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Thermoresponsive helical dendronized poly(arylacetylene)s:modulating the dynamic chirality

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Science China Chemistry 2025年

作者： Xueting lu Lei Wang Liangxuan Ren Wen Li Afang Zhang International Joint Laboratory of Biomimetic&Smart Polymers School of Materials Science and EngineeringShanghai University

Helical poly(arylacetylene)s have formed an intriguing class of polymers,whose chiralities are dynamic and liable to external *** combining dendronized polymer topology with dendritic oligoethylene glycols (OEGs),we here report on synthesis of a homologous series of thermoresponsive dendronized poly(arylacetylene)s with either poly(phenyl acetylene) or poly(naphthalene acetylene) as the backbones,and investigate tunability of their helical *** polymers carry dendritic OEG pendants with either methoxyl-or ethoxyl-terminals to tune their unprecedent thermoresponsive behaviors,and at the same time,dendritic shielding plays an important role in mediating their thermal phase transition *** of these polymers is originated from the chiral alanine or phenylalanine moieties within the dendritic pendants,which can be tailored through manipulating solvation in different organic solvents or via thermal dehydration and collapse in ***,achiral additives such as linear or dendritic OEGs and benzene derivatives can act similarly as thermal dehydration to induce chirality transitions of these polymers in aqueous phase through interplay competitions between the additives and the polymers against their hydration.

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Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

Spatial Dependent Spontaneous Emission of an Atom in a Semi-Infinite Waveguide of Rectangular Cross Section

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Communications in Theoretical Physics 2018年第1期69卷 59-67页

作者： hai-Xi song Xiao-Qi Sun Jing lu Lan Zhou Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of Physics and Synergetic Innovation Center of Quantum Effects and Applications Hunan Normal University Changsha 410081 China

We study a quantum electrodynamics(QED) system made of a two-level atom and a semi-infinite rectangular waveguide, which behaves as a perfect mirror in one end. The spatial dependence of the atomic spontaneous emission has been included in the coupling strength relevant to the eigenmodes of the waveguide. The role of retardation is studied for the atomic transition frequency far away from the cutoff frequencies. The atom-mirror distance introduces different phases and retardation times into the dynamics of the atom interacting resonantly with the corresponding transverse modes. It is found that the upper state population decreases from its initial as long as the atom-mirror distance does not vanish, and is lowered and lowered when more and more transverse modes are resonant with the atom. The atomic spontaneous emission can be either suppressed or enhanced by adjusting the atomic location for short retardation *** are partial revivals and collapses due to the photon reabsorbed and re-emitted by the atom for long retardation time.

关键词： quantum optics waveguide spontaneous emission retardation

Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

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Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu Zhang Yuqi Liu Fangxia Xu Chengcheng Zhou Kaimei lu Bin Fang Lijuan Wang Lina Huang Zifeng Xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons

Quantum transport in topological semimetals under magnetic fields (Ⅱ)

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Frontiers of physics 2019年第3期14卷 1-24页

作者： hai-Peng Sun hai-Zhou lu Department of Physics Harbin Institute of Technology Harbin 150001 China Shenzhen Institute for Quantum Science and Engineering and Department of Physics Southern University of Science and Technology Shenzhen 518055 China Shenzhen Key Laboratory of Quantum Science and Engineering Shenzhen 518055 China

We review our recent works on the quantum transport, mainly in topological semimetals and also in topological insulators, organized according to the strength of the magnetic field. At weak magnetic fields, we explain the negative magnetoresistance in topological semimetals and topological insulators by using the semiclassical equations of motion with the nontrivial Berry curvature. We show that the negative magnetoresistance can exist without the chiral anomaly. At strong magnetic fields, we establish theories for the quantum oscillations in topological Weyl, Dirac, and nodal-line semimetals. We propose a new mechanism of 3D quantum Hall effect, via the "wormhole" tunneling through the Weyl orbit formed by the Fermi arcs and Weyl nodes in topological semimetals. In the quantum limit at extremely strong magnetic fields, we find that an unexpected Hall resistance reversal can be understood in terms of the Weyl fermion annihilation. Additionally, in parallel magnetic fields, longitudinal resistance dips in the quantum limit can serve as signatures for topological insulators.

关键词： topological semimetai topological insulator quantum oscillation negative magne to resistance quantum Hall effect

Comprehensive study on the spatial distribution of heavy metals and their environmental risks in high-sulfur coal gangue dumps in China

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Journal of Environmental Sciences 2024年第2期136卷 486-497页

作者： Yingbo Dong Huan lu hai Lin School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory on Resource-oriented Treatment of Industrial Pollutants Beijing 100083China

The accumulation of coal gangue(CG)from coal mining is an important source of heavy metals(HMs)in *** spatial distribution and environment risk assessment are extremely important for the management and remediation of *** soil samples were collected from the high-sulfur CG site in northern China and analyzed for six *** results showed that the soil was heavily contaminated by Mn,Cr and Ni based on the Nemerow index,and posed seriously ecological risk depended on the geo-accumulation index,potential ecological risk index and risk assessment *** semi-variogram model and ordinary kriging interpolation accurately portrayed the spatial distribution of ***,Mn,and Cr were distributed by band diffusion,Ni was distributed by core,the distribution of Cu had obvious patchiness and Zn was more *** spatial autocorrelation indicated that all HMs had strong spatial *** BCR sequential extraction was employed to qualify the geochemical fractions of *** data indicated that Fe and Cr were dominated by residual fraction;Cu,Ni and Zn were dominated by reducible and oxidizable fractions;Mn was dominated by reducible and acid-extractable(25.38%-44.67%)*** correlation analysis showed that pH was the main control factor affecting the non-residue fractions of ***,acid production from high sulfur CG reduced soil pH by 2-3,which indirectly promoted the activity of ***,the conceptual model of HMs contamination at the CG site was proposed,which can be useful for the development of ecological remediation strategies.

关键词： High-sulfur coal gangue Soil contamination Heavy metals Spatial distribution Geochemical fractions Risk assessment

考虑场地效应的多点地震动作用下边坡永久位移分析

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岩土工程学报 2025年第1期47卷 65-75页

作者：宋健潘驭航陆朱汐姬建张飞高玉峰河海大学岩土力学与堤坝工程教育部重点实验室江苏南京210024 河海大学土木与交通学院江苏南京210024

地震动引起的边坡土层非线性动力响应可能导致坡体不同位置的地震动加速度时程不一致,从而对整个滑动体的极限平衡状态及之后的地震累积永久位移产生影响。为了研究场地效应对边坡地震永久位移的影响,基于极限平衡条分法,通过对不同土... 详细信息

地震动引起的边坡土层非线性动力响应可能导致坡体不同位置的地震动加速度时程不一致,从而对整个滑动体的极限平衡状态及之后的地震累积永久位移产生影响。为了研究场地效应对边坡地震永久位移的影响,基于极限平衡条分法,通过对不同土条赋予不同的水平和竖向地震动时程,推导出一种考虑场地效应的圆弧和任意形状滑面的多点地震作用下边坡永久位移分析方法。通过与有限差分软件FLAC的数值模拟结果进行对比,验证了该方法能够合理考虑地震动的场地效应。通过研究不同分布形式的多点地震动及竖向地震动对边坡永久位移的影响,结果表明:场地效应引起的水平地震动放大以及多点地震动不同分布模式会导致整个滑体平均地震惯性力作用位置发生改变,从而影响地震作用下滑动体沿滑面的永久变形量,竖向地震动对边坡地震位移影响较小。将方法应用于Lexington土石坝震后变形案例分析,计算得到的坝坡地震永久位移与实际震后观测值相吻合,证明了考虑场地效应的重要性及本文方法的合理性。

关键词：地震边坡稳定性场地效应永久位移极限平衡条分法多点地震动

Study on Optimal Water ControlMethods for Horizontal Wells in Bottom Water Clastic Rock Reservoirs

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Fluid Dynamics & Materials Processing 2024年第10期20卷 2377-2392页

作者： Xianghua Liu hai song lu Zhao Yan Zheng Neng Yang Dongling Qiu Sinopec Northwest Oilfield Branch Northwest Oilfield Branch of China Petroleum and Chemical CorporationUrumqi830011China School of Petroleum and Natural Gas Engineering Southwest Petroleum UniversityChengdu610500China

The segmented water control technology for bottom water reservoirs can effectively delay the entry of bottom water and adjust the production *** clarify the impact of different methods on horizontal well production with different reservoir conditions and to provide theoretical support for the scientific selection of methods for bottom water reservoirs,a numerical simulation method is presented in this study,which is able to deal with wellbore reservoir coupling under screen tube,perforation,and ICD(Inflow Control Device)*** the geological characteristics of the bottom-water conglomerate reservoir in the Triassic Formation of the Tahe Block 9 as a test case,the three aforementioned completion methods are tested to predict the transient production *** impact of completion parameters,reservoir permeability,bottom-water energy,and individual well control on the time to encounter water in horizontal wells(during a water-free production period)is discussed.A boundary chart for the selection of completion methods is introduced *** results show that the optimized ICD completion development effect for heterogeneous reservoirs is the best,followed by optimized perforation *** is the main factor affecting the performances of completion methods,while bottom water energy and single well controlled reserves have a scarce *** average permeability of the reservoir is less than 500 mD,and ICD has the best water control *** the permeability is greater than 500 mD,the water control effect of perforation completion becomes a better option.

关键词： Completion method bottom water low-permeability oil reservoir horizontal well development effect

Application of graphene vertical field effect to regulation of organic light-emitting transistors

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Chinese Physics B 2020年第5期29卷 473-478页

作者： Hang song Hao Wu hai-Yang lu Zhi-Hao Yang Long Ba State Key Laboratory of Bioelectronics Southeast UniversityNanjing 210096China

The luminescence intensity regulation of organic light-emitting transistor(OLED)device can be achieved effectively by the combination of graphene vertical field effect transistor(GVFET)and *** this paper,we fabricate and characterize the graphene vertical field-effect transistor with gate dielectric of ion-gel film,confirming that its current switching ratio reaches up to *** of the property of high light transmittance in ion-gel film,the OLED device prepared with graphene/PEDOT:PSS as composite anode exhibits good optical *** also prepare the graphene vertical organic light-emitting field effect transistor(GVOLEFET)by the combination of GVFET and graphene OLED,analyzing its electrical and optical properties,and confirming that the luminescence intensity can be significantly changed by regulating the gate voltage.

关键词： graphene vertical field effect transistor organic light-emitting transistor ion-gel film gate voltage regulation