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World Journal of Experimental Medicine 2024年第2期14卷 29-34页

作者： min Xu Li-Li Tian Xiao-Liu Li Cheng Bao hai-Wei Zhang Hong-Wei Chen Department of Rheumatology and Immunology Nanjing Drum Tower HospitalClinical College of Nanjing University of Chinese MedicineNanjing 210008Jiangsu ProvinceChina School of Life Science Nanjing Normal UniversityNanjing 210023Jiangsu ProvinceChina Department of Rheumatology and Immunology Nanjing Drum Tower HospitalNanjing 210008Jiangsu ProvinceChina Department of Rheumatology and Immunology Nanjing Pukou People’s HospitalNanjing 211800Jiangsu ProvinceChina Department of Rheumatology and Immunology Nanjing Drum Tower HospitalThe Affiliated Hospital of School of MedicineNanjing UniversityNanjing 210008Jiangsu ProvinceChina

Systemic lupus erythematosus(SLE)is a chronic autoimmune disease in which multiple organs are damaged that prevails in fertile ***,glucocorticoids and immunosuppressants are widely used to treat SLE ***,ovarian dysfunction occurs following the use of these drugs in women with ***,we summarize recent progress in terms of understanding ovarian injury,the effects of drug application and strategies to improve ovarian function in women with *** review could be helpful to precisely cure SLE in women desiring to have offspring.

关键词： Systemic lupus erythematosus Ovarian reserve Ovarian insufficiency Mesenchymal stem cells Fertility Autoimmune disease

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MyD88 L265P突变与B细胞肿瘤

中国实验血液学杂志 2014年第1期22卷 241-244页

作者：陈海敏侯健上海第二军医大学长征医院闸北分院血液科上海200070 上海第二军医大学长征医院血液科上海200003

髓样分化因子88(myeloid differentiation factor,MyD88)是一种介导多数Toll样受体(Toll-like receptors,TLR)、白介素-1受体(interleukin-1 receptor,IL-1R)、白介素-18受体(interleukin-1 8receptor,IL-18R)细胞信号传导的重要衔接蛋白,在固有免疫中起着重要的作用。近年来有研究发现,在约90%的淋巴浆细胞淋巴瘤/华氏巨球蛋白血症和约29%的激活型弥漫大B细胞淋巴瘤等B细胞肿瘤中有功能活化的MYD88 L265P突变,从而提示MyD88信号转导在B细胞肿瘤发生中有重要意义,因而MyD88抑制剂可能成为治疗B细胞肿瘤的新药。本文就MyD88 L265P突变在B细胞肿瘤发生中的最新研究进展进行综述。

关键词： MyD88 L265P突变 Toll样受体弥漫大B细胞淋巴瘤淋巴瘤

Perinatal prevalence of birth defects in the Mainland of China,2000–2021:a systematic review and meta-analysis

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World Journal of Pediatrics 2024年第7期20卷 669-681页

作者： Liang-Yu Kang Zi-Rui Guo Wei-Jing Shang Gui-Ying Cao Yi-Ping Zhang Qiao-Mei Wang hai-Ping Shen Wan-Nian Liang min Liu Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityNo.38Xueyuan RoadHaidian DistrictBeijing100191China Vanke School of Public Health Tsinghua UniversityNo.1Tsinghua GardenHaidian DistrictBeijing100084China Department of Maternal and Child Health National Health Commission of the People’s Republic of ChinaNo.1Xizhimenwai South RoadXicheng DistrictBeijingChina Institute of Healthy China Tsinghua UniversityNo.1Tsinghua GardenHaidian DistrictBeijing100084China Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of Education BeijingNo.38Xueyuan RoadHaidian DistrictBeijing100191China

Background Although birth defects are of great concern globally,the latest national prevalence has not yet been quantified in *** conducted a systematic review and meta-analysis to estimate the perinatal prevalence of birth defects in the Mainland of China between 2000 and *** We performed a systematic literature search of six databases for relevant articles published between January 1,2000,and March 1,*** included published studies that reported data on the perinatal prevalence of birth defects in the Mainland of *** DerSimonian and Laird random-effects models were used to estimate the pooled prevalence and its 95%confidence interval(CI).We also conducted subgroup analyses and univariable meta-regressions to explore differences in prevalence by time period,geographic region,and other *** We included 254 studies reporting the perinatal prevalence of birth defects and 86 studies reporting only the prevalence of specific types of birth *** on 254 studies covering 74,307,037 perinatal births and 985,115 cases with birth defects,the pooled perinatal prevalence of birth defects was 122.54(95%CI 116.20–128.89)per 10,000 perinatal births in the Mainland of China during 2000–***,the perinatal prevalence of birth defects increased from 95.60(86.51–104.69)per 10,000 in 2000–2004 to 208.94(175.67–242.22)per 10,000 in 2020–*** were also significant disparities among different geographical *** heart defects(33.35 per 10,000),clefts of the lip and/or palate(13.52 per 10,000),polydactyly(12.82 per 10,000),neural tube defects(12.82 per 10,000),and inborn errors of metabolism(11.41 per 10,000)were the five most common types of birth *** perinatal prevalence among males was significantly higher than that among females(β=2.44×10^(−3),P=0.003);a higher perinatal prevalence of birth defects was observed among perinatal births whose mothers were≥35 years(β=4.34×10^(−3),P<0.001).Conclusion Compreh

关键词： Birth defects China Perinatal Prevalence

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轮足式风电机爬壁机器人的设计与分析

机械设计 2023年第1期40卷 101-106页

作者：郜海超韩海敏河南应用技术职业学院机电工程学院河南郑州450042

为解决人工维护风电机施工难度高、效率低、劳动强度大等问题,基于爬壁机器人研究现状,提出了轮足式4吸盘风电机爬壁机器人的机械本体结构方案。采用Creo软件对机器人的前后吸盘、三腔星轮式吸盘及前后叉架等进行机械结构设计,借助CAD... 详细信息

为解决人工维护风电机施工难度高、效率低、劳动强度大等问题,基于爬壁机器人研究现状,提出了轮足式4吸盘风电机爬壁机器人的机械本体结构方案。采用Creo软件对机器人的前后吸盘、三腔星轮式吸盘及前后叉架等进行机械结构设计,借助CAD软件对机器人翻越内直角时各种运动姿态进行分析;建立数学模型,通过MATLAB软件对计算结果进行仿真分析,得出防止机器人滑落的最小安全吸附力;运用ADAMS软件对爬壁机器人虚拟模型进行运动学分析,同时应用爬壁机器人样机进行运动试验予以验证。结果表明:爬壁机器人能够在最小安全吸附力条件下,完成机器人单一曲面越障及翻越内直角时越障的运动要求,从而得出轮足式4吸盘风电机爬壁机器人设计方案可行,为后续研究提供有益参考借鉴。

关键词：爬壁机器人风力发电机机械本体力学分析

Nomogram predicting the prognosis of primary liver cancer after radiofrequency ablation combined with transcatheter arterial chemoembolization

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2630-2639页

作者： hai-Hua Shen Yu-Rong Hong Wen Xu Lei Chen Jun-min Chen Zhi-Gen Yang Cai-Hong Chen Department of Ultrasound Hangzhou Linping Hospital of Traditional Chinese MedicineHangzhou 311106Zhejiang ProvinceChina Department of Ultrasound The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Department of Nursing Hangzhou Linping Hospital of Traditional Chinese MedicineHangzhou 311106Zhejiang ProvinceChina

BACKGROUND The incidence and mortality rates of primary hepatocellular carcinoma(HCC)are high,and the conventional treatment is radiofrequency ablation(RFA)with transcatheter arterial chemoembolization(TACE);however,the 3-year survival rate is still ***,there are no visual methods to effectively predict their *** To explore the factors influencing the prognosis of HCC after RFA and TACE and develop a nomogram prediction *** Clinical and follow-up information of 150 patients with HCC treated using RFA and TACE in the Hangzhou Linping Hospital of Traditional Chinese Medicine from May 2020 to December 2022 was retrospectively collected and *** examined their prognostic factors using multivariate logistic regression and created a nomogram prognosis prediction model using the R software(version 4.1.2).Internal verification was performed using the bootstrapping *** prognostic efficacy of the nomogram prediction model was evaluated using the concordance index(CI),calibration curve,and receiver operating characteristic RESULTS Of the 150 patients treated with RFA and TACE,92(61.33%)developed recurrence and *** regression analysis identified six variables,and a predictive model was *** internal validation results of the model showed a CI of *** correction curve trend of the prognosis prediction model was always near the diagonal,and the mean absolute error before and after internal validation was *** area under the curve of the prediction model after internal verification was 0.882[95%confidence interval(95%CI):0.820-0.945],with a specificity of 0.828 and sensitivity of *** to the Hosmer-Lemeshow test,χ^(2)=3.552 and P=*** predictive model demonstrated a satisfactory calibration,and the decision curve analysis demonstrated its clinical *** The prognosis of patients with HCC after RFA and TACE is affected by several *** developed prediction model ba

关键词： Nomogram Primary liver cancer Radiofrequency ablation Transcatheter arterial chemoembolization Prognosis Influencing factors Decision curve analysis

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冷轧钢板表面锆化膜的制备及电化学性能分析

表面技术 2018年第5期47卷 208-214页

作者：郝玉林生海黎敏首钢集团有限公司技术研究院用户技术研究所北京100043

目的研究冷轧钢板表面状态对在其表面制备锆化膜性能的影响。方法以A、B、C三种不同品种的冷轧钢板为基材,在其表面制备锆化转化膜。使用扫描电子显微镜及电化学分析方法研究基材的表面状态。使用X射线荧光光谱测厚仪、辉光放电光谱仪... 详细信息

目的研究冷轧钢板表面状态对在其表面制备锆化膜性能的影响。方法以A、B、C三种不同品种的冷轧钢板为基材,在其表面制备锆化转化膜。使用扫描电子显微镜及电化学分析方法研究基材的表面状态。使用X射线荧光光谱测厚仪、辉光放电光谱仪及扫描电子显微电镜分析锆化转化膜的膜重、Zr元素随深度的分布状态及表面形貌,并分析锆化膜的电化学性能,结果 A、B、C三种基材的开路电位依次是-0.66、-0.61、-0.55 V,电荷传输电阻依次是647.9、798.8、1161?·cm^2,说明3种基材的表面活性依次减弱,表面导电能力减弱。A、B、C三种钢材表面制备的锆化膜膜重依次是87.28、65.39、31.48 mg/m^2,电荷传输电阻依次是863.7、920.8、2724?·cm^2。结论钢板表面活性会显著影响表面锆化膜的性能。钢板表面活性越大,其在锆化液中的活性也越大,锆化反应越剧烈,其表面沉积的锆化膜膜重越大,耐蚀性越弱。钢板表面沉积锆化膜后,耐蚀性增强。

关键词：冷轧钢板表面活性锆化膜耐蚀性电荷传输电阻膜重

扩张型心肌病并发充血性心力衰竭停用β受体阻滞剂后的临床不良反应观察

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临床心血管病杂志 2007年第7期23卷 496-497页

作者：闵海马进才临夏回族自治州人民医院心内科甘肃临夏731100

目的:观察扩张型心肌病(DCM)并发充血性心力衰竭(CHF)患者停止美托洛尔治疗后的临床不良反应。方法:对64例服用美托洛尔≥18个月、心功能Ⅰ～Ⅱ级、无恶性室性心律失常及快速性心律失常的患者进行停药后的临床观察,随访期6个月。结果:7... 详细信息

目的:观察扩张型心肌病(DCM)并发充血性心力衰竭(CHF)患者停止美托洛尔治疗后的临床不良反应。方法:对64例服用美托洛尔≥18个月、心功能Ⅰ～Ⅱ级、无恶性室性心律失常及快速性心律失常的患者进行停药后的临床观察,随访期6个月。结果:7例(10.9%)发生心源性猝死,6例(9.4%)出现快速性室上性心律失常,17例(26.6%)心功能恶化至Ⅲ～Ⅳ级住院治疗;停药前、停药后3个月及6个月时的LVEF为(31.2±3.0)%、(46.3±4.3)%及(38.7±7.6)%。结论:DCM并发CHF的患者服用β受体阻滞剂后停用会出现猝死、心力衰竭恶化、快速性心律失常等不良临床后果,LVEF呈先升高后降低现象,如无停药的指征,DCM并发CHF患者长期甚至终身服用β受体阻滞剂非常必要。

关键词：心肌病扩张型心力衰竭充血性 β受体阻滞剂美托洛尔

从教育治理走向教育“善治”——兼评《教育治理的逻辑》和《教育治理的战略》

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基础教育 2022年第4期19卷 106-112页

作者：柳海民东北师范大学教育学部吉林长春130024

教育治理是倡导多元主体参与教育公共事务,进而激发教育活力、提升教育效能的一种管理范式。在中国语境下,教育治理的概念框架既是制度型构的结果,也带有社会建构的特征,其目的在于实现教育“善治”,创造“好教育”。推进教育治理改革,... 详细信息

教育治理是倡导多元主体参与教育公共事务,进而激发教育活力、提升教育效能的一种管理范式。在中国语境下,教育治理的概念框架既是制度型构的结果,也带有社会建构的特征,其目的在于实现教育“善治”,创造“好教育”。推进教育治理改革,关键在于如何通过政府简政放权,赋予学校和社会更大权力,建构教育变革的新生态。《教育治理的逻辑》和《教育治理的战略》两部著作对上述问题作了有益探索和分析,为加快建设高质量教育体系,特别是建设具有中国特色的教育治理体系提供了重要的理论基础。

关键词：教育治理逻辑战略教育善治

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初始含冰量对冻结粉质砂土变形与强度的影响

岩土力学 2014年第10期35卷 2855-2860页

作者：杜海民张淑娟马巍中国科学院寒区旱区环境与工程研究所冻土工程国家重点实验室兰州730000

基于一系列同一温度、不同初始含冰量和应变率条件下的高含冰冻结粉质砂土的单轴压缩试验,开展了高含冰量对冻结粉质砂土变形行为和强度特性的初步研究。结果表明:随着试样中初始含冰量的增加,冻结粉质砂土的塑性增强,当初始含冰量超过2... 详细信息

基于一系列同一温度、不同初始含冰量和应变率条件下的高含冰冻结粉质砂土的单轴压缩试验,开展了高含冰量对冻结粉质砂土变形行为和强度特性的初步研究。结果表明:随着试样中初始含冰量的增加,冻结粉质砂土的塑性增强,当初始含冰量超过210.1%后,应力-应变曲线趋近于冰的特性,可用修正的Duncan-Chang双曲线模型较好地描述其单轴压缩应力-应变关系;当应变率为0.083×10-3 s-1和0.467×10-3 s-1时,其初始切线模量呈非线性增大,但当应变率为0.667×10-3 s-1时,初始切线模量增大到一最大值之后转而减小,并且影响程度与应变率大小有关;当初始含冰量从32.9%增加到304.0%,冻结粉质砂土强度也是先非线性增大,然后逐渐趋于稳定,两者可用对数函数关系很好地描述。其研究结果可为开展高含冰冻土区路基的稳定性评价提供基础。

关键词：高含冰冻土变形特性单轴抗压强度应变率初始含冰量

Boost VS_(2) electrochemical reactive kinetics by regulating crystallographic planes and coupling carbon matrix for high performance sodium-ion storage

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Rare Metals 2024年第1期43卷 98-112页

作者： min Zeng ming-Shan Wang Lin Chen En-Zhi Li Zhen-Liang Yang Dan Zhou hai-Jiao Xie Jun-Chen Chen Zhi-Yuan Ma Bing-Shu Guo Bo Yu Xing Li School of New Energy and Materials Southwest Petroleum UniversityChengdu 610500China Energy Storage Research Institute Southwest Petroleum UniversityChengdu 610500China Institute of Materials China Academy of Engineering PhysicsMianyang 621908China Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and TechnologyBeijingBeijing 100083China Hangzhou Yanqu Information Technology Co. Ltd.Hangzhou 310003China

Vanadium disulfide(VS_(2)) as a typical two-dimensional transition metal chalcogenide has excellent competitiveness for sodium-ion storage due to its wide layer spacing(0.575 nm),high theoretical capacity of 932mAh·g^(-1) originating from multi-electron electrochemical ***,continuous sodiation process accompanied by crystal structural evolution and collapse cause rapid capacity ***,novel few-layer VS_(2)nanosheets with open(001) crystal planes are in-situ constructed on reduced graphene oxide to solve these issues mentioned *** indicates that few-layer VS_(2)provides more Na^(+) storage activity due to the low Na^(+)surface migration energy barrier on exposed crystal(001)*** flexible and high electronic conductivity of carbon matrix also effectively builds multi-level buffer structure and electron transport kinetics to boost the Na^(+)insertion/conversion reactive activity on VS_(2) as well as Na^(+) pseudocapacitance storage kinetics on edges and defects of nano *** coupling effects result in high rate capability and long cycling stability as a battery/capacitor *** delivers conspicuous high energy density of 81 and 40 Wh·kg^(-1) at power density of 118 and 10,286W·kg^(-1),as well as 80% energy retention rate after 5000cycles,confirming its great application potential in sodiumbased storage devices.

关键词： Vanadium disulfide Reduced graphene oxide Anode Sodium-ion battery Sodium-ion capacitor