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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang qing Yao Chubing Long Pengcheng Yi Jiali song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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发展银发经济的战略设计、焦点难点及路径优化

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新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 59-69,F0002页

作者：黄石松胡清中国人民大学国家发展与战略研究院北京100872 中国人民大学老年学研究所北京100872

我国正处于由中度老龄化社会步入重度老龄化社会的进程,银发经济将逐步从“以政府为主导的事业发展”阶段转向“事业和产业协同发展”的新阶段。准确把握这一转型发展特征,适时调整工作重心和节奏,注重运用市场机制推进产业发展迫在眉... 详细信息

我国正处于由中度老龄化社会步入重度老龄化社会的进程,银发经济将逐步从“以政府为主导的事业发展”阶段转向“事业和产业协同发展”的新阶段。准确把握这一转型发展特征,适时调整工作重心和节奏,注重运用市场机制推进产业发展迫在眉睫。对银发产业进行业态划分是制定产业组织政策、产业管理政策、产业发展政策的前提和基础,文本尝试将我国银发产业划分为基础性产业、延伸性产业和战略性产业,并据此分析三类产业在发展中存在的焦点难点问题,按照分类精准施策原则,提出优化我国银发经济发展路径的政策建议。

关键词：银发经济老龄产业老龄事业战略设计业态划分

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Well-posedness of two-phase local/nonlocal integral polar models for consistent axisymmetric bending of circular microplates

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Applied Mathematics and Mechanics(English Edition) 2022年第5期43卷 637-652页

作者： hai qing State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Previous studies have shown that Eringen’s differential nonlocal model would lead to the ill-posed mathematical formulation for axisymmetric bending of circular *** on the nonlocal integral models along the radial and circumferential directions,we propose nonlocal integral polar models in this *** proposed strainand stress-driven two-phase nonlocal integral polar models are applied to model the axisymmetric bending of circular *** governing differential equations and boundary conditions(BCs)as well as constitutive constraints are *** is found that the purely strain-driven nonlocal integral polar model turns to a traditional nonlocal differential polar model if the constitutive constraints are ***,the purely strain-and stress-driven nonlocal integral polar models are ill-posed,because the total number of the differential orders of the governing equations is less than that of the BCs plus constitutive *** nominal variables are introduced to simplify the mathematical expression,and the general differential quadrature method(GDQM)is applied to obtain the numerical *** results from the current models(CMs)are compared with the data in the *** is clearly established that the consistent softening and toughening effects can be obtained for the strain-and stress-driven local/nonlocal integral polar models,*** proposed two-phase local/nonlocal integral polar models(TPNIPMs)may provide an efficient method to design and optimize the plate-like structures for microelectro-mechanical systems.

关键词： softening effect toughening effect circular microplate nonlocal integral model general differential quadrature method(GDQM)

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Finite Element Analysis of the Microstructure–Strength Relationships of Metal Matrix Composites

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Acta Metallurgica Sinica(English Letters) 2014年第5期27卷 844-852页

作者： hai qing State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and Astronautics

The influence of the shape and spatial distribution of reinforced particles on strength and damage of metal matrix composite （MMC） is investigated through finite element method under uniaxial tensile, simple shear, biaxial tensile, as well as combined tensile/shear loadings. The particle shapes change randomly from circular to regular n-sided polygon （3 ≤ n ≤ 10）; the particle alignments are determined through a sequentially random number stream and the particle locations are defined through the random sequential adsorption algorithm. The ductile failure in metal matrix and brittle failure in particles are described through damage models based on the stress triaxial indicator and maximum principal stress criterion, respectively, while the debonding behavior of interface between particles and matrix is simulated through cohesive elements. The simulation results show that, under different loadings, interface debonding is the dominated failure mechanism in MMCs and plastic deformation and ductile failure of matrix also play very important roles on the failure of MMCs.

关键词： Metal matrix composites Finite element analysis Damage Strength

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A cellulose-based lithium-ion battery separator with regulated ionic transport and high thermal stability for extreme environments

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Nano Research 2025年第1期18卷 315-322页

作者： Kun-Peng Yang song Xie Zi-Meng Han Hao-Cheng Liu Chong-Han Yin Wen-Bin Sun Zhang-Chi Ling Huai-Bin Yang De-Han Li qing-Fang Guan Shu-Hong Yu Department of Chemistry New Cornerstone Science LaboratoryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

Separators play a critical role in lithium-ion ***,the restrictions of thermal stability and inferior electrical performance in commercial polyolefin separators significantly limit their applications under harsh ***,we report a cellulose-assisted self-assembly strategy to construct a cellulose-based separator massively and *** an ultrahigh ionic conductivity in electrolytes of 3.7 mS·cm^(-1) and the ability to regulate ion transport,the obtained separator is a promising alternative for high-performance lithium-ion *** addition,integrated with high thermal stability,the cellulose-based separator endows batteries with high safety at high temperatures,greatly expanding the application scenarios of energy storage devices in extreme environments.

关键词： lithium-ion batteries bio-inspired materials battery separators cellulose nanofiber ultrahigh ionic conductivity high safety

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The mechanism and products for co-thermal extraction of biomass and low-rank coal with NMP

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International Journal of Minerals,Metallurgy and Materials 2019年第12期26卷 1512-1522页

作者： Jun Zhao hai-bin Zuo Jing-song Wang qing-guo Xue State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing

The high-value utilization of low-rank coal would allow for expanding energy sources,improving energy efficiencies,and alleviating environmental *** order to use low-rank coal effectively,the hypercoals(HPCs)were co-extracted from two types of low-rank coal and biomass via N-methyl-2-purrolidinone(NMP)under mild *** structures of the HPCs and residues were characterized by proximate and ultimate analysis,Raman spectra,and Fourier transform infrared(FT-IR)*** carbon structure changes within the raw coals and HPCs were *** individual thermal dissolution of Xibu(XB)coal,Guandi(GD)coal,and the biomass demonstrated that the biomass provided the lowest thermal dissolution yield Y1 and the highest thermal soluble yield Y2 at 280℃,and the ash content of three HPCs decreased as the extraction temperature ***-thermal extractions in NMP at various coal/biomass mass ratios were performed,demonstrating a positive synergic effect for Y2 in the whole coal/biomass mass *** maximum value of Y2 was 52.25wt% for XB coal obtained with a XB coal/biomass of 50wt% *** maximum value of Y2 was 50.77wt% for GD coal obtained with a GD coal/biomass of 1:*** difference for the optimal coal/biomass mass ratios between XB and GD coals could be attributed to the different co-extraction mechanisms for this two type coals.

关键词： low-rank coal biomass co-thermal extraction NMP hypercoal

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Treatment of simulated wastewater containing Reactive Red 195 by zero-valent iron/activated carbon combined with microwave discharge electrodeless lamp/sodium hypochlorite

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Journal of Environmental Sciences 2010年第4期22卷 512-518页

作者： Jie Fu Zhen Xu qing-Shan Li song Chen Shu-qing An qing-Fu Zeng hai-Liang Zhu State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University Nanjing 210093 China. Engineering Research Center for Clean Production of Textile Dyeing and Printing of Ministry of Education Wuhan University of Scienee & Engineering Wuhan 430073 China Pharmacy Department Shanghai Hospital of Skin Diseases and Sexually Transmitted Diseases Shanghai 200443 China

A comparative study of treatment of simulated wastewater containing Reactive Red 195 using zero-valent iron/activated carbon （ZVI/AC）, microwave discharge electrodeless lamp/sodium hypochlorite （MDEL/NaCIO） and the combination of ZVI/AC- MDEL/NaCIO was conducted. The preliminary results showed the two steps method of ZVI/AC-MDEL/NaCIO had much higher degradation efficiency than both single steps. The final color removal percentage was nearly up to 100% and the chemical oxygen demand reduction percentage was up to approximately 82%. The effects of operational parameters, including initial pH value of simulated wastewater, ZVI/AC ratio and particle size of ZVI were also investigated. In addition, from the discussion of synergistic effect between ZVI/AC and MEDL/NaCIO, we found that in the ZVI/AC-MEDL/NaCIO process, ZVI/AC could break the azo bond firstly and then MEDLfNaCIO degraded the aromatic amine products effectively. Reversing the order would reduce the degradation efficiency.

关键词： activated carbon microwave discharge electrodeless lamp Reactive Red 195 sodium hypochlorite zero-valent iron.

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Microstructure and Properties of Fe-Cr-C Hardfacing Alloys Reinforced with TiC-NbC

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Journal of Iron and Steel Research International 2016年第3期23卷 276-280页

作者： hai-yun LIU Zhi-liang song qing CAO Shao-ping CHEN qing-sen MENG College of Materials Science and Engineering Taiyuan University of Technology

The hypereutectic Fe-Cr-C hardfacing alloys with different contents of TiB_2 and Nb were prepared by selfshielded flux cored arc *** microstructure of a series of hypereutectic Fe-Cr-C hardfacing alloys added with various TiB_2 and Nb contents was investigated by using optical microscopy（OM）,scanning electron microscopy（SEM）and X-ray diffraction（XRD）.In addition,their Rockwell hardness,microhardness and resistance to abrasive wear were *** results showed that the microstructure of a series of hypereutectic Fe-Cr-C hardfacing alloys consisted mainly of martensite,austenite,primary M7C3 carbides and eutectic M7C3 *** the addition of TiB_2,a new hard-phase TiC was produced in the hardfacing *** in the alloys added with TiB_2 and Nb,a new hard composite phase TiC-NbC was *** microhardness of the matrix was improved by adding TiB_2 and Nb,but the effect on the Rockwell hardness of Fe-Cr-C hardfacing alloys was *** addition of TiB_2 and Nb can also decrease the size of the primary M7C3 carbides and make the primary M7C3 *** a result,the reinforced matrix,the more homogeneous primary M7C3 carbides,and the new hard-phase TiC-NbC all improved the wear resistance of Fe-Cr-C hardfacing alloys.

关键词： Fe-Cr-C hardfacing alloy flux-cored wire titanium diboride niobium wear resistance

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A Position-Dependent Two-Atom Entanglement in Real-Time Cavity QED System

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Communications in Theoretical Physics 2007年第1期47卷 59-62页

作者： GUO Yan-qing CAO hai-Jing song He-Shan Department of Physics Dalian Maritime University Dalian 116026 China Department of Physics Dalian University of Technology Dalian 116023 China

We study a special two-atom entanglement case in assumed cavity QED experiment in which only one atom effectively exchanges a single photon with a cavity mode. We compute two-atom entanglement under position-dependent atomic resonant dipole-dipole interaction （RDDI） for large interatomic separation limit. We show that the RDDI, even t, hat which is much smaller than the maximal atomic Rabi frequency, can induce distinct diatom entanglement. The peak entanglement reaches a maximum when RDDI strength can compare with the Rabi frequency of an atom.

关键词： two-atom entanglement cavity QED RDDI

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On the consistency of two-phase local/nonlocal piezoelectric integral model

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Applied Mathematics and Mechanics(English Edition) 2021年第11期42卷 1581-1598页

作者： Yanming REN hai qing State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China

In this paper,we propose general strain-and stress-driven two-phase local/nonlocal piezoelectric integral models,which can distinguish the difference of nonlocal effects on the elastic and piezoelectric behaviors of *** nonlocal piezoelectric model is transformed from integral to an equivalent differential form with four constitutive boundary conditions due to the difficulty in solving intergro-differential equations *** nonlocal piezoelectric integral models are used to model the static bending of the Euler-Bernoulli piezoelectric beam on the assumption that the nonlocal elastic and piezoelectric parameters are coincident with each *** governing differential equations as well as constitutive and standard boundary conditions are *** is found that purely strain-and stress-driven nonlocal piezoelectric integral models are ill-posed,because the total number of differential orders for governing equations is less than that of boundary ***,the traditional nonlocal piezoelectric differential model would lead to inconsistent bending response for Euler-Bernoulli piezoelectric beam under different boundary and loading *** nominal variables are introduced to normalize the governing equations and boundary conditions,and the general differential quadrature method(GDQM)is used to obtain the numerical *** results from current models are validated against results in the *** is clearly established that a consistent softening and toughening effects can be obtained for static bending of the Euler-Bernoulli beam based on the general strain-and stress-driven local/nonlocal piezoelectric integral models,respectively.

关键词： nonlocal piezoelectric integral model softening effect toughening effect general differential quadrature method(GDQM)

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