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N-acetylcysteine ameliorates erectile dysfunction in rats with hyperlipidemia by inhibiting oxidative stress and corpus cavernosum smooth muscle cells phenotypic modulation

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Asian Journal of Andrology 2024年第1期26卷 99-106页

作者： Wei Ding Jun-Hong Fan Li-Ren Zhong Nan-Xiong Wang Lu-Hao Liu hai-bo zhang Li Wang Ming-Qiang Wang Bing-Lin He An-Yang Wei Department of Urology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang 550002China Department of Urology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510000China Department of Urology Nanfang HospitalSouthern Medical UniversityGuangzhou 510000China Department of Urology Shenzhen Immigration Inspection General Station HospitalShenzhen 518000China Department of Organ Transplantation The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang 550002China

Hyperlipidemia is a major risk factor for erectile dysfunction(ED).Oxidative stress and phenotypic modulation of corpus cavernosum smooth muscle cells(CcSMCs)are the key pathological factors of ED.N-acetylcysteine(NAC)can inhibit oxidative stress;however,whether NAc can alleviate pathological variations in the corpus cavernosum and promote erectile function recovery in hyperlipidemic rats remains unclear.A hyperlipidemia model was established using 27 eight-week-old male Sprague-Dawley(SD)rats fed a high-fat and high-cholesterol diet(hyperlipidemic rats,HR).In addition,9 male SD rats were fed a normal diet to serve as controls(NC).HR rats were divided into three groups:HR,HR+normal saline(NS),and HR+NAC(n=9 for each group;NS or NAc intraperitoneal injections were administered daily for 16 weeks).Subsequently,the lipid profiles,erectile function,oxidative stress,phenotypic modulation markers of ccsMCs,and tissue histology were *** experimental results revealed that erectile function was significantly impaired in the HR and HR+NS groups,but enhanced in the HR+NAC *** lipid levels,over-activated oxidative stress,and multi-organ lesions observed in the HR and HR+NS groups were improved in the HR+NAC ***,the HR group showed significant phenotypic modulation of CCSMCs,which was also inhibited by NAC *** report focuses on the therapeutic effect of NAc in restoring erectile function using a hyperlipidemic rat model by preventing CcSMC phenotypic modulationand attenuating oxidativestress.

关键词： erectile dysfunction hyperlipidemia N-acetylcysteine oxidative stress henotypic modulation

Variations, effectiveness and its associated factors of a nationwide web-based hypertension management training project in China: insights from a government-led campaign for 1.2 million lay health workers

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Journal of Geriatric Cardiology 2024年第7期21卷 733-750页

作者： Wei WANG hai-bo zhang Jia-Min LIU Yan LI Na TIAN Lei YAN Jin-Xiao SONG Mei-Li LI Yue PENG Jing LI National Primary Health Care Hypertension Management Office National Clinical Research Center for Cardiovascular DiseasesNHC Key Laboratory of Clinical Research for Cardiovascular MedicationsFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

OBJECTIVES To evaluate the effectiveness of a large-scale,web-based,in-service hypertension management training project among lay health workers(LHWs) at primary care health(PHC) settings in China,and to examine the factors contributing to the variations of *** We used data from a web-based national hypertension management training project implemented in 2018,it was designed to facilitate LHWs to learn,understand,and apply the relevant knowledge and skills in hypertension management through providing training courses by use of the web-based platform with unified *** LHWs were required to participate in the exams before and after training to acquire scores for the use of evaluating their performance of hypertension management *** first used descriptive analysis to present the variations of effectiveness in hypertension management knowledge among LHWs by important ***,we used multilevel logistic regression to examine the individual and regional factors contributing to the variations and quantify the magnitude of how these factors affected training *** There were 1,208,610 LHWs who completed training and were ***,the scores of LHWs increased significantly from 62.87 ± 21.14 out of 100 in the pre-test to 88.30 ± 11.31 in the post-test by 25.43(95% confidence interval[CI]:25.40-25.47).Training contents involved in antihypertensive medication showed the lowest score(54.36) in the pre-test and soared the most after training,up to 84.22 by 54.94%.Individual factors associated with disparities in the knowledge of hypertension management decreased substantially after training,which included sex,age,education,practice type,professional level,and hierarchy of working *** variations were shown at the provincial level,with the majority of them being explained by factors at the regional *** Accessible web-based training modality,government efforts,accompa

关键词： hypertension workers nationwide

Influence of laser scanning speed on Cu-Zr-Al composite coatings on Mg alloys

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International Journal of Minerals,Metallurgy and Materials 2013年第6期20卷 568-573页

作者： Ya-li Gao Meng Jie hai-bo zhang School of Mechanical Engineering Northeast Dianli University School of Mechanical and Electrical Engineering Jilin Institute of Chemical Technology

To improve the surface properties of magnesium alloys, a study was conducted on Cu-Zr-A1 composite coatings on AZ91HP magnesium alloy by laser cladding. The influence of laser scanning speed on the microstructures and properties of the coatings was discussed. The coatings consist of amorphous phase, CusZr3, and Cul0ZrT. With the increase of laser scanning speed, the amorphous phase content of the coatings increases and reaches 60.56wt% with the laser scanning speed of 2.0 m/min. Because of the influence of laser scanning speed on the amorphous and crystal phases, the coatings show the maximum elastic modulus, hardness, and wear resistance at the laser scanning speed of 1.0 m/min. At the laser scanning speed of 2.0 m/min, the coatings have the best corrosion resistance.

关键词： magnesium alloys composite coatings amorphous laser cladding speed

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针刺治疗癌痛:从临床证据到科学研究

World Journal of Acupuncture-Moxibustion 2024年第1期34卷 74-75页

作者：何怡瀚张海波毕明刚广东省中医院/广州中医药大学第二临床医学院广州510120 国家自然科学基金委员会北京100085

The increase in cancer incidence and survival rate poses an urgent demand on palliative care and symptom management for cancer *** Chinese medicine(TCM)such as herbal medicine and acupuncture have been widely used in ... 详细信息

关键词：临床证据 acupuncture herbal

Neonatal surgical outcomes after prenatal diagnosis of complex congenital heart disease: experiences of a perinatal integrated diagnosis and treatment program

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World Journal of Pediatrics 2020年第5期16卷 494-501页

作者： Xu Liu hai-Fa Hong hai-bo zhang Zhuo-Ming Xu Jin-Fen Liu Hao zhang Department of Cardiothoracic Surgery Congenital Heart CenterShanghai Children's Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200217China/Shanghai Institute of Congenital Heart DiseasesNational Children's Medical CenterShanghaiChina Department of Cardiothoracic Surgery Congenital Heart CenterShanghai Children's Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200217China

Background This study aimed to evaluate neonatal surgical outcomes of patients diagnosed with complex congenital heart disease(CHD)during pregnancy and treated by the newly initiated"perinatal integrated diagnosis and treatment program(PIDTP)".Methods We reviewed clinical data of 207 neonates(surgical age≤28 days)who underwent cardiac surgeries in a single center from January 2017 to December 2018,including 31 patients with referrals from the"PIDTP"(integration group)and 176 patients with routine referral treatment(non-integrated group).Results In the integration group,median admission age was 0 days and median age at surgery was 4 *** the non-integrated group,median admission age was 8 days(P=0.001)and median age at surgery was 13 days(P=0.001).The emergency surgery rate in patients with duct-dependent defects was 36%in the integration group and 59%(P=0.042)in the non-integrated group,*** in-hospital mortality was 16%in the integration group and 14%(P=0.78)in the non-integrated *** 2-year cumulative survival rate after surgery was 83.9%±6.6%in the integration group and 80.3%±3.1%(P=0.744)in the non-integrated *** to multivariable regression analysis,independent risk factors for early mortality of overall neonatal cardiac surgery were low body weight,high serum lactate level,postoperative extracorporeal membrane oxygenation(ECMO)support and prolonged cardiopulmonary bypass(CPB)*** PIDTP shortens the postnatal transit interval,reduces the emergency operation rate of neonatal critical CHD,and provides better preoperative status for *** treated by the PIDTP tend to have more complicated anatomical deformity and a greater requirement for the operation and postoperative management,but early outcome and follow-up prognosis are satisfactory.

关键词： Congenital heart disease Neonates Perinatal Surgical treatment

Parameters optimization and nonlinearity analysis of grating eddy current displacement sensor using neural network and genetic algorithm

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第8期10卷 1205-1212页

作者： Hong-li QI Hui ZHAO Wei-wen LIU hai-bo zhang Department of Instrument Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China Instrumentation Science and Dynamic Measurement Laboratory North University of China Taiyuan 030051 China

A grating eddy current displacement sensor(GECDS) can be used in a watertight electronic transducer to realize long range displacement or position measurement with high accuracy in difficult industry *** parameters optimization of the sensor is essential for economic and efficient *** paper proposes a method to combine an artificial neural network(ANN) and a genetic algorithm(GA) for the sensor parameters optimization.A neural network model is developed to map the complex relationship between design parameters and the nonlinearity error of the GECDS,and then a GA is used in the optimization process to determine the design parameter values,resulting in a desired minimal nonlinearity error of about 0.11%.The calculated nonlinearity error is 0.25%.These results show that the proposed method performs well for the parameters optimization of the GECDS.

关键词： Grating eddy current displacement sensor (GECDS) Artificial neural network (ANN) Genetic algorithm (GA) Parameters optimization Nonlinearity error

Unplanned J-valve implantation during open heart surgery for severe valvular annulus and ventricle calcification

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Journal of Geriatric Cardiology 2022年第12期19卷 1003-1006页

作者： Tian-Ge LUO bo LI Jie HAN hai-bo zhang Cardiac Valve Centre Department of Cardiac SurgeryBeijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijingChina Department of Cardiac Surgery People’s Hospital of Liaoning ProvinceShenyangChina

Aortic annulus calcification(AC)and mitral AC are common in patients with cardiac valvular disease.[1]Procedures to resect or debride aortic AC and mitral AC may lead to cerebral emboli,heart failure,arrhythmia,coronary artery lesions,and even ventricular rupture.[2]Therefore,it is often a challenge for surgeons to choose an appropriate surgical strategy for patients with severe valvular AC.[3,4]A sutureless valve is a good choice,doing away with the need to take time to remove the AC,but many countries do not have this *** aortic valve implantation(TAVI)and transcatheter mitral valve replacement(TMVR)have developed rapidly during recent years.

关键词： mitral implantation calcification

The Research on Handoff Strategy in Beyond 3G Wireless Networks

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The Journal of China Universities of Posts and Telecommunications 2006年第2期13卷 26-30页

作者： CUI Hong-yan TIAN Hui XU hai-bo zhang Ping College of Telecommunication Engineering Beijing University of Posts and Telecommunications Beijing 100876 P.R. China

One of the major challenges for beyond third generation mobile .systems is efficient mobility management. This paper proposes a distributed dynamic management .scheme of handoff based on B3G networks. This scheme can reduce the cost of update signalling and transmitting packets, and improve the system capability. In this scheme, the dynamic building network approach is adopted to deduce the update signalling cost. We implement the distributed dynamic management scheme of handoff in a simulation platform and compare its performance with that of general centralized handoff management schemes. Our simulation results indicate that our scheme is capable of reducing the update handoff latency, and enhancing the performance.

关键词： B3G IPv6 handoff AP CA

Structure of D Pair in Collective States of Nuclei

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Communications in Theoretical Physics 2006年第6X期46卷 1047-1051页

作者： LU Da-hai zhang bo PI Shi DENG Wei-Zhen CHEN Xiao-Lin Institute of Theoretical Physics Peking University. Beijing 100871 China

As a successive work a modified D pair independent of the S pair treated in our previous papers is introduced to avoid the seniority mixing problem. The structure amplitudes of this D pair and S pair are determined si... 详细信息

关键词： D pair collective state structure amplitudes