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Combining CUBIC Optical Clearing and Thy1-YFP-16 Mice to Observe Morphological Axon Changes During Wallerian Degeneration

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Current Medical Science 2021年第5期41卷 944-952页

作者： Yu-song YUAN Fei YU su-ping NIU Hao LU Yu-hui KOU hai-lin XU Department of Trauma and Orthopaedics Peking University People's HospitalPeking University'Beijing 100044China National and Local Joint Engineering Research Center of Orthopaedic Biomaterials Department of Bone&Joint SurgeryPeking University Shenzhen HospitalShenzhen 518036China Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijing 100044China Office of Academic Research Peking University People's HospitalPeking UniversityBeijing 100044China Diabetic Foot Treatment Center Peking University People's HospitalPeking University'Beijing 100044China

Objective:Wallerian degeneration is a pathological process closely related to peripheral nerve regeneration following injury,and includes the disintegration and phagocytosis of peripheral nervous system ***,morphological changes are observed by performing immunofluorescence staining after sectioning,which results in the loss of some histological *** purpose of this study was to explore a new,nondestmetive,and systematic method for observing axonal histological changes during Wallerian ***:Thirty male Thy1-YFP-16 mice(SPF grade,6 weeks old,20±5 g)were randomly selected and divided into clear,unobstructed brain imaging cocktails and computational analysis(CUBIC)optical clearing(n=15)and traditional method groups(n=15).Five mice in each group were sacrificed at 1st,3rd,and 5th day following a crush *** histological axon changes were observed by CUBIC light optical clearing treatment,direct tissue section imaging,and HE ***:The results revealed that,compared with traditional imaging methods,there was no physical damage to the samples,which allowed for three-dimensional and deep-seated tissue imaging through *** image information could be nicely obtained by direct fluorescence imaging and HE staining,but it was difficult to obtain image information of the entire *** the same time,the image information obtained by fluorescence imaging and HE staining was partially ***:The combining of CUBIC and Thy1-YFP transgenic mice allowed for a clear and comprehensive observation of histological changes of axons in Wallerian degeneration.

关键词： Wallerian degeneration axon optical clearing clear,unobstructed brain imaging cocktails and computational analysis Thy1-YFP transgenic mice

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Enhanced dielectric,ferroelectric,and optical properties in rare earth elements doped PMN-PT thin films

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Journal of Advanced Ceramics 2021年第1期10卷 98-107页

作者： Shun ZHOU Dabin lin Yongming su lin ZHANG Weiguo LIU Thin Film and Optical Manufacturing Technology Key Laboratory of Ministry of EducationXi’an Technological UniversityXi’an 710032China Electronic Materials Research Laboratory Key Laboratory of the Ministry of Education&International Center for Dielectric ResearchSchool of Electronic Science and EngineeringFaculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China

Rare earth(RE=La^(3+),Sm^(3+),Pr^(3+))ion doped Pb(Mgi/3Nb2/3)O3-PbTi03(RE-PMN-PT)ferroelectric thin films with compositions near the morphotropic phase boundary were grown on the Pt/TiO_(2)/S i02/Si(100)substrate using sol-gel/spin coating *** phase structure,electrical properties,and photoluminescence performance of thin films were investigated *** highly(100)-preferred orientation was obtained in pure perovskite Sm-PMN-0.30PT thin films with an average grain size of 131 *** 2.5%Sm^(3+)doping,the PMN-0.30PT thin films exhibited a triple enhancement of dielectric permittivity with a maximum value of 3500 at 1 kHz,a low dielectric loss of 1.3%,and high remanent polarization of 17.5μC/cm^(2)at room *** visible light and near-infrared band,the transmittance rate increased with PT content and showed the highest value of 85%in 2.5%*** addition,the films presented strong red-orange emission at 599 nm,which was sensitively in temperature range of 248-273 K corresponding to the rhombohedral to monoclinic phase transition temperature.

关键词： PMN-PT rare earth doping dielectric ferroelectric photoluminescence

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A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties

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Neural Regeneration Research 2025年第7期20卷 2084-2094页

作者： Tong Li Quhan Cheng Jingai Zhang Boxin Liu Yu Shi Haoxue Wang Lijie Huang su Zhang Ruixin Zhang Song Wang Guangxu Lu Peifu Tang Zhongyang Liu Kai Wang Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijingChina Department of Training and Sports Medicine Characteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Medical School of Chinese PLA BeijingChina Key Laboratory of Bioactive Materials for the Ministry of Education College of Life SciencesNankai UniversityTianjinChina Department of Orthopedics Tianjin HospitalTianjinChina Department of Rehabilitation Medicine Er Quan Hospital of PAPWuxiJiangsu ProvinceChina

Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor *** an alternative,nerve guidance conduits may be *** ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve *** designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align ***,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber *** presence of aligned fibers on the inner surface can promote the extension of nerve cells along the *** helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide *** novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关键词： aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance

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New iterative schemes for strongly relatively nonexpansive mappings and maximal monotone operators

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Applied Mathematics(A Journal of Chinese Universities) 2010年第2期25卷 199-208页

作者： WEI Li su Yong-fu ZHOU hai-yun School of Mathematics and Statistics Hebei University of Economics and Business Shijiazhuang 050061 China Department of Mathematics Tianjin Polytechnic University Tianjin 300160 China Institute of Mathematics and Computer Sciences Hebei Normal University Shijiazhuang 050016 China

In this paper, some new iterative schemes for approximating the common element of the set of fixed points of strongly relatively nonexpansive mappings and the set of zero points of maximal monotone operators in a real uniformly smooth and uniformly convex Banach space are proposed. Some weak convergence theorems are obtained, which extend and complement some previous work.

关键词： Strongly relatively nonexpansive mapping maximal monotone operator zero point fixed point,weak convergence.

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Iterative convergence theorems for maximal monotone operators and relatively nonexpansive mappings

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Applied Mathematics(A Journal of Chinese Universities) 2008年第3期23卷 319-325页

作者： WEI Li su Yong-fu ZHOU hai-yun School of Math. and Statist. Hebei Univ. of Economics and Business Shijiazhuang 050061 China Dept. of Math. Tianjin Polytechnic Univ. Tianjin 300160 China Institute of Appl. Math. and Mech. Ordnance Engineer. College Shijiazhuang 050003 China

In this paper, some iterative schemes for approximating the common element of the set of zero points of maximal monotone operators and the set of fixed points of relatively nonexpansive mappings in a real uniformly smooth and uniformly convex Banach space are proposed. Some strong convergence theorems are obtained, to extend the previous work.

关键词： maximal monotone operator relatively nonexpansive mapping strong convergence zero point fixed point

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Penetration and internal blast behavior of reactive liner enhanced shaped charge against concrete space

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Defence Technology（防务技术） 2022年第6期18卷 952-962页

作者： Hao Zhang Yuan-feng Zheng Qing-bo Yu Chao Ge Cheng-hai su hai-fu Wang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081PR China

Penetration and internal blast behavior of reactive liner enhanced shaped charge against concrete space were investigated through experiments and *** volume of the enclosed concrete space is about 15 m^(3).The reactive liner enhanced shaped charge utilizes reactive copper double-layered liner,which is composed of an inner copper liner and an outer reactive liner,while the reactive material liner is fabricated by PTFE/Al(Polytetrafluoroethylene/Aluminum)powders through cold-pressing and *** explosion experiments show that,compared with the shaped charge which utilizes copper liner,the penetration cavity diameter and spalling area of concrete by the novel shaped charge were enlarged to 2 times and 4 times,***,the following reactive material had blast effect and produced significant overpressure inside the concrete closed *** analysis indicates concrete strength and detonation pressure of reactive material both affect the penetration cavity *** the blast behavior of reactive material inside the concrete space,developing TNT equivalence model and simulated on AUTODYN-3 D for *** results reproduced propagation process of the shock wave in concrete space,and revealed multi-peaks phenomenon of overpressure-time ***,the empirical relationship between the peak overpressure and relative distance for the shock wave of reactive material was proposed.

关键词： Shaped charge Penetration Blast Concrete Numerical simulation

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Microfluidic chip of concentration gradient and fluid shear stress on a single cell level

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Chinese Chemical Letters 2022年第6期33卷 3133-3138页

作者： Xuexia lin Jianlong su Shufeng Zhou Department of Chemical Engineering&Pharmaceutical Engineering College of Chemical EngineeringHuaqiao UniversityXiamen 361021China

Concentration gradient and fluid shear stress(FSS)for cell microenvironment were investigated through microfluidic *** Darcy–Weisbach equation combined with computational fluid dynamics modeling was exploited to design the microfluidic chip,and the FSS distribution on the cell model with varying micro-channels(triangular,conical,and elliptical).The diffusion with the incompressible laminar flow model by solving the time-dependent diffusion–convection equation was applied to simulate the gradient profiles of concentration in the *** the study of single cell in-depth,the FSS was investigated by the usage of polystyrene particles and the concentration diffusion distribution was studied by the usage of different colors of dyes.A successful agreement between model simulations and experimental data was ***,based on the established method,the communication between individual cells was envisaged and *** developed method provides valuable insights and allows to continuously improve the design of microfluidic devices for the study of single cell,the occurrence and development of tumors,and therapeutic applications.

关键词： Concentration gradient Fluid shear stress Single particle Computational fluid dynamics Microfluidic chip

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巨菌草对宁夏中度盐碱地土壤酶活性、微生物群落结构和功能多样性的影响

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福建农林大学学报（自然科学版） 2025年第1期54卷 125-134页

作者：李子森周童晖苏德伟谢晶刘斌林占熺林冬梅福建农林大学国家菌草工程技术研究中心福建福州350002

【目的】探究种植巨菌草后中度盐碱地的根际微生物群落结构和多样性,为利用巨菌草改良宁夏中度盐碱地提供依据。【方法】采用微量法测定土壤酶活性,采用高通量测序法测定土壤细菌及真菌的群落结构及功能多样性。【结果】种植巨菌草后,... 详细信息

【目的】探究种植巨菌草后中度盐碱地的根际微生物群落结构和多样性,为利用巨菌草改良宁夏中度盐碱地提供依据。【方法】采用微量法测定土壤酶活性,采用高通量测序法测定土壤细菌及真菌的群落结构及功能多样性。【结果】种植巨菌草后,土壤容重下降8.96%,含盐量下降71.90%,有机质含量上升35.25%,碱解氮含量下降56.20%,有效磷、速效钾含量分别上升81.97%和2.51%,改良后土壤碱性磷酸酶、蔗糖酶活性分别上升16.87%和6.14%,种植巨菌草后土壤真菌Simpson指数、Shannon指数与对照组之间存在显著差异。在群落结构方面,种植巨菌草增加了绿弯菌门、粘菌门、疣微菌门、担子菌门、霉菌门、芽枝霉门、毛霉门、油壶菌门和罗兹菌门的相对丰度。微生物群落OTU数上,种植巨菌草后细菌OTU数比CK增加了0.74%,真菌OTU数比CK减少了42.24%。土壤微生物群落物种差异分析表明,试验组和CK之间细菌和真菌门的类别差异较大。冗余分析表明,有机质含量、土壤碱性酶活性、有效磷含量和水溶性盐质量分数是引起种植巨菌草后根际土壤环境改变的主要因子。【结论】种植巨菌草可以提高中度盐碱地土壤酶活性和微生物多样性,改善土壤微生物群落环境。

关键词：巨菌草中度盐碱地土壤酶活性高通量测序微生物多样性

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Reliable resource allocation with RF fingerprinting authentication in secure IoT networks

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Science China(Information Sciences) 2022年第7期65卷 51-66页

作者： Weiwei WU su HU Di lin Gang WU National Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of China

The unprecedented growth of the Internet of Things(Io T) has led to a huge amount of wireless resource consumption in a network. Due to limited wireless resources, a network can only guarantee the quality of service(QoS) of authenticated users rather than that of all users. By acknowledging this limitation,we realise that user authentication would be a big issue in Io T networks. Although traditional authentication methods can enhance network security to a certain extent, their vulnerability to malicious attacks and the relevant complicated computations restrict Io T deployments. In this paper, a radio frequency(RF)fingerprinting based authentication scheme is proposed under the architecture of convolutional neural network(CNN). It can effectively prevent unauthenticated users from consuming valuable wireless resources and significantly improve QoS performance for legitimate users. By solving an NP-hard optimization problem with the objective of minimizing efficient energy density, we demonstrate an approximate optimal resource allocation scheme in consideration of an RF-fingerprinting based authentication process. The analytic results show that our proposed scheme can dramatically reduce the efficient energy density compared with traditional cryptography based authentication schemes.

关键词： user authentication Internet of things convolutional neural network RF fingerprinting NP-hard optimization problem

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Glycosyltransferases and non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2016年第8期22卷 2483-2493页

作者： Yu-Tao Zhan hai-Ying su Wei An Department of Gastroenterology Beijing Tongren Hospital Capital Medical University Department of Obstetrics and Gynecology Shandong Jining First People’s Hospital Department of Cell Biology Municipal Laboratory for Liver Protection and Regulation of Regeneration Capital Medical University

Non-alcoholic fatty liver disease(NAFLD) is the most common form of chronic liver disease and its incidence is increasing worldwide. However, the underlying mechanisms leading to the development of NAFLD are still not fully understood. Glycosyltransferases(GTs) are a diverse class of enzymes involved in catalyzing the transfer of one or multiple sugar residues to a wide range of acceptor molecules. GTs mediate a wide range of functions from structure and storage to signaling, and play a key role in many fundamental biological processes. Therefore, it is anticipated that GTs have a role in the pathogenesis of NAFLD. In this article, we present an overview of the basic information on NAFLD, particularly GTs and glycosylation modification of certain molecules and their association with NAFLD pathogenesis. In addition, the effects and mechanisms of some GTs in the development of NAFLD are summarized.

关键词： Non-alcoholic fatty liver disease Pathogenesis Glycosyltransferases Glycosylation

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