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Responsiveness and minimal clinically important difference of the Chinese version of the Low Vision Quality of Life Questionnaire after cataract surgery

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 504-509页

作者： Wen-Wen Xue Pei Zhang hai-dong zou Department of Ophthalmology Shanghai Eye Diseases Prevention and Treatment Center Department of Ophthalmology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Department of Ophthalmology Shanghai Gonghui Hospital

AIM: To investigate the Chinese version of the Low Vision Quality of Life Questionnaire(CLVQOL) as an instrument for obtaining clinically important changes after cataract ***: Patients underwent cataract surgery in Shanghai General Hospital, Shanghai Jiao Tong University, who fit the inclusion criteria were recruited. Two CLVQOLs were administered, including a preoperative CLVQOL and a CLVQOL at the end of the 3 mo follow-up period, and were completed using face-to-face interviews or phone interviews conducted by trained investigators. The minimal clinically important difference(MCID) was calculated using an anchor-based method and a distribution method. In addition, the responsiveness of the questionnaire was ***: A total of 155 residents were enrolled. The average visual acuity(VA) preoperatively was 0.08(SD=0.05), and it increased to 0.47(SD=0.28) at the end of followup. Statistically significant positive changes in the CLVQOL scores indicated significant improvement of vision related quality of life after cataract surgery. With the larger value between the two results as the final value, the MCID values of the CLVQOL(scores of the four scales as well as the total score) were 8.94, 2.61, 4.34, 3.10 and 17.63, respectively. The CLVQOL has both good internal and external ***: CLVQOL scores are appropriate instruments for obtaining clinically important changes after cataract surgery. This study is an effective exploration for establishingcataract surgery efficacy standards, which helps clinical and scientific research workers in ophthalmology to gain a more in-depth understanding when using CLVQOL.

关键词： responsiveness minimal clinically important difference Chinese Version of the Low Vision Quality of Life Questionnaire Chinese

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Prevalence and risk factors of diabetic retinopathy in patients with type 2 diabetes in Shanghai

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International Journal of Ophthalmology(English edition) 2021年第7期14卷 1066-1072页

作者： Pei Zhang Wen-Wen Xue Xiao-Bo Huang Yi Xu Li-Na Lu Kai-Rong Zheng hai-dong zou Department of Ophthalmology Shanghai Gonghui HospitalShanghai 200041China Department of Ophthalmology Shanghai Eye Disease Prevention and Treatment CenterShanghai 200040China Department of Ophthalmology the Second Affiliated Hospital of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

AIM:To investigate the prevalence of diabetic retinopathy(DR)in residents of Shanghai and analyze the risk factors of ***:This study involved 7233 patients with diabetes in *** demographic data of the participants were collected using a questionnaire *** examination,laboratory tests,and ophthalmological examinations were *** professional ophthalmologists diagnosed and graded DR by fundus examination and then combined the results with fundus *** unconditional multivariate Logistic regression analysis was used to determine the risk ***:In total,6978 patients with type 2 diabetes in Shanghai with a mean age of 68.33±8.40 y were recruited,including 2975 males(42.6%)and 4003 females(57.4%).Overall,1184 patients were diagnosed with DR,with a prevalence rate of 16.97%.Regression analysis showed that duration of diabetes(OR 1.061,95%CI 1.049-1.073),high systolic blood pressure(SBP;OR 1.071,95%CI 1.037-1.106),increased glycosylated hemoglobin level(OR 1.234,95%CI 1.162-1.311),high blood glucose level(OR 1.061,95%CI 1.023-1.099),increased neutrophil-to-lymphocyte ratio(NLR;OR 1.132,95%CI 1.053-1.217)and mean platelet volume(MPV;OR 1.077,95%CI 1.016-1.142)were risk factors of ***,hematocrit(HCT;OR 0.971,95%CI 0.954-0.988)and mean corpuscular volume(MCV;OR 0.980,95%CI 0.965-0.994)were protective ***:The prevalence rate of DR in Shanghai is 16.97%.The duration of diabetes,high SBP,increased glycosylated hemoglobin,NLR,and MPV were determined as risk factors of DR.

关键词： type 2 diabetes diabetic retinopathy prevalence neutrophil-to-lymphocyte ratio

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Photopic pupil size change in myopic orthokeratology and its influence on axial length elongation

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International Journal of Ophthalmology(English edition) 2022年第8期15卷 1322-1330页

作者： Meng-Jun Zhu Li Ding Lin-Lin Du Jun Chen Xian-Gui He Shan-Shan Li hai-dong zou Shanghai Eye Disease Prevention&Treatment Center/Shanghai Eye Hospital Shanghai 200040China Shanghai General Hospital National Clinical Research Center for Eye DiseasesShanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye DiseasesShanghai 200080China

AIM:To explore the photopic pupil size behavior in myopic children undergoing overnight orthokeratology(ortho-k)over 1-year period and its effects on the axial ***:A total of 202 Chinese myopic children were enrolled in this prospective clinical *** subjects in ortho-k group and eighty-eight subjects in spectacle group completed the 1-year *** length(AL)was measured before enrollment and every 6mo after the start of *** photopic pupil diameter(PPD)was determined using the Pentacam AXL and measured in an examination room with lighting of 300-310 *** multiple linear regression analysis was used to identify variables contribution to axial ***:Compared with spectacle group,the average 1-year axial elongation was significantly slower in the ortho-k group(0.25±0.27 vs 0.44±0.23 mm,P0.05,Bonferroni correction).The 4.81 mm PPD may be a possible cutoff point in the ortho-k *** with PPD below or equal to 4.81 mm tended to have smaller axial elongation compared to subjects with PPD above 4.81 mm after 1-year period(t=-3.09,P=0.003).In ortho-k group,univariate analyses indicated that those with older age,greater degree of myopia,longer AL,smaller baseline PPD(PPDbaseline)experienced a smaller change in *** multivariate analyses,older age,greater AL and smaller PPDbaseline were associated with smaller increases in *** spectacle group,PPD tended to be stable(P>0.05,Bonferroni correction)and did not affect axial ***:PPDs experience significantly decreases at 1-month and 3-month ortho-k *** with smaller PPD tend to experience slower axial elongation and may benefit more from ortho-k.

关键词： orthokeratology myopia axial length pupil diameter accommodation

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Macular choroidal thickness in Chinese preschool children: decrease with axial length but no evident change with age

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International Journal of Ophthalmology(English edition) 2019年第9期12卷 1465-1473页

作者： Xian-Gui He Jun-Jie Deng Yao Yin Bo Zhang Shu-Yu Xiong Jian-Feng Zhu hai-dong zou Xun Xu Ling Wang Department of Maternal and Child Health School of Public HealthKey Laboratory of Public Health SafetyMinistry of EducationFudan UniversityShanghai 200032China Department of Preventative Ophthalmology Shanghai Eye Disease Prevention and Treatment CenterShanghai Eye HospitalShanghai 200040China Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai 200080China

AIM: To explore the distribution pattern of macular choroidal thickness(ChT) and its association with age as well as refractive status in Chinese ***: School-based, cross-sectional study. A total of 550 healthy preschool children aged 3 to 6 years old from 6 kindergartens were enrolled. Comprehensive ocular examinations, including measurement of visual acuity, axial length, intraocular pressure and slit-lamp examination before cycloplegia, as well as refraction measurement and sweptsource optical coherence tomography(SS-OCT) examination after cycloplegia, were performed. The macular ChT in each sector of the ETDRS grid was measured by the builtin software of ***: The mean central ChT of the participants was 312±59 μm. The mean axial length and spherical equivalent refraction were 22.36±0.72 mm and 1.51±0.83 D, respectively. Axial length increased with age(P0.05). The central ChT of 3-4, 5 and 6 years old children was 314±59 μm, 312±60 μm and 312±59 μm, respectively(P=0.920). No difference was observed in ChT in most of the sectors between genders. No statistical significant difference was observed among different refractive groups(all P>0.05), though the ChT of each sector seemed to be smaller in myopic children. Axial length and weight were the independent factors of central Ch T. Children with longer axial length(β=-21.184, P<0.001) and smaller weight(β=1.502, P=0.041) tended to have thinner ***: In preschool children, the ChT remains relatively stable with age, while a negative association between ChT and axial length existed. This will be helpful to elucidate the characteristics of ChT during the early refractive development.

关键词： preschool children choroidal thickness refractive error optical coherence tomography

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TCERG1L hypermethylation is a risk factor of diabetic retinopathy in Chinese children with type 1 diabetes

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 537-544页

作者： Yu Qian Ying Xiao Qiu-Rong Lin Zhao-Yu Xiang Li-Pu Cui Jia-Qi Sun Si-Cong Li Xin-Ran Qin hai-dong zou Chen-Hao Yang Pei-Yao Jin Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai First People’s HospitalShanghai 200080China Shanghai Eye Diseases Prevention&Treatment Center Shanghai Eye HospitalShanghai 200040China National Clinical Research Center for Eye Diseases Shanghai Clinical Research Center for Eye DiseasesShanghai Key Clinical SpecialtyShanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghai 200080China Department of Ophthalmology Children’s Hospital of Fudan UniversityShanghai 201102China

●AIM:To identify the differential methylation sites(DMS)and their according genes associated with diabetic retinopathy(DR)development in type 1 diabetes(T1DM)children.●METHODS:This study consists of two surveys.A total of 40 T1DM children was included in the first *** no participant has DR,retina thinning was used as a surrogate indicator for *** lowest 25%participants with the thinnest macular retinal thickness were included into the case group,and the others were *** DNA methylation status was assessed by the Illumina methylation 850K array BeadChip assay,and compared between the case and control *** DMS with a potential role in diabetes were *** second survey included 27 T1DM children,among which four had *** methylation patterns of the four DMS identified by 850K were compared between participants with and without DR by pyrosequencing.●RESULTS:In the first survey,the 850K array revealed 751 sites significantly and differentially methylated in the case group comparing with the controls(|Δβ|>0.1 and Adj.P0.05)between participants with and without DR.●CONCLUSION:The hypermethylation of the TCERG1L gene is a risk factor for DR development in Chinese children with T1DM.

关键词： DNA methylation 850K array pyrosequencing diabetic retinopathy type 1 diabetes children

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Effect of lamellarization on the microstructure and mechanical properties of marine 10Ni5CrMoV steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 402-413页

作者： Tao zou Yanwu dong Zhouhua Jiang Shuyang Du Yushuo Li School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Key Laboratory for Ecological Metallurgy of Multimetallic Ores(Ministry of Education) Northeastern UniversityShenyang 110819China

Multistage heat treatment involving quenching(Q),lamellarizing(L),and tempering(T)is applied to marine 10Ni5CrMoV *** microstructure and mechanical properties were studied by multiscale characterizations,and the kinetics of reverse austenite transformation,strain hardening behavior,and toughening mechanism were further *** lamellarized specimens possess low yield strength but high toughness,especially cryogenic *** leads to the development of film-like reversed austenite at the martensite block and lath boundaries,refining the martensite structure and lowering the equivalent grain *** analysis of austenite reversion based on the JMAK model shows that the isothermal transformation is dominated by the growth of reversed austenite,and the maximum transformation of reversed austenite is reached at the peak temperature(750℃).The strain hardening behavior based on the modified Crussard-Jaoul analysis indicates that the reversed austenite obtained from lamellarization reduces the proportion of martensite,significantly hindering crack propagation via martensitic transformation during the *** a consequence,the QLT specimens exhibit high machinability and low yield *** with the QT specimen,the ductile-brittle transition temperature of the QLT specimens decreases from-116 to-130℃due to the low equivalent grain size and reversed austenite,which increases the cleavage force required for crack propagation and absorbs the energy of external load,*** work provides an idea to improve the cryogenic toughness of marine 10Ni5CrMoV steel and lays a theoretical foundation for its industrial application and comprehensive performance improvement.

关键词： 10Ni5CrMoV steel lamellarizing reversed austenite cryogenic toughness ductile-brittle transition temperature

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内皮抑素在抗新生血管性眼病治疗中的研究进展

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国际眼科杂志 2011年第12期11卷 2138-2140页

作者：薛文文邹海东上海交通大学附属第一人民医院眼科中国上海市200080

眼部新生血管性疾病严重危害视力,目前的动物实验已证明内皮抑素(endostatin,ES)有望成为一种新型、有效的抑制眼部新生血管的药物。我们就ES在抗新生血管性眼病治疗中的研究进展作一综述。

关键词：内皮抑素眼部新生血管治疗方法

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Causes of Severe Visual Impairment and Blindness in Schools for the Blind

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Chinese Medical Journal 2018年第19期131卷 2354-2356页

作者： Hui-Yi Jin Jiang-Nan He Jian-Feng Zhu Shan-Shan Li Li-Na Lu Xian-Gui He Hong-Mei Xu Xun-Jie Chen hai-dong zou Department of Preventative Ophthalmology Shanghai Eye Disease Prevention and Treatment Center Shanghai 200040 China Department of Ophthalmology Shanghai General Hospital Shanghai Jiao Tong University Shanghai 200080 China Department of Health Service Shanghai Blind and Low Vision Children School Shanghai 200336 China

To the Editor： Reduced vision impacts not only the individual but also the family, community, and public health. It leads to a significant economic burden, including increased education cost, reduced personal income, and loss of productivity for caregivers, and numerous intangible consequences, such as loss of independence, reduced quality of life, and excess morbidity for individuals. An estimated 19 million of the world＇s children are visually impaired, while 1.4 million are blind, according to the World Health Organization （WHO） criteria. Therefore, the control of visual impairment or blindness （VI/BL） in children is still one of the priority areas of the WHO＇s ＂Vision 2020： the Right to Sight＂ program.

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Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury

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Neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： Mou Gao Qin dong Dan zou Zhijun Yang Lili Guo Ruxiang Xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and *** previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological ***,the mechanism of CXCR4 upregulation in induced neural stem cells remains *** this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury ***,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell microglia neuroinflammation

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超声乳化白内障吸除术后泪膜和泪液分泌变化的Meta分析

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国际眼科杂志 2010年第8期10卷 1513-1515页

作者：朱明明余勇夫邹海东上海交通大学附属第一人民医院眼科中国上海市200080 复旦大学公共卫生学院卫生统计学和社会医学教研室中国上海市200032

目的:探讨超声乳化白内障吸除术对泪膜及泪液分泌变化的影响。方法:检索PubMed,Web of knowledge、中华期刊网和中国生物医学文献数据库,辅以Google网络检索和手工检索,筛选得到6篇2000-01/2009-08发表的关于超声乳化白内障吸除术对泪... 详细信息

目的:探讨超声乳化白内障吸除术对泪膜及泪液分泌变化的影响。方法:检索PubMed,Web of knowledge、中华期刊网和中国生物医学文献数据库,辅以Google网络检索和手工检索,筛选得到6篇2000-01/2009-08发表的关于超声乳化白内障吸除术对泪膜和泪液分泌变化影响的研究,以手术前与术后3mo泪膜破裂时间(break-up time,BUT)和基础泪液分泌试验(SchirmerⅠtest,SⅠt)均数差值(relativedifference,RD)为效应指标,应用随机效应模型对入选文献的数据资料进行Meta分析。结果:术后3mo时BUT仍低于手术前水平,差异有统计学意义[RD的加权平均估计值为1.34,95%可信区间为(0.40,2.30),P=0.01]。术后3mo时SⅠt值略低于手术前水平,但差异无统计学意义[RD的加权平均估计值为0.80,95%可信区间为(-0.14,1.75),P=0.10]。结论:术后3mo时,超声乳化白内障吸除术后泪膜稳定性仍降低,但基础泪液分泌量已基本恢复至术前水平。

关键词：超声乳化白内障吸除术泪液 Meta分析

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