>0 are constants,constants,p*=N-P/Np is the ... 详细信息

关键词： p-Kirchhoff equation normalized solution mountain-pass lemma

Heterogeneous Image Knowledge Driven Visual Perception

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 255-257页

作者： lan Yan Wenbo Zheng Fei-Yue Wang IEEE the College of Computer Science and Electronic Engineering Hunan UniversityChangsha 410082China the School of Computer Science and Artificial Intelligence Wuhan University of TechnologyWuhan 430070China the State Key Laboratory for Management and Control of Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China

Dear Editor,This letter is concerned with visual perception closely related to heterogeneous images.Facing the huge challenge brought by different image modalities,we propose a visual perception framework based on heterogeneous image knowledge,i.e.,the domain knowledge associated with specific vision tasks,to better address the corresponding visual perception problems.

关键词： Visual visual knowledge

Construction method of quantitative evaluation model for the maturity of Korla fragrant pear

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International Journal of Agricultural and Biological Engineering 2022年第4期15卷 243-250页

作者： Shihui Yu Yurong Tang haipeng lan Xiaolong Li Hong Zhang Yong Zeng Hao Niu Xiaozhen Jin Yang Liu College of Mechanical and Electrical Engineering Tarim UniversityAlaer 843300XinjiangChina College of Mechanical and Electronic Engineering Shandong Agricultural UniversityTai’an271018ShandongChina Zibo Agricultural Machinery Service Center Zibo 255000ShandongChina

The maturity variation laws of Korla fragrant pears were explored for a quantitative evaluation of harvest maturity to solve the reasonable matching between harvest maturity of Korla fragrant pears and market quality demands.Korla fragrant pears from different harvesting periods were chosen as the research objects.Some quality indexes were chosen as the evaluation indexes per industry standards,including hardness,soluble solid content(SSC),single-fruit weight,fruit longitudinal diameter,fruit equatorial diameter,pericarp color parameters(L*,a*,and b*),and titratable acid.Variation data of these quality indexes with accumulated temperature were collected.Scores of several quality indexes were gained through principal component analysis.A mathematical model of scores and accumulated temperatures was constructed.On this basis,a quantitative maturity model of Korla fragrant pears was constructed.Results demonstrate that SSC,single-fruit weight,fruit longitudinal diameter,fruit equatorial diameter,L*,a*,and b*are significantly and positively correlated with the accumulated temperature.Meanwhile,hardness and titratable acid showed significant negative correlations with the accumulated temperature.Relations between scores of principal components and accumulated temperature conform to the Sigmoidal model.The constructed quantitative maturity model of Korla fragrant pears can quantify the maturity of pears.Research conclusions can provide insight into the harvest periods,evaluate Korla fragrant pears’maturity,and lay a theoretical foundation for quantitative research on fruit maturity.

关键词： Korla fragrant pear quantitative evaluation maturity principal component analysis accumulated temperature

A Brief of Cold Spell Warning Actions of the National Meteorological Center of China Meteorological Administration

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China CDC weekly 2024年第5期6卷 88-91页

作者： Taiyuan Zhang Mengxue Zhang Qiutong Li Yu lan Huafeng Meteorological Media Group of China Meteorological Administration(CMA) BeijingChina National Institute of Environmental Health Chinese Center for Disease Control and PreventionBeijingChina The National Meteorological Center of China Meteorological Administration(CMA) BeijingChina

The“Outline for High-Quality Development of Meteorology(2022-2035)”was published by the State Council of the People’s Republic of China in April 2022(1).This publication highlights the essential role of meteorological disaster warnings,particularly cold spell warnings,in preventing and mitigating disasters.The outline also sets forth stricter expectations for enhancing the overall capacity of society in terms of meteorological disaster preparedness and response.

关键词： disaster meteorological warning