T2 Mapping and Fat Quantification of Thigh Muscles in Children with Duchenne Muscular Dystrophy
作者机构：Department of RadiologyPeking University First HospitalBeijing 100034China Department of NeurologyPeking University First HospitalBeijing 100034China Department of RadiologySecond Affiliated Hospital of Anhui Medical UniversityHefei 230601China
出 版 物：《Current Medical Science》 (当代医学科学（英文）)
年 卷 期：2019年第39卷第1期
页 面：138-145页
核心收录：
学科分类：10[医学]
主 题：T2 mapping Duchenne muscular dystrophy skeletal muscle fat infiltration
摘 要：Quantitative magnetic resonance image(MRI)in individual muscles may be useful for monitoring disease progression in Duchenne muscular dystrophy(DMD).The purpose of this study w批to measure丁2 relaxation time of thigh muscles in children with DMD and healthy boys,and to correlate the T2 relaxation time of muscles with the fat fraction(FF)at quantitative magnetic resonance and results of clinical ***-two boys with DMD and 18 healthy boys were evaluated with T2 mapping and three-point Dixon ***,body mass index(BMI),muscle strength assessment,timed functional tests(time to walk or run 10 metres,rise from the floor and ascend four stairs),and the North Star Ambulatory Assessment(NSAA)were ***’s correlation was used to assess the relationships between FF and clinical assessments and T2 relaxation *** mean T2 relaxation time of thigh muscles in DMD was significantly longer than that in the control group(P0.05),except for the gracilis(P=0.952).The gracilis,sartorius and adductor longus were relatively spared by fatty infiltration in DMD *** T2 relaxation time was correlated significantly with the mean FF in all ***,BMI,total muscle strength score,timed functional tests and NSAA were significantly correlated with the overall mean T2 relaxation time.T2 mapping may prove clinically useful in monitoring muscle changes as a result of the disease process and in predicting the outcome of DMD patients.
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