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Enhance liquid nitrogen fracturing performance on hot dry rock by cyclic injection

Petroleum Science 2023年第2期20卷 951-972页

作者： Chun-Yang Hong Rui-Yue Yang Zhong-Wei Huang Xiao-ying zhuang hai-Tao Wen Xiao-Li Hu State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China Chair of Computational Science and Simulation Technology Faculty of Mathematics and PhysicsLeibniz Universität HannoverHannover30167Germany

Producing complex fracture networks in a safe way plays a critical role in the hot dry rock (HDR) geothermal energy exploitation. However, conventional hydraulic fracturing (HF) generally produces high breakdown pressure and results only in single main fracture morphology. Furthermore, HF has also other problems such as the increased risk of seismic events and consuption of large amount of water. In this work, a new stimulation method based on cyclic soft stimulation (CSS) and liquid nitrogen (LN2) fracturing, known as cyclic LN2 fracturing is explored, which we believe has the potential to solve the above issues related to HF. The fracturing performances including breakdown pressure and fracture morphology on granites under true-triaxial stresses are investigated and compared with cyclic water fracturing. Cryo-scanning electron microscopy (Cryo-SEM) tests and X-ray computed tomography (CT) scanning tests were used for quantitative characterization of fracture parameters and to evaluate the cyclic LN2 fracturing performances. The results demonstrate that the cyclic LN2 fracturing results in reduced breakdown pressure, with between 21% and 67% lower pressure compared with using cyclic water fracturing. Cyclic LN2 fracturing tends to produce more complex and branched fractures, whereas cyclic water fracturing usually produces a single main fracture under a low number of cycles and pressure levels. Thermally-induced fractures mostly occur around the interfaces of different particles. This study shows the potential benefits of cyclic LN2 fracturing on HDR. It is expected to provide theoretical guidance for the cyclic LN2 fracturing application in HDR reservoirs.

关键词： Hot dry rock Liquid nitrogen fracturing Cyclic injection Thermal stress Fatigue damage

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Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

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Neural Regeneration Research 2025年第1期20卷 265-276页

作者： Yao Yuan Lingqi Yu Xudong zhuang Dongjing Wen Jin He Jingmei Hong Jiayu Xie Shengan Ling Xiaoyue Du Wenfeng Chen Xinrui Wang Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian ProvinceChina NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate(Fujian Maternity and Child Health Hospital) FuzhouFujian ProvinceChina Medical Research Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology and Institute of Neurology of The First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina

Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory *** develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause *** located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)*** addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive *** these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut *** found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in *** heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal *** Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.

关键词： ATP1A1 Atpα bang-sensitive paralysis Charcot-Marie-Tooth disease type 2 CRISPR/Cas9 homology-directed repair Na^(+)/K^(+)-ATPase point mutation seizures sodium pump

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Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping zhuang Jiali Wu Yu Wang Hanlin Huang Jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

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Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua zhuang Yan Liu Jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

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Identification of human cytochrome P450 and UGT enzymes involved in the metabolism of ferulic acid, a major bioactive component in traditional Chinese medicines

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Chinese Journal of Natural Medicines 2017年第9期15卷 695-702页

作者： zhuang Xiao-Mei CHEN Lin TAN Yan YANG hai-ying LU Chuang GAO Yue LI Hua State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and Toxicology Beijing100850 China Institute of Radiation Medicine Beijing 100850 China Department of DMPK Biogen USA

Ferulic acid(FA) is an active component of herbal medicines. One of the best documented activities of FA is its antioxidant property. Moreover, FA exerts antiallergic, anti-inflammatory, and hepatoprotective effects. However, the metabolic pathways of FA in humans remain unclear. To identify whether human CYP or UGT enzymes are involved in the metabolism of FA, reaction phenotyping of FA was conducted using major CYP-selective chemical inhibitors together with individual CYP and UGT Supersomes. The CYPand/or UGT-mediated metabolism kinetics were examined simultaneously or individually. Relative activity factor and total normalized rate approaches were used to assess the relative contributions of each major human CYPs towards the FA metabolism. Incubations of FA with human liver microsomes(HLM) displayed NADPH-and UDPGA-dependent metabolism with multiple CYP and UGT isoforms involved. CYPs and UGTs contributed equally to the metabolism of FA in HLM. Although CYP1 A2 and CYP3 A4 appeared to be the major contributors in the CYP-mediated clearance, their contributions to the overall clearance are still minor(< 25%). As a constitute of many food and herbs, FA poses low drug-drug interaction risk when co-administrated with other herbs or conventional medicines because multiple phase I and phase II enzymes are involved in its metabolism.

关键词： Ferulic acid Herb-drug interaction Reaction phenotyping Human liver microsomes

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Japanese encephalitis following liver transplantation: A rare case report

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World Journal of Clinical Cases 2020年第2期8卷 337-342页

作者： Zhi-Li Qi Li-ying Sun Jing Bai hai-Zhou zhuang Mei-Li Duan Department of Intensive Care Unit Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Beijing Key Laboratory of Tolerance Induction and Organ Protection in Transplantation Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

BACKGROUND Japanese encephalitis(JE) is a serious public health concern with a high mortality rate in many Asian countries. For many years, JE virus(JEV) was considered the major cause of viral encephalitis in Asia. Although most JE cases are asymptomatic, the case fatality rate approaches 30%, and approximately 30%–50% of survivors have long-term neurological sequelae. To the best of our knowledge, JEV infection has never been reported following liver *** SUMMARY We report a case of a woman who underwent liver transplantation for autoimmune liver disease but presented with fever and neurological symptoms 13 d after transplantation. Magnetic resonance imaging revealed JEV infection,and positive immunoglobulin M antibody to JEV in blood and cerebrospinal fluid confirmed JE. The patient was treated with antiviral agents, immune regulation,and organ function support. No neurological sequelae were present after 1 year of *** Imaging and lumbar puncture examination should be performed as soon as possible in patients with fever and central nervous system symptoms after liver transplantation, and the possibility of atypical infection should be considered,which is helpful for early diagnosis and improved prognosis.

关键词： Liver transplantation Japanese encephalitis virus Neurological complications Infection Case report

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Estimating optimal substitution scale of urban gasoline taxis by electric taxis in the era of green energy:a case study of Zhengzhou City

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Geo-Spatial Information Science 2023年第3期26卷 514-539页

作者： Zhixiang Fang Xiaofan Wang ying zhuang Xianglong Liu State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhanChina Key Laboratory of Advanced Public Transportation Science China Academy of Transportation SciencesBeijingChina

Electric Taxis(ETs)are the most favored alternatives to Gasoline Taxis(GTs)in cities that aim to reduce environmental *** to develop a reasonable scale on which GTs are substituted by ETs remains a challenge to governments due to the dynamics and complexity of the taxi *** address this challenge,this paper develops a discrete-event-based simulation framework to simulate participants in the system and estimate the results under different substitution scales,which are helpful to understanding the status changing law of entities under different substitution scales,such as the operating indices of ETs,the unsatisfied travel requirements of passengers,and the usage state of charging *** framework abstracts the behavioral process of ETs into three elements,namely,entity,behavior,and *** entities are constructed from the information derived from the trajectory *** behaviors are defined by rules following behavioral logic under anxiety psychology,which is caused by the limited range of *** events are triggered based on rules from *** the help of this framework,a multi-objective optimization model is developed to obtain the optimal substitution scale of GTs in the case study area of Zhengzhou ***,the approach could provide a practical tool to address this challenge,which could support further studies of the effect of ETs on urban taxis.

关键词： Electric Taxi(ET) substitution scale discrete-event simulation decision support multi-objective optimization

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The Oncogenesis of Glial Cells in Diffuse Gliomas and Clinical Opportunities

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Neuroscience Bulletin 2023年第3期39卷 393-408页

作者： Qiyuan zhuang Hui Yang ying Mao Department of Neurosurgery Huashan HospitalFudan UniversityShanghai 200040China National Center for Neurological Disorders Huashan HospitalFudan UniversityShanghai 200040China Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration Huashan HospitalFudan UniversityShanghai 200040China Institute for Translational Brain Research Fudan UniversityShanghai 200032China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute for Translational Brain ResearchInstitutes of Brain ScienceFudan UniversityShanghai 200032China Neurosurgical Institute of Fudan University Shanghai 200032China

Glioma is the most common and lethal intrinsic primary tumor of the *** controversial origins may contribute to its heterogeneity,creating challenges and difficulties in the development of *** the components constituting tumors,glioma stem cells are highly plastic subpopulations that are thought to be the site of tumor *** stem cells/progenitor cells and oligodendrocyte progenitor cells are possible lineage groups populating the bulk of the tumor,in which gene mutations related to cell-cycle or metabolic enzymes dramatically affect this *** approaches have revealed the tumor-promoting properties of distinct tumor cell states,glial,neural,and immune cell populations in the tumor *** between tumor cells and other normal cells manipulate tumor progression and influence sensitivity to ***,we discuss the heterogeneity and relevant functions of tumor cell state,microglia,monocyte-derived macrophages,and neurons in glioma,highlighting their bilateral effects on ***,we describe potential therapeutic approaches and targets beyond standard treatments.

关键词： Glioma origin Stem/progenitor cell Oncometabolite Immune heterogeneity Neuron-tumor interaction

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Chinese Medicine Treatment on Graft-Versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

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Chinese Journal of Integrative Medicine 2020年第5期26卷 324-329页

作者： WU Xiao-long zhuang hai-feng ZHAO Yan-na YU Xiao-ling DAI Tie-ying GAO Rui-lan Institute of Hematology Research the First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou(310006)China

Graft-versus-host disease(GVHD)is the most common complication after allogeneic hematopoietic stem cell transplantation,and also an important factor affecting the survival and quality of life in patients after ***,immunosuppressive therapy is commonly used for GVHD,but the curative effect is not *** to effectively prevent and treat GVHD is one of the difficulties to be solved urgently in the field of *** this paper,we summarize the latest progress in pathogenesis,prevention and treatment of GVHD with Chinese medicine(CM).We hope it will provide ideas and methods for exploring the mechanism and establishing a new comprehensive therapy for GVHD with CM.

关键词： Chinese medicine hematopoietic stem cell transplantation graft-versus-host disease

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Resilient tightly coupled INS/UWB integration method for indoor UAV navigation under challenging scenarios

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Defence Technology（防务技术） 2023年第4期22卷 185-196页

作者： Qian Meng Yang Song Sheng-ying Li Yuan zhuang Key Laboratory of Micro-Inertial Instrument and Advanced Navigation Technology Southeast UniversityNanjing210096China Department of Mechanical Engineering Hong Kong Polytechnic UniversityHong KongChina State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhanChina

Based on the high positioning accuracy,low cost and low-power consumption,the ultra-wide-band(UWB)is an ideal solution for indoor unmanned aerial vehicle(UAV)localization and ***,the UWB signals are easy to be blocked or reflected by obstacles such as walls and furniture.A resilient tightly-coupled inertial navigation system(INS)/UWB integration is proposed and implemented for indoor UAV navigation in this paper.A factor graph optimization(FGO)method enhanced by resilient stochastic model is established to cope with the indoor challenging *** deal with the impact of UWB non-line-of-sight(NLOS)signals and noise uncertainty,the conventional neural net-works(CNNs)are introduced into the stochastic modelling to improve the resilience and reliability of the *** on the status that the UWB features are limited,a‘two-phase'CNNs structure was designed and implemented:one for signal classification and the other one for measurement noise *** proposed resilient FGO method is tested on flighting UAV platform under actual indoor challenging *** to classical FGO method,the overall positioning errors can be decreased from about 0.60 m to centimeter-level under signal block and reflection *** superiority of resilient FGO which effectively verified in constrained environment is pretty important for positioning accuracy and integrity for indoor navigation task.

关键词： Unmanned aerial vehicle(UAV) Resilient navigation Indoor positioning Factor graph optimization Ultra-wide band(UWB)

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