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Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia:randomized trials and multiomics analysis

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Military Medical Research 2024年第1期11卷 19-33页

作者： liang-Kun Guo yi Su Yu-Ya-Nan zhang Hao Yu Zhe Lu Wen-Qiang li Yong-feng Yang Xiao Xiao Hao Yan Tian-Lan Lu jun li Yun-Dan liao Zhe-Wei Kang li-Fang Wang Yue li Ming li Bing liu hai-liang huang Lu-Xian Lv yin Yao Yun-Long Tan Gerome Breen Ian Everall Hong-Xing Wang Zhuo huang Dai zhang Wei-hua Yue institute of Mental health Peking University Sixth HospitalBeijing 100191China National Clinical Research Center for Mental Disorders Peking University Sixth HospitalBeijing 100191China NHC Key Laboratory of Mental health and Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder(2018RU006) Chinese Academy of Medical SciencesBeijing 100191China Peking University huilongguan Clinical Medical School Beijing Huilongguan HospitalBeijing 100096China Department of Psychiatry Jining Medical UniversityJining 272067ShandongChina henan Key Lab of Biological Psychiatry the Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 435001HenanChina Key Laboratory of Animal Models and human Disease Mechanisms of the chinese academy of sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China institute of Psychiatry Psychology and NeuroscienceKing’s College LondonLondon WC2R 2LSUK State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Analytic and Translational Genetics Unit Massachusetts General HospitalBostonMA 02114USA Stanley Center for Psychiatric Research the Broad Institute of MIT and HarvardCambridgeMA 02141USA Department of Medicine Harvard Medical SchoolBostonMA 02115USA Department of Biostatistics and Computational Biology School of Life SciencesFudan UniversityShanghai 200438China Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Natural and Biomimetic Drugs Key Laboratory for Neuroscience for Ministry of EducationSchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China PKU-IDG/McGovern institute for Brain Research Peking UniversityBeijing 100871China chinese institute for Brain Research Beijing 102206China

Background:Choosing the appropriate antipsychotic drug(APD)treatment for patients with schizophrenia(SCZ)can be challenging,as the treatment response to APD is highly variable and difficult to predict due to the lack of effective *** studies have indicated the association between treatment response and genetic and epigenetic factors,but no effective biomarkers have been ***,further research is imperative to enhance precision medicine in SCZ ***:Participants with SCZ were recruited from two randomized *** discovery cohort was recruited from the CAPOC trial(n=2307)involved 6 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,Quetiapine,Aripiprazole,Ziprasidone,and Haloperidol/Perphenazine(subsequently equally assigned to one or the other)*** external validation cohort was recruited from the CAPEC trial(n=1379),which involved 8 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,and Aripiprazole ***,healthy controls(n=275)from the local community were utilized as a genetic/epigenetic *** genetic and epigenetic(DNA methylation)risks of SCZ were assessed using the polygenic risk score(PRS)and polymethylation score,*** study also examined the genetic-epigenetic interactions with treatment response through differential methylation analysis,methylation quantitative trait loci,colocalization,and promoteranchored chromatin *** learning was used to develop a prediction model for treatment response,which was evaluated for accuracy and clinical benefit using the area under curve(AUC)for classification,R^(2) for regression,and decision curve ***:Six risk genes for SCZ(liNC01795,DDHD2,SBNO1,KCNG2,SEMA7A,and RUFY1)involved in cortical morphology were identified as having a genetic-epigenetic interaction associated with treatment *** developed and externally validated predictio

关键词： Schizophrenia Antipsychotic drug Treatment response Prediction model Genetics Epigenetics

Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study

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World Journal of hepatology 2024年第5期16卷 809-821页

作者： Yuan-Yao zhang Sen Luo hai li Shu-Ning Sun Xian-Bo Wang Xin Zheng Yan huang Bei-ling li Yan-Hang Gao Zhi-Ping Qian feng liu Xiao-Bo Lu jun-Ping liu Hao-Tang Ren Yu-Bao Zheng hua-Dong Yan Guo-Hong Deng liang Qiao Yan zhang Wen-yi Gu Xiao-Mei Xiang yi Zhou yi-Xin Hou Qun zhang Yan Xiong Cong-Cong Zou jun Chen Ze-Bing huang Xiu-hua Jiang Ting-Ting Qi Yuan-Yuan Chen Na Gao Chun-Yan liu Wei Yuan Xue Mei Jing li Tao li Rong-Jiong Zheng Xin-yi Zhou jun Zhao Zhong-Ji Meng Department of Infectious Disease Institute of Biomedical ResearchRegulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key LaboratoryHubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver CancerTaihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200120China Department of Infectious Diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400000China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvinceChina hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin institute of hepatology Nankai University Second People's HospitalTianjin 300192China Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of Infectious Diseases and hepatology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Infectious Diseases The Thir

BACKGROUND Acute-on-chronic liver disease(AoCLD)accounts for the majority of patients hospitalized in the Department of hepatology or Infectious *** To explore the characterization of AoCLD to provide theoretical guidance for the accurate diagnosis and prognosis of *** Patients with AoCLD from the chinese Acute-on-Chronic liver Failure(ACLF)study cohort were included in this *** clinical characteristics and outcomes,and the 90-d survival rate associated with each clinical type of AoCLD were analyzed,using the Kaplan-Meier method and the log-rank *** A total of 3375 patients with AoCLD were enrolled,including 1679(49.7%)patients with liver cirrhosis acute decompensation(LC-AD),850(25.2%)patients with ACLF,577(17.1%)patients with chronic hepatitis acute exacer-bation(CHAE),and 269(8.0%)patients with liver cirrhosis active phase(LC-A).The most common cause of chronic liver disease(CLD)was HBV infection(71.4%).The most common precipitants of AoCLD was bacterial infection(22.8%).The 90-d mortality rates of each clinical subtype of AoCLD were 43.4%(232/535)for type-C ACLF,36.0%(36/100)for type-B ACLF,27.0%(58/215)for type-A ACLF,9.0%(151/1679)for LC-AD,3.0%(8/269)for LC-A,and 1.2%(7/577)for *** HBV infection is the main cause of CLD,and bacterial infection is the main precipitant of *** most common clinical type of AoCLD is *** diagnosis and timely intervention are needed to reduce the mortality of patients with LC-AD or ACLF.

关键词： Acute-on-chronic liver disease Acute-on-chronic liver failure liver cirrhosis Clinical features Prognosis

Prospective study of light dark matter search with a newly proposed DarkSHINE experiment

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Science china(physics,Mechanics & Astronomy) 2023年第1期66卷 124-138页

作者： Jing Chen Ji-Yuan Chen jun-feng Chen Xiang Chen Chang-Bo Fu jun Guo Le he Zheng-Ting he Kim Siang Khaw Jia-lin li liang li Shu li Meng Lv Dan-Ning liu Han-Qing liu Kun liu Qi-Bin liu Yang liu Ze-Jia Lu Cen Mo Si-Yuan Song Xiao-Long Wang Yu-feng Wang Zhen Wang Zi-Rui Wang Wei-Hao Wu Dao Xiang hai-jun Yang jun-hua zhang Yu-Lei zhang Zhi-Yu Zhao Xu-liang Zhu Chun-Xiang Zhu yi-Fan Zhu Tsung-DaoLee institute Shanghai Jiao Tong UniversityShanghai 201210China institute of Nuclear and Particle physics School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Key Laboratory for Particle Astrophysics and Cosmology(MOE) Shanghai Key Laboratory for Particle Physics and Cosmology(SKLPPC)Shanghai 200240China Center for High Energy physics Peking UniversityBeijing 10087lChina School of Mechanical and Electronic Engineering Suzhou UniversitySuzhou 234000China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200240China School of Electronics Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China R&D Center Shanghai Instituteof CeramicsChinese Academyof SciencesShanghai 20189China Key Laboratory of Nuclear physics and lon-beam Application(MOE) Fudan UniversityShanghai 200443China institute of Modern physics Fudan UniversityShanghai 200443China IKey Laboratory for Laser Plasmas(MOE) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China zhangjiang institute for Advanced Study Shanghai JiaoTong UniversityShanghai 200240.China College of literature Scienceand the ArtsUniversity of MichiganAnn Arbor MI 48109-1040USA Deparment of physics Swiss Federal Institnute of Technology ZurichZurich 8093Swizerland

Dark photons have been well motivated as strong candidates for dark force carriers and light dark matter in the sub-GeV mass *** with collider experiments,fixed-target experiments provide a complementary approach to searching for dark photons,particularly in the lower mass *** have studied the physics potential of the electron-on-target experiment based on the shanghai SHINE facility,which provides 10 MHz single electron beam at 8 GeV *** analysis focuses on dark photons being produced via electron and nucleon interaction and then decays to dark matter candidates,which escape detection as missing momentum in the *** experiment takes advantage of using missing momentum to enhance signal versus background separation *** this study,signal samples as a function of dark photon mass and an inclusive background sample with 2.5 billion events are simulated with *** better background estimates,major rare background processes have also been *** paper presents the experiment and detector design,signal and background simulations,analysis strategy,and the prospective study of the experiment *** 9×10^(14) electron-on-target events(about three years running),this experiment is expected to rule out most of the sensitive regions predicted by popular dark photon models.

关键词： dark matter dark photon electron-on-target experiment

chinese expert consensus on organ protection of transplantation(2022 edition)

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hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 516-526页

作者： Jian-hui li Xiao Xu Yan-feng Wang hai-Yang Xie Jing-Yu Chen Nian-Guo Dong Mitesh Badiwala li-Ming Xin Roberto Vanin Pinto Ribeiro Hao yin Hao zhang Jian-Zheng zhang feng huo Jia-yin Yang Hong-Ji Yang hui Pan Shao-Guang li yin-Biao Qiao Jia Luo Hao-Yu li jun-jun Jia Hao Yu Han liang Si-Jia Yang Hao Wang Zhong-Yang liu li-Cheng zhang Xiao-yi hu Hao Wu yi-Qing hu Pei-Fu Tang Qi-Fa Ye Shu-Sen Zheng Department of hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of hepatobiliary and Pancreatic Surgery Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310000China Zhongnan Hospital of Wuhan University Institute of Hepatobiliary Diseases of Wuhan UniversityTransplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationWuhan 430062China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Wuxi Lung Transplantation Center Wuxi People’s Hospital Affiliated with Nanjing Medical UniversityWuxi 214023China Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Peter Munk Cardiac Centre Toronto General Hospital-University Health NetworkTorontoCanada School of Computer Engineering and Science Shanghai UniversityShanghai 200444China Organ Transplant Center Shanghai Changzheng HospitalShanghai 200003China Department of Orthopedics Chinese PLA General HospitalBeijing 100039China National Clinical Research Center for Orthopedics Sports Medicine&RehabilitationBeijing 100039China Department of Surgery General Hospital of Guangzhou Military Command of PLAGuangzhou 510040China Department of liver Surgery Liver Transplantation CenterWest China Hospital of Sichuan UniversityChengdu 610041China Organ Transplantation Center Sichuan Provincial People’s Hospital and School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of Lung Transplantation The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Division of hepatobiliary Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Introduction Organ transplantation increases survival and improves qual-ity of life to many patients with end-stage organ ***-gan shortage is a worldwide problem that restricts organ trans-plantation[1].Organ procurement and preservation as well as ischemia-reperfusion injury(IRI)after transplantation are the im-portant factors affecting prognosis of *** the de-velopment of organ transplantation technology in the 20th cen-tury,organ protection technology has been a most promising con-cept in this *** preservation solutions such as the Collins solution,University of Wisconsin(UW)solution,and histidine-tryptophan-ketoglutarate(HTK)solution were developed sequen-tially[2],which developed rapidly in static cold storage(SCS)*** remains the standard preservation technique for organ transplantation[2].

关键词： organ preservation transplantation

Multiplexed imaging of tumor immune microenvironmental markers in locally advanced or metastatic non-small-cell lung cancer characterizes the features of response to PD-1 blockade plus chemotherapy

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Cancer Communications 2022年第12期42卷 1331-1346页

作者： fengying Wu Tao Jiang Gongyan Chen Yunchao huang Jianying Zhou lizhu lin Jifeng feng Zhehai Wang Yongqian Shu jianhua Shi yi hu Qiming Wang ying Cheng jianhua Chen Xiaoyan lin Yongsheng Wang Jianan huang Jiuwei Cui Lejie Cao Yunpeng liu yiping zhang Yueyin Pan jun Zhao liPing Wang jianhua Chang Qun Chen Xiubao Ren Wei zhang Yun Fan Zhiyong he Jian Fang Kangsheng Gu Xiaorong Dong Tao zhang Wei Shi Jianjun Zou Xuejuan Bai Shengxiang Ren Caicun Zhou Department of Thoracic Medical Oncology Shanghai Pulmonary HospitalTongji University School of MedicineShanghai 200433P.R.China Department of Respiratory Medicine Harbin Medical University Cancer HospitalHarbinHeilongjiang 150000P.R.China Department of Thoracic Surgery Oncology Yunnan Cancer Hospital&The Third Affiliated Hospital of Kunming Medical University&Yunnan Cancer CenterKunmingYunnan 650118P.R.China Department of Respiratory Medicine The First Affiliated Hospital of Zhejiang UniversityHangzhouZhejiang 310009P.R.China Department of Oncology Center The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhouGuangdong 510405P.R.China Department of Thoracic Medical Oncology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjingJiangsu 210009P.R.China Department of Respiratory Shandong Cancer Hospital&InstituteJinanShandong 250117P.R.China Department of Oncology Jiangsu Province HospitalNanjingJiangsu 210000P.R.China Department of Medical Oncology Linyi Cancer HospitalLinyiShandong 276000P.R.China Department of Oncology Chinese PLA General HospitalBeijing 100853P.R.China Department of Respiratory Medicine Henan Cancer HospitalZhengzhouHenan 450000P.R.China Department of Thoracic Oncology Jilin Cancer HospitalChangchunJilin 130012P.R.China Department of Medical Oncology-Chest Hunan Cancer HospitalChangshaHunan 410006P.R.China Department of Oncology Fujian Medical University Union HospitalFuzhouFujian 350001P.R.China Department of Thoracic Medical Oncology West China HospitalSichuan UniversityChengduSichuan 610000P.R.China Department of Respiration First Affiliated Hospital of Suzhou UniversitySuzhouJiangsu 215002P.R.China Department of Medical Oncology The First Bethune Hospital of Jilin UniversityChangchunJilin 130021P.R.China Pulmonary and Critical Care Medicine The First Affiliated Hospital University of Science Technology of ChinaHefeiAnhui 230036P.R.China De

Background:Although programmed cell death 1(PD-1)blockade plus chemotherapy can significantly prolong the progression-free survival(PFS)and overall survival(OS)in first-line settings in patients with driver-negative advanced non-small-cell lung cancer(NSCLC),the predictive biomarkers remain ***,we investigated the predictive value of tumor immune microenvironmental marker expression to characterize the response features to PD-1 blockade plus ***:Tumor tissue samples at baseline were prospectively collected from 144 locally advanced or metastatic NSCLC patients without driver gene alterations who received camrelizumab plus chemotherapy or chemotherapy *** immune microenvironmental markers,including PD-1 ligand(PDL1),CD8,CD68,CD4 and forkhead box P3,were assessed using multiplex immunofluorescence(mIF)***-Meier curveswere used to determine treatment outcome differences according to their expression *** profiles were compared between tumors with distinct expression levels of these markers and their ***:Responders had significantly higher CD8/PD-L1(P=0.015)or CD68/PD-L1 co-expression levels(P=0.021)than non-responders in the camrelizumab plus chemotherapy group,while no difference was observed in the chemotherapy *** with high CD8/PD-L1 or CD68/PD-L1 co-expression level was associated with significantly longer PFS(P=0.002,P=0.024;respectively)and OS(P=0.006,P=0.026;respectively)than those with low co-expression in camrelizumab plus chemotherapy *** comparing survival in the camrelizumab plus chemotherapy with chemotherapy by CD8/PD-L1 co-expression stratification,significantly better PFS(P=0.003)and OS(P=0.032)were observed in high co-expression *** predictive value of CD8/PD-L1 and CD68/PD-L1 co-expression remained statistically significant for PFS and OS when adjusting clinicopathological *** the prevalence of TP53 or KRAS mutations was similar bet

关键词： Non-small-cell lung cancer PD-1 CD8 CD68 tumor immune microenvironment

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LPTS抗体的制备和活性检测

中国生物工程杂志 2004年第3期24卷 44-47页

作者：李义良宋海赵静张红锋李载平赵慕钧中国科学院上海生物化学与细胞生物学研究所上海200031 华东师范大学生命科学学院上海200062

LPTS是利用定位候选克隆策略 ,得到的一个新的肝相关候选肿瘤抑制基因 (anovelliver relatedputativetumorsuppressor) ,为了进一步研究其结构与功能 ,利用DNA重组技术 ,将LPTS的cDNA克隆到融合表达载体pET 2 4a中 ,在E .coli中表达 ,以... 详细信息

LPTS是利用定位候选克隆策略 ,得到的一个新的肝相关候选肿瘤抑制基因 (anovelliver relatedputativetumorsuppressor) ,为了进一步研究其结构与功能 ,利用DNA重组技术 ,将LPTS的cDNA克隆到融合表达载体pET 2 4a中 ,在E .coli中表达 ,以Ni+柱亲和层析 ,获得纯化的 6×His LPTS融合蛋白。以此为抗原免疫新西兰大白兔获得多克隆抗体 ,EliSA法检测其滴度达 2 0 0 0 0以上 ,经亲和层析纯化 ,Western印迹结果表明 ,该纯化抗体可与真核表达的HA LPTS蛋白和内源性的LPTS蛋白特异性结合 ;免疫荧光分析显示SMMC 772 1细胞内源性表达的LPTS蛋白呈点状分布于细胞核内。以上结果表明获得了效价高 ,活性强的针对LPTS蛋白的多克隆抗体。

关键词： LPTS 抗体活性亲和层析免疫荧光特异性肝癌

Clinical practice guideline for transurethral plasmakinetic resection of prostate for benign prostatic hyperplasia(2021 Edition)

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Military Medical Research 2022年第5期9卷 515-533页

作者： Xian-Tao Zeng ying-hui Jin Tong-Zu liu Fang-Ming Chen De-Gang Ding Meng Fu Xin-Quan Gu Bang-Min Han Xing huang Zhi Hou Wan-li hu Xin-li Kang Gong-hui li Jian-Xing li Pei-jun li Chao-Zhao liang Xiu-heng liu Zhi-Yu liu Chun-Xiao liu Jiu-Min liu Guang-heng Luo yi Luo Wei-jun Qin Jian-Hong Qiu Jian-Xin Qiu Xue-jun Shang Ben-Kang Shi Fa Sun Guo-Xiang Tian Ye Tian feng Wang feng Wang yin-huai Wang Yu-Jie Wang Zhi-Ping Wang Zhong Wang Qiang Wei Min-hui Xiao Wan-hai Xu Fa-Xian yi Chao-Yang Zhu Qian-Yuan Zhuang li-Qun Zhou Xiao-feng Zou Nian-Zeng Xing Da-lin he Xing-huan Wang 无 Department of Urology Institute of UrologyZhongnan Hospital of Wuhan UniversityWuhan430071China Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan430071China Department of Urology Tianjin Third Central Hospital Affiliated To Nankai UniversityTianjin300170China Department of Urology Henan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhou450003China Department of Urology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing102218China Department of Urology China-Japan Union Hospital of Jilin UniversityChangchun130033China Department of Urology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China Department of Urology Qinghai University Affiliated HospitalXi’ning810012China Department of Urology People’s Hospital of Hainan ProvinceHainan Affiliated Hospital of Hainan Medical University HaikouHaikou570311China Department of Urology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou310016China Department of Urology General Hospital of Ningxia Medical UniversityYinchuan750003China Department of Urology The First Affiliated Hospital of Anhui Medical UniversityHefei230022China Department of Urology Renmin Hospital of Wuhan UniversityWuhan430060China Department of Urology The Second Hospital of Dalian Medical UniversityDalian116023LiaoningChina Department of Urology Zhujiang Hospital of Southern Medical UniversityGuangzhou510282China Department of Urology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou510080China Department of Urology Surgery Guizhou Province People’s HospitalGuiyang550002China Department of Urology Xijing Hospital of Air Force Military Medical UniversityXi’an710032China Department of Urology The 980St Hospital of the PLA Joint Logistics Support Force(Bethune International Peace Hospital of PLA)Shijiazhuang050082China Department of Urology

Benign prostatic hyperplasia (BPH) is highly prevalent among older men, impacting on their quality of life, sexual function, and genitourinary health, and has become an important global burden of disease. Transurethral plasmakinetic resection of prostate (TUPKP) is one of the foremost surgical procedures for the treatment of BPH. It has become well established in clinical practice with good efficacy and safety. In 2018, we issued the guideline “2018 Standard Edition”. However much new direct evidence has now emerged and this may change some of previous recommendations. The time is ripe to develop new evidence-based guidelines, so we formed a working group of clinical experts and methodologists. The steering group members posed 31 questions relevant to the management of TUPKP for BPH covering the following areas: questions relevant to the perioperative period (preoperative, intraoperative, and postoperative) of TUPKP in the treatment of BPH, postoperative complications and the level of surgeons’ surgical skill. We searched the literature for direct evidence on the management of TUPKP for BPH, and assessed its certainty generated recommendations using the grade criteria by the European Association of Urology. Recommendations were either strong or weak, or in the form of an ungraded consensus-based statement. Finally, we issued 36 statements. Among them, 23 carried strong recommendations, and 13 carried weak recommendations for the stated procedure. They covered questions relevant to the aforementioned three areas. The preoperative period for TUPKP in the treatment of BPH included indications and contraindications for TUPKP, precautions for preoperative preparation in patients with renal impairment and urinary tract infection due to urinary retention, and preoperative prophylactic use of antibiotics. Questions relevant to the intraoperative period incorporated surgical operation techniques and prevention and management of bladder explosion. The application to different

关键词： Transurethral plasmakinetic resection of prostate Benign prostatic hyperplasia Recommendation Treatment Guideline

Prevalence and clinical characteristics of autoimmune liver disease in hospitalized patients with cirrhosis and acute decompensation in china

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World Journal of Gastroenterology 2022年第31期28卷 4417-4430页

作者： Zi-Xuan Shen Dan-Dan Wu Jie Xia Xian-Bo Wang Xin Zheng Yan huang Bei-ling li Zhong-Ji Meng Yan-Hang Gao Zhi-Ping Qian feng liu Xiao-Bo Lu Jia Shang hua-Dong Yan Yu-Bao Zheng Wen-yi Gu Yan zhang Jian-yi Wei Wen-Ting Tan yi-Xin Hou Qun zhang Yan Xiong Cong-Cong Zou jun Chen Ze-Bing huang Xiu-hua Jiang Sen Luo Yuan-Yuan Chen Na Gao Chun-Yan liu Wei Yuan Xue Mei Jing li Tao li Xin-yi Zhou Guo-Hong Deng Jin-jun Chen Xiong Ma hai li Department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China shanghai institute of Digestive Disease Key Laboratory of Gastroenterology and HepatologyChinese Ministry of HealthShanghai Jiao Tong UniversityShanghai 200001China Department of Infectious Diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400038China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100102China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Infectious Disease Taihe HospitalHubei University of MedicineShiyan 430418Hubei ProvinceChina Department of hepatology The First Hospital of Jilin UniversityChangchun 130031Jilin ProvinceChina Department of liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 201508China Tianjin institute of hepatology Nankai University Second People’s HospitalTianjin 300102China Department of Infectious Diseases and hepatology The Second Hospital of Shandong UniversityJinan 250033Shandong ProvinceChina Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054XinjiangChina Department of Infectious Diseases Henan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina Department of Infectious Diseases Hwamei HospitalThe Second Hospital of NingboUniversity of Chinese Academy of SciencesNingbo 315153Zhejiang ProvinceChina Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 5

BACKGROUND Autoimmune liver disease(AILD)has been considered a relatively uncommon disease in china,epidemiological data for AILD in patients with cirrhosis and acute decompensation(AD)is *** To investigate the prevalence,outcome and risk factors for AILD in cirrhotic patients complicated with AD in *** We collected data from patients with cirrhosis and AD from two prospective,multicenter cohorts in hepatitis B virus endemic *** were regularly followed up at the end of 28-d,90-d and 365-d,or until death or liver transplantation(LT).The primary outcome in this study was 90-d LTfree ***-on-chronic liver failure(ACLF)was assessed on admission and during 28-d hospitalization,according to the diagnostic criteria of the European Association for the Study of the liver(EASL).Risk factors for death were analyzed with logistic regression *** In patients with cirrhosis and AD,the overall prevalence of AILD was 9.3%(242/2597).Prevalence of ACLF was significantly lower in AILD cases(14%)than those with all etiology groups with cirrhosis and AD(22.8%)(Phe prevalence rates of primary biliary cirrhosis(PBC),autoimmune hepatitis(AIH)and PBC-AIH overlap syndrome(PBC/AIH)were 50.8%,28.5%and 12.0%,*** ACLF patients,the proportions of PBC,AIH and PBC/AIH were 41.2%,29.4% and 20.6%.28-d and 90-d mortality were 43.8% and 80.0% in AILD-related *** etiology of AILD had no significant impact on 28-d,90-d or 365-d LTfree mortality in patients with cirrhosis and AD in both univariate and multivariate *** bilirubin(TB),hepatic encephalopathy(he)and blood urea nitrogen(BUN)were independent risk factors for 90-d LT-free mortality in multivariate *** development of ACLF during hospitalization only independently correlated to TB and international normalized *** AILD was not rare in hospitalized patients with cirrhosis and AD in china,among which PBC was the m

关键词： Prevalence Autoimmune liver disease Cirrhosis and acute decompensation Mortality Acuteon-chronic liver failure

Group-scale asymmetric abundance structures in the NGC 533 group

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Research in Astronomy and Astrophysics 2012年第1期12卷 63-74页

作者： jun-hua Gu hai-Guang Xu Jing-ying Wang Yu Wang Shao-feng Xu Zhen-Zhen Qin li-yi Gu Tao An Zhong-li zhang Min Lei Department of physics Shanghai Jiao Tong University Shanghai 200240 China shanghai Astronomical Observatory Shanghai 200030 China. Department of physics School of Science The University of Tokyo 7-3-1 Hongo Bunkyo-kuTokyo 113-0033 Japan Max-Planck-institute of Astrophysics Karl-Schwarzschild-Str. 1 Postfach 1317 85741Garching Munich Germany School of Mechanical Engineering Shanghai Jiao Tong University Shanghai 200240 China

By performing a two dimensional spectral analysis on the galaxy group NGC 533 with high-quality Chandra data, we find that the metal abundance distribution in this group is anisotropic. In the area around 2.5′ from the center, we find two concentrations of high abundance structures, in which the abundances are significantly higher than their surrounding regions at the 90% confidence level. We find that the total iron mass in these two regions agrees with the iron mass synthesized in the central dominant galaxy in n 19＋0.08 Gyr. The double-sided configuration of the high abun- 0.03 dance structure, together with the point-like radio emission in the center suggests that the abundance structures could have been transported from the center to their present positions by active galactic nucleus （AGN） activity. We further calculate the energy required for transport, and find that it could have been supplied during an AGN period. However, considering that this group is reported to have experienced a recent merger, the possibility that this merger is responsible for the abundance structures still cannot be excluded.

关键词： galaxies: clusters: individual (NGC 533) -- galaxy: abundances -- in-tergalactic medium -- X-rays: galaxies: clusters