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Hydrophobic modification of polysaccharides and the construction and properties of their micelles:a review of applications in the field of biomedicine

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Science China Chemistry 2024年第6期67卷 1881-1903页

作者： Dayang Wang Xiaohua Li Huanchen Yao Xin liu Yan Gao hailin.Cong Bing Yu Youqing Shen College of Chemistry and Chemical Engineering College of Life SciencesCollege of Materials Science and EngineeringInstitute of Biomedical Materials and EngineeringQingdao UniversityQingdao266071China State Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao UniversityQingdao266071China School of Materials Science and Engineering Shandong University of TechnologyZibo255000China Key Laboratory of Biomass Chemical Engineering of Ministry of Education Center for Bionanoengineeringand Department of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China

Nanomedicine delivery technology plays an important role in modern medicine and has shown good therapeutic effects in scientific *** have the characteristics of wide sources,excellent biocompatibility,and *** addition,there are multifunctional groups on the main chain of polysaccharides,which can be surface-modified or functionalized to have targeting ability through specific sugar *** polysaccharide micelles with good biocompatibility,degradability,high safety,easy structural modification,and special core-shell structure are regarded as ideal carriers for ***,this review is focused on the hydrophobic modification designs of polysaccharides,the preparation methods and characteristics of micelles,and the applications of amphiphilic polysaccharide micelles in the field of *** is expected to provide some ideas and inspiration for the design of polysaccharide drug carriers.

关键词： polysaccharide hydrophobic modification micelle drug delivery biomedicine

Three-dimensional breast cancer tumor models based on natural hydrogels:a review

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第9期25卷 736-755页

作者： Yan SHU Bing LI hailin.MA Jiaqi liu Yuen Yee CHENG Xiangqin LI Tianqing liu Chuwei YANG Xiao MA Kedong SONG State Key Laboratory of Fine Chemicals Dalian R&D Center for Stem Cell and Tissue EngineeringDalian University of TechnologyDalian116024China Institute for Biomedical Materials and Devices Faculty of ScienceUniversity of Technology SydneySydneyNSW2007Australia Emergency Center The Second Hospital of Dalian Medical UniversityDalian116023China Department of Anesthesia The First Affiliated Hospital of Dalian Medical UniversityDalian116011China

Breast cancer is the most common cancer in women and one of the deadliest cancers *** to the distribution of tumor tissue,breast cancer can be divided into invasive and non-invasive *** cancer cells in invasive breast cancer pass through the breast and through the immune system or systemic circulation to different parts of the body,forming metastatic breast *** resistance and distant metastasis are the main causes of death from breast *** on breast cancer has attracted extensive attention from *** vitro construction of tumor models by tissue engineering methods is a common tool for studying cancer mechanisms and anticancer drug *** tumor microenvironment consists of cancer cells and various types of stromal cells,including fibroblasts,endothelial cells,mesenchymal cells,and immune cells embedded in the extracellular *** extracellular matrix contains fibrin proteins(such as types Ⅰ,Ⅱ,Ⅲ,Ⅳ,Ⅵ,and Ⅹ collagen and elastin)and glycoproteins(such as proteoglycan,laminin,and fibronectin),which are involved in cell signaling and binding of growth *** current traditional two-dimensional(2D)tumor models are limited by the growth environment and often cannot accurately reproduce the heterogeneity and complexity of tumor tissues in ***,in recent years,research on three-dimensional(3D)tumor models has gradually increased,especially 3D bioprinting models with high precision and *** with a 2D model,the 3D environment can better simulate the complex extracellular matrix components and structures in the tumor ***-dimensional models are often used as a bridge between 2D cellular level experiments and animal *** matrix,gelatin,sodium alginate,and other natural materials are widely used in the construction of tumor models because of their excellent biocompatibility and non-immune ***,we review various natural scaffold materials and con

关键词： Breast cancer Tumor microenvironment 3D tumor model Decellularized extracellular matrix Natural scaffold materials

Discovery and Significance of Layered Chromite Mineralization in Mafic-Ultramafic Rocks from the Gayahe Area of the East Kunlun Orogenic Belt,Northwestern China

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Journal of Earth Science 2024年第4期35卷 1367-1372页

作者： Shao-Yong Jiang hailin.Xie Wenqi Ren Bin Wang Feng Yuan Xiufeng liu Hui-Min Su State Key Laboratory of Geological Processes and Mineral Resources Collaborative Innovation Center for Exploration of Strategic Mineral ResourcesSchool of Earth ResourcesChina University of GeosciencesWuhan 430074China Qinghai Engineering Research Center of Deep Exploration Technology for Large and Ultra-Large Gold Deposits around Qaidam Basin First Geological Exploration Institute of Qinghai ProvinceHaidong 810600China

0 INTRODUCTION Chromium(Cr)is one of the most important strategic critical metals in *** primary chromite deposits can be divided into two types according to their geological setting and occurrences:podiform chromite and stratiform/layered chromite(Stowe,1994;Paktunc,1990).Podiform chromites mainly occur in ophiolites or mantle peridotites(Yang et al.,2022,2010;Bao et al.,1999).

关键词： China mantle setting

Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K/Akt/mTOR pathway

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Science China(Life Sciences) 2024年第9期67卷 1849-1866页

作者： Kumar Ganesan Cong Xu Jianming Wu Bing Du Qingqing liu Yue Sui Cailu Song Jinhui Zhang hailin.Tang Jianping Chen School of Chinese Medicine LKS Faculty of MedicineThe University of Hong KongHong Kong 999077China School of Pharmacy Southwest Medical UniversityEducation Ministry Key Laboratory of Medical ElectrophysiologySichuan Key Medical Laboratory of New Drug Discovery and Druggability EvaluationLuzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia MedicaSouthwest Medical UniversityLuzhou 646000China College of Food Science South China Agricultural UniversityGuangzhou 510642China State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510080China

The spreading of cancer cells from the primary tumor site to other parts of the body,known as metastasis,is the leading cause of cancer recurrence and mortality in patients with triple-negative breast cancer(TNBC).Overexpression of epidermal growth factor receptor(EGFR)is observed in approximately 70%of TNBC *** is crucial for promoting tumor metastasis and associated with poor ***,it is vital to identify effective therapeutic strategies targeting EGFR ***,an isoflavonoid found in various plants,such as clover and soybeans,has been shown to have anticancer properties in several *** the present study,we aimed to investigate the effects of ononin on TNBC lung metastasis and the associated molecular *** used various assays,including cell viability,colony formation,Transwell,wound healing,ELISA,Western blotting,and staining techniques,to achieve this *** results demonstrated that ononin effectively suppressed cellular proliferation and induced apoptosis,as evidenced by the cell viability assay,colony formation assay,and expression of apoptosis markers,and reduced the metastatic capabilities of TNBC *** effects were achieved through the direct suppression of cell adhesion,invasiveness and ***,in TNBC xenograft lung metastatic models,ononin treatment significantly reduced tumor growth and lung ***,ononin reversed the epithelial-mesenchymal transition(EMT)by downregulating the expression of EMT markers and matrix metalloproteinases,as confirmed by Western blot ***,ononin treatment reduced EGFR phosphorylation and suppressed the PI3K,Akt,and m TOR signaling pathways,which was further confirmed using EGFR agonists or ***,ononin treatment did not exert any toxic effects on liver or kidney *** conclusion,our findings suggest that ononin is a safe and potentially therapeutic treatment for TNBC metastasis that targets the EGFRm

关键词： ononin TNBC breast cancer lung metastasis EGFR PI3k/Akt EMT therapeutic effect

CircMYBL2 facilitates hepatocellular carcinoma progression by regulating E2F1 expression

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Oncology Research 2024年第6期32卷 1129-1139页

作者： JUNZHE YI BINBIN LI XIAOMIN YIN LINGRUI liu CAILU SONG YING ZHAO MANBO CAI hailin.TANG DONG CHEN NING LYU State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou510060China Department of Medical Oncology The Third People’s Hospital of YongzhouYongzhou425000China Department of Radiotherapy The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang421001China Center of Hepato-Pancreato-Biliary Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou510080China

Circular RNAs(circRNAs)have been recognized as pivotal regulators in tumorigenesis,yet the biological functions as well as molecular mechanisms of the majority of circRNAs in hepatocellular carcinoma(HCC)remain *** sought to unveil the expression profile and biological role of circMYBL2 in *** microarray analyses were conducted to probe the expression profile of circMYBL2 in HCC cells,and qRT‒PCR analysis was then performed in HCC cell lines and tissues,revealing significant upregulation of *** experiments were conducted to evaluate the biological function of circMYBL2 in HCC ***,bioinformatics analysis,qRT‒PCR analysis,luciferase reporter assays,and western blot analysis were employed to investigate the interplay among circMYBL2,miR-1205,and ***2 was found to exhibit marked upregulation in tumor tissues as well as HCC cell *** expression of circMYBL2 increased the proliferation and migration of HCC cells,whereas circMYBL2 knockdown elicited contrasting ***,our results indicated that circMYBL2 promoted E2F1 expression and facilitated HCC progression by sponging *** findings revealed that circMYBL2 contributed to HCC progression through the circMYBL2/miR-1205/E2F1 axis,suggesting the potential of circMYBL2 as a novel target for HCC treatment or a prognostic biomarker for HCC.

关键词： Circular RNAs circMYBL2 miR-1205 E2F1 Hepatocellular carcinoma

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基于人机协同决策的运输调度优化研究

交通运输系统工程与信息 2024年第2期24卷 136-148页

作者：刘涛尤海林西南交通大学交通运输与物流学院成都611756 西南交通大学综合交通大数据应用技术国家工程实验室成都611756 西南交通大学系统科学与工程研究院成都611756 宜宾西南交通大学研究院四川宜宾644000

为求解带柔性约束的运输调度问题,本文提出一个基于逆差函数的人机协同决策方法。该方法主要包括两个阶段,第1阶段,借助数学规划模型,利用计算机的强大计算能力,快速求解得到问题的一个可行解;第2阶段,借助逆差函数模型,利用人类自身的... 详细信息

为求解带柔性约束的运输调度问题,本文提出一个基于逆差函数的人机协同决策方法。该方法主要包括两个阶段,第1阶段,借助数学规划模型,利用计算机的强大计算能力,快速求解得到问题的一个可行解;第2阶段,借助逆差函数模型,利用人类自身的知识与经验,在考虑柔性约束的情形下,进一步优化第1阶段的可行解。两个阶段通过逆差函数图像构成的图形用户界面进行实时交互,实现人机协同决策。通过网约定制公交车辆调度和民航飞机调度两个案例问题的求解,验证基于逆差函数的人机协同决策方法的有效性。计算结果表明:该方法可实现车次链/航班链的自动化构建和空驶车次的自动化插入,有助于求解带有复杂柔性约束的运输调度问题。

关键词：系统工程人机协同决策逆差函数运输调度交互式优化

The burgeoning importance of PIWI-interacting RNAs in cancer progression

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Science China(Life Sciences) 2024年第4期67卷 653-662页

作者： Xinpei Deng Tianle Liao Jindong Xie Da Kang Yiwei He Yuying Sun Zhangling Wang Yongluo Jiang Xuan Miao Yixuan Yan hailin.Tang Lewei Zhu Yutian Zou Peng liu State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China School of Medicine Sun Yat-sen UniversityShenzhen 518107China Key Laboratory of Cardiovascular and Cerebrovascular Medicine Nanjing Medical UniversityNanjing 211166China Guanghua School of Stomatology Sun Yat-sen UniversityGuangzhou 510062China The First People’s Hospital of Foshan Foshan 528000China

PIWI-interacting RNAs(pi RNAs)are a class of small noncoding RNA molecules that specifically bind to piwi protein family members to exert regulatory functions in germ *** studies have found that pi RNAs,as tissue-specific molecules,both play oncogenic and tumor suppressive roles in cancer progression,including cancer cell proliferation,metastasis,chemoresistance and ***,the atypical manifestation of pi RNAs and PIWI proteins in various malignancies presents a promising strategy for the identification of novel biomarkers and therapeutic targets in the diagnosis and management of ***,the precise functions of pi RNAs in cancer progression and their underlying mechanisms have yet to be fully *** review aims to examine current research on the biogenesis and functions of pi RNA and its burgeoning importance in cancer progression,thereby offering novel perspectives on the potential utilization of pi RNAs and piwi proteins in the management and treatment of advanced cancer.

关键词： PIWI-interacting RNAs/piRNAs cancer progression metastasis chemoresistance stemness

Lactobacillus from fermented bamboo shoots prevents inflammation in DSS-induced colitis mice via modulating gut microbiome and serum metabolites

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Food Science and Human Wellness 2024年第5期13卷 2833-2846页

作者： Xiangru liu Xiaoling Lu Hao Nie Jing Yan Zhiwen Ma hailin.Li Shixin Tang Qi Yin Jingfu Qiu School of Public Health Chongqing Medical UniversityChongqing 400016China

Fermented bamboo shoots(FBS)is a region-specific food widely consumed in Southwestern China,with Lactobacillus as the predominant fermenting ***,the probiotic potential of Lactobacillus derived from FBS reminds largely unexplored,especially for diseases with a low prevalence in areas consuming FBS,namely,inflammatory bowel *** this study,Lactiplantibacillus pentosus YQ001 and Lentilactobacillus senioris YQ005 were screening by in vitro probiotic tests to further investigate the probioticlike bioactivity in dextran sulfate sodium(DSS)-induced ulcerative colitis(UC)*** exhibited more positive probiotic effects than Lactobacillus rhamnosus GG in preventing intestinal inflammatory *** results revealed that both strains improved the abundance of deficient intestinal microbiota in UC mice,including Muribaculaceae and *** the serum metabolome,they modulated the DSS-disturbed levels of metabolites,with significant increment of cinnamic ***,they reduced the expression levels of interleukin-1β(IL-1β),interleukin-6(IL-6)inflammatory factors and increased zonula occludens-1(ZO-1),Occludin,and cathelicidin-related antimicrobial peptide(CRAMP)in the ***,these results demonstrated that Lactobacillus *** derived from FBS showed promising probiotic activity based on the gut microbiome homeostasis modulation,anti-inflammation and intestinal barrier protection in UC mice.

关键词： Fermented bamboo shoots Lactobacillus Probiotic activity Gut microbiome modulation Ulcerative colitis

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基于制动特征自学习的磁浮列车强化学习制动控制

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西南交通大学学报 2024年第4期59卷 839-847页

作者：刘鸿恩胡闽胜胡海林江西理工大学永磁磁浮技术与轨道交通研究院江西赣州341000 江西省磁悬浮技术重点实验室江西赣州341000 北京全路通信信号研究设计院集团有限公司北京100073

精准、平稳停车是磁浮列车自动驾驶制动控制的重要目标.中低速磁浮列车停站制动过程受到电-液混合制动状态强耦合等影响,基于制动特性机理模型的传统制动控制方法难以保障磁浮列车的停车精度和舒适性.本文提出一种基于混合制动特征自学... 详细信息

精准、平稳停车是磁浮列车自动驾驶制动控制的重要目标.中低速磁浮列车停站制动过程受到电-液混合制动状态强耦合等影响,基于制动特性机理模型的传统制动控制方法难以保障磁浮列车的停车精度和舒适性.本文提出一种基于混合制动特征自学习的磁浮列车强化学习制动控制方法.首先,采用长短期记忆网络建立磁浮列车混合制动特征模型,结合磁浮列车运行环境和状态数据进行动态制动特征自学习;然后,根据动态特征学习结果更新强化学习的奖励函数与学习策略,提出基于深度强化学习的列车制动优化控制方法;最后,采用中低速磁浮列车现场运行数据开展仿真实验.实验结果表明:本文所提出的制动控制方法较传统方法的舒适性和停车精度分别提高41.18%和22%,证明了本文建模与制动优化控制方法的有效性.

关键词：磁浮列车制动控制多目标优化控制强化学习制动特征自学习