Aldehyde dehydrogenase 2 overexpression inhibits neuronal apoptosis after spinal cord ischemia/reperfusion injury

作     者：Xing-zhen Liu Xin Sun Kang-ping Shen Wen-jie Jin Zhi-yi Fu Hai-rong Tao Zhi-xing Xu 

作者机构：Shanghai Key Laboratory of Orthopedic Implants Department of Orthopedic surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2017年第12卷第7期

页      面：1166-1171页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by the Natural Science Research Fund Project of Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine of China,No.syz2014-014 

主　　题：nerve regeneration spinal cord ischemia/reperfusion injury aldehyde dehydrogenase 2 alcohol apoptosis oxidative stress terminaldeoxynucleotidyl transferase dUTP nick-end labeling neural regeneration 

摘      要：Aldehyde dehydrogenase 2（ALDH2）is an important factor in inhibiting oxidative stress and has been shown to protect against renal ischemia/reperfusion ***,we hypothesized that ALDH_2 could reduce spinal cord ischemia/reperfusion *** cord ischemia/reperfusion injury was induced in rats using the modified Zivin＇s method of clamping the abdominal *** successful model establishment,the agonist group was administered a daily consumption of 2.5%*** 7 days post-surgery,the Basso,Beattie,and Bresnahan score significantly increased in the agonist group compared with the spinal cord ischemia/reperfusion injury ***_2expression also significantly increased and the number of apoptotic cells significantly decreased in the agonist group than in the spinal cord ischemia/reperfusion injury *** analysis revealed that ALDH_2 expression negatively correlated with the percentage of TUNEL-positive cells（r=-0.485,P〈0.01）.In summary,increased ALDH_2 expression protected the rat spinal cord against ischemia/reperfusion injury by inhibiting apoptosis.