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Advances in magnetic nanoparticle-based magnetic resonance imaging contrast agents

Nano Research 2023年第11期16卷 12531-12542页

作者： Huan Zhang Xiao Li Liu hai ming fan Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry and Materials ScienceNorthwest UniversityXi’an 710127China Department of Radiology Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 519000China Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationProvincial Key Laboratory of Biotechnology of Shaanxi ProvinceNorthwest UniversityXi’an 710069China Institute of Regenerative and Reconstructive Medicine Med-X InstituteFirst Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710049China National Local Joint Engineering Research Center for Precision Surgery&Regenerative Medicine Shaanxi Provincial Center for Regenerative Medicine and Surgical EngineeringFirst Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China

Magnetic resonance imaging(MRI)has revolutionized medical imaging diagnostics with the advantages of non-invasive nature,absence of ionizing radiation,unrestricted penetration depth,high-resolution imaging of soft tissues,organs and blood vessels,and multi-parameter and multi-sequence *** agents(CAs)are crucial for enhancing image quality,detecting molecular-level changes,and providing comprehensive diagnostic information in contrast enhanced ***,the performance of clinical Gd-based CAs represents a limitation to the improvement of MRI sensitivity,specificity,and versatility,thereby impeding the achievement of satisfactory imaging *** recent years,the development of magnetic nanoparticle-based CAs has emerged as a promising avenue to enhance the capabilities of ***,we review the advances in magnetic nanoparticle-based MRI CAs,including blood pool CAs,biochemically-targeted CAs,stimulus-responsive CAs,and ultra-high field MRI CAs,as well as the use of CAs for cell labeling and ***,we offer insights into the future prospects and challenges associated with the integration of these nanoparticles into clinical practice.

关键词： magnetic resonance imaging magnetic nanoparticle blood pool contrast agents biochemically-targeted contrast agents stimulus-responsive contrast agents

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Magnetic nanoparticles based cancer therapy: current status and applications

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Science China(Life Sciences) 2018年第4期61卷 400-414页

作者： Huan Zhang Xiao Li Liu Yi fan Zhang Fei Gao Ga Long Li Yuan He ming Li Peng hai ming fan Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education College of Chemistry and Materials Science Northwest University CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology

Nanotechnology holds a promising potential for developing biomedical nanoplatforms in cancer therapy. The magnetic nanoparticles, which integrate uniquely appealing features of magnetic manipulation, nanoscale heat generator, localized magnetic field and enzyme-mimics, prompt the development and application of magnetic nanoparticles-based cancer medicine. Considerable success has been achieved in improving the magnetic resonance imaging(MRI) sensitivity, and the therapeutic function of the magnetic nanoparticles should be given adequate attention. This work reviews the current status and applications of magnetic nanoparticles based cancer therapy. The advantages of magnetic nanoparticles that may contribute to improved therapeutics efficacy of clinic cancer treatment are highlighted here.

关键词： magnetic nanoparticles therapeutic delivery magnetic hyperthermia treatment theranostics

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Preparation and performance of fluorescent polyacrylamide microspheres as a profile control and tracer agent

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Petroleum Science 2015年第3期12卷 483-491页

作者： Wan-Li Kang Lei-Lei Hu Xiang-Feng Zhang Run-Mei Yang hai-ming fan Jie Geng School of Petroleum Engineering China University of Petroleum EOR Research Institute China University of Petroleum(Beijing)

Polyacrylamide microspheres have been suc- cessfully used to reduce water production in reservoirs, but it is impossible to distinguish polyacrylamide microspheres from polyacrylamide that is used to enhance oil recovery and is already present in production fluids. In order to detect polyacrylamide microspheres in the reservoir pro- duced fluid, fluorescent polyacrylamide microspheres P（AM-BA-AMCO）, which fluoresce under ultraviolet irradiation, were synthesized via an inverse suspension polymerization. In order to keep the particle size distribu- tion in a narrow range, the synthesis conditions of the polymerization were studied, including the stirring speed and the concentrations of initiator, NaaCO3, and dispersant. The bonding characteristics of microspheres were deter- mined by Fourier transform infrared spectroscopy. The surface morphology of these microspheres was observed under ultraviolet irradiation with an inverse fluorescence microscope. A laboratory evaluation test showed that the fluorescent polymer microspheres had good water swelling capability, thus they had the ability to plug and migrate in a sand pack. The plugging rate was 99.8 % and the residual resistance coefficient was 800 after microsphere treatment in the sand pack. Furthermore, the fluorescent microspheres and their fragments were accurately detected under ultra- violet irradiation in the produced fluid, even though theyhad experienced extrusion and deformation in the sand pack.

关键词： Inverse suspension polymerization Fluorescence Polyacrylamide microsphere Narrow sizedistribution - Profile control performance

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Advanced Biomedical Magnetic Nanoplatforms

Advanced Biomedical Magnetic Nanoplatforms

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2017年中国药学大会暨第十七届中国药师周

作者： hai ming fan College of Chemistry ＆ Materials Science Northwest University

＜正＞Superparamangetic iron oxide（SPIO）formulations have been demonstrated the great potential for various biomedical applications such as protein/cell separation,biosensor,drug delivery,magnetic resonance imaging（MRI）and magnetic hyperthermia *** the application of these nanoparticles for cancer diagnostics and therapy has been largely hindered by poor stability,weak magnetic properties,insufficient MR detection sensitivity and low thermal conversion *** strategies that include structure,composition,size and surface optimization have been developed in our recent works towards

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Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： ming‑Yuan Yu Jing Wu Guang Yin fan‑Zhen Jiao Zhong‑Zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

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基于ADSP328的无位置传感器BLDCM控制系统

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微特电机 2002年第3期30卷 42-43页

作者：宋海龙杨明范宇徐殿国哈尔滨工业大学哈尔滨150001

给出了基于专用电机控制芯片ADSP328的无刷直流电动机控制系统硬件方案和控制策略,结构简单、可靠,成本低,是一种很好的控制方案。

关键词： ADSP328 无位置传感器 BLDCM 控制系统无刷直流电动机

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牙哈2-3凝析油气田产量变化特征及预测

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天然气工业 2007年第2期27卷 87-89页

作者：邓军洪玉娟瞿加元王海范明国中国石油塔里木油田公司

牙哈2-3凝析油气田是目前我国发现的最大整装凝析油气田,采用循环注气开发,由于其凝析油含量高、相态变化复杂,给生产动态的预测带来了很大困难。为此,在对产量变化特征和影响产量的敏感性因素进行的基础上,预测了注气结束后凝析油的含... 详细信息

牙哈2-3凝析油气田是目前我国发现的最大整装凝析油气田,采用循环注气开发,由于其凝析油含量高、相态变化复杂,给生产动态的预测带来了很大困难。为此,在对产量变化特征和影响产量的敏感性因素进行的基础上,预测了注气结束后凝析油的含量。研究表明:地层中析出的凝析油饱和度较低,不会形成气液两相流动;储层中的反凝析现象对天然气产量影响小,而凝析油产量则受反凝析和处理量的限制,凝析油含量下降符合指数递减规律。经综合分析后预测:到2009年注气结束时,凝析油采出程度将达到28.79%,高于开发方案所设计的25.89%。

关键词：塔里木盆地凝析油气田产量循环注气反凝析采出程度

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新型农村集体经济促进农民共同富裕的演进逻辑和创新路径

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西北农林科技大学学报（社会科学版） 2025年第1期25卷 69-77页

作者：樊晓燕蒋明西安交通大学马克思主义学院西安710049 西安理工大学马克思主义学院西安710048

新型农村集体经济具有市场性和社区性,农民共同富裕强调发展性和共享性两个维度的目标,二者在基本原则的人民性、实现途径的互助性和目标指向的全面性上相契合,这是构建新型农村集体经济促进农民共同富裕理论分析框架的基础。理论发展... 详细信息

新型农村集体经济具有市场性和社区性,农民共同富裕强调发展性和共享性两个维度的目标,二者在基本原则的人民性、实现途径的互助性和目标指向的全面性上相契合,这是构建新型农村集体经济促进农民共同富裕理论分析框架的基础。理论发展、实践探索和现实需求是揭示新型农村集体经济促进农民共同富裕内在逻辑演进的三个方面:理论逻辑是坚持公有制基础上农村集体经济制度的理论创新;历史逻辑是中国特色农业农村现代化的发展历程;现实逻辑是发展新型农村集体经济对乡村全面振兴的重大意义。由此从产权制度、分配制度和基层治理制度创新的整体视角提出新型农村集体经济促进农民共同富裕的创新路径。坚持以人民为中心的发展理念,发挥新型农村集体经济的战略作用,探索新型农村集体经济的发展规律是新型农村集体经济促进农民共同富裕需要坚持的重要原则。

关键词：新型农村集体经济农民共同富裕制度创新

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Evolution of Quantum State for Mesoscopic Circuits with Dissipation

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Communications in Theoretical Physics 2005年第6X期44卷 1045-1049页

作者： WAN Hua-ming LUO hai-Mei WANG Yi-fan University of Science & Technology of Suzhou Suzhou 215011 China Department of Physics Jiangxi Normal University Nanchang 330027 China Nanchang Institute of Aeronautical Technology Nanchang 330034 China

Based on the maximum entropy principle, we present a density matrix of mesoscopic RLC circuit to make it possible to analyze the connection of the initial condition with temperature. Our results show that the quantum state evolution is closely related to the initial condition, and that the system evolves to generalized coherent state if it is in ground state initially, and evolves to squeezed state if it is in excited state initially.

关键词： mesoscopic RLC circuit the maximum entropy principle density matrix

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Progranulin:A promising biomarker and therapeutic target for fibrotic diseases

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3312-3326页

作者： fan Yang ming-Han Cheng hai-Feng Pan Jian Gao Pediatric Translational Medicine Institute Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghai 200000China Department of Ophthalmology the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefei 230022China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province Hefei 230022China

Progranulin(PGRN),a multifunctional growth factor-like protein expressed by a variety of cell types,serves an important function in the physiologic and pathologic processes of fibrotic diseases,including wound healing and the inflammatory *** was discovered to inhibit proinflammation effect by competing with tumor necrosis factor-alpha(TNF-a)binding to TNF ***,excessive tissue repair in the development of inflammation causes tissue *** investigations have indicated the significance of PGRN in regulating inflammatory ***,multiple studies have shown that PGRN was linked to fibrogenesis,and was considered to monitor the formation of fibrosis in multiple organs,including liver,cardiovascular,lung and *** paper is a comprehensive review summarizing our current knowledge of PGRN,from its discovery to the role in *** is followed by an in-depth look at the characteristics of PGRN,consisting of its structure,basic function and intracellular ***,we will discuss the potential of PGRN in the diagnosis and treatment of fibrosis.

关键词： Progranulin Fibrotic disease Fibrosis Inflammation Biomarker Therapeutic target PGRN/TNFR interaction Signaling pathway

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