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铁路计算机应用 2004年第1期13卷 28-31页

作者：杨海峰唐堃须德北京交通大学计算机科学与信息技术学院北京100044 铁道科学研究院电子计算技术研究所北京100081

介绍蓝牙及其协议栈体系结构;讨论了蓝牙耳机的基本概念及其应用模型,最后详细阐述了该蓝牙耳机系统的设计和具体实现。

关键词：蓝牙耳机音频网关同步面向连接异步无连接链路蓝牙协议栈

High-precision tip positioning composite feedforward control of linear colocated motion systems with Bi-Loop iterative feedforward tuning

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Science China Technological Sciences 2025年

作者： Junyu HU Yourui TAO Shanhu LI xu HAN College of Mechanical and Vehicle Engineering Hunan University State Key Laboratory of Reliability and Intelligence of Electrical Equipment Hebei University of Technology

To enhance the tip positioning accuracy and robustness against disturbances of linear colocated motion systems, a novel composite feedforward (COMFF) control with Bi-Loop iterative feedforward tuning (IFFT) is proposed. The tip positioning error consists of the coupled tip residual vibration and linear motor tracking error. Given the influence of nonlinear friction and load flexibility, the topology of COMFF is designed as decoupled structures so that COMFF can suppress the tip residual vibration and compensate for the linear motor tracking error compatibly. Furthermore, Bi-Loop IFFT is built to improve the robustness of COMFF in high-precision motor tracking performance. In the state space of the linear motor tracking error based on the projection theorem, two loops are performed in parallel along the iteration direction. One is the P-type iteration loop that drives linear motor tracking errors to converge to the zero state. The other is the observation loop constructed by the recursive least square with forgetting factors to accelerate the P-type iteration loop. Driven by the P-type iteration loop with the aid of the observation loop, the proposed COMFF is integrated with fast convergence and high robustness when confronted with model disturbances. The effectiveness of the proposed COMFF combined with Bi-Loop IFFT is validated by experiments.

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Effects of mesoscale gravity waves on sporadic E simulated by a one-dimensional dynamic model

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Earth and Planetary Physics 2025年第1期9卷 1-9页

作者： xu Zhou ZeZhong Li XinAn Yue LiBo Liu Key Laboratory of Earth and Planetary Physics/Heilongjiang Mohe National Geophysical Observatory/Beijing National Observatory of Space Environment Institute of Geology and GeophysicsChinese Academy of Sciences(CAS)Beijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China CAS Center for Excellence in Comparative Planetology/CAS Key Laboratory of Geospace Environment/Mengcheng National Geophysical Observatory University of Science and Technology of ChinaHefei 230026China

In addition to being driven by tidal winds,the sporadic E(Es)layers are modulated by gravity waves(GWs),although the effects are not yet comprehensively *** this article,we discuss the effects of mesoscale GWs on the Es layers determined by using a newly developed model,MISE-1D(one-dimensional Model of Ionospheric Sporadic E),with low numerical dissipation and high *** by the wind fields resolved by the high-resolution version of the Whole Atmosphere Community Climate Model with thermosphere and ionosphere extension(WACCM-X),the MISE-1D simulation revealed that GWs significantly influence the evolution of the Es layer above 100 km but have a very limited effect at lower *** effects of GWs are diverse and complex,generally including the generation of fluctuating wavelike structures on the Es layer with frequencies similar to those of the *** mesoscale GWs can also cause increases in the density of Es layers,or they can disperse or diffuse the Es layers and increase their *** addition,the presence of GWs is a key factor in sustaining the Es layers in some cases.

关键词： sporadic E ion tidal layer gravity waves numerical simulation

Advances in the Development of Gradient Scaffolds Made of Nano‑Micromaterials for Musculoskeletal Tissue Regeneration

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Nano-Micro Letters 2025年第3期17卷 455-500页

作者： Lei Fang Xiaoqi Lin Ruian xu Lu Liu Yu Zhang Feng Tian Jiao Jiao Li Jiajia xue Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China School of Biomedical Engineering Faculty of Engineering and ITUniversity of Technology SydneySydneyNSW 2007Australia

The intricate hierarchical structure of musculoskeletal tissues,including bone and interface tissues,necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered *** has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic *** on the anatomical characteristics of bone and interfacial tissues,this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues,specifically focusing on methods used to construct compositional and structural gradients within the *** latest applications of gradient scaffolds for the regeneration of bone,osteochondral,and tendon-to-bone interfaces are ***,the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed,as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

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云多租数据库资源规划调度技术综述

软件学报 2025年第1期36卷 446-468页

作者：刘海龙王硕侯舒峰徐海洋李战怀西北工业大学计算机学院大数据存储与管理工业和信息化部重点实验室(西北工业大学)

云多租数据库具有按需付费、按需扩展、免部署、高可用、自带运维能力、资源共享等诸多优势,可以大大降低用户使用数据库服务的成本.现在越来越多的企业和个人开始在数据库即服务(DaaS)平台托管他们的数据库服务. DaaS平台需要按照用户... 详细信息

云多租数据库具有按需付费、按需扩展、免部署、高可用、自带运维能力、资源共享等诸多优势,可以大大降低用户使用数据库服务的成本.现在越来越多的企业和个人开始在数据库即服务(DaaS)平台托管他们的数据库服务. DaaS平台需要按照用户服务水平协议(SLA)为诸多租户提供服务,同时也需要保障平台收益.但是,由于租户及其负载具有动态性、异构性和竞争性等特点,如何在遵循SLA的同时根据负载自适应规划调度资源同时兼顾平台收益对于DaaS平台来说是一件极具挑战性的工作.针对云多租数据库中比较常见的类型,如关系型数据库,详细分析了当前云多租数据库资源规划调度技术所面临的挑战,提炼了关键科学问题,给出了技术框架,然后从资源规划调度技术、资源预估技术、资源弹性伸缩技术以及数据库资源规划调度工具等4个方面对现有研究工作进行了总结和分析,并且展望了未来的研究方向.

关键词：多租户云数据库资源规划调度资源预估资源弹性伸缩关系数据库云原生多模数据库

A froth velocity measurement method based on improved U-Net++semantic segmentation in flotation process

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1816-1827页

作者： Yiwei Chen Degang xu kun Wan School of Automation Central South UniversityChangsha 410083China

During flotation,the features of the froth image are highly correlated with the concentrate grade and the corresponding working *** static features such as color and size of the bubbles and the dynamic features such as velocity have obvious differences between different working *** extraction of these features is typically relied on the outcomes of image segmentation at the froth edge,making the segmentation of froth image the basis for studying its visual ***,the absence of scientifically reliable training data with label and the necessity to manually construct dataset and label make the study difficult in the mineral *** solve this problem,this paper constructs a tungsten concentrate froth image dataset,and proposes a data augmentation network based on Conditional Generative Adversarial Nets(cGAN)and a U-Net++-based edge segmentation *** performance of this algorithm is also evaluated and contrasted with other algorithms in this *** the results of semantic segmentation,a phase-correlationbased velocity extraction method is finally suggested.

关键词： froth flotation froth segmentation froth image data augmentation velocity extraction image features

Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： Qing He Zhen Wang Yuchen Wang Mengjie Zhu Zhile Liang Kanghong Zhang Yuge xu Gong Chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming

Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei Li Xiaoxiao xu xuan Wu Jiarui Li Shiling Chen Danyang Chen Gaigai Li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： Zhenzhong Zheng Jialin Chen Jinghong xu Bin Jiang Lei Li Yawei Li Yuliang Dai Bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomarkers candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral blood RNA profiles spinal cord injury

Current and Potential Roles of Ferroptosis in Bladder Cancer

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Current Medical Science 2024年第1期44卷 51-63页

作者： Wen-xin AN Radheshyam Gupta kun Zhai Ya-ru WANG Wan-hai xu Yan CUI Department of Urology Harbin Medical University Cancer HospitalHarbin 150081China Department of Internal Medical Oncology Harbin Medical University Cancer HospitalHarbin 150081China

Ferroptosis,a type of regulated cell death driven by iron-dependent lipid peroxidation,is mainly initiated by extramitochondrial lipid peroxidation due to the accumulation of iron-dependent reactive oxygen *** is a prevalent and primitive form of cell *** cellular metabolic processes regulate ferroptosis,including redox homeostasis,iron regulation,mitochondrial activity,amino acid metabolism,lipid metabolism,and various disease-related signaling *** plays a pivotal role in cancer therapy,particularly in the eradication of aggressive malignancies resistant to conventional *** studies have explored the connection between ferroptosis and bladder cancer,focusing on its incidence and treatment *** biomolecules and tumor-associated signaling pathways,such as p53,heat shock protein 1,nuclear receptor coactivator 4,RAS-RAF-MEK,phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin,and the Hippo-tafazzin signaling system,exert a moderating influence on ferroptosis in bladder *** inducers,including erastin,artemisinin,conjugated polymer nanoparticles,and quinazolinyl-arylurea derivatives,hold promise for enhancing the effectiveness of conventional anticancer medications in bladder cancer *** conventional therapeutic drugs and treatment methods related to ferroptosis offers a promising approach for the treatment of bladder *** this review,we analyze the research on ferroptosis to augment the efficacy of bladder cancer treatment.

关键词： ferroptosis bladder cancer ferroptosis-associated tumor signaling pathway ferroptosis inducer