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高超声速通气模型喷管出口气流参数测量试验技术研究

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实验流体力学 2017年第6期31卷 86-92,99页

作者：舒海峰何超郭雷涛许晓斌范孝华中国空气动力研究与发展中心超高速空气动力研究所四川绵阳621000 高超声速冲压发动机技术国防科技重点实验室四川绵阳621000

准确测量内流道出口参数是获得高超声速通气模型内流道气动特性的基础。目前采用的单排测压耙或多排测压耙、固定位置测量的方法不能全面而准确地反映出口流动的实际情况,因此开展了新方法的研究工作。选取一个去除所有安定面和舵面的... 详细信息

准确测量内流道出口参数是获得高超声速通气模型内流道气动特性的基础。目前采用的单排测压耙或多排测压耙、固定位置测量的方法不能全面而准确地反映出口流动的实际情况,因此开展了新方法的研究工作。选取一个去除所有安定面和舵面的带进气道升力体布局飞行器模型作为研究对象,开展了试验方法研究:用CFD方法研究相邻静压管之间不同距离以及静压管与气流夹角对测量结果的影响;研制了专用的三自由度压力测量装置;开展了Ma6条件下的风洞试验,获得了喷管出口附近的壁面压力、出口处的静压和皮托压力。试验结果表明:壁面压力和出口静压总体呈两侧高、中间低的趋势;模型壁面温度对重复性精度有较大影响;测压排架与喷管壁面之间的相互干扰对静压测量准度产生影响。

关键词：内流道吸气式飞行器皮托压力静压风洞试验

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基于小波重构的天平动态特性数据处理技术

北京航空航天大学学报 2023年第6期49卷 1362-1371页

作者：张峻宾许晓斌王雄蒋万秋舒海峰孙鹏中国空气动力研究与发展中心超高速空气动力研究所绵阳621000

针对风洞试验模型会产生受迫振动,测力天平测量的数据是模型受迫振动和受到气动力的混叠影响测力数据精度的问题,提出基于小波重构的天平动态特性数据处理技术。通过在模型上安装加速度计敲击模型获取受迫振动数据,再对受迫振动数据通... 详细信息

针对风洞试验模型会产生受迫振动,测力天平测量的数据是模型受迫振动和受到气动力的混叠影响测力数据精度的问题,提出基于小波重构的天平动态特性数据处理技术。通过在模型上安装加速度计敲击模型获取受迫振动数据,再对受迫振动数据通过快速傅里叶变换(FFT)分析确定滤波频率阈值,采用小波重构技术实现滤波。通过投影公式计算动态补偿系数,通过补偿系数对天平测量的气动力实现补偿。试验数据分析发现,基于小波重构的天平动态特性数据处理技术,可得到固定的补偿系数,在试验环境中,干扰信号最大能衰减到15.69%,具有重要的工程应用价值。

关键词：小波重构天平动态特性数据处理补偿系数

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Estimation of Physiologic Ability and Surgical Stress scoring system for predicting complications following abdominal surgery: A metaanalysis spanning 2004 to 2022

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 215-227页

作者： Tian-shu Pang Li-Ping Cao Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina

BACKGROUND Postoperative complications remain a paramount concern for surgeons and healthcare *** To present a comprehensive analysis of the Estimation of Physiologic Ability and Surgical Stress(E-PASS)scoring system’s efficacy in predicting postoperative complications following abdominal *** A systematic search of published studies was conducted,yielding 17 studies with pertinent *** such as preoperative risk score(PRS),surgical stress score(SSS),comprehensive risk score(CRS),postoperative complications,post-operative mortality,and other clinical data were collected for *** plots were employed for continuous and binary variables,withχ2 tests assessing heterogeneity(P value).RESULTS Patients experiencing complications after abdominal surgery exhibited significantly higher E-PASS scores compared to those without complications[mean difference and 95%confidence interval(CI)of PRS:0.10(0.05-0.15);SSS:0.04(0.001-0.08);CRS:0.19(0.07-0.31)].Following the exclusion of low-quality studies,results remained valid with no discernible *** analysis indicated that variations in sample size and age may contribute to hetero-geneity in CRS *** variable meta-analysis demonstrated a correlation between high CRS and increased postoperative complication rates[odds ratio(OR)(95%CI):3.01(1.83-4.95)],with a significant association observed between high CRS and postoperative mortality[OR(95%CI):15.49(3.75-64.01)].CONCLUSION In summary,postoperative complications in abdominal surgery,as assessed by the E-PASS scoring system,are consistently linked to elevated PRS,SSS,and CRS *** CRS scores emerge as risk factors for heightened morbidity and *** study establishes the accuracy of the E-PASS scoring system in predicting postoperative morbidity and mortality in abdominal surgery,underscoring its potential for widespread adoption in effective risk assessment.

关键词： Estimation of Physiologic Ability and Surgical Stress scoring system Preoperative risk score Surgical stress score Comprehensive risk score Complications

Network pharmacology and molecular dynamics study of the effect of the Astragalus-Coptis drug pair on diabetic kidney disease

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World Journal of Diabetes 2024年第7期15卷 1562-1588页

作者： Mo-Yan Zhang shu-Qin Zheng Liaoning University of Traditional Chinese Medicine Liaoning University of Traditional Chinese MedicineShenyang 110847Liaoning ProvinceChina Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110032Liaoning ProvinceChina

BACKGROUND Diabetic kidney disease(DKD)is the primary cause of end-stage renal *** Astragalus-Coptis drug pair is frequently employed in the management of ***,the precise molecular mechanism underlying its therapeutic effect remains *** To investigate the synergistic effects of multiple active ingredients in the Astragalus-Coptis drug pair on DKD through multiple targets and *** The ingredients of the Astragalus-Coptis drug pair were collected and screened using the TCMSP database and the SwissADME *** targets were predicted using the SwissTargetPrediction database,while the DKD differential gene expression analysis was obtained from the Gene Expression Omnibus *** targets were acquired from the GeneCards,Online Mendelian Inheritance in Man database,and DisGeNET databases,with common targets identified through the Venny *** protein-protein interaction network and the“disease-active ingredient-target”network of the common targets were constructed utilizing the STRING database and Cytoscape software,followed by the analysis of the interaction relationships and further screening of key targets and core active *** Ontology(GO)function and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichments were performed using the DAVID *** tissue and organ distributions of key targets were *** and AutoDock software validate the molecular docking between the core ingredients and key ***,molecular dynamics(MD)simulations were conducted to simulate the optimal complex formed by interactions between core ingredients and key target *** A total of 27 active ingredients and 512 potential targets of the Astragalus-Coptis drug pair were *** were 273 common targets between DKD and the Astragalus-Coptis drug *** protein-protein interaction network topology analysis,we identified 9 core active ingredients and 10 key *** and KEGG pathwa

关键词： Astragalus membranaceus Coptis chinensis Franch Diabetic kidney disease Network pharmacology Molecular docking Molecular dynamics simulation

Nogo-A蛋白参与癫痫发生机制的研究进展

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中华神经科杂志 2019年第11期52卷 967-973页

作者：章津伟陈涛余思逊树海峰匡永勤成都医学院临床医学系 610500 西部战区总医院神经外科成都610083

髓鞘相关蛋白Nogo-A最早被认为是轴突生长抑制因子,参与神经系统多种病理生理调节。近年来越来越多的研究表明,Nogo-A蛋白通过参与调控树突可塑性、介导神经异常迁移、调节胶质细胞活化等与癫痫的发生有着密切的关系。文中将对近年来Nog... 详细信息

髓鞘相关蛋白Nogo-A最早被认为是轴突生长抑制因子,参与神经系统多种病理生理调节。近年来越来越多的研究表明,Nogo-A蛋白通过参与调控树突可塑性、介导神经异常迁移、调节胶质细胞活化等与癫痫的发生有着密切的关系。文中将对近年来Nogo-A在癫痫发生中的联系研究进展做一综述。

关键词： Nogo-A 癫痫树突胶质细胞神经迁移

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Therapeutic effect and psychological impact of aspirin plus edaravone on patients with cerebral infarction

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World Journal of Psychiatry 2024年第5期14卷 644-652页

作者： Tian-shu Wang Li-Jun Jing Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

BACKGROUND Cerebral infarction(CI)is characterized by a high prevalence,disability,and *** or improper treatment greatly affects patient *** To explore the drug efficacy of aspirin plus edaravone and to explore their effect on quality of life(QOL),anxiety and depression in CI *** We retrospectively analyzed the records of 124 CI patients treated between June 2019 and February 2021 who were assigned to an observation group(OG)(combination therapy of aspirin and edaravone,65 patients)or a control group(CG)(aspirin monotherapy,59 patients).The therapeutic effects,pre-and posttreatment National Institutes of Health Stroke Scale(NIHSS)scores,activities of daily living,degree of cognitive impairment,protein levels of glial fibrillary acidic protein(GFAP),neuron-specific enolase(NSE)and S-100B,occurrence of adverse reactions,and serum high-sensitivity C-reactive protein(hs-CRP),interleukin(IL)-6 and tumor necrosis factor(TNF)-αwere evaluated,detected and compared between the two ***,posttreatment QOL,anxiety,and depression were assessed by the Medical Outcomes Study 36-Item Short Form Health Survey Scale,Self-rating Depression Scale(SDS),and Self-rating Anxiety Scale(SAS),*** Compared with the CG,the OG had markedly better therapeutic effects,greater improvements in activities of daily living,and better alleviation in cognitive dysfunction after treatment,as well as lower posttreatment NIHSS scores and serum NSE,GFAP,S-100B,hs-CRP,IL-6,and TNF-αlevels;the OG was similar to the CG in terms of adverse reactions but was better than the CG in terms of posttreatment QOL;and the OG also had lower SDS and SAS scores than the CG after *** Aspirin plus edaravone had a good curative effect on *** can reverse cranial nerve damage in patients,improve neurological function and prognosis,and alleviate inflammation,anxiety,and depression;thus,it is considered safe and worthy of clinical application.

关键词： Aspirin Edaravone Cerebral infarction Efficacy Quality of life

Effect of Down-regulation of MMP-2 by Quercetin on the Migration and Invasion of Uterine Fibroids Cells through the cAMP Signaling Pathway

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Chinese Journal of Biomedical Engineering 2024年第2期33卷 54-61页

作者： LIN shu-ping ZOU Xiao-fen Longyan First Affiliated Hospital of Fujian Medical University

Objective: To investigate the effect of down-regulation of matrix metalloproteinase-2(MMP-2) by down-regulating the cyclic adenosine monophosphate(cAMP) signaling pathway on the migration and invasion of uterine fibroids ***: A total of 65 female SD rats were randomly divided into five groups after being adaptively fed for 7 d. Except for the blank group, the remaining four groups of rats were injected with 0.05 mg/(100 g·d) estradiol benzoate and 0.5 mg/(100g·d) progesterone into the muscle to establish a uterine fibroids rat model. After successful modeling, the blank group and model group were given 200 mg/(kg·d) physiological saline by gavage,the low-dose group was given 100 mg/(kg·d) mifepristone by gavage, the medium-dose group was given 200 mg/(kg·d) mifepristone by gavage, and the high-dose group was given 300 mg/(kg·d) mifepristone by gavage. After continuous gavage treatment for 21 d,serum and uterine tissues were collected from rats to observe and compare the expression levels of MMP-2 mRNA, TIMP-2 mRNA, estradiol(E2), cAMP signaling pathway related proteins, and the migration and invasive ability of uterine fibroids cells in the five groups of rats. Results: The expression levels of MMP-2 mRNA and E2in the high-dose group were lower than those in the low-dose group and the medium-dose group, and the expression level of TIMP-2 mRNA was higher than that in the low-dose group and the medium-dose group(P<0.05). The number of cell migration in a single visual field of rats in the high-dose group was lower than that in the low-dose group and the medium-dose group(P<0.05). The number of cell invasion in a single visual field of rats in the high-dose group was lower than that in the low-dose group and the medium-dose group(P<0.05). The mRNA expression levels of cAMP, PDE and PK in the high-dose group were higher than those in the low-dose group, and the mRNA expression levels of AC in the high-dose group were lower than those in the low-dose group(P<0.

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Transformer-Based Cloud Detection Method for High-Resolution Remote Sensing Imagery

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Computers, Materials & Continua 2024年第7期80卷 661-678页

作者： Haotang Tan Song Sun Tian Cheng Xiyuan shu Key Laboratory of GIS Application Research School of Geography and TourismChongqing Normal UniversityChongqing401331China College of Computer and Information Science Chongqing Normal UniversityChongqing401331China Department of Military Installations Army Logistics AcademyChongqing401331China

Cloud detection from satellite and drone imagery is crucial for applications such as weather forecasting and *** the limitations of conventional convolutional neural networks,we propose an innovative transformer-based *** method leverages transformers,which are adept at processing data sequences,to enhance cloud detection ***,we introduce a Cyclic Refinement Architecture that improves the resolution and quality of feature extraction,thereby aiding in the retention of critical details often lost during cloud *** extensive experimental validation shows that our approach significantly outperforms established models,excelling in high-resolution feature extraction and precise cloud *** integrating Positional Visual Transformers(PVT)with this architecture,our method advances high-resolution feature delineation and segmentation ***,our research offers a novel perspective for surmounting traditional challenges in cloud detection and contributes to the advancement of precise and dependable image analysis across various domains.

关键词： Cloud transformer image segmentation remotely sensed imagery pyramid vision transformer

Mechanism Design for Ancillary Service Market Considering Social Welfare and Fairness

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1000-1010页

作者： Zhi Wu Yuanxi Wu Wei Gu Zheng Xu shu Zheng Jingtao Zhao School of Electrical Engineering Southeast UniversityNanjing 210096China NARI Technology Co. Ltd.Nanjing 211106China IEEE CSEE

Increasing penetration of distributed energy resources in the distribution network(DN)is threatening safe operation of the DN,which necessitates setup of the ancillary service market in the *** the ancillary service market,distribution system operator(DSO)is responsible for safety of the DN by procuring available capacities of *** existing studies,this paper proposes a novel market mechanism composed of two parts:choice rule and payment *** proposed choice rule simultaneously considers social welfare and fairness,encouraging risk-averse aggregators to participate in the ancillary service *** is then formulated as a linear programming problem,and a distributed solution using the multi-cut Benders decomposition is ***,successful implementation of the choice rule depends on each aggregator’s truthful adoption of private ***,a payment rule is also designed,which is proved to possess two properties:incentive compatibility and individual *** results demonstrate effectiveness of the proposed choice rule on improving fairness and verify properties of the payment rule.

关键词： Aggregator ancillary service market distributed mechanism fairness mechanism design