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Effects of Al addition on bainite transformation and properties of high-strength carbide-free bainitic steels

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Journal of Iron and Steel Research International 2019年第8期26卷 846-855页

作者： Jun-yu Tian Guang Xu Ming-xing Zhou hai-jiang hu Zheng-liang Xue The State Key Laboratory of Refractories and Metallurgy Hubei Collaborative Innovation Center for Advanced Steels Wuhan University of Science and Technology Wuhan 430081 Hubei China

The effects of aluminum addition on bainite transformation and properties of carbide-free bainitic steels containing 0.22 wt.% carbon were investigated by two different types of heat treatment processes: continuous cooling process (CCP) and isothermal transformation process (ITP). The results indicate that for the CCP treatment, Al addition significantly promoted the ferrite and bainite transformation;however, it did not significantly increase the product of tensile strength and total elongation (PSE). For the ITP treatment, Al addition significantly promoted the kinetics of bainite transformation, and thus, more bainite was formed with Al addition;however, it was found that Al addition resulted in a decrease in tensile strength and an increase in elongation of the tested bainitic steels. Moreover, the effects of Al addition on comprehensive property were profoundly dependent on austempering temperatures. When the austempering temperature was higher (430℃), PSE significantly increased with Al addition, whereas it decreased at the lower austempering temperature (400℃). Therefore, it can be concluded that the effects of Al on properties of bainitic steels were more significant at higher austempering temperatures.

关键词： Aluminum Bainite transformation Continuous cooling Isothermal transformation Mechanical property

In situ observations of austenite grain growth in Fe-C-Mn-Si super bainitic steel

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International Journal of Minerals,Metallurgy and Materials 2013年第11期20卷 1060-1066页

作者： Feng Liu Guang Xu Yu-long Zhang hai-jiang hu Lin-xin Zhou Zheng-liang Xue The Key Laboratory of the Ministry of Education of China for Ferrous Metallurgy and Resources Utilization Wuhan University of Science and Technology State Key Laboratory of Development and Application Technology of Automotive Steels (Baosteel Group) Daye Special Steel Co. Ltd. hubei Xinyegang Steel Co. Ltd.

In situ observations of austenite grain growth in Fe-C-Mn-Si super bainitic steel were conducted on a high-temperature laser scanning confocal microscope during continuous heating and subsequent isothermal holding at 850, 1000, and 1100℃ for 30 min. A grain growth model was proposed based on experimental results. It is indicated that the austenite grain size increases with austenitizing temperature and holding time. When the austenitizing temperature is above 1100℃, the austenite grains grow rapidly, and abnormal austenite grains occur. In addition, the effect of heating rate on austenite grain growth was investigated, and the relation between austenite grains and bainite morphology after bainitic transformations was also discussed.

关键词： bainitic steel austenite grain growth kinetics bainitic transformations

Gold Nanoparticulate Thin Films Fabricated by the Electrostatic Self-Assembly Process

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Journal of Wuhan University of Technology(Materials Science) 2002年第1期17卷 38-41页

作者：余海湖 Wuhan University of Technology

Gold colloids were prepared by citrate-induced reduction of hydrogen tetrachloroaurale, and gold nanoparticles were electrostatically self-assembled with poly( diallyldimethylammonium chloride) into multi-layer thin films on si/icon and quartz substrates. The paniculate thin films were characterized by UV-vis spea-troscopy, surface, enhanced Raman scattering, atomic force microscopy and resistivity measurements. Due to the interparticle coupling between individual gold particles, an obvious collective particle plasmon resonance was ob-served on UV-vis spectra , and the particulate thin films exhibited a strong SERS effect. For multilayer thin films with a high particle coverage on substrates , resistivity of the order of 10-4 Ω·cm was yielded.

关键词： gold colloid nanoparticle electrostatic self-assembly thin film

Lipid levels and insulin resistance markers in patients with colorectal cancer:Propensity score matching analysis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 130-142页

作者： Ren-Hao hu Dong-Yi Yan Ke-hui Zhang Di Zhang Xi-Mao Cui Xiao-hua jiang Shun Zhang Department of Gastrointestinal Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China School of Medicine Tongji UniversityShanghai 200092China Department of Emergency Medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

BACKGROUND Colorectal cancer(CRC)is a prevalent malignant neoplasm characterized by subtle early *** To investigate the correlation among serum lipid profiles,the triglyceride-glucose(TyG)index,and the atherosclerotic index(AI)in patients with ***,it explored the clinical diagnostic utility of combining serum lipids with cancer antigens in the context of *** A retrospective analysis encompassed 277 patients with CRC and 1034 healthy *** Following propensity score matching,patients with CRC exhibited significantly reduced levels of serum triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol,and low-density lipoprotein cholesterol(LDL-C),as well as a diminished TyG ***,they displayed elevated AI levels compared to their healthy *** in advanced stages exhibited lower serum levels of TG,TC,and LDL-C compared to those in early *** with positive lymph node metastasis demonstrated reduced levels of TG,LDL-C,and the TyG *** operating characteristic analysis revealed that the combination of the TyG index,carcinoembryonic antigen,and carbohydrate antigen 19-9 yielded the highest positive prediction rate for CRC at 75.3%.CONCLUSION Preoperative serum lipid profiles exhibit a robust association with patients with *** concurrent assessment of multiple serum lipids and cancer antigens effectively enhances the diagnostic accuracy for CRC.

关键词： Colorectal cancer Serum lipids Triglyceride-glucose index Atherosclerotic index Diagnostic marker

Targeting STAT3 with SH-4-54 suppresses stemness and chemoresistance in cancer stem-like cells derived from colorectal cancer

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World Journal of Clinical Oncology 2025年第2期16卷 63-75页

作者： Xu-Fan Zhang Qian Chen Qin jiang Qiong-Ying hu Department of Nuclear Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina College of Medical Technology Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina Department of Laboratory Medicine Hospital of Mianyang Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina Department of Laboratory Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina

BACKGROUND Over the years,the numbers of treatment options for colorectal cancer(CRC)have increased,leading to notable improvements in the overall survival of CRC *** therapy may initially yield positive results,the development of drug resistance can result in treatment failure and cancer *** resistance is often attributed to the presence of cancer stem cells(CSCs).These CSCs not only contribute to therapeutic resistance but also play crucial roles in the initiation and development of tumor *** To investigate the antitumor effects of SH-4-54,which are mediated by targeting CSCs relative to treatment *** CSCs were enriched by culturing CRC cells in serum-free *** of stemness and IL-6/JAK2/STAT3 signaling were detected by Western *** of CSC malignancy,including proliferation,invasion,and tumor formation,were *** In this study,we employed SH-4-54,which exhibits anticancer activity in solid tumors through targeting the SH2 domain of both the signal transducer and activator of transcription(STAT)3 and the STAT5,and evaluated its effects on stemness and chemoresistance in colorectal *** expected,SH-4-54 treatment inhibited the phosphorylation of STAT3(p-STAT3)and decreased the percentage of ALDH1A1-positive CRC *** addition of SH-4-54 dissociated colorectal spheroids and decreased the expression of stemness markers,including ALDH1A1,CD44 and ***-4-54 treatment decreased IL-6/JAK2/STAT3 signaling by inhibiting p-STAT3 and thus inhibited spheroid formation by SW480 and LoVo ***,SH-4-54 treatment inhibited indicators of malignancy,including cell proliferation,invasion,and tumor formation,in CSCs in vitro and in ***,SH-4-54 treatment significantly increased chemosensitivity to *** Taken together,these results indicate that SH-4-54 is a promising molecule that exerts antitumor effects on colorectal CSCs by inhibiting STAT3 signaling.

关键词： SH-4-54 Colorectal cancer Cancer stem-like cells Stemness Chemosensitivity

Comparison of different versions of the quick sequential organ failure assessment for predicting in-hospital mortality of sepsis patients:A retrospective observational study

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World Journal of Emergency Medicine 2022年第2期13卷 114-119页

作者： hai hu Jing-yuan jiang Ni Yao Emergency Office of West China Hospital Sichuan UniversityChengdu 610041China China International Emergency Medical Team Chengdu 610041China Emergency Department West China HospitalSichuan UniversityChengdu 610041China West China School of Nursing Sichuan UniversityChengdu 610041China Department of Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041China

BACKGROUND:The quick sequential organ failure assessment(qSOFA)is recommended to identify sepsis and predict sepsis ***,some studies have recently shown its poor performance in sepsis mortality *** enhance its effectiveness,researchers have developed various revised versions of the qSOFA by adding other parameters,such as the lactate-enhanced qSOFA(LqSOFA),the procalcitonin-enhanced qSOFA(PqSOFA),and the modified qSOFA(MqSOFA).This study aimed to compare the performance of these versions of the qSOFA in predicting sepsis mortality in the emergency department(ED).METHODS:This retrospective study analyzed data obtained from an electronic register system of adult patients with sepsis between January 1 and December 31,*** operating characteristic(ROC)curve analyses were performed to determine the area under the curve(AUC),with sensitivity,specificity,and positive and negative predictive values calculated for the various ***:Among the 936 enrolled cases,there were 835 survivors and 101 *** AUCs of the LqSOFA,MqSOFA,PqSOFA,and qSOFA were 0.740,0.731,0.712,and 0.705,*** sensitivity of the LqSOFA,MqSOFA,PqSOFA,and qSOFA were 64.36%,51.40%,71.29%,and 39.60%,*** specificity of the four scores were 70.78%,80.96%,61.68%,and 91.62%,*** LqSOFA and MqSOFA were superior to the qSOFA in predicting in-hospital ***:Among patients with sepsis in the ED,the performance of the PqSOFA was similar to that of the qSOFA and the values of the LqSOFA and MqSOFA in predicting in-hospital mortality were greater compared to *** the added parameter of the MqSOFA was more convenient compared to the LqSOFA,the MqSOFA could be used as a candidate for the revised qSOFA to increase the performance of the early prediction of sepsis mortality.

关键词： Quick sequential organ failure assessment In-hospital mortality Sepsis Lactate-enhanced qSOFA Modified qSOFA

Query Acceleration of Graph Databases by ID Caching Technology

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Journal of Electronic Science and Technology 2019年第1期17卷 41-50页

作者： Wei jiang hai-Bo hu Liu-Gen Xu the School of Information and Software Engineering University of Electronic Science and Technology of China

In this paper, we approach the design of ID caching technology(IDCT) for graph databases, with the purpose of accelerating the queries on graph database data and avoiding redundant graph database query operations which will consume great computer resources. Traditional graph database caching technology(GDCT)needs a large memory to store data and has the problems of serious data consistency and low cache utilization. To address these issues, in the paper we propose a new technology which focuses on ID allocation mechanism and high-speed queries of ID on graph databases. Specifically, ID of the query result is cached in memory and data consistency is achieved through the real-time synchronization and cache memory adaptation. In addition, we set up complex queries and simple queries to satisfy all query requirements and design a mechanism of cache replacement based on query action time, query times, and memory capacity, thus improving the performance *** experiments show the superiority of our techniques compared with the traditional query approach of graph databases.

关键词： Cache graph database query efficiency

Rate Constants for Reaction Between Hydroxyl Radical and Dimethyl Sulfide Under Real Atmospheric Condition

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Chinese Journal of Chemical Physics 2008年第5期21卷 407-414页

作者： hai-tao Wang Chang-jiang hu Yu-jing Mu Yu-jie Zhang Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beifing 100085 China

The rate constants of the reaction between hydroxyl radical （OH-） and dimethyl sulfide （DMS） were investigated by using the relative methods in air, N2, and 02. Strong influences of ground state oxygen O（3p） on DMS consumption were found by the photolysis of HONO and CH3ONO as OH. sources, and the rate constants obtained in these systems varied significantly. The rate constants of the reaction between DMS and OH- （generated by photolysis of H2 O2） at room temperature were 8.56 × 10^-12, 11.31× 10^-12, and 4.50× 10^-12 cm3/（molecule.s）, in air, O2, and N2, respectively. The temperature dependence of the rate constants for OH- with DMS over the temperature range of 287-338 K was also investigated in nitrogen and air, and the Arrhenius expression was obtained as follows： kaire=（7.24±0.28）× 10^-13exp[（770.7±E97.2）/T], kN2 =（3.40±0.15） × 10^-11 exp[-- （590.3±165.9）/T].

关键词： Dimethyl sulfide Hydroxyl radical Ground state oxygen Kinetics

Improvement Design for Distributed Real-Time Stream Processing Systems

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Journal of Electronic Science and Technology 2019年第1期17卷 3-12页

作者： Wei jiang Liu-Gen Xu hai-Bo hu Yue Ma the School of Information and Software Engineering University of Electronic Science and Technology of China the Department of Computer Science and Engineering University of Notre Dame

In the era of Big Data, typical architecture of distributed real-time stream processing systems is the combination of Flume, Kafka, and Storm. As a kind of distributed message system, Kafka has the characteristics of horizontal scalability and high throughput, which is manly deployed in many areas in order to address the problem of speed mismatch between message producers and consumers. When using Kafka, we need to quickly receive data sent by producers. In addition, we need to send data to consumers quickly. Therefore, the performance of Kafka is of critical importance to the performance of the whole stream processing system. In this paper, we propose the improved design of real-time stream processing systems, and focus on improving the Kafka's data loading *** use Kafka cat to transfer data from the source to Kafka topic directly, which can reduce the network transmission. We also utilize the memory file system to accelerate the process of data loading, which can address the bottleneck and performance problems caused by disk I/O. Extensive experiments are conducted to evaluate the performance, which show the superiority of our improved design.

关键词： Kafka Kafka cat memory file system message queue real-time stream processing system