检索结果-南通市图书馆

Rosmarinic acid elicits neuroprotection in ischemic stroke via Nrf2 and heme oxygenase 1 signaling

Neural Regeneration Research 2018年第12期13卷 2119-2128页

作者： hai-ying cui Xiang-Jian Zhang Yi Yang Cong Zhang Chun-Hua Zhu Jiang-Yong Miao Rong Chen Department of Neurology Second Hospital of hebei Medical university Shijiazhuang Hebei Province China Hebei Key Laboratory of Vascular Homeostasis and Hebei Collaborative Innovation Center for Cardiocerebrovascular Disease ShijiazhuangHebei Province China

Rosmarinic acid（RA） can elicit a neuroprotective effect against ischemic stroke, but the precise molecular mechanism remains poorly understood. In this study, an experimental ischemic stroke model was established in CD-1 mice（Beijing Vital River Laboratory Animal Technology, Beijing, China） by occluding the right middle cerebral artery for 1 hour and allowing reperfusion for 24 hours. After intraperitoneally injecting model mice with 10, 20, or 40 mg/kg RA, functional neurological deficits were evaluated using modified Longa scores. Subsequently, cerebral infarct volume was measured using TTC staining and ischemic brain tissue was examined for cell apoptosis with TUNEL staining. Superoxide dismutase activity and malondialdehyde levels were measured by spectrophometry. Expression of heme oxygenase-1（HO-1）, nuclear factor erythroid 2-related factor 2（Nrf2）, Bcl-2, Bax, Akt, and phospho-Ser473 Akt proteins in ischemic brain tissue was detected by western blot, while mRNA levels of Nrf2, HO-1, Bcl-2, and Bax were analyzed using real time quantitative PCR. In addition, HO-1 enzyme activity was measured spectrophotometrically. RA（20 and 40 mg/kg） greatly improved neurological function, reduced infarct volume, decreased cell apoptosis, upregulated Bcl-2 protein and mRNA expression, downregulated Bax protein and mRNA expression, increased HO-1 and Nrf2 protein and mRNA expression, increased superoxide dismutase activity, and decreased malondialdehyde levels in ischemic brain tissue of model mice. However, intraperitoneal injection of a HO-1 inhibitor（10 mg/kg zinc protoporphyrin IX） reversed the neuroprotective effects of RA on HO-1 enzyme activity and Bcl-2 and Bax protein expression. The PI3 K/Akt signaling pathway inhibitor LY294002（10 mM） inhibited Akt phosphorylation, as well as Nrf2 and HO-1 expression. Our findings suggest that RA has anti-oxidative and anti-apoptotic properties that protect against ischemic stroke by a mechanism involving upregulation of Nrf2 and HO

关键词： cerebral ischemia/reperfusion rosmarinic acid cellular apoptosis oxidative injury neuroprotection Bcl-2 Bax Nrf2 heme oxygenase 1 PI3K/Akt signal pathway neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Characteristics of High-power GaAs Laser Beams and Their Coupling with Fibers

引用

Semiconductor Photonics and Technology 2005年第4期11卷 233-238页

作者： YU Henry hai-ying cui Bi-feng TIAN Zeng-xia LIU ying ZOU De-shu SHEN Guang-di Beijing Laboratory of Optoelectron. Technol. Beijing University of Technology Beijing 100022 CHN

The beams of 980nm high-power LDs are analyzed, and the reasons that aspect ratio of LD beams is high are explained. It is certified by the test that cylindrical lens can efficiently compress the perpendicular divergence angle of the beam. Some typical and popular lensed fibers were compared and analyzed according to coupling characteristics. The factors which affect the coupling efficiency and tolerance of the wedged-shaped GRIN tipped lensed fiber are pointed out, and some methods to reduce the coupling loss of the lensed fibers are proposed finally.

关键词： GaAs LD Lensed fibers Optical coupling mode GRIN fibers

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

新源山地草甸类草地自然保护区植物生活型的研究

引用

新疆师范大学学报（自然科学版） 1995年第1期14卷 81-85页

作者：海鹰张洪江崔大方新疆师范大学地理系新疆维吾尔自治区草原总站新疆师范大学生物系

新源山地草甸类草地自然保护区位于新源县东南部,那拉提山与塔什帕尔山之间的恰普克河山间谷地。是1986年经新疆维吾尔自治区人民政府批准建立的新疆第一个山地草甸类草地自然保护区,1993年又被列入中国“人与生物圈网络”(MAB)。1994年... 详细信息

新源山地草甸类草地自然保护区位于新源县东南部,那拉提山与塔什帕尔山之间的恰普克河山间谷地。是1986年经新疆维吾尔自治区人民政府批准建立的新疆第一个山地草甸类草地自然保护区,1993年又被列入中国“人与生物圈网络”(MAB)。1994年6～7间,笔者等参加了自治区草原总站组织的综合考察。根据实地考察,笔者对保护区内的种子植物生活型进行了研究,提出了生活型分类式,并对各生活型类群的组成进行了初步划分和探讨,为进一步进行研究和保护利用提供了依据。

关键词：新源山地种子植物生活型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Novel Model for Describing Rail Weld Irregularities and Predicting Wheel-Rail Forces Using a Machine Learning Approach

引用

Computer Modeling in Engineering & Sciences 2025年第1期142卷 555-577页

作者： Linlin Sun Zihui Wang Shukun cui Ziquan Yan Weiping Hu Qingchun Meng State Key Laboratory of High-Speed Railway Track System China Academy of Railway Sciences Corporation LimitedBeijing100081China Railway Engineering Research Institute China Academy of Railway Sciences Corporation LimitedBeijing100081China School of Aeronautic Science and Engineering Beihang UniversityBeijing100191China

Rail weld irregularities are one of the primary excitation sources for vehicle-track interaction dynamics in modern high-speed *** can cause significant wheel-rail dynamic interactions,leading to wheel-rail noise,component damage,and *** researchers have employed the vehicle-track interaction dynamic model to study the dynamic interactions between wheel and rail induced by rail weld geometry ***,the cosine wave model used to simulate rail weld irregularities mainly focuses on the maximum value and neglects the geometric *** this study,novel theoretical models were developed for three categories of rail weld irregularities,based on measurements of the high-speed railway from Beijing to *** vertical dynamic forces in the time and frequency domains were compared under different running *** forces generated by the rail weld irregularities that were measured and modeled,respectively,were compared to validate the accuracy of the proposed ***,based on the numerical study,the impact force due to rail weld irrregularity is modeled using an Artificial Neural Network(ANN),and the optimum combination of parameters for this model is *** results showed that the proposed model provided a more accurate wheel/rail dynamic evaluation caused by rail weld irregularities than that established in the *** ANN model used in this paper can effectively predict the impact force due to rail weld irrregularity while reducing the computation time.

关键词： Rail weld irregularity high-speed railway vehicle-track coupled dynamics wheel/rail dynamic vertical force artificial neural networks

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

超声乳化吸出联合小梁切除术治疗青光眼合并白内障

引用

眼外伤职业眼病杂志 2008年第12期30卷 931-934页

作者：郭海科崔颖张洪洋金海鹰李倩广东省人民医院眼科广州510080

目的评价晶状体超声乳化吸出折叠式人工晶状体植入联合小梁切除术的效果和安全性以及手术技术的进步。方法对47例（53眼）青光眼合并白内障手术进行回顾性临床分析。随访12-18个月。手术技术的改进包括抗代谢药物的使用；双切口法；可... 详细信息

目的评价晶状体超声乳化吸出折叠式人工晶状体植入联合小梁切除术的效果和安全性以及手术技术的进步。方法对47例（53眼）青光眼合并白内障手术进行回顾性临床分析。随访12-18个月。手术技术的改进包括抗代谢药物的使用；双切口法；可调节缝线及以穹隆为基底的结膜瓣等4方面。结果53眼中49眼（92．45％）眼压控制在21mmHg以下（1mmHg=0．133kPa），其中28眼（52．83％）在15mmHg以下。眼压由术前平均（25．17±3．70）mrnHg降至术后（16．79±2．78）mmHg，（t=21．60，P=0．000）；使用抗青光眼药物由术前平均（1．89±0．49,）种减少到术后仅8眼（15．09％）需1种。39眼（73．58％）获得≥0．5校正视力，术后视力较术前明显提高（z=-5．845，P〈0．001）。术后早期发生纤维素性葡萄膜炎9眼，浅前房2眼，低眼压黄斑水肿2眼，脉络膜脱离1眼。结论超声乳化白内障吸出人工晶状体植入联合小梁切除术可以在降低眼压的同时恢复视力，减少抗青光眼药物的使用。改良的联合手术技术提高了效果和安全性。

关键词：超声乳化白内障吸出联合小梁切除术青光眼白内障

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

引用

Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-cui Mao Hui-Lin Jiang Bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

高度近视准分子激光角膜原位磨镶术后并发开角型青光眼的早期诊断

引用

眼科研究 2010年第5期28卷 441-444页

作者：曾锦郭海科崔颖谢文娟李仲明廖伟雄广东省医学科学院广东省眼病防治研究所广东省人民医院眼科广州510080

目的探讨高度近视行准分子激光角膜原位磨镶术(LASIK)后开角型青光眼患者的临床特征。方法回顾性分析2008年7月—2009年6月以屈光回退或眩光为主诉复诊的高度近视行LASIK术后患者13例25眼的临床资料;所有患者屈光回退现象均发生在术后2a... 详细信息

目的探讨高度近视行准分子激光角膜原位磨镶术(LASIK)后开角型青光眼患者的临床特征。方法回顾性分析2008年7月—2009年6月以屈光回退或眩光为主诉复诊的高度近视行LASIK术后患者13例25眼的临床资料;所有患者屈光回退现象均发生在术后2a,其中男8例,女5例;平均年龄30.1岁,均进行视力、屈光度、角膜地形图、Goldman眼压、眼轴、视野及OCT检查,原发性开角型青光眼的诊断依据全国青光眼学组建议的诊断标准,所有患者术前均签署知情同意书。结果 12例23眼中,术后平均回退屈光度为(-1.57±0.36)D,裸眼视力0.42±0.14;1例患者双眼眩光加重,瞳孔散大,直径为4.5～5.0mm,夜间瞳孔直径为5.8～6.1mm;6例12眼术后校正眼压为21～26mmHg,合并有视网膜神经纤维层(RNFL)变薄及相应的青光眼典型视野改变;7例13眼屈光回退者中OCT检查RNFL变薄者3例5眼,用眼过度致视疲劳者4例8眼。结论高度近视患者行LASIK2a后出现视力下降及眩光现象,且单纯以屈光回退及光学区过小无法解释者,要考虑到并发开角型青光眼的可能。

关键词：高度近视准分子激光角膜原位磨镶术青光眼

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The complex effects of miR-146a in the pathogenesis of Alzheimer's disease

引用

Neural Regeneration Research 2025年第5期20卷 1309-1323页

作者： Yunfan Long Jiajia Liu Yu Wang haidong Guo Guohong cui Department of Neurology Shanghai No.9 People’s HospitalShanghai Jiaotong University School of MedicineShanghaiChina Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina School of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Neurology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina

Alzheimer's disease is a neurodegenerative disorder characterized by cognitive dysfunction and behavioral *** plaques formed through the extracellular deposition of amyloid-βproteins,as well as neurofibrillary tangles formed by the intracellular deposition of hyperphosphorylated tau proteins,comprise two typical pathological features of Alzheimer's *** symptomatic treatment,there are no effective therapies for delaying Alzheimer's disease ***(miR)are small,non-coding RNAs that negatively regulate gene expression at the transcriptional and translational levels and play important roles in multiple physiological and pathological ***,miR-146a,a NF-κB-regulated gene,has been extensively implicated in the development of Alzheimer's disease through several *** has demonstrated substantial dysregulation of miR-146a both during the initial phases and throughout the progression of this *** R-146a is believed to reduce amyloid-βdeposition and tau protein hyperphosphorylation through the TLR/IRAK1/TRAF6 pathway;however,there is also evidence supporting that it can promote these processes through many other pathways,thus exacerbating the pathological manifestations of Alzheimer's *** has been widely reported that miR-146a mediates synaptic dysfunction,mitochondrial dysfunction,and neuronal death by targeting m RNAs encoding synapticrelated proteins,mitochondrial-related proteins,and membrane proteins,as well as other *** the impact on glial cells,miR-146a also exhibits differential *** one hand,it causes widespread and sustained inflammation through certain pathways,while on the other hand,it can reverse the polarization of astrocytes and microglia,alleviate neuroinflammation,and promote oligodendrocyte progenitor cell differentiation,thus maintaining the normal function of the myelin sheath and exerting a protective effect on *** this review,we provide a

关键词： Alzheimer's disease amyloid-β glial cells microRNAs miR-146a neuroinflammatory

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research status and prospects of the fractal analysis of metal material surfaces and interfaces

引用

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 20-38页

作者： Qinjin Dai Xuefeng Liu Xin Ma Shaojie Tian Qinghe cui Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China Laboratory for Advanced Materials Processing of Ministry of Education University of Science and Technology BeijingBeijing 100083China School of Mechanical and Electrical Engineering Xinjiang Institute of EngineeringUrumqi 830023China

As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine *** analysis has been used to characterize the shapes of metal materials at various scales and *** methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and ***,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal *** the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear *** relationship between the fractal dimensions and properties of metal material surfaces and interfaces is *** from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be *** is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.

关键词： metal material surfaces and interfaces fractal analysis fractal dimension homogeneity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A new horizon for neuroscience:terahertz biotechnology in brain research

引用

Neural Regeneration Research 2025年第2期20卷 309-325页

作者： Zhengping Pu Yu Wu Zhongjie Zhu Hongwei Zhao Donghong cui Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Kangci Hospital of JiaxingTongxiangZhejiang ProvinceChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghaiChina National Facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain *** this article,we review the development of terahertz biotechnology and its applications in the field of *** evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin *** vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric *** the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic ***,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical *** review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关键词： biological effect brain neuron neuropsychiatry neuroscience non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：