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Changes in neurological and pathological outcomes in a modified rat spinal cord injury model with closed canal

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Neural Regeneration Research 2020年第4期15卷 697-704页

作者： Xin Sun Xing-Zhen Liu Jia Wang hai-rong tao Tong Zhu Wen-Jie Jin Kang-Ping Shen Shanghai Key Laboratory of Orthopedic Implants Department of Orthopedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Pathology Shanghai Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Most animal spinal cord injury models involve a laminectomy,such as the weight drop model or the transection ***,in clinical practice,many patients undergo spinal cord injury while maintaining a relatively complete spinal ***,open spinal cord injury models often do not simulate real injuries,and few previous studies have investigated whether having a closed spinal canal after a primary spinal cord injury may influence secondary ***,we aimed to assess the differences in neurological dysfunction and pathological changes between rat spinal cord injury models with closed and open spinal ***-Dawley rats were randomly divided into three *** the sham group,the tunnel was expanded only,without inserting a screw into the spinal *** the spinal cord injury with open canal group,a screw was inserted into the spinal canal to cause spinal cord injury for 5 minutes,and then the screw was pulled out,leaving a hole in the vertebral *** the spinal cord injury with closed canal group,after inserting a screw into the spinal canal for 5 minutes,the screw was pulled out by approximately 1.5 mm and the flat end of the screw remained in the hole in the vertebral plate so that the spinal canal remained closed;this group was the modified model,which used a screw both to compress the spinal cord and to seal the spinal *** 7 days post-operation,the Basso-Beattie-Bresnahan scale was used to measure changes in neurological ***-eosin staining was used to assess *** evaluate the degree of local secondary hypoxia,immunohistochemical staining and western blot assays were applied to detect the expression of hypoxia-inducible factor 1α(HIF-1α)and vascular endothelial growth factor(VEGF).Compared with the spinal cord injury with open canal group,in the closed canal group the Basso-Beattie-Bresnahan scores were lower,cell morphology was more irregular,the percentage of morphologically normal neurons was lower

关键词： Basso-Beattie-Bresnahan scores closed spinal canal HIF-1α hypoxia model nerve regeneration open spinal canal rat secondary injury spinal cord injury VEGF

Aldehyde dehydrogenase 2 overexpression inhibits neuronal apoptosis after spinal cord ischemia/reperfusion injury

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Neural Regeneration Research 2017年第7期12卷 1166-1171页

作者： Xing-zhen Liu Xin Sun Kang-ping Shen Wen-jie Jin Zhi-yi Fu hai-rong tao Zhi-xing Xu Shanghai Key Laboratory of Orthopedic Implants Department of Orthopedic surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China

Aldehyde dehydrogenase 2（ALDH2）is an important factor in inhibiting oxidative stress and has been shown to protect against renal ischemia/reperfusion ***,we hypothesized that ALDH_2 could reduce spinal cord ischemia/reperfusion *** cord ischemia/reperfusion injury was induced in rats using the modified Zivin＇s method of clamping the abdominal *** successful model establishment,the agonist group was administered a daily consumption of 2.5%*** 7 days post-surgery,the Basso,Beattie,and Bresnahan score significantly increased in the agonist group compared with the spinal cord ischemia/reperfusion injury ***_2expression also significantly increased and the number of apoptotic cells significantly decreased in the agonist group than in the spinal cord ischemia/reperfusion injury *** analysis revealed that ALDH_2 expression negatively correlated with the percentage of TUNEL-positive cells（r=-0.485,P〈0.01）.In summary,increased ALDH_2 expression protected the rat spinal cord against ischemia/reperfusion injury by inhibiting apoptosis.

关键词： nerve regeneration spinal cord ischemia/reperfusion injury aldehyde dehydrogenase 2 alcohol apoptosis oxidative stress terminaldeoxynucleotidyl transferase dUTP nick-end labeling neural regeneration

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改进蚁群算法在公路煤运路径选择中的应用

计算机工程与应用 2009年第12期45卷 239-241,245页

作者：荣海涛宁宣熙南京航空航天大学经济与管理学院南京210016

分析了公路煤运的特点,从选择策略和信息素挥发速度两方面简要改进了基本蚁群算法,较好地克服了其最优解不稳定和易陷入局部最优解的缺点;根据煤炭联盟运输调度模型的特点,从构造三类分支回路入手构造了模型的可行解,解决了用蚁群算法... 详细信息

分析了公路煤运的特点,从选择策略和信息素挥发速度两方面简要改进了基本蚁群算法,较好地克服了其最优解不稳定和易陷入局部最优解的缺点;根据煤炭联盟运输调度模型的特点,从构造三类分支回路入手构造了模型的可行解,解决了用蚁群算法时不易发现可行解的问题;最后用改进的蚁群算法对模型进行了求解,实验分析结果表明算法有效。

关键词：运输调度蚁群算法物流路径选择

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一种综合性的单一煤炭集配中心选址方法

工业工程 2010年第3期13卷 111-115页

作者：荣海涛宁宣熙南京航空航天大学经济与管理学院江苏南京210016

针对单一煤炭集配中心选址的特点,将重心法和模糊综合评价法相结合,提出一种综合性选址方法,并将该方法应用于山西某煤炭集配中心的选址。结果表明该选址方法具有良好的针对性和可操作性。

关键词：煤炭集配中心选址重心法模糊综合评价法

民俗旅游舞台表演真实性解析——以《魅力湘西》为例

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淮北职业技术学院学报 2009年第4期8卷 34-36页

作者：荣海涛浙江国际海运职业技术学院海洋旅游学院浙江舟山316021

民俗旅游舞台表演是通过对当地民俗旅游文化要素的深入挖掘及精心的舞台包装,以舞台表演形式呈现给游客的歌舞节目表演,其真实性的具体表现由多种因素制约。从《魅力湘西》的成功我们可以看出,民俗旅游舞台表演对民族原生态文化表现的... 详细信息

民俗旅游舞台表演是通过对当地民俗旅游文化要素的深入挖掘及精心的舞台包装,以舞台表演形式呈现给游客的歌舞节目表演,其真实性的具体表现由多种因素制约。从《魅力湘西》的成功我们可以看出,民俗旅游舞台表演对民族原生态文化表现的真实程度,最终应当由大众旅游消费者决定,并通过自己的旅游真实性体验感来解读。

关键词：民俗旅游舞台表演真实性《魅力湘西》

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试论唐代文人游仙诗仙人意象类型

宁波职业技术学院学报 2007年第1期11卷 76-79页

作者：荣海涛浙江国际海运职业技术学院浙江舟山316021

以仙人意象作为核心考察对象和切入点,研究唐代文人游仙诗所具有的重要意义。与唐以前的游仙诗相比,唐代文人游仙诗的仙人意象具有两个特点:一是意象原型来源更加广泛,二是意象类型更加丰富。从意象内涵出发,可将唐代文人游仙诗仙人意... 详细信息

以仙人意象作为核心考察对象和切入点,研究唐代文人游仙诗所具有的重要意义。与唐以前的游仙诗相比,唐代文人游仙诗的仙人意象具有两个特点:一是意象原型来源更加广泛,二是意象类型更加丰富。从意象内涵出发,可将唐代文人游仙诗仙人意象分为三大类:一是类型化仙人,二是凡人成仙者,三是个性鲜明的天界众仙。

关键词：游仙诗仙人意象意象内涵类型

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探析运动员荣誉权

军事体育进修学院学报 2007年第4期26卷 6-9页

作者：荣海涛韦国娟南京师范大学体育科学学院江苏南京210097

运动员作为一个特殊群体,运动员荣誉权的特殊性显而易见,本文从运动员荣誉权的内涵,法律属性,法律特征及构成要件来分析、探讨运动员荣誉权问题。

关键词：荣誉荣誉权运动员荣誉权

Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： Qian Yin Fan Wen Zhigang tao hai Pu Tianci Deng Yaoyao Meng Qingbin Meng Hongwen Jing Bo Meng Jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin Dai Lei Ye tao Song Shuai Huang Jia Wang tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2