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Molecular movements of trehalose inside a single network enabling a rapidly-recoverable tough hydrogel

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International Journal of Smart and Nano Materials 2022年第4期13卷 575-596页

作者： Xiaowen Huang Jimin Fu Huiyan Tan Yan Miu Mengda Xu Qiuhua Zhao Yujie Xie Shengtong sun haimin Yao Lidong Zhang School of Chemistry and Molecular Engineering East China Normal UniversityShanghaiChina Department of Mechanical Engineering the Hong Kong Polytechnic UniversityHong Kong SARChina State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyCenter for Advanced Low-dimension MaterialsDonghua UniversityShanghaiChina The Hong Kong Polytechnic University Shenzhen Research Institute ShenzhenChina

It remains a challenge to achieve rapidly recoverable hydrogels by molecular hydrogen-bonding interaction because of its slow inter-action *** work for the first time reports a trehalose(Tre)-based molecular movement mechanism inside a single network of polyacrylamide(PAM)that accelerates the kinetics of hydrogenbonding interaction,and thereby endows the hydrogel with high toughness and rapid shape and mechanical *** resultant PAM@Tre hydrogel is capable of full shape recovery after 10,000 loading/unloading cycles at a strain of 500%.Even after being stretched at a strain of 2500%,it can recover to its original shape within 10 ***,the molecular movement of trehalose also endows the PAM@Tre hydrogel with fracture energy and toughness as high as~9000 J m^(-2) and~1600 kJ m^(-3),respec-tively,leading to strong resistance to both static and dynamic *** PAM@Tre hydrogel is thus believed to have enormous potentials in protection devices,bionic skin,soft actuator,and stretchable electronics.

关键词： molecular motility highly recoverable tough hydrogels puncture resistance molecular dynamics simulation

Irreversible rapid changes of magnetic field associated with the 2012 October 23 circular near-limb X1.8 Flare

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Research in Astronomy and Astrophysics 2016年第6期16卷 99-104页

作者： Dan-Dan Ye Chang Liu haimin Wang Space Weather Research Laboratory and Big Bear Solar Observatory New Jersey Institute of TechnologyUniversity Heights

It has been found that photospheric magnetic fields can change in accordance with restructuring of the three-dimensional magnetic field following solar eruptions. Previous studies mainly use vector mag- netic field data taken for events near the disk center. In this paper, we analyze the magnetic field evolution associated with the 2012 October 23 X1.8 flare in NOAA AR 11598 that is close to the solar limb, using both the 45 s cadence line-of-sight and 12 min cadence vector magnetograms from the Helioseismic and Magnetic Imager on board Solar Dynamics Observatory. This flare is classified as a circular-ribbon flare with spine-fan type magnetic topology containing a null point. In the line-of-sight magnetograms, there are two apparent polarity inversion lines （PILs）. The PIL closer to the limb is affected more by the projection effect. Between these two PILs there lie positive polarity magnetic fields, which are surrounded by negative polarity fields outside the PILs. We find that after the flare, both the apparent limb-ward and disk-ward negative fluxes decrease, while the positive flux in-between increases. We also find that the horizontal mag- netic fields have a significant increase along the disk-ward PIL, but in the surrounding area, they decrease. Synthesizing the observed field changes, we conclude that the magnetic fields collapse toward the surface above the disk-ward PIL as depicted in the coronal implosion scenario, while the peripheral field turns to a more vertical configuration after the flare. We also suggest that this event is an asymmetric circular-ribbon flare： a flux rope is likely present above the disk-ward PIL. Its eruption causes instability of the entire fan-spine structure and the implosion near that PIL.

关键词： sun flares -- sun magnetic field

慢性粒-单核细胞白血病合并结外非霍奇金淋巴瘤的临床特征分析

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诊断学理论与实践 2018年第1期17卷 76-81页

作者：李佳明张苏江王莹严泽莹刘之茵孙海敏陈玉宝陈钰罗方秀孙静上海交通大学医学院附属瑞金医院北院血液科上海200030 上海交通大学医学院附属瑞金医院北院病理科上海201801 全景医学影像诊断中心上海200030

目的 :探讨慢性粒-单核细胞白血病(chronic myelomonocytic leukemia,CMML)合并结外非霍奇金淋巴瘤(non-Hodgkin's lymphoma,NHL)患者的临床特征及其鉴别诊断。方法 :回顾性分析2例CMML合并结外NHL患者的临床资料、影像学检查、病理形... 详细信息

目的 :探讨慢性粒-单核细胞白血病(chronic myelomonocytic leukemia,CMML)合并结外非霍奇金淋巴瘤(non-Hodgkin's lymphoma,NHL)患者的临床特征及其鉴别诊断。方法 :回顾性分析2例CMML合并结外NHL患者的临床资料、影像学检查、病理形态学及免疫组织化学(免疫组化)标志特征,并复习国内外相关文献进行探讨。结果:2例CMML合并结外NHL患者均为老年女性,因乏力或出现相应部位肿瘤侵犯症状就诊。例1患者诊断为CMML后发生NHL,例2患者则同时诊断为CMML和NHL。实验室检查示,2例患者的外周血白细胞计数增高,以单核细胞为主;乳酸脱氢酶升高;骨髓增生活跃伴有病态造血;细胞免疫表型为CD14+CD64+;染色体荧光原位杂交分析BCR-ABL为阴性(-)。PET/CT检查显示2例患者均未发现骨髓高代谢灶,例1患者表现为小肠异常高代谢,最大标准化摄取值(maximum standard uptake values,SUVmax)值为12.60;例2患者表现为肺内异常高代谢,SUVmax值为6.72。病理检查提示2例患者均为B细胞来源的NHL;免疫组化检查结果提示,LCA、CD20、CD79a、Bcl-6、Ki-67均为阳性,CD5、CD10、CD3、Cylin D1、CD56、CD23、CD21阴性。结论:CMML合并结外NHL罕见,患者缺乏特异性的临床表现,而结合实验室、影像学检查及组织病理、免疫组化检查进行分析,可提高其诊断的准确率。

关键词：慢性粒-单核细胞白血病非霍奇金淋巴瘤诊断

The change of magnetic inclination angles associated with the X3.4 flare on December 13,2006

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Science China(Physics,Mechanics & Astronomy) 2009年第11期52卷 1702-1706页

作者： LI YiXuan JING Ju TAN ChangYi WANG haimin Center for Solar-Terrestrial Research New Jersey Institute of TechnologyNewarkNJ 07102USA

Recent studies showed a consistent pattern of changes in the sunspot structure associated with major flares: part of the peripheral penumbral regions vanishes during flares, and meanwhile, the umbral cores and/or inner penumbral regions are darkened. To understand the underlying physics of these observations, we compare the magnetic inclination angle in the decayed peripheral and the enhanced inner penumbral regions before and after the 4B/X3.4 flare of 2006 December 13 by using the high-resolution vector magnetograms from Hinode. We find that the mean inclination angle in the decayed penumbra increases after the flare while that in the enhanced penumbra near flaring neutral line decreases. The result confirms the previous idea that two components of a δ sunspot become connected after flares. As a result of new connection, peripheral penumbral fields change from a more inclined to a more vertical configuration and transverse fields in umbral core and inner penumbral regions increase substantially (Liu et al. 2005). The flare-associated changes of Doppler width as well as other parameters (the transverse field strength, continuum intensity and filling factor) are also presented.

关键词： sun:magnetic fields sun:photosphere sun:flares

地西他滨联合芦可替尼方案治疗初诊慢性粒单核细胞白血病的临床分析

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国际输血及血液学杂志 2019年第6期42卷 482-487页

作者：李佳明陈玉宝张苏江严泽莹王莹刘之茵孙海敏陈钰上海交通大学医学院附属瑞金医院北院血液科 201801

目的分析地西他滨联合芦可替尼方案治疗初诊慢性粒单核细胞白血病(CMML)患者的临床疗效,并探索相关基因突变对患者疗效及预后的影响.方法选择2016年3月至2018年8月于上海交通大学附属瑞金医院北院血液科收治的5例初诊为CMML患者为研... 详细信息

目的分析地西他滨联合芦可替尼方案治疗初诊慢性粒单核细胞白血病(CMML)患者的临床疗效,并探索相关基因突变对患者疗效及预后的影响.方法选择2016年3月至2018年8月于上海交通大学附属瑞金医院北院血液科收治的5例初诊为CMML患者为研究对象.其中,男性患者为3例,女性为2例,中位年龄为60岁.本研究治疗方案为地西他滨联合芦可替尼:地西他滨20 mg/(m^2·d),d1~3,芦可替尼5~10 mg/d,d1~28,4周为1个疗程.每个疗程结束后,均对患者骨髓细胞形态学进行复查,以评价疗效,并且观察患者治疗相关不良反应.于治疗前、后分别检测患者骨髓标本中22种急性髓细胞白血病(AML)/骨髓增生异常综合征(MDS)相关基因突变频率(VAF).随访时间截至2019年5月1日,随访间隔为1个月.回顾性分析5例CMML患者的临床特征及疗效,以及治疗前、后患者相关基因VAF的改变.本研究遵循的程序符合2013年修订的《世界医学协会赫尔辛基宣言》要求,并且与所有受试者签署临床研究知情同意书.结果 ①5例接受地西他滨联合芦可替尼方案治疗的患者中,3例患者治疗有效,其中患者2获得完全缓解(CR),患者3获得血液学改善(HI),患者5获得骨髓缓解(mCR).患者4治疗无效.患者1疾病进展(PD).全部患者的脾体积较治疗前均有缩小(缩小比例>50%).②5例患者化疗后均出现骨髓抑制,其中患者3骨髓抑制最为严重,骨髓抑制期最长,达2个月;患者1、3和4胸部CT检查结果示肺部感染,经积极抗感染治疗后获得好转;患者1与患者4出现腹泻;患者3出现轻度肝功能损害;患者5出现便秘,经对症支持治疗后均好转.③与治疗前相比,治疗后6个月,患者1骨髓标本中JAK2 V617F VAF(17%下降至0)、SRSF2 P95H VAF(44%下降至39%)降低,CBL H398P VAF(15%上升至60%)、TET2 Q273fs VAF(87%上升至95%)升高;患者2的SRSF2 P95L VAF(69%下降至49%)、CBL R420Q VAF(45%下降至1%)降低,ASXL1 G710fs VAF(47%上升至49%)几乎无变化,TET2 L1721W VAF(32%上升至50%)升高;患者4的SRSF2 P95L VAF(29%下降至7%)、TET2 Q705X VAF(95%下降至62%)降低,ASXL1 G642fs VAF(18%上升至39%)升高;治疗后2个月,患者4骨髓标本中CBL W408S VAF(29%上升至31%)几乎无变化;患者5中TET2 R550X VAF(21%下降至13%)、CBL C396R VAF(44%下降至26%)降低,TET2 C1298Y VAF(22%下降至13%)几乎无变化.结论地西他滨联合芦可替尼方案治疗初治CMML,可以有效改善患者临床症状,提高疗效.基于单基因VAF评价临床疗效仍存在很大程度的变异性,因此有待大样本、前瞻性研究予以验证.

关键词：白血病,粒-单核细胞,慢性突变治疗结果地西他滨芦可替尼

CLAG方案治疗复发、难治急性髓系白血病疗效、安全性分析及随访

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内科理论与实践 2019年第2期14卷 116-120页

作者：刘之茵陈钰陈玉宝严泽莹王莹李佳明孙海敏张苏江上海交通大学医学院附属瑞金医院北院血液科上海201801

目的:观察CLAG方案(克拉屈滨+阿糖胞苷+粒细胞集落刺激因子)治疗难治、复发急性髓系白血病(acute myeloid leukemia,AML)的疗效、安全性和不良反应。方法 :回顾性分析2015年7月至2018年1月我院收治的使用CLAG方案±地西他滨治疗的7例难... 详细信息

目的:观察CLAG方案(克拉屈滨+阿糖胞苷+粒细胞集落刺激因子)治疗难治、复发急性髓系白血病(acute myeloid leukemia,AML)的疗效、安全性和不良反应。方法 :回顾性分析2015年7月至2018年1月我院收治的使用CLAG方案±地西他滨治疗的7例难治、复发AML患者,观察其疗效和不良反应,并进行随访。收集国内关于CLAG方案治疗复发、难治AML的相关文献,进行综合分析。结果:7例患者经CLAG方案±地西他滨化学治疗(化疗)1个疗程后, 4例完全缓解(complete remission,CR),3例未缓解(non-remission,NR)。主要不良反应为骨髓抑制(7例),血流感染、肠道感染和消化道出血各1例,无化疗相关死亡。4例CR与2例NR患者行异基因造血干细胞移植(allogeneic hematopoietic stem cell transplantation,allo-HSCT)。最终选入5篇文献进行分析,CR率在34.6%～78.8%之间,加上本研究7例患者共104例, CR患者为61例。结论:CLAG方案对难治、复发AML有效,化疗所致骨髓抑制较重,但安全性良好,患者可耐受。一旦获得CR,尽快行allo-HSCT以延长生存期。

关键词： CLAG方案复发难治急性髓系白血病地西他滨

单药地西他滨比较沙利度胺联合全反式维A酸治疗1型骨髓增生异常综合征

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内科理论与实践 2018年第2期13卷 98-102页

作者：李佳明张苏江严泽莹王莹刘之茵孙海敏陈玉宝陈钰上海交通大学医学院附属瑞金医院北院血液科上海201801

目的 :比较单药地西他滨(DAC)与沙利度胺联合全反式维A酸(TAT)治疗低危及中危-1型骨髓增生异常综合征(MDS)的临床疗效。方法:回顾性分析11例接受DAC治疗和25例接受沙利度胺联合TAT治疗的MDS患者临床资料,采用二代测序检测MDS患者常见突... 详细信息

目的 :比较单药地西他滨(DAC)与沙利度胺联合全反式维A酸(TAT)治疗低危及中危-1型骨髓增生异常综合征(MDS)的临床疗效。方法:回顾性分析11例接受DAC治疗和25例接受沙利度胺联合TAT治疗的MDS患者临床资料,采用二代测序检测MDS患者常见突变基因,探讨2种治疗方案的临床疗效和影响因素。结果:DAC治疗组总有效率54.5%,其中3例(27.3%)获完全缓解(CR),2例(18.2%)获部分缓解(PR),1例(9.1%)获血液学改善(HI),持续有效5例(83.3%),中位无进展生存(PFS)时间为12个月。TAT治疗组总有效率36.0%,9例(36.0%)获HI,持续有效4例(44.4%),中位PFS时间为9个月。伴有基因突变患者采用DAC治疗较TAT治疗有较长的PFS时间,差异有统计学意义(P<0.05)。在TAT治疗组中,骨髓原始细胞≤2%是影响临床疗效HI的重要指标,HI与非HI组差异有统计学意义(P<0.05)。结论:DAC治疗低危及中危-1型MDS患者临床疗效优于TAT,尤其对于存在MDS基因突变的患者;TAT治疗方案可提高患者的HI。

关键词：地西他滨沙利度胺全反式维A酸骨髓增生异常综合征

The correlation between expansion speed and magnetic field in solar flare ribbons

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Science China(Physics,Mechanics & Astronomy) 2009年第11期52卷 1754-1759页

作者： XIE WenBin WANG haimin JING Ju BAO XingMing ZHANG HongQi Key Laboratory of Solar Activity National Astronomical Observatories of ChinaBeijing 100012China Physics Department New Jersey Institute of TechnologyNewarkNJ07102USA Jilin Normal University Jilin 136000China

In this paper, we study the correlation between the expansion speed of two-ribbon flares and the magnetic field measured in the ribbon location, and compare such correlation for two events with different magnetic configurations. These two events are: an M1.0 flare in the quiet sun on September 12, 2000 and an X2.3 flare in Active Region NOAA 9415 on April 10, 2001. The magnetic configuration of the M1.0 flare is simple, while that of X2.3 event is complex. We have derived a power-law correlation between the ribbon expansion speed (V r) and the longitudinal magnetic field (Bz) with an empirical relationship V r = A×Bz-δ, where A is a constant and δ is the index of the power-law correlation. We have found that δ for the M1.0 flare in the simple magnetic configuration is larger than that for the X2.3 flare in the complex magnetic configuration.

关键词： solar activity solar flares solar magnetic field

SETD2基因与骨髓增生异常综合征的相关研究

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临床血液学杂志 2020年第6期33卷 776-782页

作者：彭真萍李佳明陈玉宝王莹严泽莹刘之茵孙海敏陈欣洁安然陈钰上海交通大学医学院附属瑞金医院北院检验科上海201801 上海交通大学医学院附属瑞金医院北院血液科

目的:探讨SETD2基因与骨髓增生异常综合征(MDS)相关临床预后的关系。方法:应用靶向二代基因测序技术,检测我院180例MDS患者的43个MDS相关基因,并观察SETD2基因对患者原始细胞、血红蛋白、生存时间、无进展生存时间以及治疗效果的影响。... 详细信息

目的:探讨SETD2基因与骨髓增生异常综合征(MDS)相关临床预后的关系。方法:应用靶向二代基因测序技术,检测我院180例MDS患者的43个MDS相关基因,并观察SETD2基因对患者原始细胞、血红蛋白、生存时间、无进展生存时间以及治疗效果的影响。结果:180例MDS患者中,我们发现SETD2基因突变包括SETD2 p.L2486R,SETD2 p.E1142G,TET2 p.T2388fs和SETD2 p.F1116fs;单核苷酸多态性包括SETD2 p.M761I,SETD2 p.E639K,SETD2 p.P193L,SETD2 p.M1080I,SETD2 p.N1155K和SETD2 p.P1962L,其中,SETD2 p.M761I,SETD2 p.E639K,SETD2 p.P193L和SETD2 p.M1080I四种SNP位点经预测分析具有危害性和致病性。携带危害性SETD2基因异常的患者共14例,其中同时携带TP53基因突变者占50.0%,同时携带TET基因突变者占28.6%,同时携带ASXL1基因突变者占21.4%。携带SETD2基因异常的MDS患者表现为较高的原始细胞水平(P<0.05);并且单变量和多变量生存分析表明,SETD2基因异常与MDS患者总生存时间和无进展生存时间显著相关(P<0.05)。结论:SETD2基因异常与MDS疾病进展迅速以及不良预后密切相关。

关键词：基因突变骨髓增生异常综合征无进展生存 SETD2