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基于SSAE的地震属性融合技术

地球物理学进展 2024年第2期39卷 647-660页

作者：周单钟晗中石化石油物探技术研究院有限公司南京211103

地震属性是地下介质的综合反映,与地质目标往往不具备一一对应的关系,这就导致单一属性在解释时不可避免的存在多解性,为解决这一难题,地震属性融合技术应用而生.传统的基于线性变换的主成分分析(Principal Component Analysis,PCA)方... 详细信息

地震属性是地下介质的综合反映,与地质目标往往不具备一一对应的关系,这就导致单一属性在解释时不可避免的存在多解性,为解决这一难题,地震属性融合技术应用而生.传统的基于线性变换的主成分分析(Principal Component Analysis,PCA)方法是一种较为有效的地震属性融合技术,但它在面对复杂非线性的地震属性融合问题时,不能有效提取其中的非线性特征.因此,本文提出了基于栈式稀疏自编码器(Stack Sparse Auto Encoders,SSAE)的非线性地震属性融合技术.SSAE是一种深度学习网络,能够充分地挖掘数据的非线性特征,通过不断学习,自适应地融合各种属性中蕴含的有效信息.本文首先介绍了地震属性的优选、标准化处理方法,然后阐述了基于PCA、SSAE的属性融合方法的基本原理;最后通过两种方法在两个经典模型、一个正演模型及三个应用实例的对比分析,表明SSAE对于非线性数据拥有更好的融合效果,且对于多尺度、多属性、宽方位等不同类型的属性数据也具备普适性.SSAE融合属性集合了多种属性的特征信息,有效降低了解释的多解性,提升了储层预测的精度,可为同类型工区提供借鉴.

关键词：多解性非线性地震属性融合主成分分析栈式稀疏自编码器

基于安全深度强化学习的电网有功频率协同优化控制

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上海交通大学学报 2024年第5期58卷 682-692页

作者：周毅周良才史迪赵小英闪鑫国家电网有限公司华东分部上海200002 AINERGY 美国圣塔克拉拉95051 国电南瑞科技股份有限公司南京210024

可再生能源占比不断增加给互联电网频率控制带来严峻考验.由于常规的自动发电控制(AGC)策略没有考虑电网潮流安全约束,所以传统方法根据专家知识和经验进行尝试性发电机功率调整,需耗费较多时间;基于最优电力潮流的互联电网AGC优化模型... 详细信息

可再生能源占比不断增加给互联电网频率控制带来严峻考验.由于常规的自动发电控制(AGC)策略没有考虑电网潮流安全约束,所以传统方法根据专家知识和经验进行尝试性发电机功率调整,需耗费较多时间;基于最优电力潮流的互联电网AGC优化模型由于非凸性和大规模性,求解时间较长且存在收敛性问题.鉴于常规深度强化学习具有“离线训练、在线端对端形成策略”的优点,但在动作探索过程中无法保证系统安全性,提出一种基于安全深度强化学习的电网有功频率协同优化控制方法.首先,将电网频率控制建模为约束马尔可夫决策过程,对决策过程添加相关安全约束进行智能体设计;然后,基于华东电网实际系统算例对智能体进行训练和性能提升;最后,对比智能体决策与常规AGC策略效果.结果表明:所提方法在多种运行方式下可快速生成有功频率控制策略,且保证系统频率恢复过程中电网的安全性,可辅助调度员在线决策.

关键词：有功频率协同控制人工智能深度强化学习约束马尔可夫决策过程智能体

lncRNA Gm20257 alleviates pathological cardiac hypertrophy by modulating the PGC-1α-mitochondrial complex IV axis

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FRONTIERS OF MEDICINE 2024年第4期18卷 664-677页

作者： Yu, Tong Gao, Qiang Zhang, Guofang Li, Tianyu Liu, Xiaoshan Li, Chao Zheng, Lan Sun, Xiang Wu, Jianbo Cao, Huiying Bi, Fangfang Wang, Ruifeng Liang, haihai Li, Xuelian zhou, Yuhong Lv, Lifang shan, Hongli shanghai Univ Engn Sci Inst Frontier Med Technol Shanghai Frontiers Sci Res Ctr Druggabil Cardiovas Shanghai 201620 Peoples R China Harbin Med Univ Sch Basic Med Dept Physiol Harbin 150081 Peoples R China Harbin Med Univ Ctr Funct Expt Teaching Sch Basic Med Harbin 150081 Peoples R China Harbin Med Univ Coll Pharm Dept Pharmacol State Key Lab Frigid Zone Cardiovasc DisState Pro Harbin 150081 Peoples R China

Pathological cardiac hypertrophy, a major contributor to heart failure, is closely linked to mitochondrial function. The roles of long noncoding RNAs (lncRNAs), which regulate mitochondrial function, remain largely unexplored in this context. Herein, a previously unknown lncRNA, Gm20257, was identified. It markedly increased under hypertrophic stress in vivo and in vitro. The suppression of Gm20257 by using small interfering RNAs significantly induced cardiomyocyte hypertrophy. Conversely, the overexpression of Gm20257 through plasmid transfection or adeno-associated viral vector-9 mitigated angiotensin II-induced hypertrophic phenotypes in neonatal mouse ventricular cells or alleviated cardiac hypertrophy in a mouse TAC model respectively, thus restoring cardiac function. Importantly, Gm20257 restored mitochondrial complex IV level and enhanced mitochondrial function. Bioinformatics prediction showed that Gm20257 had a high binding score with peroxisome proliferator-activated receptor coactivator-1 (PGC-1 alpha), which could increase mitochondrial complex IV. Subsequently, Western blot analysis results revealed that Gm20257 substantially affected the expression of PGC-1 alpha. Further analyses through RNA immunoprecipitation and immunoblotting following RNA pull-down indicated that PGC-1 alpha was a direct downstream target of Gm20257. This interaction was demonstrated to rescue the reduction of mitochondrial complex IV induced by hypertrophic stress and promote the generation of mitochondrial ATP. These findings suggest that Gm20257 improves mitochondrial function through the PGC-1 alpha-mitochondrial complex IV axis, offering a novel approach for attenuating pathological cardiac hypertrophy.

关键词： lncRNA Gm20257 cardiac hypertrophy PGC-1 alpha mitochondrial complex IV ATP LONG NONCODING RNA HEART-FAILURE CARDIOMYOPATHY REGULATOR

Diagnosis of indirectly driven double shell targets with point-projection hard x-ray radiography

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Matter and Radiation at Extremes 2024年第2期9卷 50-62页

作者： Chao Tian Minghai Yu Lianqiang shan Fengjuan Wu Bi Bi Qiangqiang Zhang Yuchi Wu Tiankui Zhang Feng Zhang Dongxiao Liu Weiwu Wang Zongqiang Yuan Siqian Yang Lei Yang Zhigang Deng Jian Teng Weimin zhou Zongqing Zhao Yuqiu Gu Baohan Zhang Science and Technology on Plasma Physics Laboratory Laser Fusion Research CenterChina Academy of Engineering PhysicsMianyang 621900People’s Republic of China Joint Laboratory for Extreme Conditions Matter Properties Southwest University of Science and TechnologyMianyang 621010People’s Republic of China IFSA Collaborative Innovation Center Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

We present an application of short-pulse laser-generated hard x rays for the diagnosis of indirectly driven double shell targets. Coneinserted double shell targets were imploded through an indirect drive approach on the upgraded SG-II laser facility. Then, based on thepoint-projection hard x-ray radiography technique, time-resolved radiography of the double shell targets, including that of their near-peakcompression, were obtained. The backlighter source was created by the interactions of a high-intensity short pulsed laser with a metalmicrowire target. Images of the target near peak compression were obtained with an Au microwire. In addition, radiation hydrodynamicsimulations were performed, and the target evolution obtained agrees well with the experimental results. Using the radiographic images, arealdensities of the targets were evaluated.

关键词： double projection point

Clinical efficacy,bone density,and follow-up in implant and orthodontic treatment for inclined adjacent teeth

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World Journal of Clinical Cases 2024年第24期12卷 5542-5548页

作者： Yi Yang Shun-Cheng zhou Yi-Hui Ma Xiang Wang Qing-shan Dong Department of Stomatology General Hospital of Central Theater CommandWuhan 430012Hubei ProvinceChina

BACKGROUND Tooth defects can cause elongation of occlusal teeth,leading to insufficient repair *** combination of dental implant restoration and orthodontic treatment of oblique adjacent teeth has a significant therapeutic *** To explore clinical efficacy,bone density,and follow-up of implant and orthodontic treatment for patients with inclined adjacent *** In total,98 patients with oblique adjacent teeth were randomly assigned to implant restoration combined with orthodontic treatment(group A,n=49)or to receive implant restoration alone(group B,n=49).Changes in alveolar ridge bone density and apical bone density were observed before and after treatment in the two *** in chewing function and language function were compared between the two groups of ***-up lasted for 12 mo after repair to observe any adverse reactions in the oral *** The clinical effective rates of group A and group B were 97.96%and 85.71%,respectively,with group A having a higher clinical effective rate than group *** treatment,the bone density of the alveolar ridge and apical bone in both groups decreased compared to before treatment,while the chewing and language functions *** changes in various indicators in group A were more *** treatment,the satisfaction rate of group A(97.96%)was higher than that of group B(79.59%).The incidence of adverse reactions in group A(2.04%)was lower than that in group B(24.49%).CONCLUSION The amalgamation of implant restoration and orthodontic treatment for adjacent tilted teeth demonstrates notable clinical efficacy,diminishes alveolar bone resorption,and fosters patient functional rehabilitation while exhibiting negligible adverse reactions.

关键词： Dental implant restoration Orthodontic correction Tilt adjacent teeth Clinical curative effect Alveolar bone mineral density

Study of tree shrew biology and models: A booming and prosperous field for biomedical research

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Zoological Research 2024年第4期45卷 877-909页

作者： Yong-Gang Yao Li Lu Rong-Jun Ni Rui Bi Ceshi Chen Jia-Qi Chen Eberhard Fuchs Marina Gorbatyuk Hao Lei Hongli Li Chunyu Liu Long-Bao Lv Kyoko Tsukiyama-Kohara Michinori Kohara Claudia Perez-Cruz Gregor Rainer Bao-Ci shan Fang Shen An-zhou Tang Jing Wang Wei Xia Xueshan Xia Ling Xu Dandan Yu Feng Zhang Ping Zheng Yong-Tang Zheng Jumin zhou Jiang-Ning zhou Key Laboratory of Genetic Evolution and Animal Models Yunnan Key Laboratory of Animal Models and Human Disease MechanismsKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility) and National Resource Center for Non-Human PrimatesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Mental Health Center and Psychiatric Laboratory West China HospitalSichuan UniversityChengduSichuan 610041China Sichuan Clinical Medical Research Center for Mental Disorders ChengduSichuan 610044China German Primate Center Leibniz Institute of Primate ResearchGöttingen 37077Germany Department of Optometry and Vision Science School of OptometryUniversity of Alabama at BirminghamBirminghamAL 35294USA State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanHubei 430071China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubei 430074China Soong Ching Ling Institute of Maternity and Child Health International Peace Maternity and Child Health HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Transboundary Animal Diseases Center Joint Faculty of Veterinary MedicineKagoshima UniversityKagoshima-cityKagoshima 890-8580Japan Department of Microbiology and Cell Biology Tokyo Metropolitan Institute of Medical ScienceTokyo 156-8506Japan Pharmacology Department CinvestavMexico City 07360Mexico Department of Medicine University of FribourgFribourg CH-1700Switzerland Beijing Engineering Research Center of Radiog

The tree shrew(Tupaia belangeri)has long been proposed as a suitable alternative to non-human primates(NHPs)in biomedical and laboratory research due to its close evolutionary relationship with *** recent years,significant advances have facilitated tree shrew studies,including the determination of the tree shrew genome,genetic manipulation using spermatogonial stem cells,viral vector-mediated gene delivery,and mapping of the tree shrew brain ***,the limited availability of tree shrews globally remains a substantial challenge in the ***,determining the key questions best answered using tree shrews constitutes another *** shrew models have historically been used to study hepatitis B virus(HBV)and hepatitis C virus(HCV)infection,myopia,and psychosocial stress-induced depression,with more recent studies focusing on developing animal models for infectious and neurodegenerative *** these efforts,the impact of tree shrew models has not yet matched that of rodent or NHP models in biomedical *** review summarizes the prominent advancements in tree shrew research and reflects on the key biological questions addressed using this *** emphasize that intensive dedication and robust international collaboration are essential for achieving breakthroughs in tree shrew *** use of tree shrews as a unique resource is expected to gain considerable attention with the application of advanced techniques and the development of viable animal models,meeting the increasing demands of life science and biomedical research.

关键词： Tree shrew Animal model Neurodegenerative diseases Infectious diseases Neuroscience Phenome

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软件运行时配置研究综述

软件学报 2024年第1期35卷 63-86页

作者：周书林李姗姗董威王戟廖湘科国防科技大学计算机学院湖南长沙410073

运行时配置为用户使用软件提供了灵活性和可定制性,但其巨大的规模和复杂的机制也带来了巨大的挑战.大量学者和研究机构针对软件运行时配置展开了研究,以提升软件系统在复杂外部环境中的可用性和适应性.建立运行时配置研究分析框架,从... 详细信息

运行时配置为用户使用软件提供了灵活性和可定制性,但其巨大的规模和复杂的机制也带来了巨大的挑战.大量学者和研究机构针对软件运行时配置展开了研究,以提升软件系统在复杂外部环境中的可用性和适应性.建立运行时配置研究分析框架,从配置分析与理解、配置缺陷检测与故障诊断、配置应用3个阶段对现有研究工作进行归类和分析,总结归纳现有研究的不足和面临的挑战,并对未来的研究趋势进行展望,对下一步研究具有一定的指导意义.

关键词：运行时配置配置理解配置缺陷检测配置故障诊断配置应用

点云空间与反射强度融合的非结构化道路可行驶区域检测

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控制理论与应用 2024年第5期41卷 847-854页

作者：周越洋徐江钟珊龚声蓉东北石油大学计算机与信息技术学院黑龙江大庆163319 常熟理工学院计算机科学与工程学院江苏苏州215500

可行驶区域检测旨在检测和提取智能车辆在道路上可行进的区域,目前主流的检测方法主要基于三维激光雷达的空间特征实现,难以处理路面边缘无清晰空间特征的非结构化道路.为此,本文提出了一种基于点云空间和反射强度融合的非结构化道路可... 详细信息

可行驶区域检测旨在检测和提取智能车辆在道路上可行进的区域,目前主流的检测方法主要基于三维激光雷达的空间特征实现,难以处理路面边缘无清晰空间特征的非结构化道路.为此,本文提出了一种基于点云空间和反射强度融合的非结构化道路可行驶区域检测方法.首先,通过融合反射强度因子改进了基于空间特征的柱坐标系检测模型;然后,使用强度和降维空间检测对检测精度较低的环形检测模型进行优化,并将其与柱坐标系检测模型联合使用以提高方法检测准确率;最后,在自录实际道路数据集上进行对比实验.实验结果表明本文方法显著提高了非结构化道路可行驶区域检测的成功率与精确率,在结构化道路上也具有良好效果.

关键词：智能驾驶非结构化道路三维激光雷达反射强度空间分布区域检测

基于真实科研情境培养科学思维——以“细胞呼吸”专题复习为例

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生物学教学 2024年第2期49卷 36-39页

作者：王山周梅中国人民大学附属中学朝阳学校北京100028

真实科研情境可以创造良好的科学思维范式,有助于培养科学精神,提升科学素养。以“细胞呼吸”专题复习为例,基于真实科研情境,创设思维环境,通过对实验数据的解读、分析,对实验方案的设计及评价改进等,构建成纤维细胞生长因子21(FGF21)... 详细信息

真实科研情境可以创造良好的科学思维范式,有助于培养科学精神,提升科学素养。以“细胞呼吸”专题复习为例,基于真实科研情境,创设思维环境,通过对实验数据的解读、分析,对实验方案的设计及评价改进等,构建成纤维细胞生长因子21(FGF21)调控细胞呼吸路径的模型,亲历科研工作者解决科学问题的思路和方法,提升学生科学思维。

关键词：真实科研情境科学思维专题复习细胞呼吸高中生物学