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Nomogram predicting the prognosis of primary liver cancer after radiofrequency ablation combined with transcatheter arterial chemoembolization

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2630-2639页

作者： hai-Hua Shen Yu-Rong Hong Wen Xu lei Chen Jun-Min Chen Zhi-Gen Yang Cai-Hong Chen Department of Ultrasound Hangzhou Linping Hospital of Traditional Chinese MedicineHangzhou 311106Zhejiang ProvinceChina Department of Ultrasound The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Department of Nursing Hangzhou Linping Hospital of Traditional Chinese MedicineHangzhou 311106Zhejiang ProvinceChina

BACKGROUND The incidence and mortality rates of primary hepatocellular carcinoma(HCC)are high,and the conventional treatment is radiofrequency ablation(RFA)with transcatheter arterial chemoembolization(TACE);however,the 3-year survival rate is still ***,there are no visual methods to effectively predict their *** To explore the factors influencing the prognosis of HCC after RFA and TACE and develop a nomogram prediction *** Clinical and follow-up information of 150 patients with HCC treated using RFA and TACE in the Hangzhou Linping Hospital of Traditional Chinese Medicine from May 2020 to December 2022 was retrospectively collected and *** examined their prognostic factors using multivariate logistic regression and created a nomogram prognosis prediction model using the R software(version 4.1.2).Internal verification was performed using the bootstrapping *** prognostic efficacy of the nomogram prediction model was evaluated using the concordance index(CI),calibration curve,and receiver operating characteristic RESULTS Of the 150 patients treated with RFA and TACE,92(61.33%)developed recurrence and *** regression analysis identified six variables,and a predictive model was *** internal validation results of the model showed a CI of *** correction curve trend of the prognosis prediction model was always near the diagonal,and the mean absolute error before and after internal validation was *** area under the curve of the prediction model after internal verification was 0.882[95%confidence interval(95%CI):0.820-0.945],with a specificity of 0.828 and sensitivity of *** to the Hosmer-Lemeshow test,χ2=3.552 and P=*** predictive model demonstrated a satisfactory calibration,and the decision curve analysis demonstrated its clinical *** The prognosis of patients with HCC after RFA and TACE is affected by several *** developed prediction model based

关键词： Nomogram Primary liver cancer Radiofrequency ablation Transcatheter arterial chemoembolization Prognosis Influencing factors Decision curve analysis

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DCVAE-adv:A Universal Adversarial Example Generation Method for White and Black Box Attacks

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Tsinghua Science and Technology 2024年第2期29卷 430-446页

作者： lei Xu Junhai Zhai College of Mathematics and Information Science Hebei UniversityBaoding 071002China

Deep neural network(DNN)has strong representation learning ability,but it is vulnerable and easy to be fooled by adversarial *** order to handle the vulnerability of DNN,many methods have been *** general idea of existing methods is to reduce the chance of DNN models being fooled by observing some designed adversarial examples,which are generated by adding perturbations to the original *** this paper,we propose a novel adversarial example generation method,called *** from the existing methods,DCVAE-adv constructs adversarial examples by mixing both explicit and implicit perturbations without using original ***,the proposed method can be applied to both white box and black box *** addition,in the inference stage,the adversarial examples can be generated without loading the original images into memory,which greatly reduces the memory *** compared DCVAE-adv with three most advanced adversarial attack algorithms:FGSM,AdvGAN,and AdvGAN++.The experimental results demonstrate that DCVAE-adv is superior to these state-of-the-art methods in terms of attack success rate and transfer ability for targeted *** code is available at https://***/xzforeverlove/DCVAE-adv.

关键词： deep neural network adversarial examples white box attack black box attack robustness

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Dynamical localization in a non-Hermitian Floquet synthetic system

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Chinese Physics B 2024年第5期33卷 147-151页

作者：可汗张嘉明霍良赵文垒 School of Science Jiangxi University of Science and TechnologyGanzhou 341000China School of Information Engineering Jiangxi University of Science and TechnologyGanzhou 341000China

We investigate the non-Hermitian effects on quantum diffusion in a kicked rotor model where the complex kicking potential is quasi-periodically modulated in the time *** synthetic space with arbitrary dimension can be created by incorporating incommensurate frequencies in the quasi-periodical *** the Hermitian case,strong kicking induces the chaotic diffusion in the four-dimension momentum space characterized by linear growth of mean *** find that the quantum coherence in deep non-Hermitian regime can effectively suppress the chaotic diffusion and hence result in the emergence of dynamical ***,the extent of dynamical localization is dramatically enhanced by increasing the non-Hermitian ***,the quasi-energies become complex when the non-Hermitian parameter exceeds a certain threshold *** quantum state will finally evolve to a quasi-eigenstate for which the imaginary part of its quasi-energy is large *** exponential localization length decreases with the increase of the non-Hermitian parameter,unveiling the underlying mechanism of the enhancement of the dynamical localization by nonHermiticity.

关键词： Floquet system non-Hermitian physics dynamical localization

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Detection of Novel BEST1 Variations in Autosomal Recessive Bestrophinopathy Using Third-generation Sequencing

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Current Medical Science 2024年第2期44卷 419-425页

作者： Jia-xun LI Ling-rui MENG Bao-ke HOU Xiao-lu HAO Da-jiang WANG Ling-hui QU Zhao-hui LI lei ZHANG Xin JIN Department of Senior Ophthalmology the Third Medical Center of PLA General HospitalBeijing 100853China Department of Ophthalmology the 74th Army Group HospitalGuangzhou 510318China

Objective:Autosomal recessive bestrophinopathy(ARB),a retinal degenerative disease,is characterized by central visual loss,yellowish multifocal diffuse subretinal deposits,and a dramatic decrease in the light peak on *** potential pathogenic mechanism involves mutations in the BEST1 gene,which encodes Ca2+-activated Cl−channels in the retinal pigment epithelium(RPE),resulting in degeneration of RPE and *** this study,the complete clinical characteristics of two Chinese ARB families were ***:Pacific Biosciences(PacBio)single-molecule real-time(SMRT)sequencing was performed on the probands to screen for disease-causing gene mutations,and Sanger sequencing was applied to validate variants in the patients and their family ***:Two novel mutations,c.202T>C(chr11:61722628,p.Y68H)and c.867+97G>A,in the BEST1 gene were identified in the two Chinese ARB *** novel missense mutation BEST1 c.202T>C(p.Y68H)resulted in the substitution of tyrosine with histidine in the N-terminal region of transmembrane domain 2 of *** novel variant,BEST1 c.867+97G>A(chr11:61725867),located in intron 7,might be considered a regulatory variant that changes allele-specific binding affinity based on motifs of important transcriptional ***:Our findings represent the first use of third-generation sequencing(TGS)to identify novel BEST1 mutations in patients with ARB,indicating that TGS can be a more accurate and efficient tool for identifying mutations in specific *** novel variants identified further broaden the mutation spectrum of BEST1 in the Chinese population.

关键词： autosomal recessive bestrophinopathy BEST1 gene third-generation sequencing mutation

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Extended finite element-based cohesive zone method for modeling simultaneous hydraulic fracture height growth in layered reservoirs

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 2960-2981页

作者： lei Yang Baixi Chen Hopkins Extreme Materials Institute Johns Hopkins UniversityBaltimoreMD21218USA School of Civil Engineering The University of SydneyNSW2006Australia Department of Mechanical Engineering University of Wisconsin-Madison1513 University AvenueMadisonWI53706-1572USA Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

In this study,a fully coupled hydromechanical model within the extended finite element method(XFEM)-based cohesive zone method(CZM)is employed to investigate the simultaneous height growth behavior of multi-cluster hydraulic fractures in layered porous reservoirs with modulus *** coupled hydromechanical model is first verified against an analytical solution and a laboratory ***,the fracture geometry(***,aperture,and area)and fluid pressure evolutions of multiple hydraulic fractures placed in a porous reservoir interbedded with alternating stiff and soft layers are investigated using the *** stress and pore pressure distributions within the layered reservoir during fluid injection are also *** simulation results reveal that stress umbrellas are easily to form among multiple hydraulic fractures’tips when propagating in soft layers,which impedes the simultaneous height *** is also observed that the impediment effect of soft layer is much more significant in the fractures suppressed by the preferential growth of adjoining *** that,the combined effect of in situ stress ratio and fracturing spacing on the multi-fracture height growth is presented,and the results elucidate the influence of in situ stress ratio on the height growth behavior depending on the fracture ***,it is found that the inclusion of soft layers changes the aperture distribution of outmost and interior hydraulic *** results obtained from this study may provide some insights on the understanding of hydraulic fracture height containment observed in filed.

关键词： Hydraulic fracturing Layered reservoir Simultaneous height growth In situ stress Fracture spacing Extended finite element method(XFEM) Cohesive zone method(CZM)

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The Role of Underlying Boundary Forcing in Shaping the Recent Decadal Change of Persistent Anomalous Activity over the Ural Mountains

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Advances in Atmospheric Sciences 2024年第8期41卷 1496-1510,1661-1667页

作者： Ting lei Shuanglin LI Climate Change Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Beijing Meteorological Service Center Beijing 100089China University of Chinese Academy of Sciences Beijing 100049China Department of Atmospheric Science China University of GeosciencesWuhan 430074China

Observational analyses demonstrate that the Ural persistent positive height anomaly event(PAE) experienced a decadal increase around the year 2000, exhibiting a southward displacement afterward. These decadal variations are related to a large-scale circulation shift over the Eurasian Continent. The effects of underlying sea ice and sea surface temperature(SST) anomalies on the Ural PAE and the related atmospheric circulation were explored by Atmospheric Model Intercomparison Project(AMIP) experiments from the Coupled Model Intercomparison Project Phase 6 and by sensitivity experiments using the Atmospheric General Circulation Model(AGCM). The AMIP experiment results suggest that the underlying sea ice and SST anomalies play important roles. The individual contributions of sea ice loss in the Barents-Kara Seas and the SST anomalies linked to the phase transition of the Pacific Decadal Oscillation(PDO) and Atlantic Multidecadal Oscillation(AMO) are further investigated by AGCM sensitivity experiments isolating the respective *** sea ice decline in Barents-Kara Seas triggers an atmospheric wave train over the Eurasian mid-to-high latitudes with positive anomalies over the Urals, favoring the occurrence of Ural PAEs. The shift in the PDO to its negative phase triggers a wave train propagating downstream from the North Pacific. One positive anomaly lobe of the wave train is located over the Ural Mountains and increases the PAE there. The negative-to-positive transition of the AMO phase since the late-1990s causes positive 500-h Pa height anomalies south of the Ural Mountains, which promote a southward shift of Ural PAE.

关键词： Ural persistent anomaly Pacific decadal oscillation Atlantic multidecadal oscillation sea ice loss in Barents-Kara Seas

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The Short-Duration Heavy Rainfall in Different Quadrants of Northeast China Cold Vortices

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Journal of Meteorological Research 2024年第2期38卷 321-338页

作者： lei YANG Yongguang ZHENG Liaoning Meteorological Disaster Monitoring and Early Warning Center Shenyang 110166 National Meteorological Centre China Meteorological AdministrationBeijing 100081 China Meteorological Administration Tornado key Laboratory Foshan 528315

The Northeast China cold vortex(NCCV)is one of the main synoptic-scale systems causing short-duration heavy rainfall(SDHR)in Northeast *** conditions(e.g.,water vapor,instability,and vertical wind shear)are known to be distinctly different over the four quadrants of NCCVs,rendering prediction of the SDHR related to NCCVs(NCCV_SDHR)more *** on 5-yr hourly rainfall observations from 3196 automatic weather stations and ERA5 reanalysis data,10,232 NCCV_SDHR events were identified and divided into four quadrant groups according to their relative position to the center of the NCCV(CVC).The results show that the southeast quadrant features the highest frequency of SDHR,with stronger intensity,longer duration,and wider coverage;and the SDHR in different quadrants presents different formation mechanisms and varied temporal evolution.A new coordinate system is established relative to the CVC that uses the CVC as the origin and the radius of the NCCV(r CV)as the unit *** this new coordinate system,all of the NCCV_SDHR events in the 5-yr study period are *** is found that the occurrence frequency of NCCV_SDHR initially increases and then decreases with increasing distance from the *** highest frequency occurs mainly between 0.8 and 2.5 times r CV from the CVC in the southeast *** can be attributed to the favorable conditions,such as convergence of the low-level shear line and abundant water vapor,which are concentrated in this ***,high-frequency NCCV_SDHR larger than 50 mm(NCCV_SDHR50)is observed to be closer to the *** NCCV_SDHR50occurs,the NCCV is in closer proximity to the subtropical high,resulting in stronger low-level convergence and more abundant water ***,there are lower lifting condensation levels and stronger 0-6-and 0-1-km vertical wind shears in these *** findings provide a valuable reference for more accurate prediction of NCCV_SDHR.

关键词： Northeast China cold vortex short-duration heavy rainfall statistical characteristics environmental conditions

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Towards catalytic reactions of Cu single-atom catalysts:Recent progress and future perspective

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Chinese Chemical Letters 2024年第2期35卷 197-207页

作者： Yitao Zhao lei Tao Jiangsu Province Engineering Research Center of Special Functional Textile Materials Changzhou Vocational Institute of Textile and GarmentChangzhou 213164China Jiangsu key Laboratory of Advanced Catalytic Materials and Technology Advanced Catalysis and Green Manufacturing Collaborative Innovation CenterSchool of Petrochemical EngineeringChangzhou UniversityChangzhou 213164China

One of the urgent and challenging topics in diversified sustainable energy conversion is the development of high-performance,low-cost,and well durable *** single-atom catalysts(SACs)have become promising catalysts for diversified sustainable energy conversion due to their capability to maximize the utilization efficiency,acquire modulated electronic structure and optimized binding strength with *** this review,we have provided an interview of the recent progress achieved in the field of electrocatalysis,photocatalysis,and heterogeneous reaction based on Cu *** by this review,we have summarized some advanced synthetic strategies for the construction of Cu ***,the performance-improving strategies are discussed in terms of the coordination environments of the reaction center,reaction mechanism and selectivity,based on free energy diagram and electron structure ***,the remaining issues,challenges,and opportunities of Cu SACs are also provided,affording a perspective for future *** review not only offers us a deep understanding on the catalytic mechanism of Cu SACs for energy conversion,but also encourages more endeavors in prompting their practical application.

关键词： Cu SACs Energy conversion Catalysis Coordination environment

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Promoted hydrogenation of CO2 to methanol over single-atom Cu sites with Na+-decorated microenvironment

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National Science Review 2024年第06期 264-272页

作者： Li-Li Ling Xinyu Guan Xiaoshuo Liu Xiao-Mei lei Zhongyuan Lin hai-Long Jiang Hefei National Research Center for Physical Sciences at the Microscale Department of Chemistry University of Science and Technology of China School of Energy and Power Engineering North China Electric Power University School of Energy and Environment Southeast University

Although single-atom Cu sites exhibit high efficiency in CO2hydrogenation to methanol,they are prone to forming Cu nanoparticles due to reduction and aggregation under reaction conditions,especially at high ***,single-atom Cu sites stabilized by adjacent Na+ions have been successfully constructed within a metal-organic framework（MOF）-based catalyst,namely *** is found that the electrostatic interaction between the Na+and Hδ-species plays a pivotal role in upholding the atomic dispersion of Cu in MOF-808-NaCu during CO2hydrogenation,even at temperatures of up to 275℃.This exceptional stabilization effect endows the catalyst with excellent activity(306 g·kgcat-1·h-1),high selectivity to methanol（93%） and long-term stability at elevated reaction temperatures,far surpassing the counterpart in the absence of Na+（denoted as MOF-808-Cu）.This work develops an effective strategy for the fabrication of stable single-atom sites for advanced catalysis by creating an alkali-decorated microenvironment in close proximity.

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Water-Excluding Underwater Glue Induced by Marangoni Effect

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CCS Chemistry 2024年第5期6卷 1289-1299页

作者： ke Zhang Xizi Wan Zi-Yu Liu Feilong Zhang Jingwei Lu Jingxin Meng Ye Tian Haeshin Lee lei Jiang Shutao Wang CAS key Laboratory of Bio-Inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190 Green Catalysis Center College of ChemistryZhengzhou UniversityZhengzhou 450001 University of Chinese Academy of Sciences Beijing 100049 Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190 Beijing key Laboratory for Bioengineering and Sensing Technology School of Chemistry and Biological EngineeringUniversity of Science and Technology BeijingBeijing 100083 The Graduate School of Nanoscience and Technology Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141

Marangoni effect at the two-phase interface with different surface tension as a unique mass transfer phenomenon has been widely used in daily life and ***,their marvelous liquid-driving capability between miscible liquids has long been ignored,especially in water ***,we first reveal a distinct underwater Marangoni effect between the solvent of glues and the water layer on solid *** by the Marangoni effect,organic solvents with water solubility,high dielectric constant,and low diffusivity could effectively exclude the interfacial water layer,enabling direct and effective contact between glues and solid *** experimental results and theoretical simulation proved that a relatively large ratio of the Marangoni number in the horizontal direction and to the vertical direction ensured an effective underwater adhesion of the water-excluding *** surface engineering approach provides an alternative to the traditional methods of molecular engineering for realizing underwater adhesion.

关键词： Marangoni effect underwater adhesion dynamic water-excluding water layer solvent diffusion

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