Macular choroidal thickness in Chinese preschool children: decrease with axial length but no evident change with age

作     者：Xian-Gui He Jun-Jie Deng Yao Yin Bo Zhang Shu-Yu Xiong Jian-Feng Zhu Hai-Dong Zou Xun Xu Ling Wang 

作者机构：Department of Maternal and Child HealthSchool of Public HealthKey Laboratory of Public Health SafetyMinistry of EducationFudan UniversityShanghai 200032China Department of Preventative OphthalmologyShanghai Eye Disease Prevention and Treatment CenterShanghai Eye HospitalShanghai 200040China Department of OphthalmologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai 200080China 

出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)

年 卷 期：2019年第12卷第9期

页      面：1465-1473页

核心收录：

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

基　　金：Supported by Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai(No.2017YQ019) Key Discipline of Public Health-Eye health in Shanghai(No.15GWZK0601) Overseas High-end Research Team-Eye health in Shanghai(No.GWTD2015S08) 

主　　题：preschool children choroidal thickness refractive error optical coherence tomography 

摘      要：AIM: To explore the distribution pattern of macular choroidal thickness(ChT) and its association with age as well as refractive status in Chinese ***: School-based, cross-sectional study. A total of 550 healthy preschool children aged 3 to 6 years old from 6 kindergartens were enrolled. Comprehensive ocular examinations, including measurement of visual acuity, axial length, intraocular pressure and slit-lamp examination before cycloplegia, as well as refraction measurement and sweptsource optical coherence tomography(SS-OCT) examination after cycloplegia, were performed. The macular ChT in each sector of the ETDRS grid was measured by the builtin software of ***: The mean central ChT of the participants was 312±59 μm. The mean axial length and spherical equivalent refraction were 22.36±0.72 mm and 1.51±0.83 D, respectively. Axial length increased with age(P0.05). The central ChT of 3-4, 5 and 6 years old children was 314±59 μm, 312±60 μm and 312±59 μm, respectively(P=0.920). No difference was observed in ChT in most of the sectors between genders. No statistical significant difference was observed among different refractive groups(all P0.05), though the ChT of each sector seemed to be smaller in myopic children. Axial length and weight were the independent factors of central Ch T. Children with longer axial length(β=-21.184, P0.001) and smaller weight(β=1.502, P=0.041) tended to have thinner ***: In preschool children, the ChT remains relatively stable with age, while a negative association between ChT and axial length existed. This will be helpful to elucidate the characteristics of ChT during the early refractive development.