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Inhibition of FOXO3a/BIM signaling pathway contributes to the protective effect of salvianolic acid A against cerebral ischemia/reperfusion injury

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Acta Pharmaceutica Sinica B 2019年第3期9卷 505-515页

作者： Junke Song Wen Zhang Jinhua Wang haiguang yang Qimeng Zhou Haigang Wang Li Li Guanhua Du State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100050China Beijing Key Laboratory of Drug Target Identification and Drug Screening Institute of Materia MedicaChinese Academy of MedicalSciences and Peking Union Medical CollegeBeijing100050China

Salvianolic acid A(SalA) is an effective compound extracted from traditional Chinese medicine Salvia miltiorrhiza Bunge. The Forkhead box O3a(FOXO3a) signaling pathway plays crucial roles in the modulation of ischemia-induced cell apoptosis. However, no information about the regulatory effect of SalA on FoxO3a is available. To explore the anti-cerebral ischemia effect and clarify the therapeutic mechanism of SalA, SH-SY5Y cells and Sprague–Dawley rats were applied, which were exposed to oxygen glucose deprivation/reoxygenation(OGD/R) and middle cerebral artery occlusion/reperfusion(MCAO/R) injuries, respectively. The involved pathway was identified using the specific inhibitor LY294002. Results showed that SalA concentration-dependently inhibited OGD/R injury triggered cell viability loss. SalA reduced cerebral infarction, lowered brain edema, improved neurological function, and inhibited neuron apoptosis in MCAO/R rats, which were attenuated by the treatment of phosphatidylinositol-4,5-bisphosphate 3-kinase(PI3K) specific inhibitor LY294002. SalA time-and concentration-dependently upregulated the phosphorylation levels of protein kinase B(AKT) and its downstream protein FOXO3a. Moreover, the nuclear translocation of FOXO3a was inhibited by SalA both in vivo and in vitro, which was also reversed by LY294002. The above results indicated that SalA fought against ischemia/reperfusion damage at least partially via the AKT/FOXO3a/BIM pathway.

关键词： Salvianolic acid A Ischemia reperfusion FOXO3a BIM Neuroprotection

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Screening, Characterization and Evaluation of Mangiferin Polymorphs

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Natural Products and Bioprospecting 2020年第4期10卷 187-200页

作者： Shiying yang Qi Zhou Baoxi Zhang Li Zhang Dezhi yang haiguang yang Guanhua Du yang Lu Beijing Key Laboratory of Polymorphic Drugs Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Beijing Key Laboratory of Drug Targets and Screening Research Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Mangiferin is a compound with many pharmacological activities and exists in many natural *** and hydrate of mangiferin have been reported separately in two literatures,but the polymorphism of this compound has not been realized until this *** this study,polymorph screening of mangiferin has been carried out and five forms have been obtained including three new forms never *** solid state characterization methods,such as powder X-ray diffraction,differential scanning calorimetry and thermogravimetry,are used to identify and characterize all of mangiferin *** comparison of the crystallographic data and hirshfeld surface analysis were first reported for mangiferin anhydrous and ***,the studies on stability,transformation and solubility have been undertaken,the results prompt that form V can be used as the dominant polymorph for the development of innovative pharmaceuticals.

关键词： Mangiferin Polymorph screening Characterize Stability Solubility

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Anomalous refinement and uniformization of grains in metallic thin films

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Nano Research 2023年第12期16卷 13358-13365页

作者： Lei Wang Shu Wang Xiaofeng Wang Jianming Zhang Jianjie Dong Bin Wei haiguang yang Zhongchang Wang Ziyang Zhang ChuanFei Guo Qian Liu Chinese Academy of Sciences(CAS)Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology&University of Chinese Academy of SciencesBeijing 100190China College of Mathematics and Physics Qingdao University of Science and TechnologyQingdao 266061China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China School of Materials Sun Yat-Sen UniversityGuangzhou 510275China International Iberian Nanotechnology Laboratory(INL) Department of Quantum and Energy MaterialsBraga 4715-330Portugal School of Electronic and Information Engineering Qingdao UniversityQingdao 266071China The MOE Key Laboratory of Weak-Light Nonlinear Photonics and TEDA Applied Physics Institute and School of Physics Nankai UniversityTianjin 300457China

When a laser beam writes on a metallic film,it usually coarsens and deuniformizes grains because of Ostwald ripening,similar to the case of *** we show an anomalous refinement effect of metal grains:A metallic silver film with large grains melts and breaks into uniform,close-packed,and ultrafine(~10 nm)grains by laser direct writing with a nanoscale laser spot size and nanosecond pulse that causes localized heating and adaptive *** method exhibits high controllability in both grain size and uniformity,which lies in a linear relationship between the film thickness(h)and grain size(D),D∝*** linear relationship is significantly different from the classical spinodal dewetting theory obeying a nonlinear relationship(D∝h5/3)in common laser *** also demonstrate the application of such a silver film with a grain size of~10.9 nm as a surface-enhanced Raman scattering chip,exhibiting superhigh spatial-uniformity and low detection limit down to 10-15 *** anomalous refinement effect is general and can be extended to many other metallic films.

关键词： laser direct writing anomalous refinement localized heating ripening linear relationship

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Mechanism study and uric acid reduce effects of theaflavin on potassium oxonate induced hyperuricemia in mice

Mechanism study and uric acid reduce effects of theaflavin o...

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第十一届海峡两岸心血管科学研讨会、2017年全国心脑血管药理学术会议、中国卒中学会第一次新药研讨会

作者： Zhou Qimeng Wang Haigang Zhao Xiaoyue yang haiguang Du Guanhua Institute of Materia Medica Chinese Academy of medical science and Peking Union Medical College

Background:Hyperuricemia is an independent risk factor for cardiovascular ***,it's also tightly relative with hypertension and metabolic *** were reported as materials that has anti-hyperlipidemia,anti-inflammatory,antioxidant and anti-tumor *** study observes theaflavins' effect of reducing uric acid level and its mechanism in hyperuricemia mice induced by potassium oxonate.

关键词： Mechanism study and uric acid reduce effects of theaflavin on potassium oxonate induced hyperuricemia in mice

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Black tea extract ameliorates fatty liver and fatty kidney in HFD-induced obese mice

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Food Science and Human Wellness 2024年

作者： Peng Ma Li Zhang Zijing Wang Tianshu Xu haiguang yang Biyu Hou Yiwei Li Ping He Sin Man Lam Guanghou Shui Xiangyan Li Guanhua Du Jian Ying Guifen Qiang Institute of Materia Medica， Chinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening Research Inner Mongolia Clinical College， Inner Mongolia Medical University Faculty of Environment and Life， Beijing University of Technology State Key Laboratory of Molecular Developmental Biology， Institute of Genetics and Developmental Biology， Chinese Academy of Sciences Northeast Asia Research Institute of Traditional Chinese Medicine， Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy， Ministry of Education， Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine， Changchun University of Chinese Medicine Wuhan Polytechnic University， Nutrition and Health Research Institute，School of Life Science and Technology， School of Food Science and Engineering

Black tea is a kind of full-fermented tea with therapeutic potential for metabolic diseases. Ectopic lipid deposition (ELD) is an essential risk factor for organ injury in metabolic syndrome， especially in liver and kidney， for which effective interventions are lacking. Here， we explored whether black tea extract (BTE) improves fatty liver and fatty kidney， as well as identified the potential lipid biomarkers for ELD and lipid targets of BTE on the improvement of ELD. Transcriptome data from diet-induced obese (DIO) mice were analyzed to confirm high-fat-diet feeding disturbs lipid metabolism in the liver and kidney. BTE prominently inhibited body weight gain， improved glucose metabolism， as well as reduced lipid droplet accumulation in the liver and kidney. Moreover， lipidomic profiling analyses identified 28 lipid classes in the liver while 29 in the kidney with that up-regulated glycerides and phosphatidylcholines (PC)， as well as down-regulated cardiolipin (CL) were the characteristic changes in ELD. BTE prominently reduced glycerides in ELD， thereby constituting the basis of its anti-ELD effect. Specifically， BTE displayed stronger effects on lowering cholesterol ester (CE) in fatty liver， while also affecting phospholipids and sphingolipids in fatty kidney. Ultimately， integrative analysis identified CE18:2 and triglyceride (TAG) 56:4 (20:2) as the potential lipid biomarkers for BTE in improvement of ELD. BTE could be an effective food supplement for the prevention and treatment of ELD. Notably， CE18:2 and TAG56:4 (20:2)， as the potential lipid biomarkers， may facilitate the research and development of anti-ELD drug.

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北京电视中心综合业务楼超高层钢结构施工安全防护技术

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建筑技术 2005年第2期36卷 101-104页

作者：齐明杨海光北京建工集团总承包二部北京100045

北京电视中心综合业务楼为超高层钢结构建筑,具有体量巨大、结构形式复杂、安全施工要求高、安全防护难度大等特点,在结构施工期间采用了多种安全实用的防护形式。该系统形式简单,装拆方便,安全可靠,实用性强,保证了施工的安全。

关键词：超高层建筑钢结构安全防护

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多向共振教学法在研究生管理类课程案例教学中的应用

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学位与研究生教育 2006年第5期 44-48页

作者：夏维力杨海光西北工业大学管理学院

针对当前研究生管理类课程案例教学中存在的问题,提出了基于思维、情感、信息、环境协调等多方面多向共振的案例教学法,从心理学、系统论的角度对该教学方法的理论基础进行了研究,并介绍了该方法的实施步骤。

关键词：多向共振教学法案例教学

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中频磁控溅射钛酸锶钡薄膜的结构及性能

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稀有金属材料与工程 2007年第A01期36卷 970-972页

作者：廖家轩李恩求田忠许江杨海光电子科技大学电子科学技术研究院四川成都610054

用中频磁控溅射制备了钛酸锶钡Ba0.6Sr0.4TiO3(简称MF-BST)薄膜,并对该薄膜进行原位晶化。XPS表明,MF-BST薄膜的表面成分Ba0.58Sr0.42Ti1.01O2.95和膜体成分Ba0.6Sr0.4TiO3接近,主要由钙钛矿结构的BST组成。AFM表明,MF-BST薄膜的表面光滑致密。XRD表明,MF-BST薄膜晶化完全,呈(111)择优。XTEM观察及XPS刻蚀表明MF-BST/Pt界面过渡层约2nm厚,含少量的TixPtyOz。MF-BST薄膜电容器具有高达1200的介电常数及低达10-9A/cm2的漏电流密度。同时,该薄膜的结构及介电性能与射频磁控溅射及非原位晶化的Ba0.6Sr0.4TiO3(简称RF-BST)薄膜进行了比较。

关键词：中频磁控溅射钛酸锶钡薄膜钙钛矿结构

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Industrial wastewater treatment using airlift bioreactor

Industrial wastewater treatment using airlift bioreactor

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第六届化学工程与生物技术展览暨会议

作者： CHEN Shailin,FAN Yi,yang haiguang,DING Fuxin (Department of Chemical Engineering,Tsinghua University,Beijing 100084,P.R.China)

＜正＞ A novel wastewater treatment process,using airlift bioreactor as aeration device,was proposed in this *** of this process in industrial wastewater treatment was illustrated by several practical *** the results in practices have shown that airlift bioreactor has a good technical feasibility and a promising market future in the field of industrial wastewater treatment.

关键词： Industrial wastewater airlift bioreactor activated sludge process porous carriers

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水泥混凝土路面板脱空检测方法研究

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油气田地面工程 2023年第9期42卷 57-61页

作者：杨海光大庆油田设计院有限公司

为了及时预防和处治路面板脱空问题,延续和提高道路服务质量,准确判定板底的脱空状况,采用地震波法检测水泥混凝土路面板脱空动力响应。室内试验通过传感器采集和分析水泥混凝土路面板的应变和加速度。结果表明:随着路面板的脱空面积增... 详细信息

为了及时预防和处治路面板脱空问题,延续和提高道路服务质量,准确判定板底的脱空状况,采用地震波法检测水泥混凝土路面板脱空动力响应。室内试验通过传感器采集和分析水泥混凝土路面板的应变和加速度。结果表明:随着路面板的脱空面积增加,板的应变变大,振动时间变长,最大振幅的频率降低,振动加速度变大,而且板顶应变小于板底应变,随着落锤高度变化,试验结果也不同;非脱空水泥混凝土路面板的应变和振动时间以及最大加速度远小于脱空水泥混凝土路面板,脱空水泥混凝土路面板最大振幅对应的频率要更小。

关键词：道路工程水泥混凝土路面板角隅脱空纵缝脱空地震波法

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