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Microstructure evolution and liquid phase separation in Ta-O hypermonotectic melts during laser-cladding

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China Foundry 2018年第3期15卷 222-227页

作者： hai-ou Yang Meng Wang Xin lin Wei-dong huang State Key Laboratory of Solidification Processing Northwestern Polvtechnical University Xi'an Shaanxi 710072 PR China MHT Key Laboratory of Metal High Performance Additive Manufacturing and Innovative Design Northwestern Polytechnical University Xi'an Shaanxi 710072 PR China

A three-layer Ta_2O_5-containing coating was successfully fabricated by laser cladding on a pure Ta substrate. The maximum thickness of such a coating is about 1.6 mm. The microstructure, phase constitution and elemental distribution in the coating were investigated. Results show that the coating has been metallurgically bonded to the Ta substrate and the microstructure exhibits a graded change along the deposition direction from Ta substrate to the top of coating. In the layers I and II of the graded coating, the microstructure evolution can be confi rmed as a result of hypomonotectic reaction, but in the layer Ⅲ it was formed by hypermonotectic reaction. At the top of coating, the microstructure was still homogeneous although liquid phase separation had occurred, which can be attributed to the fact that the O-rich droplets do not have enough time to fl oat at high cooling rate. The theoretical calculation results show that during laser cladding, the solidifi cation time of the melt pool was less than 0.1 s, which fi ts well with the results from the experiment.

关键词： Laser cladding liquid phase separation microstructure evolution homogeneous structure

Expanding horizons in overcoming therapeutic resistance in castration-resistant prostate cancer:targeting the androgen receptor-regulated tumor immune microenvironment

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Cancer Biology & Medicine 2023年第8期20卷 568-574页

作者： Bisheng Cheng hai huang Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Castration-resistant prostate cancer(CRPC)poses a major treatment challenge,because disease progression occurs despite androgen deprivation therapy(ADT)*** therapeutic resistance in CRPC remains a critical unmet need in clinical *** androgen receptor(AR)signaling pathway plays a critical role in prostate cancer development and progression,and is also involved in regulating the tumor immune microenvironment(TIME).

关键词： therapeutic cancer resistance

Structural optimization for multiple structure cases and multiple payload cases with a two-level multipoint approximation method

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Chinese Journal of Aeronautics 2016年第5期29卷 1273-1284页

作者： An haichao Chen Shenyan huang hai School of Astronautics Beihang University

This paper is to address structural optimization problems where multiple structure cases or multiple payload cases can be considered simultaneously. Both types of optimization problems involve multiple finite element models at each iteration step, which draws high demands in opti- mization methods. Considering the common characteristic for these two types of problems, which is that the design domain keeps the same no matter what the structure cases or payload cases are, both problems can be formulated into the unified expressions. A two-level multipoint approxima- tion （TMA） method is firstly improved with the use of analytical sensitivity analysis for structural mass, and then this improved method is utilized to tackle these two types of problems. Based on the commercial finite element software ***/Nastran, an optimization system for multiple structure cases and multiple payload cases is developed. Numerical examples are conducted to verify its feasibility and efficiency, and the necessity for the simultaneous optimizations of multiple structure cases and multiple payload cases are illustrated as well.

关键词： Multipoint approximation Multiple payload cases Multiple structure cases Sensitivity analysis Structural optimization

东江河口典型河段溶解氧时空动态及低氧成因解析

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湖泊科学 2025年第1期37卷 112-121页

作者：黄广灵黄本胜刘达邱静黄国如华南理工大学土木与交通学院广州510640 广东省水利水电科学研究院广州510635 广东省流域水环境治理与水生态修复重点实验室广州510635 华南理工大学亚热带建筑与城市科学全国重点实验室广州510640

为解析东江南支流低氧现象的成因,并为水环境治理提供科学依据,本研究分别于2019年春季和夏季对该河流的主要断面进行了水质监测。监测结果显示,东江南支流的溶解氧(DO)水平从中游道滘镇的6.93 mg/L降至出海口处的4.08 mg/L。DO与影响... 详细信息

为解析东江南支流低氧现象的成因,并为水环境治理提供科学依据,本研究分别于2019年春季和夏季对该河流的主要断面进行了水质监测。监测结果显示,东江南支流的溶解氧(DO)水平从中游道滘镇的6.93 mg/L降至出海口处的4.08 mg/L。DO与影响因子的相关性分析显示,DO与水温呈显著负相关,与盐度呈正相关,而与氨氮和总磷等营养物质呈显著负相关。这些营养物质的增加与DO的降低在空间上呈显著重叠,特别是在夏季。研究结果表明,东江南支流低氧现象受物理、化学和生物因素的共同影响,其中温度升高和营养物质浓度增加使得中下游水体的氧气消耗加快,河道汇流处的断面缩窄和下游水体的透光性差引起DO补给不足,从而导致下游沙田泗盛断面经常性出现氧亏(低氧)现象。

关键词：东江南支流溶解氧低氧营养物珠江

Tolvaptan regulates aquaporin-2 and fecal water in cirrhotic rats with ascites

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World Journal of Gastroenterology 2016年第12期22卷 3363-3371页

作者： Chao Chen Ren-Pin Chen hai-Hua lin Wen-You Zhang Xie-lin huang Zhi-Ming huang Department of Gastroenterology the First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000 Zhejiang Province China Ren-Ji College of Wenzhou Medical University Wenzhou 325000 Zhejiang Province China

AIM: To investigate the role of tolvaptan in regulating aquaporin(AQP)-2 expression and fecal water content in cirrhotic rats with ***: Cirrhosis with ascites was induced in rats by repetitive dorsal injection of CCl4 for 14 wk. In total, 84 cirrhotic rats with ascites divided into three groups(vehicle, 3 mg/kg and 5 mg/kg tolvaptan), and then further divided into five subgroups(days 1, 2, 3, 4, and 5). Blood samples were obtained to measure vasopressin and sodium concentrations. Rats were killed and colonic mucosa was scraped for analysis of protein expression and AQP-2 transcriptional level. The whole layer was fixed for hematoxylin&eosin(HE) staining and feces were collected for determination of fecal water content. CONCLUSION: Compared with vehicle, vasopressin decreased significantly in the tolvaptan groups from day 2 to a similar level in each treatment group. AQP-2 showed significant upregulation in cirrhotic rats with ascites compared with an untreated control group(100% ± 22.9% vs 22.2% ± 10.23%, P line at day 4 at the latest in both treatment groups, and did not correspond to the change in AQP-2 expression. HE staining of the colonic mucosa showed no mucosal damage related to ***: Upregulation of AQP-2 in the distal colon is found in cirrhotic rats with ascites. Tolvaptan inhibits its expression and may decrease water reabsorption and induce diarrhea.

关键词： Tolvaptan Aquaporin-2 Cirrhosis Ascites

Role of epithelial-to-mesenchymal transition in the pulmonary fi brosis induced by paraquat in rats

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World Journal of Emergency Medicine 2021年第3期12卷 214-220页

作者： Jian-hua Yi Zhao-cai Zhang Mei-bian Zhang Xin He Hao-ran lin hai-wen huang hai-bin Dai Yu-wen huang Emergency Department the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China Scientifi c Research Department the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 301051China Shangyu People’s Hospital Shaoxing 312300China Pharmacy Department the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China

BACKGROUND:This study aims to explore the characteristics of the epithelial-to-mesenchymal transition(EMT)process and its underlying molecular mechanisms in the period of paraquat(PQ)-induced pulmonary fi brosis(PF).METHODS:Picrosirius red staining and collagen volume fraction were utilized to evaluate the pathological changes of PQ-induced PF in ***,Western blot,and real-time reverse transcriptase-polymerase chain reaction(RT-PCR)were used to measure the protein and gene expression of EMT markers,EMT-associated transcription factors,and regulators of EMT-related pathways,***:The collagen deposition in the alveolar septum and increased PF markers were characteristics of pathological changes in PQ-induced PF,reached a peak on day 14 after PQ poisoning,and then decreased on day *** protein and gene expression of the fibrosis marker,EMT markers,transcription factors,and regulators of EMT-related signaling pathways signifi cantly increased at diff erent time points after PQ poisoning compared with corresponding controls(Pling pathways(P0.05).CONCLUSIONS:EMT process plays a role in the PQ-induced PF,in which most PF and EMT markers have a peak phenomenon,and its underlying molecular mechanisms might be determined by further studies.

关键词： Pulmonary fibrosis Paraquat Epithelial-to-mesenchymal transition Rats

Microstructure Evolution and Mechanism of Strength Development of Fly Ash Paste

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 152-163页

作者： MA Shuzhao WU Shunchuan huang Mingqing CHENG haiyong JIANG Guanzhao NIU Yonghui LIU Zemin SUN Wei Faculty of Land Resources Engineering Kunming University of Science and TechnologyKunming 650093China Zijin School of Ge-ology and Mining Fuzhou UniversityFuzhou 350108China

Three types of activators such as sodium hydroxide,calcium oxide and triethanolamine(TEA)are used to establish different activation environments to address the problems associated with the process of activating fly ash *** conducted mechanical tests and numerical simulations to understand the evolution of microstructure,and used environmental scanning electron microscopy(ESEM)and energy dispersive spectroscopy(EDS)techniques to analyze the microenvironments of the *** mechanical properties of fly ash paste under different activation conditions and the changes in the microstructure and composition were *** results revealed that under conditions of low NaOH content(1%-3%),the strength of the sample increased *** the content exceeded 4%,the rate of increase in strength *** on the results,the optimal NaOH content was identified,which was about 4%.A good activation effect,especially for short-term activation(3-7 d),was achieved using TEA under high doping *** activation effect was poor for long-term strength after 28 *** CaO content did not significantly affect the degree of activation *** maximum effect was exerted when the content of CaO was 2%.The virtual cement and concrete testing laboratory(VCCTL)was used to simulate the hydration process,and the results revealed that the use of the three types of activators accelerated the formation of Ca(OH)_(2) in the *** activators also corroded the surface of the fly ash particles,resulting in a pozzolanic *** active substances in fly ash were released efficiently,and hydration was *** pores were filled with hydration products,and the microstructure changed to form a new frame of paste filling that helped improve the strength of fly ash paste.

关键词： paste filling fly ash activator unconfined compressive strength microstructure hydration simulation

Robust fault-tolerant attitude control for satellite with multiple uncertainties and actuator faults

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Chinese Journal of Aeronautics 2020年第12期33卷 3380-3394页

作者： Liming FAN hai huang Kaixing ZHOU School of Astronautics Beihang UniversityBeijing 102206China Beijing Institute of Electronic System Engineering Beijing 100854China

In this paper,the satellite attitude control system subject to parametric perturbations,external disturbances,time-varying input delays,actuator faults and saturation is *** order to make the controller architecture simple and practical,the closed-loop system is transformed into a disturbance-free nominal system and an equivalent disturbance *** equivalent disturbance represents all above uncertainties and actuator failures of the original *** a robust controller is proposed in a simple composition consisting of a nominal controller and a robust *** nominal controller is designed for the transformed nominal *** robust compensator is developed from a second-order filter to restrict the influence of the equivalent *** analysis indicates that both attitude tracking errors and compensator states can converge into the given neighborhood of the origin in finite *** verify the effectiveness of the proposed control law,numerical simulations are carried out in different *** results demonstrate that the high-precision attitude tracking control can be achieved by the proposed fault-tolerant control ***,multiple system performances including the control accuracy and energy consumption index are fully discussed under a series of compensator parameters.

关键词： Actuator faults Fault-tolerant systems Input delays Multiple uncertainties Satellite attitude control

Laser assisted phase transformation of carbon-based transition metal oxide electrode for high-performance supercapacitor application

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Science China Chemistry 2025年

作者： Mingzhen Xiu Jianghong Zhang Yu Lu Xun Cao Kang huang Siyu Zhu Bowei Zhang Yu Liang Chunwang Zhao Junsheng Wu Yizhong huang School of Materials Science and Engineering Nanyang Technological University Energy Research Institute Interdisciplinary Graduate Programme Nanyang Technological University Institute of Sustainability for Chemicals Energy and Environment Agency for Science Technology and ResearchSingapore Institute of Advanced Materials and Technology University of Science and Technology Beijing School of Materials Science and Technology Shenyang University of Chemical Technology School of Materials Science and Hydrogen Energy Foshan University

Transitional metal oxides have a wide range of applications due to their superior *** enhanced performance of metal oxide relies on their desirable oxidation states,which is challenging to achieve and requires complex *** study demonstrates a facile strategy enabling rapid phase transformation of transition metal *** approach involves synthesis of a tetragonal Mn3O4/carbon cloth composite using the liquid plasma discharge deposition （LPDD） technique,followed by laser irradiation with the presence of ethylene glycol under an N2gas *** resulting face-centered cubic MnO/carbon cloth electrode exhibits an excellent capacitance of 1,125 F g-1at 2 A g-1,with remarkable capacitance retention of 95%after10,000 *** approach can be extended to other transition metals including Co,Cu,Cr,Fe,Ni,and *** simulations reveal the significance of ethylene glycol and the underlying mechanism associated with the phase transformation of transition metal *** present study offers a powerful technique for the phase transformation of transition metal oxide which can guide the development of new electrode materials with enhanced electrochemical properties for high-performance energy storage applications.

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