检索结果-南通市图书馆

Ligustrazine monomer against cerebral ischemia/reperfusion injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2015年第5期10卷 832-840页

作者： hai-jun gao Peng-fei Liu Pei-wen Li Zhuo-yan Huang Feng-bo Yu Ting Lei Yong Chen Ye Cheng Qing-chun Mu hai-yan Huang Department of Neurosurgery First Bethune Hospital of Jilin University Department of Neurosurgery Hongqi Hospital of Mudanjiang Medical University Clinical Medical College of Beihua University School of Pharmacy Mudanjiang Medical University

Ligustrazine （2,3,5,6-tetramethylpyrazine） is a major active ingredient of the Szechwan lovage rhizome and is extensively used in treatment of ischemic cerebrovascular disease. The mecha- nism of action of ligustrazine use against ischemic cerebrovascular diseases remains unclear at present. This study summarizes its protective effect, the optimum time window of administra- tion, and the most effective mode of administration for clinical treatment of cerebral ischemia/ reperfusion injury. We examine the effects of ligustrazine on suppressing excitatory amino acid release, promoting migration, differentiation and proliferation of endogenous neural stem cells. We also looked at its effects on angiogenesis and how it inhibits thrombosis, the inflammatory response, and apoptosis after cerebral ischemia. We consider that ligustrazine gives noticeable protection from cerebral ischemia/reperfusion injury. The time window of ligustrazine admin- istration is limited. The protective effect and time window of a series of derivative monomers of ligustrazine such as 2-[（1,1-dimethylethyl）oxidoimino]methyl]-3,5,6-trimethylpyrazine, CXC137 and CXC 195 after cerebral ischemia were better than ligustrazine.

关键词： nerve regeneration ligustrazine ischemia cerebral ischemia/reperfusion injury neuralregeneration

Structural and microwave absorption properties of CoFe_(2)O_(4)/residual carbon composites

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 221-232页

作者： Yuanchun Zhang Shengtao gao Xingzhao Zhang Dacheng Ma Chuanlei Zhu jun He Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHuainan 232001China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

Electromagnetic interference,which necessitates the rapid advancement of substances with exceptional capabilities for bsorbing electromagnetic waves,is of urgent concern in contemporary *** this work,CoFe_(2)O_(4)/residual carbon from coal gasification fine slag(CFO/RC)composites were created using a novel hydrothermal *** mechanisms for microwave absorption,including conductive loss,natural resonance,interfacial dipole polarization,and magnetic flux loss,are involved in these ***,compared with pure residual carbon materials,this composite offers superior capabilities in microwave *** 7.76GHz,the CFO/RC-2 composite achieves an impressive minimum reflection loss(RL_(min))of-43.99 dB with a thickness of 2.44 ***,CFO/RC-3 demonstrates an effective absorption bandwidth(EAB)of up to 4.16 GHz,accompanied by a thickness of *** study revealed the remarkable capability of the composite to diminish electromagnetic waves,providing a new generation method for microwave absorbing materials of superior quality.

关键词： coal gasification slag residual carbon hydrothermal method microwave absorption CoFe_(2)O_(4)

Long-term follow-up of crush versus no crush technique for coronary artery bifurcation lesions

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2009年第6期122卷 627-631页

作者： gao Zhan YANG Yue-jin XU Bo CHEN Ji-lin QIAO Shu-bin LI Jian-jun QIN Xue-wen YAO Min WU Yong-jian YUAN Jin-qing CHEN Jue LIU hai-bo DAI jun gao Run-lin Department of Cardiology Cardiovascular Institute & Fu Wai Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100037 China

Background Lesions at coronary bifurcations always are a big challenge for interventionists even with the advent of drug eluting stents （DES）. Even as more clinical trials are published, operators still can not confirm that one strategy is more efficient than another. Selection of patients and short term follow-up contribute to the difficulty in comparing strategies. Methods From April 2004 to April 2008, 505 consecutive Chinese patients underwent DES implantation for true bifurcation lesions; including 258 using crush strategy （213 male, （56.7＋10.8） years old） and 247 using no crush strategy （206 male, （58.1＋10.1） years old） were analyzed. Results The follow-up period ranged from 237 to 1223 days, average （537＋340） days for the crush group and （538＋351） days for the no crush group. There was no significant difference of major adverse cardiac events （MACE） rate between the two groups （10.1% vs 12.1%; P=-0.481）, nor in cardiac death, nonfatal myocardial infarction （MI） or in the target vessel revascularization （TVR）（0.4% vs 1.6%; P=0.207, 2.7% vs 2.8; P=1.000 and 7.0% vs 7.7%; P=0.865）. The stent thrombosis rate was similar in the two groups （1.6% vs 2.0%; P=0.409）, late and very late stent thrombosis in both groups were very low （0.4% vs 0.4%; P=-1.000）. Seven-month angiographic follow-up showed no significant difference of the restenosis rate between the two groups （11.0% vs 13.5%; P=0.786）. During the follow-up, cardiac death, nonfatal MI, TVR and ST free survival rate showed no significant difference between the two groups. The only variant identified as a predictor of MACE was percutaneous coronary intervention （PCI） in the first two years, which accounted for 47% of patients of all cases in four years. Conclusion Crush technique showed similar long-term clinical effect compared with other two DES techniques for coronary bifurcation lesions, the surgeons＇ skills are very important for reducing clinical events.

关键词： percutaneous coronary intervention drug eluting stent bifurcation

The Mechanism of Heating Rate on the Secondary Recrystallization Evolution in Grain Oriented Silicon Steel

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 275-282页

作者： gao Qian LI jun WANG Xianhui CAO Laifu GONG Jian LI Bo Central Iron and Steel Research Institute Group Beijing 100081China Shougang Zhixin Electromagnetic Material R&D(Beijing)Co. Ltd.Beijing 101300China Beijing Shougang Co. Ltd.Qian’an 064404China

Grain-oriented silicon steels were prepared at different heating rates during high temperature annealing,in which the evolution of magnetic properties,grain orientations and precipitates were *** illustrate the Zener factor,the diameter and number density of precipitates of interrupted testing samples were statistically *** effect of precipitate ripening on the Goss texture and magnetic property was *** indicated that the trend of Zener factor was similar under different heating rates,first increasing and then decreasing,and that the precipitate maturing was greatly inhibited as the heating rate *** recrystallization was developed at the temperature of 1010℃when a heating rate of 5℃/h was used,resulting in Goss,Brass and{110}oriented grains growing abnormally and a magnetic induction intensity of ***,increasing the heating rate to 20℃/h would inhibit the development of undesirable oriented grains and obtain a sharp Goss ***,when the heating rate was extremely fast,such as 40℃/h,poor secondary recrystallization was developed with many island grains,corresponding to a decrease in magnetic induction intensity to 1.87 *** a suitable heating rate of 20℃/h,the sharpest Goss texture and the highest magnetic induction of 1.94 T with an onset secondary recrystallization temperature of 1020℃were found among the experimental variables in this *** heating rate affected the initial temperature of secondary recrystallization by controlling the maturation of precipitates,leading to the deviation and dispersion of Goss texture,thereby reducing the magnetic properties.

关键词： high temperature annealing heating rate secondary recrystallization grain oriented silicon steel

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

物理气相输运法生长AlN六方微晶柱

无机材料学报 2017年第2期32卷 215-218页

作者：王华杰刘学超孔海宽忻隽高攀卓世异施尔畏中国科学院上海硅酸盐研究所上海201800 中国科学院大学北京100049

采用物理气相输运法（Physical Vapor Transport, PVT）, 在1700 - 1850°C生长温度下制备出AlN六方微晶柱; 晶柱长度在1 cm左右, 宽度在200 -400 μm, 光学显微镜下观察为六棱柱形状并呈透明浅黄色光泽; 扫描电子显微镜和原子力显微镜... 详细信息

采用物理气相输运法（Physical Vapor Transport, PVT）, 在1700 - 1850°C生长温度下制备出AlN六方微晶柱; 晶柱长度在1 cm左右, 宽度在200 -400 μm, 光学显微镜下观察为六棱柱形状并呈透明浅黄色光泽; 扫描电子显微镜和原子力显微镜测试表明： AlN晶柱表面为整齐台阶状形貌, 台阶宽度为2- 4 μm, 高度在几个纳米; 拉曼光谱测试AlN晶柱具有良好结晶质量。PVT 法生长AlN六方微晶柱主要是在偏低温度下AlN晶体生长速率较慢, Al原子和N原子有足够时间迁移到能量较低位置结晶生长, 进而沿着〈0001〉方向形成柱状结构。AlN六方微晶柱是对一维半导体材料领域的补充, 通过对晶柱尺寸及杂质控制的进一步研究, 有望在微型光电器件领域表现出应用价值。

关键词： III-V族半导体氮化铝(AlN)晶体六方微米柱物理气相输运(PVT)

在线全文

学校读者我要写书评

暂无评论

基于划分子集的属性约简算法

山东大学学报（工学版） 2011年第4期41卷 24-28页

作者：翟俊海高原原王熙照陈俊芬河北省机器学习与计算智能重点实验室河北大学数学与计算机学院河北保定071002

Pawlak提出的基于属性重要度的约简算法是常用的算法之一,它通过计算等价关系对论域划分的粒度来度量属性的重要度。但用该算法计算每一个属性的重要度时,都要计算不同等价关系对整个论域的划分,计算复杂度非常高。受决策树划分子集思... 详细信息

Pawlak提出的基于属性重要度的约简算法是常用的算法之一,它通过计算等价关系对论域划分的粒度来度量属性的重要度。但用该算法计算每一个属性的重要度时,都要计算不同等价关系对整个论域的划分,计算复杂度非常高。受决策树划分子集思想的启发,对基于属性重要度的属性约简算法进行了改进,提出了一种基于划分子集的属性约简算法。在核属性集形成划分的基础上,通过在核属性中添加非核属性从而形成更细的划分,如此反复。在保持正域不变的框架下,形成最细化分的属性集就是一个约简。理论分析显示该算法减少了求属性约简的计算时间复杂度,提高了求属性约简的效率。

关键词：粗糙集属性约简计算复杂度划分子集信息系统

Study on Plasma Concentration and Bioavailability of Wogonin in Beagle's Dogs

在线全文

学校读者我要写书评

暂无评论

Chinese Herbal Medicines 2011年第2期3卷 144-149页

作者： LI Jian-chun1,2,CHEN Fei-hu1,DONG hai-jun3,gao Shu3 1.College of Pharmacy,Anhui Medical University,Hefei 230032,China 2.Department of pharmacy,Bengbu Medical College,Bengbu 233030,China 3.Hefei Con-source Medicine Technology Co.,Ltd,Hefei 230088,China College of Pharmacy Anhui Medical University Hefei 230032 China Department of pharmacy Bengbu Medical College Bengbu 233030 China College of Pharmacy Anhui Medical University Hefei 230032 China Hefei Con-source Medicine Technology Co. Ltd Hefei 230088 China

Objective To develop an LC-MS/MS method for determining the concentration of wogonin in dog plasma and investigate the pharmacokinetics and bioavailability by different administrations of wogonin in Beagle’s *** LC-MS/MS was employed in determining the concentration of wogonin with the selected ion monitoring model after liquid-liquid extraction with ethyl acetate of dog plasma *** lower limit of quantification was 0.105 μg/*** ions were at m/z 285.0→270.0 for wogonin and 373.3→305.3 for *** a randomized,self-control,and cross-over study,six male Beagle’s dogs were treated with different administration methods in three test *** parameters were calculated with DAS software(Ver.2.0).Results The calibration curve was linear in the range of 0.105-107.36 μg/L for wogonin in dog plasma *** main pharmacokinetic parameters of ig administration(native drug of 15 mg/kg and solution preparation of 5 mg/kg) and iv route were as follows:Cmax(2.5 ± 1.1),(7.9 ± 3.3),and(6838.7 ± 1322.1) μg/L,tmax(0.7 ± 0.3) and(0.3 ± 0.2) h for the both former,AUC0-t(7.1 ± 2.0),(21.0 ± 3.2),and(629.7 ± 111.8) μg.h/*** absolute bioavailability of native and solution of wogonin were(0.59 ± 0.35)% and(3.65 ± 2.00)%,*** The validated method is convenient,sensitive,and specific,and the improvement of wogonin solubility could remarkably increase the absolute bioavailability.

关键词： Beagle's dogs bioavailability LC-MS/MS pharmacokinetics solubility wogonin

Systematical identification of regulatory GPCRs by single-cell trajectory inference reveals the role of ADGRD1 and GPR39 in adipogenesis

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年

作者： Chuan Ye Xuemei Wang jun Lin Chenyang Wu Yuhua gao Chenghao Guo Yunxi Liao Ziyan Rao Shaodong Huang Weixuan Chen Ying Huang Jinpeng Sun Dongyu Zhao Changtao Jiang Center of Basic Medical Research Institute of Medical Innovation and ResearchPeking University Third Hospital Department of Physiology and Pathophysiology School of Basic Medical SciencesPeking University Department of Biomedical Informatics School of Basic Medical SciencesPeking University State Key Laboratory of Vascular Homeostasis and Remodeling Peking University Center for Obesity and Metabolic Disease Research School of Basic Medical SciencesPeking University State Key Laboratory of Female Fertility Promotion Center for Reproductive MedicineDepartment of Obstetrics and GynecologyPeking University Third Hospital National Clinical Research Center for Obstetrics and Gynecology Peking University Third Hospital Department of Endocrinology and Metabolism Peking University Third Hospital Key Laboratory Experimental Teratology of the Ministry of Education Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesCheeloo College of MedicineShandong University Department of Immunology School of Basic Medical SciencesPeking University

Adipogenesis is the healthy expansion of white adipose tissue (WAT),serving as a compensatory response to maintain metabolic homeostasis in the presence of excess energy in the ***,the identification of novel regulatory molecules in adipogenesis,specifically membrane receptors such as G protein-coupled receptors (GPCRs),holds significant clinical *** receptors can serve as viable targets for pharmaceuticals,offering potential for restoring metabolic homeostasis in individuals with *** utilized trajectory inference methods to analyze three distinct single-nucleus sequencing (sNuc-seq) datasets of adipose tissue and systematically identified GPCRs with the potential to regulate *** verification in primary adipose progenitor cells (APCs) of mice,we discovered that ADGRD1 promoted the differentiation of APCs,while GPR39 inhibits this *** the obese mouse model induced by a high-fat diet(HFD),both gain-of-function and loss-of-function studies validated that ADGRD1 promoted adipogenesis,thereby improving metabolic homeostasis,while GPR39 inhibited adipogenesis,leading to metabolic ***,through the analysis of 2,400 ChIP-seq data and 1,204 bulk RNA-seq data,we found that the transcription factors (TFs) MEF2D and TCF12 regulated the expression of ADGRD1and GPR39,*** study revealed the regulatory role of GPCRs in adipogenesis,providing novel targets for clinical intervention of metabolic dysfunction in obese patients.

关键词：

落实编排规范,提高学报质量——执行《中国高等学校社会科学学报编排规范》的体会

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

唐山师专学报 2000年第6期22卷 78-80页

作者：任海生高俊霞唐山师专学报编辑部河北唐山063000

学报编排规范化是学术期刊传播发展的必然要求,高校学报在执行《中国高等学校社会科学学报编排规范》时既要坚持“统一”,又要追求个性风格。《编排规范》应在参考文献的著录方式等方面进行完善。

关键词：高校学报编排规范化著录格式学术期刊编辑