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Influence of ginsenoside on expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in the medial septum of aged rats

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Neural Regeneration Research 2008年第5期3卷 490-493页

作者： Liang Zeng haihua zhao Yongli Lu Wenbo Dai Department of Anatomy Shenyang Medical College Shenyang 110034 Liaoning Province China Department of Anatomy China Medical University Shenyang 110001 Liaoning Province China Department of Pathology First People＇s Hospital Shenyang 110041 Liaoning Province China

BACKGROUND： It has beenshown that ginsenoside, the effective component of ginseng, can enhance expression of choline acetyl transferase, as well as brain-derived neurotrophic factor （BDNF） and its receptor tyrosine kinase B （TrkB）, in cholinergic neurons of the basal forebrain. OBJECTIVE： To qualitatively and quantitatively verify the influence of ginsenoside on expression of BDNF and its receptor, TrkB, in the medial septum of aged rats, and to provide a molecular basis for clinical application. DESIGN~ TIME AND SETTING： A contrast study, which was performed in the Department of Anatomy, China Medical University, and the Department of Anatomy, Shenyang Medical College between December 2005 and May 2007. MATERIALS： Thirty-five, healthy, female, Sprague Dawley rats were selected for this study. Ginsenoside （81% purity） was provided by Jilin Ji＇an Wantai Chinese Medicine Factory; anti-BDNF antibody, anti-TrkB antibody, and their kits were provided by Wuhan Boster Company. METHODS： A total of 35 rats were divided into three groups： young （four months old）, aging （26 months old）, and ginsenoside. Rats in the ginsenoside group were administered ginsenoside （25 mg/kg/d） between 17 months and 26 months. MAIN OUTCOME MEASURES： Immunohistochemistry and in situ hybridization were used to measure expression of BDNF and TrkB in the medial septum of aged rats, and the detected results were expressed as gray values. RESULTS：（1） Qualitative detection： using microscopy, degenerative neurons were visible in the medial septum in the aging group. However, neuronal morphology in the ginsenoside group was similar to neurons in the young group. （2） Quantitative detection： the mean gray value of BDNF-positive and TrkB-positive products in the aging group were significantly higher than in the young group （t = 3.346, 4.169, P 〈 0.01）; however, the mean gray value in the ginsenoside group was significantly lower than in the aging group （t = 2.432, 2.651, P 〈 0.01）. CONCLUSION： Ginsenoside c

关键词： BDNF TrkB ginsenoside medial septum aged rat

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Effects of ginsenoside on brain-derived neurotrophic factor and tyrosine kinase B mRNA expression in the hippocampal formation of aged rats

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Neural Regeneration Research 2008年第7期3卷 723-727页

作者： Hong Lai Wensu Liu zhaosheng Li haihua zhao Yongli Lü Department of Anatomy College of Basic Medical Science China Medical University Shenyang 110001 Liaoning Province China School of Geophysics and Information Technology China University of Geosciences Beijing

BACKGROUND： There are a limited number of studies involving the effects of ginsenosides, the active component of ginseng, on expression of hippocampal TrkB mRNA in aged rats. OBJECTIVE： To observe expression of brain-derived neurotrophic factor （BDNF） and tyrosine kinase B （TrkB） mRNA in the hippocampal formation of aged rats, as well as changes after ginsenoside administrated. DESIGN, TIME AND SETTING： A randomized, controlled experiment was performed at the Department of Anatomy, College of Basic Medical Sciences, China Medical University in March 2005. MATERIALS： A total of 39 female, Wistar rats were randomly divided into 3 groups （n = 13 each）： young （3-5 months old）, aged （27 months old）, and ginsenoside group （received 25mg/kg/d ginsenoside in the drinking water between 17 and 27 months of age）. METHODS： Following anesthesia, the rats were exsanguinated and perfused transcardially with chilled, heparinized, 0.9% saline. The brains were removed and post-fixed in 40 g/L paraformaldehyde/phosphate buffer for 20 minutes, and further incubated in 30% sucrose/phosphate buffer overnight. MAIN OUTCOME MEASURES： In situ hybridization, immunohistochemistry, and image analysis were used to investigate expression of BDNF and TrkB mRNA in the hippocampal formation. RESULTS： The expression levels of BDNF in the hippocampal CA3 and CA1 of aged rats was significantly less than the young group （t = 2.879, 1.814, 1.984, P 〈 0.05）. BDNF expression was significantly greater in the dentate gyrus of the ginsenoside group, compared with the aging group （t = 1.943, P 〈 0.01）. The expression of TrkB mRNA in the hippocampal CA3, CA1, and dentate gyrus of aged rats was less than the young group （t = 3.540, 3.629, 17.905, P 〈 0.01）. TrkB mRNA expression in the CA3 region and dentate gyrus of the ginsenoside group was significantly greater compared with the aging group （t = 1.293, 3.386, P 〈 0.05, 0.01 ）. CONCLUSION： BDNF and TrkB mRNA expression in the hippocampal formation

关键词： ginsenosides brain-derived neurotrophic factor tyrosine kinase B hippocampus

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Facile ball-milled synthesis of SnS2-carbon nanocomposites with superior lithium storage

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Progress in Natural Science:Materials International 2018年第6期28卷 676-682页

作者： haihua zhao Hong Zeng Ying Wu Wen Qi Shengen Zhang Bo Li Yunhui Huang Central Iron and Steel Research Institute Institute for Advanced Materials Technology and School of Materials Science and Engineering University of Science and Technology Beijing Beijing Key Laboratory of Energy Nanomaterials Advance Technology & Materials Co. Ltd China Iron & Steel Research Institute Group Materials Center Beijing Institute of Collaborative Innovation 5. State Key Laboratory of Material Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology

A facile high-energy ball-milling method was developed to synthesize SnS2-carbon(SnS2/C-x(x = 40, 50, 60 wt%)) nanocomposites. The results showed that as anode materials for lithium-ion batteries(LIBs), the SnS2-C nanocomposites exhibited high discharge capacity and excellent cycling stability. For the optimized SnS2/C-50 wt% nanocomposite, a discharge capacity as high as 700 mA h g-1and the initial coulombic efficiency of 80.8% were achieved at a current density of 100 mA g-1. The unique structure with SnS2nanoparticles(NPs)embedded into carbon network provided abundant Li-ion storage sites, high electronic conductivity and fast ion diffusion. The ball-milled synthesis is applicable for large-scale preparation of new sulfide-based anode materials with good performance for LIBs.

关键词： SnS2-carbon Nanocomposites Ball milling Anode Lithium-ion battery

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Influence of post-grown treatments on CuInS_2 thin films prepared by sulphurization of Cu-In films

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Rare Metals 2008年第5期27卷 490-495页

作者： YAN Youhua LIU Yingchun FANG Ling zhao haihua LI Deren LU Zhichao ZHOU Shaoxiong Advanced Technology ＆ Materials Co. Ltd. China Iron ＆ Steel Research Institute Group Beijing 100081 China

Polycrystalline CuInS2 （CIS） films were prepared by sulphurization of Cu-In films. The surface morphology and phase composition of the as-grown film, the KCN-etched film, and the annealed KCN-etched film were investigated. During the sulphurization, the secondary CuxS phase segregated on the surface of the as-grown films. To improve the crystalline quality of CuInS2 films, a series of post-grown treatments, such as KCN-etching and vacuum annealing KCN-etched films, were performed on the as-grown films. Both as-grown and post-treated films were characterized by X-ray diffraction （XRD）, scanning electron microscopy （SEM）, and energy dispersive spectroscopy （EDS）. The results indicated that a CuxS secondary phase segregated on the surface of the as-grown film, which could be removed effectively by KCN etching. After the vacuum annealing treatment, the KCN-etched film had a sphalerite structure with （112） preferred orientation. Meanwhile, the crystalline quality of the CIS film was significantly improved, which provided a novel method to improve the performance of thin film solar cells.

关键词： solar energy CuInS2 thin film KCN etching annealing treatment sulphurization

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Immobilization of Chiral Catalyst on Amorphous Al2O3 for the Selective Hydrogenation of Ethyl 1H-Indole-2-carboxylate

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Chemical Research in Chinese Universities 2014年第2期30卷 284-288页

作者： GUAN Ruqi CHAO Guoku YE Caiping WANG Yuxiang LIU Yanmei LI haihua zhao Yajuan TAI Yulei College of Chemistry and Materials Engineering Wenzhou University Wenzhou 325027 P.R.China

Ru-B/γ-Al2O3 catalyst was prepared by reductant impregnation method,which was applied in the selective hydrogenation of ethyl 1H-indole-2-carboxylate for producing ethyl 2,3,3a,7a-tetrahydro-1H-indole-2-carboxylate with hydrogen as ***,we discussed the influences of substrate concentration,reaction solvent,hydrogenation temperature,initial hydrogen pressure and reaction time on the catalytic performance of the as-prepared *** obtained Ru-B/γ-Al2O3 catalyst showed a high-efficiency for the selective hydrogenation of ethyl 1H-indole-2-carboxylate（＞99％ conversion and selectivity） in i-propanol used as solvent at a concentration of 10％（mass fraction） of ethyl 1H-indole-2-carboxylate,a pressure of hydrogen of 6 MPa and a reaction temperature of 373 K.

关键词： Selective hydrogenation Supported amorphous catalyst Ru-B/γ-Al2O3 Indole derivative

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隐性走滑断层的识别方法及其走滑量的计算——以渤海湾盆地济阳坳陷为例

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石油物探 2021年第1期60卷 157-166页

作者：穆星赵海华中国石油化工股份有限公司胜利油田分公司勘探开发研究院山东东营257015

走滑断层对我国东部陆相盆地油气勘探具有重要意义,以往研究多关注大型走滑断层,忽视了小型或者隐性走滑断层。近年来在济阳坳陷陆续发现了一系列NNE向和NNW向的小型或隐性走滑断层,研究形成了此类断层的识别方法。利用走滑断层近等间... 详细信息

走滑断层对我国东部陆相盆地油气勘探具有重要意义,以往研究多关注大型走滑断层,忽视了小型或者隐性走滑断层。近年来在济阳坳陷陆续发现了一系列NNE向和NNW向的小型或隐性走滑断层,研究形成了此类断层的识别方法。利用走滑断层近等间距分布、多发生在构造性质转换处以及多条近平行断层收敛处的特点,首先识别出可能存在隐性断层的区域,再采用相干分析等方法进行走滑断层的精细解释,然后采用垂直断层两侧地震剖面处滑动扫描拼接方法、紧邻断层两侧平行地震剖面反射特征对比方法、平面地震属性切片、早期构造的切割、断层两侧伸展量差异估算等方法,定量地计算走滑量,进一步确定隐性走滑断层。将上述方法分别应用于济阳坳陷车镇凹陷车57地区、大王庄次洼PX722井区以及临南洼陷兴隆寺地区,识别出了相应的隐性走滑断层,而后依据不同地区的地质情况,采用不同的方法计算得到误差较小的走滑量,最后结合油气勘探实践,确定了隐性走滑断层,并证实隐性走滑断层对油气聚集具有重要的控制作用。上述隐性走滑断层的识别方法及其走滑量的计算方法对类似地区隐性走滑断层的识别具有借鉴意义。

关键词：隐性走滑断层识别方法走滑量计算地震剖面滑动扫描与对比地震属性切片伸展量估算济阳坳陷油气控制

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我国上市银行高管薪酬影响因素的实证分析——基于2001-2008年的数据

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江淮论坛 2011年第2期 34-38页

作者：赵海华复旦大学金融研究院上海200433

本文运用我国14家上市商业银行的有关数据,实证分析了高管薪酬与银行经营绩效、资产规模、公司治理之间的关系。实证结果表明,总体上我国上市银行的高管薪酬与盈利水平正相关,与风险管理水平的关系不大。从银行业总体数据来看,高管薪酬... 详细信息

本文运用我国14家上市商业银行的有关数据,实证分析了高管薪酬与银行经营绩效、资产规模、公司治理之间的关系。实证结果表明,总体上我国上市银行的高管薪酬与盈利水平正相关,与风险管理水平的关系不大。从银行业总体数据来看,高管薪酬与资产规模关系不大,但就单个银行来说,高管薪酬与资产规模正相关。在公司治理方面,高管薪酬与第一大股东持股比例关系不显著,但与第一大股东性质具有显著的相关性,与第二至第五大股东的持股比例具有较明显的显著关系,与董事会、监事会规模、结构关系不大。

关键词：上市银行高管薪酬经营业绩公司治理资产规模

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灰阶序列极值分析海洋污染贡献权重动态预测

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科技通报 2014年第4期30卷 19-21页

作者：赵海华湖北工程学院城市建设学院湖北孝感432100

提出了一种动态层次灰阶序列分析的灰色靶关联环境污染贡献权重动态预测算法,进行复杂环境海洋污染动态预测及相关监测实验和仿真研究,对环境监测数据进行分类和关联匹配,不需要人工干预即可计算污染物污染贡献程度权重值,根据计算模型... 详细信息

提出了一种动态层次灰阶序列分析的灰色靶关联环境污染贡献权重动态预测算法,进行复杂环境海洋污染动态预测及相关监测实验和仿真研究,对环境监测数据进行分类和关联匹配,不需要人工干预即可计算污染物污染贡献程度权重值,根据计算模型对整体海域水域状况进行模拟分析。监测数据仿真实验表明模型可以准确预测海洋的污染状况,对污染区域污染源进行定位,对海洋整体的污染情况进行评判,为海洋环境保护提供有力的数据分析支持与科学的决策。

关键词：海洋污染动态预测灰色靶关联污染权重分析

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基于时间-微多普勒谱的进动锥体目标参数估计

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现代雷达 2014年第8期36卷 17-21页

作者：叶显赵海华成都西科微波通讯有限公司解放军63610部队

空间目标的微多普勒信息对于目标的形状及运动参数提取和目标识别具有重要价值。文中针对进动的平底锥形目标,分析了锥顶和锥底散射中心的瞬时微多普勒之间的关系,并在此基础上提出了一种只利用锥顶和一个锥底散射中心的瞬时速度测量值... 详细信息

空间目标的微多普勒信息对于目标的形状及运动参数提取和目标识别具有重要价值。文中针对进动的平底锥形目标,分析了锥顶和锥底散射中心的瞬时微多普勒之间的关系,并在此基础上提出了一种只利用锥顶和一个锥底散射中心的瞬时速度测量值估计目标高度、底面半径和进动角的新方法。最后,通过电磁仿真数据验证了文中所提方法的有效性。

关键词：微多普勒谱进动锥体目标形状参数估计进动参数估计

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中国都市农业发展的问题及对策

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改革与战略 2015年第12期31卷 83-85页

作者：占绍文赵海华西安建筑科技大学管理学院陕西西安710055

都市农业具有农业、文化产业等多产业融合的特点,符合绿色发展、持续发展的要求,在新常态下,是区域产业升级发展的重要选择。基于对快速发展的都市农业园区的深入调查,文章认为,都市农业园区的建设存在差异性不足、与当地实际结合不够... 详细信息

都市农业具有农业、文化产业等多产业融合的特点,符合绿色发展、持续发展的要求,在新常态下,是区域产业升级发展的重要选择。基于对快速发展的都市农业园区的深入调查,文章认为,都市农业园区的建设存在差异性不足、与当地实际结合不够紧密、产业链条过短等问题,发展都市农业应该与当地文化、美丽乡村建设等深度融合,各地应系统地思考都市农业的发展战略、规划和实施路径。

关键词：都市农业文化产业产业链

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