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Successful treatment of pulmonary hypertension in a neonate with bronchopulmonary dysplasia: A case report and literature review

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World Journal of Clinical Cases 2022年第32期10卷 11898-11907页

作者： Jiao Li Jing Zhao Xiao-Yan Yang Jing Shi hai-ting liu Department of Pediatrics West China Second University HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Neonatal Ward West China Second University HospitalSichuan UniversityChengdu 610066Sichuan ProvinceChina

BACKGROUND Pulmonary hypertension(PH)is a severe complication of bronchopulmonary dysplasia(BPD)in premature neonates and is closely related to ***,there is no effective and safe treatment for PH due to BPD in *** treatment for cases of BPD-associated PH with Tadalafil combined with bosentan is *** case may make a significant contribution to the literature because PH is difficult to manage as a serious complication of BPD in preterm *** is high,especially when it is complicated by heart *** SUMMARY An extremely premature neonate with a gestational age of 26+5 wk and birth weight of 0.83 kg was diagnosed with BPD associated with PH;oral sildenafil did not improve the *** infant experienced sudden cardiac arrest and serious heart failure with severe *** a series of treatments,including cardiopulmonary resuscitation,mechanical ventilation,and inhaled nitric oxide(iNO),the respiratory and circulatory status improved but the pulmonary artery pressure remained *** oral sildenafil was replaced with oral tadalafil and bosentan;pulmonary artery pressure improved,and the infant recovered at our *** 2 years of follow-up,she is in good condition,without any cardiovascular *** INO can effectively improve the respiratory and circulatory status of infants with PH associated with premature BPD.B-type natriuretic peptide should be routinely measured during hospitalization to evaluate the risk and prognosis of BPD-associated PH in preterm *** combined with bosentan for the treatment of PH associated with premature BPD was better than sildenafil in this *** studies are needed to explore the efficacy and safety of different vasodilators in the treatment of PH associated with premature BPD.

关键词： Premature Bronchopulmonary dysplasia Pulmonary hypertension Treatment Case report

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The sugar transporter system of strawberry:genome-wide identification and expression correlation with fruit soluble sugar-related traits in a Fragaria×ananassa germplasm collection

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Horticulture Research 2020年第1期7卷 1303-1321页

作者： hai-ting liu Ying Ji Ya liu Shu-Hua Tian Qing-Hua Gao Xiao-Hua Zou Jing Yang Chao Dong Jia-Hui Tan Di-An Ni Ke Duan Shanghai Key Laboratory of Protected Horticultural Technology Forestry and Fruit Tree Research InstituteShanghai Academy of Agricultural Sciences(SAAS)Shanghai 201403China Ecological Technique and Engineering College Shanghai Institute of TechnologyShanghai 201418China Environmental Engineering College Suzhou Polytechnic Institute of AgricultureSuzhou 215008China

Sugar from plant photosynthesis is a basic requirement for life *** transporters are the proteins that mediate sugar allocation among or within source/sink *** transporters of the major facilitator superfamily(MFS)targeting carbohydrates represent the largest family of sugar transporters in many ***(Fragaria×ananassa Duchesne)is an important crop appreciated worldwide for its unique fruit *** involvement of MFS sugar transporters(STs)in cultivated strawberry fruit sugar accumulation is largely *** this work,we characterized the genetic variation associated with fruit soluble sugars in a collection including 154 ***,a total of 67 ST genes were identified in the v4.0 genome integrated with the v4.0.a2 protein database of ***,the dominant subgenome provider for modern cultivated *** analysis updated the nomenclature of strawberry ST *** the chromosomal distribution and structural characteristics of the ST family were ***-RT-PCR analysis in nine tissues from *** screened 34 highly expressed ST genes in *** three varieties with dramatically differing fruit sugar levels,qPCR integrated with correlation analysis between ST transcript abundance and sugar content identified 13 sugar-correlated *** correlations were re-evaluated across 19 varieties,including major commercial cultivars grown in ***,a model of the contribution of the sugar transporter system to subcellular sugar allocation in strawberry fruits was *** work highlights the involvement of STs in controlling strawberry fruit soluble sugars and provides candidates for the future functional study of STs in strawberry development and responses and a new approach for strawberry genetic engineering and molecular breeding.

关键词： straw Fragaria Sugar

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MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self‑Powered Motion Sensing

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Nano-Micro Letters 2025年第3期17卷 265-279页

作者： Yu‑Ze Wang Yu‑Chang Wang ting‑ting liu Quan‑Liang Zhao Chen‑Sha Li Mao‑Sheng Cao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China School of Materials Science and Engineering Peking UniversityBeijing 100871People’s Republic of China School of Mechanical and Material Engineering North China University of TechnologyBeijing 100144People’s Republic of China Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080People’s Republic of China

Polymeric microwave actuators combining tissue-like softness with programmablemicrowave-responsive deformation hold great promise for mobile intelligentdevices and bionic soft robots. However, their application is challenged by restricted electromagneticsensitivity and intricate sensing coupling. In this study, a sensitized polymericmicrowave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx(MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique spacechargepolarization and interfacial polarization, resulting in significant improvements of230% in the dielectric loss factor and 830% in the apparent efficiency of electromagneticenergy harvest. The sensitized microwave actuation demonstrates as the shortenedresponse time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (upto 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combinesdriving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of ~ 3 mV) duringactuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approachfor developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator

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急性淋巴细胞性白血病患儿泼尼松试验敏感与不敏感者临床及形态学、免疫学、细胞遗传学特征研究

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中华儿科杂志 2007年第11期45卷 865-867页

作者：刘海婷李强郭霞四川大学华西第二医院儿科成都610041

泼尼松试验对小儿急性淋巴细胞性白血病（ALL）的预后价值已得到广泛认同，我们根据泼尼松试验结果，将我院2000年3月-2006年1月收治的133例ALL患儿分为泼尼松不敏感（PPR）和泼尼松敏感（PGR）两组，比较了二者的临床及形态学、免疫学... 详细信息

泼尼松试验对小儿急性淋巴细胞性白血病（ALL）的预后价值已得到广泛认同，我们根据泼尼松试验结果，将我院2000年3月-2006年1月收治的133例ALL患儿分为泼尼松不敏感（PPR）和泼尼松敏感（PGR）两组，比较了二者的临床及形态学、免疫学、细胞遗传学（MIC）特征，为今后临床按危险度进行分层的治疗方案以及ALL患者的个体化治疗提供依据。

关键词：小儿急性淋巴细胞性白血病白血病患儿泼尼松形态学免疫学遗传学特征临床试验

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Potential dependence in electrocatalysis: a theoretical perspective

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Science China Chemistry 2025年第1期 21-25页

作者： Leyu liu Zhaoming Xia Zeyu Wang Yinjuan Chen hai Xiao Department of Chemistry Tsinghua University Fundamental Science Center of Rare Earths Ganjiang Innovation Academy Chinese Academy of Sciences Key Laboratory of Advanced Catalytic Materials and Technology Advanced Catalysis and Green Manufacturing Collaborative Innovation Center Changzhou University

Electrocatalysis is a key technology for the new energy era and sustainable development, serving as the interface for interconversion of electrical and chemical energies, which spans a wide spectrum of applications in sustainable energy and environmental engineering. Electrocatalytic reactions including electrochemical CO2reduction reaction （eCO2RR）, hydrogen evolution reaction （HER）, and oxygen evolution/reduction reactions （OER/ORR）, hold essential promise for renewable energy technologies as well as complement the biogeochemical carbon and oxygen cycles.

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Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting liu Wei Huang Jiayi Wen Xin Xiong ting Xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

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Investigation on the interaction of dispersed and elongated bubbles based on laser-induced fluorescence

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Optoelectronics Letters 2025年

作者： XUE ting SHI Ruini liu Jinshun WANG haixia WU Yan School of Electrical and Information Engineering， Tianjin University

The purpose of this paper is to investigate the interaction between dispersed and elongated bubbles in horizontal slug flow utilizing the laser-induced fluorescence method. A Segmentation method based on the fuzzy C-mean (FCM) algorithm is proposed to effectively separate elongated bubbles from the liquid phase， and an extreme value extraction method is developed to calculate the number of dispersed bubbles in front of the nose of elongated bubbles. Moreover， the velocity offsets of elongated bubbles with and without dispersed bubbles are calculated separately based on contour extraction. In addition， the effect of dispersed bubbles on the fluctuating offsets of the nose tip position and velocity of elongated bubbles are statistically investigated under different flow velocities. The experimental results show that the increase of the gas-liquid flow velocity exacerbates the radial deviation of the nose tip and the fluctuation of axial velocity.

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Engineering high-performance chemiluminescent probes via enzymatic pocket targeting: high-throughput screening for ultralong afterglow imaging of orthotopic hepatocellular carcinoma

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Science China Chemistry 2025年

作者： Shuai Huang Shuaige Bai ting Luo Bin Feng Min liu Fan Zheng Shuang Huang Yanpeng Fang Dan Ding Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South University College of Life Sciences Nankai University

Hepatocellular carcinoma （HCC） is a highly aggressive liver malignancy and the main form of liver cancer. Early diagnosis and treatment of HCC can effectively reduce mortality. Carboxylesterase （CE）-specific detection and imaging can be used for early diagnosis and image-guided surgical of HCC. However, traditional optical probes suffer from poor selectivity and low imaging signal-to-noise ratio. Here, we have constructed a series of chemiluminescent probes for carboxylesterase detection based on the strategy of enzymatic pocket-oriented steric tailoring techniques. The probes with different unique and excellent properties have been obtained through the structure-based steric hindrance adjustment on the recognition site. Here, CE-2 has been successfully used for high-throughput screening of rapid carboxylesterase inhibitors due to its extremely low detection limit (2.5×10-4U mL-1) and fast recognition ability. CE-3 has been successfully used for image-guided surgery of orthotopic hepatocellular carcinoma due to its ultra-long chemiluminescence imaging （over 12 h） of hepatocellular carcinoma. This study may promote advances in the rapid detection and screening of inhibitory drugs for CE and the field of surgical navigation in HCC.

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基于合成孔径方法的潜艇二维高频声散射特性分析

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系统仿真学报 2009年第23期21卷 7433-7435,7463页

作者：杨海亮唐劲松徐海亭刘丹丹海军工程大学电子工程学院武汉430033 中国科学院声学研究所北海站青岛242600

水下复杂形状目标的散射特性预测一般采用真实孔径成像,但其存在图像分辨率难以提高,无法获取复杂目标的精细结构特征的弱点。而相比之下,合成孔径声纳成像方位分辨率很高,成像质量有较大改善,因此我们依据潜艇散射的物理声学Kirchhoff... 详细信息

水下复杂形状目标的散射特性预测一般采用真实孔径成像,但其存在图像分辨率难以提高,无法获取复杂目标的精细结构特征的弱点。而相比之下,合成孔径声纳成像方位分辨率很高,成像质量有较大改善,因此我们依据潜艇散射的物理声学Kirchhoff积分原理和CAD技术,通过对潜艇建模仿真得到其散射回波数据,进而采用合成孔径技术实现对潜艇二维声散射特性的分析,得到了高分辨率的二维声图像.在一些水下装备的研制论证阶段,采用该方法可以有效地预测其散射特性,为设计低目标强度的装备提供依据。

关键词：散射特性 Kirchhoff积分建模合成孔径声纳

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Magnitude and uniformity improvement of the received optical power for an indoor VLC system jointly assisted by angle-diversity transceivers and STAR-IRS

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Optoelectronics Letters 2025年

作者： YANG ting WANG Ping HE Huimeng XIONG Yingfei SUN Yanzhe liu Qi School of Telecommunications Engineering， Xidian University

To improve the quality of the illumination distribution， one novel indoor visible light communication (VLC) system， which is jointly assisted by the angle-diversity transceivers and simultaneous transmission and reflection-intelligent reflecting surface (STAR-IRS)， has been proposed in this work. A Harris Hawks optimizer algorithm (HHOA)-based two-stage alternating iteration algorithm (TSAIA) scheme is presented to jointly optimize the magnitude and uniformity of the received optical power. Besides， to demonstrate the superiority of the proposed strategy， several benchmark schemes are simulated and compared. Results showed that compared to other optimization strategies， the TSAIA scheme is more capable of balancing the average value and variance of the received optical power when the maximal ratio combining (MRC) strategy is adopted at the receiver. Moreover， as the number of the STAR-IRS elements increases， the optical power variance of the system optimized by TSAIA scheme would become smaller while the average optical power would get larger. This study will benefit the design of received optical power distribution for indoor VLC systems.

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