Successful treatment of pulmonary hypertension in a neonate with bronchopulmonary dysplasia: A case report and literature review

作     者：Jiao Li Jing Zhao Xiao-Yan Yang Jing Shi Hai-Ting Liu 

作者机构：Department of PediatricsWest China Second University HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Neonatal WardWest China Second University HospitalSichuan UniversityChengdu 610066Sichuan ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2022年第10卷第32期

页      面：11898-11907页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

基　　金：Supported by The Clinical Research Fund of West China Second University Hospital Sichuan University No.KL109(to Li J) No.KL014(to Yang XY) and No.KL075(to Shi J) 

主　　题：Premature Bronchopulmonary dysplasia Pulmonary hypertension Treatment Case report 

摘      要：BACKGROUND Pulmonary hypertension(PH)is a severe complication of bronchopulmonary dysplasia(BPD)in premature neonates and is closely related to ***,there is no effective and safe treatment for PH due to BPD in *** treatment for cases of BPD-associated PH with Tadalafil combined with bosentan is *** case may make a significant contribution to the literature because PH is difficult to manage as a serious complication of BPD in preterm *** is high,especially when it is complicated by heart *** SUMMARY An extremely premature neonate with a gestational age of 26+5 wk and birth weight of 0.83 kg was diagnosed with BPD associated with PH;oral sildenafil did not improve the *** infant experienced sudden cardiac arrest and serious heart failure with severe *** a series of treatments,including cardiopulmonary resuscitation,mechanical ventilation,and inhaled nitric oxide(iNO),the respiratory and circulatory status improved but the pulmonary artery pressure remained *** oral sildenafil was replaced with oral tadalafil and bosentan;pulmonary artery pressure improved,and the infant recovered at our *** 2 years of follow-up,she is in good condition,without any cardiovascular *** INO can effectively improve the respiratory and circulatory status of infants with PH associated with premature BPD.B-type natriuretic peptide should be routinely measured during hospitalization to evaluate the risk and prognosis of BPD-associated PH in preterm *** combined with bosentan for the treatment of PH associated with premature BPD was better than sildenafil in this *** studies are needed to explore the efficacy and safety of different vasodilators in the treatment of PH associated with premature BPD.