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液压油湿法过滤性的影响因素研究

润滑油 2024年第2期39卷 57-59页

作者：黄歆杨绳政梁安德闫亚娟谭金海广西北海玉柴马石油高级润滑油有限公司广西北海536000

文章研究了液压油湿法过滤性的影响因素,分别对基础油种类、添加剂类型和生产灌装前过滤3个因素进行了考察。结果发现:对于相同类型添加剂,Ⅰ类基础油的湿法过滤性比Ⅱ类基础油表现更好;不同类型添加剂表现的湿法过滤性不同;试验前进行... 详细信息

文章研究了液压油湿法过滤性的影响因素,分别对基础油种类、添加剂类型和生产灌装前过滤3个因素进行了考察。结果发现:对于相同类型添加剂,Ⅰ类基础油的湿法过滤性比Ⅱ类基础油表现更好;不同类型添加剂表现的湿法过滤性不同;试验前进行油品灌装过滤的预处理,比不进行处理的湿法过滤性结果更好。

关键词：液压油湿法过滤性基础油添加剂生产过滤

Toll样受体4、核因子-κb通路在溃疡性结肠炎发病机制中的应用

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蚌埠医学院学报 2013年第1期38卷 16-19页

作者：李雅琳郑海伦王启之于东红柳青燕善军柯希全蚌埠医学院第一附属医院消化内科安徽蚌埠233004 蚌埠医学院第一附属医院病理科安徽蚌埠233004

目的:通过研究Toll样受体4(Toll-like receptor,TLR4)、髓样分化分子88(myeloid differentiation factor,Myd88)、核因子-κb(nuclear factor-κb,NF-κb)在溃疡性结肠炎(ulcerative colitis,UC)大鼠模型结肠组织中的表达以及外周血中白细胞介素1(interleukin-1,IL-1)的表达水平,探讨TLR4/NF-κb信号通路在UC发病中的作用。方法:将健康SD大鼠40只随机分为模型组(A组)和正常对照组(B组),每组各20只,运用复合法(三硝基苯磺酸+乙醇)制备细胞免疫反应性UC大鼠模型,造模成功后,进行大体形态损伤评分,HE染色观察大鼠结肠黏膜组织学改变,采用RT-PCR法检测UC各组大鼠结肠黏膜组织中TLR4、Myd88和NF-κb表达,采用ELISA法检测外周血中IL-1的表达。结果:与B组比较,A组大鼠结肠黏膜大体形态评分、组织学损伤评分、结肠黏膜组织中TLR4、Myd88和NF-κb的表达及外周血中IL-1的表达均显著增高(P<0.01)。结论:UC大鼠模型中TLR4、Myd88、NF-κb和IL-1的表达明显升高,TLR4可能通过介导NF-κb引发信号通路下游的基因表达,从而导致炎症因子的释放。

关键词：溃疡性结肠炎 Toll样受体4 髓样分化分子88 核因子-κb 白细胞介素1

Salvia miltiorrhiza extract may exert an anti-obesity effect in rats with high-fat diet-induced obesity by modulating gut microbiome and lipid metabolism

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World Journal of Gastroenterology 2022年第43期28卷 6131-6156页

作者： Zi-Li Ai Xian Zhang Wei Ge You-Bao Zhong hai-Yan Wang zheng-Yun Zuo Duan-Yong Liu Department of Postgraduate Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina Department of Proctology Affiliated Hospital of Jiangxi University of Chinese MedicineNanchang 330006Jiangxi ProvinceChina Laboratory Animal Research Center for Science and Technology Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina Formula-Pattern Research Center Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina

BACKGROUND Studies have shown that a high-fat diet(HFD) can alter gut microbiota(GM)homeostasis and participate in lipid metabolism disorders associated with ***, regulating the construction of GM with the balance of lipid metabolism has become essential for treating obesity. Salvia miltiorrhiza extract(Sal), a common traditional Chinese medicine, has been proven effective against atherosclerosis, hyperlipidemia, obesity, and other dyslipidemia-related *** To investigate the anti-obesity effects of Sal in rats with HFD-induced obesity, and explore the underlying mechanism by focusing on GM and lipid *** Obesity was induced in rats with an HFD for 7 wk, and Sal(0.675 g/1.35 g/2.70g/kg/d) was administered to treat obese rats for 8 wk. The therapeutic effect was evaluated by body weight, body fat index, waistline, and serum lipid level. Lipid factors(cAMP, PKA, and HSL) in liver and fat homogenates were analyzed by ELISA. The effect of Sal on GM and lipid metabolism was assessed by 16S rRNAbased microbiota analysis and untargeted lipidomic analysis(LC-MS/MS),*** Sal treatment markedly reduced weight, body fat index, serum triglycerides(TG), total cholesterol(TC), low-density lipoprotein, glucose, free fatty acid, hepatic lipid accumulation, and adipocyte vacuolation, and increased serum high-density lipoprotein(HDL-C) in rats with HFD-induced obesity. These effects were associated with increased concentrations of lipid factors such as c AMP, PKA, and HSL in the liver and adipose tissues, enhanced gut integrity, and improved lipid metabolism. GM analysis revealed that Sal could reverse HFD-induced dysbacteriosis by promoting the abundance of Actinobacteriota and Proteobacteria, and decreasing the growth of Firmicutes and Desulfobacterita. Furthermore, LC-MS/MS analysis indicated that Sal decreased TGs(TG18:2/18:2/20:4, TG16:0/18:2/22:6), DGs(DG14:0/22:6, DG22:6/22:6), CL(18:2/18:1/18:1/20:0), and increased ceramides

关键词： Salvia miltiorrhiza extract Obesity Gut microbiota Lipid metabolism High fat diet

T2 Mapping and Fat Quantification of Thigh Muscles in Children with Duchenne Muscular Dystrophy

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Current Medical Science 2019年第1期39卷 138-145页

作者： Liang YIN Zhi-ying XIE hai-yan XU Sui-sheng zheng Zhao-xia WANG Jiang-xi XIAO Yun YUAN Department of Radiology Peking University First HospitalBeijing 100034China Department of Neurology Peking University First HospitalBeijing 100034China Department of Radiology Second Affiliated Hospital of Anhui Medical UniversityHefei 230601China

Quantitative magnetic resonance image(MRI)in individual muscles may be useful for monitoring disease progression in Duchenne muscular dystrophy(DMD).The purpose of this study w批to measure丁2 relaxation time of thigh muscles in children with DMD and healthy boys,and to correlate the T2 relaxation time of muscles with the fat fraction(FF)at quantitative magnetic resonance and results of clinical ***-two boys with DMD and 18 healthy boys were evaluated with T2 mapping and three-point Dixon ***,body mass index(BMI),muscle strength assessment,timed functional tests(time to walk or run 10 metres,rise from the floor and ascend four stairs),and the North Star Ambulatory Assessment(NSAA)were ***’s correlation was used to assess the relationships between FF and clinical assessments and T2 relaxation *** mean T2 relaxation time of thigh muscles in DMD was significantly longer than that in the control group(P<0.05),except for the gracilis(P=0.952).The gracilis,sartorius and adductor longus were relatively spared by fatty infiltration in DMD *** T2 relaxation time was correlated significantly with the mean FF in all ***,BMI,total muscle strength score,timed functional tests and NSAA were significantly correlated with the overall mean T2 relaxation time.T2 mapping may prove clinically useful in monitoring muscle changes as a result of the disease process and in predicting the outcome of DMD patients.

关键词： T2 mapping Duchenne muscular dystrophy skeletal muscle fat infiltration

早期手术治疗无神经损伤的脊柱胸腰段骨折的疗效及安全性分析

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局解手术学杂志 2024年第7期33卷 599-603页

作者：简争光王海龙苏晓东李关兴巨积辉苏州瑞华骨科医院脊柱外科江苏苏州215104

目的探讨早期手术治疗无神经损伤的脊柱胸腰段骨折的临床疗效及安全性。方法回顾性分析我院脊柱外科收治的80例无神经损伤的脊柱胸腰段骨折患者的临床资料,根据手术时机不同,将骨折后72 h内进行手术者纳入早期手术组(n=41),将骨折后7... 详细信息

目的探讨早期手术治疗无神经损伤的脊柱胸腰段骨折的临床疗效及安全性。方法回顾性分析我院脊柱外科收治的80例无神经损伤的脊柱胸腰段骨折患者的临床资料,根据手术时机不同,将骨折后72 h内进行手术者纳入早期手术组(n=41),将骨折后72 h至2周内进行手术者纳入择期手术组(n=39),手术方式均为经Wiltse入路伤椎置钉短节段固定。比较2组患者手术时间、术中失血量、住院时间、并发症发生率,比较2组患者术前、术后1周、术后1年视觉模拟量表(VAS)评分、Oswestry功能障碍指数(ODI)、伤椎前缘高度压缩率及矢状位Cobb角,比较2组患者术后1周、术后1年伤椎前缘高度压缩及矢状位Cobb角较术前改善率。结果 2组患者手术时间、术中失血量及并发症总发生率比较,差异均无统计学意义(P>0.05)。早期手术组患者住院时间短于择期手术组,差异有统计学意义(P0.05)。2组患者术后1周、术后1年伤椎前缘高度压缩率及矢状位Cobb角均低/小于术前,差异有统计学意义(P0.05),术后1周、术后1年早期手术组患者伤椎前缘高度压缩率及矢状位Cobb角均低/小于择期手术组,差异有统计学意义(P<0.05)。早期手术组患者术后1周、术后1年伤椎前缘高度压缩较术前改善率及伤椎矢状位Cobb角较术前改善率优于择期手术组,差异均有统计学意义(P<0.05)。结论早期手术治疗无神经损伤的脊柱胸腰段骨折安全,可明显缩短住院时间,骨折复位质量好,疗效确切,但术前要做好病情评估,确保手术安全。

关键词：脊柱胸腰段骨折手术时机早期手术择期手术椎弓根螺钉

Prevalence and risk factors of diabetic retinopathy in patients with type 2 diabetes in Shanghai

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International Journal of Ophthalmology(English edition) 2021年第7期14卷 1066-1072页

作者： Pei Zhang Wen-Wen Xue Xiao-Bo Huang Yi Xu Li-Na Lu Kai-Rong zheng hai-Dong Zou Department of Ophthalmology Shanghai Gonghui HospitalShanghai 200041China Department of Ophthalmology Shanghai Eye Disease Prevention and Treatment CenterShanghai 200040China Department of Ophthalmology the Second Affiliated Hospital of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

AIM:To investigate the prevalence of diabetic retinopathy(DR)in residents of Shanghai and analyze the risk factors of ***:This study involved 7233 patients with diabetes in *** demographic data of the participants were collected using a questionnaire *** examination,laboratory tests,and ophthalmological examinations were *** professional ophthalmologists diagnosed and graded DR by fundus examination and then combined the results with fundus *** unconditional multivariate Logistic regression analysis was used to determine the risk ***:In total,6978 patients with type 2 diabetes in Shanghai with a mean age of 68.33±8.40 y were recruited,including 2975 males(42.6%)and 4003 females(57.4%).Overall,1184 patients were diagnosed with DR,with a prevalence rate of 16.97%.Regression analysis showed that duration of diabetes(OR 1.061,95%CI 1.049-1.073),high systolic blood pressure(SBP;OR 1.071,95%CI 1.037-1.106),increased glycosylated hemoglobin level(OR 1.234,95%CI 1.162-1.311),high blood glucose level(OR 1.061,95%CI 1.023-1.099),increased neutrophil-to-lymphocyte ratio(NLR;OR 1.132,95%CI 1.053-1.217)and mean platelet volume(MPV;OR 1.077,95%CI 1.016-1.142)were risk factors of ***,hematocrit(HCT;OR 0.971,95%CI 0.954-0.988)and mean corpuscular volume(MCV;OR 0.980,95%CI 0.965-0.994)were protective ***:The prevalence rate of DR in Shanghai is 16.97%.The duration of diabetes,high SBP,increased glycosylated hemoglobin,NLR,and MPV were determined as risk factors of DR.

关键词： type 2 diabetes diabetic retinopathy prevalence neutrophil-to-lymphocyte ratio

Urinary trypsin inhibitor attenuates hepatic ischemia-reperfusion injury by reducing nuclear factor-kappa B activation

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Hepatobiliary & Pancreatic Diseases International 2009年第1期8卷 53-58页

作者： Wu, Yi-Jun Ling, Qi Zhou, Xin-Hui Wang, Yan Xie, hai-Yang Yu, Ji-Ren zheng, Shu-Sen Zhejiang Univ Sch Med Affiliated Hosp 1 Dept Gen Surg Hangzhou 310003 Zhejiang Peoples R China Zhejiang Univ Sch Med Affiliated Hosp 1 Dept Gynecol Hangzhou 310003 Zhejiang Peoples R China

BACKGROUND: Urinary trypsin inhibitor (UTI) inhibits the inflammatory response and protects against ischemia-reperfusion (I/R) injury. The inflammatory response is mediated by nuclear factor-kappa B (NF-kappa B) and its related target genes and products such as vascular endothelial cell adhesion molecule and CXC chemokines. We aimed to assess the roles of those mediators in a UTI-treated mouse model of hepatic I/R injury. METHODS: Treatment group 1 (UTI given 5 minutes prior to liver ischemia), treatment group 2 (UTI given 5 minutes after the anhepatic phase) and a control group were investigated. Blood and liver samples were obtained and compared at 1, 3, 6 and 24 hours after reperfusion. RESULTS: Attenuation of pathological hepatocellular damage was greater in the treatment groups than in the control group (P < 0.05). Compared with the control group, the UTI treatment groups showed significantly lower serum alanine aminotransferase and aspartate aminotransferase levels, decreased myeloperoxidase activity, and reduced NF-kappa B activation. Also downregulated was the expression of tumor necrosis factor-alpha, cytokine-induced neutrophil chemoattractant, and macrophage inflammatory protein-2 at the mRNA level. P-selectin protein and intercellular adhesion molecule-1 protein expression were also downregulated. In addition, the treatment group I showed a better protective effect against I/R injury than the treatment group 2. CONCLUSIONS: UTI reduces NF-kappa B activation and downregulates the expression of its related mediators, followed by the inhibition of neutrophil aggregation and infiltration in hepatic I/R injury. The protective role of UTI is more effective in prevention than in treatment.

关键词： ischemia-reperfusion injury nuclear factor-kappa B tumor necrosis factor-alpha urinary trypsin inhibitor

Intravenous leiomyomatosis with different surgical approaches:Three case reports

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World Journal of Clinical Cases 2019年第3期7卷 347-356页

作者： Jie He zheng-Bo Chen San-Ming Wang Mu-Biao Liu Zhi-Gang Li hai-Yan Li Gang Zhao Department of Cardiovascular Surgery Guangdong Cardiovascular InstituteGuangdong General Hospital Guangdong Academy of Medical Sciences Department of Vascular Surgery Guangdong Cardiovascular Institute Guangdong General Hospital Guangdong Academy of Medical Sciences Department of Gynecology and Obstetrics Guangdong General Hospital Guangdong Academy of Medical Sciences

BACKGROUND Intravenous leiomyomatosis(IVL) is a rare and complicated disease, which requires surgery by a multidisciplinary team. However, the optimal surgical approach has not been *** SUMMARY Here we report three cases of IVL treated with different surgical approaches. All patients presented with circulation symptoms. Two patients had lower extremity edema and the other had cardiopalmus. The diagnosis of IVL was confirmed based on the imagining examinations and pathological findings. All patients underwent surgical treatment and were discharged without any *** Preoperative examination is crucial for surgical planning and surgical approach is dependent on the patient's condition and tumor involvement.

关键词： Intravenous leiomyomatosis Surgery Cardiac tumors Case report Minimally-invasive

Impact of Interfacial Trap Density of States on the Stability of Amorphous InGaZnO-Based Thin-Film Transistors

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Chinese Physics Letters 2012年第6期29卷 249-252页

作者： HUANG Xiao-Ming WU Chen-Fei LU hai XU Qing-Yu ZHANG Rong zheng You-Dou Jiangsu Provincial Key Laboratory of Advanced Photonic and Electronic Materials and School of Electronic Science and EngineeringNanjing UniversityNanjing 210093 Department of Physics Southeast UniversityNanjing 211189

The impact of interfacial trap states on the stability of amorphous indium-gallium-zinc oxide thin film transistors is studied under positive gate bias *** increasing stress time,the device exhibits a large positive drift of threshold voltage while maintaining a stable sub-threshold swing and a constant field-effect mobility of channel *** threshold voltage drift is explained by charge trapping at the high-density trap states near the channel/dielectric interface,which is confirmed by photo-excited charge-collection spectroscopy measurement.

关键词： charge Impact trapping