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Focus on Health: 6th ed.

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Hepatocellular adenoma in the paediatric population:Molecular classification and clinical associations

2003年

作者： hahn Dale B.

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World Journal of Gastroenterology 2020年第19期26卷 2294-2304页

作者： Elan hahn Juan Putra Division of Pathology Department of Paediatric Laboratory Medicinethe Hospital for Sick ChildrenToronto M5G 1X8ONCanada Department of Laboratory Medicine and Pathobiology University of TorontoToronto M5S 1A8ONCanada

Hepatocellular adenomas(HCAs)represent rare,benign liver tumours occurring predominantly in females taking oral *** children,HCAs comprise less than 5%of hepatic tumours and demonstrate association with various *** contemporary classification of HCAs,based on their distinctive genotypes and clinical phenotypes,includes hepatocyte nuclear factor 1 homeobox alpha-inactivated HCAs,beta-catenin-mutated HCAs,inflammatory HCAs,combined beta-catenin-mutated and inflammatory HCAs,sonic hedgehogactivated HCAs,and unclassified *** children,there is a lack of literature on the characteristics and distribution of HCA *** this review,we summarized different HCA subtypes and the clinicopathologic spectrum of HCAs in the paediatric population.

关键词： Paediatric Hepatocellular adenoma Malignant transformation Beta-catenin HNF1A Glycogen storage disorders

Heat shock and other apoptosis-related proteins as therapeutic targets in prostate cancer

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Asian Journal of Andrology 2014年第3期16卷 359-363页

作者： Costantine Albany Noah M hahn Indiana University Health Melvin and Bern Simon Cancer Center Indianapolis IN USA.

Defects within apoptotic pathways have been implicated in prostate cancer （PCa） tumorigenesis, metastatic progression and treatment resistance. A hallmark of cancers is the ability to derail apoptosis by inhibiting the apoptotic signal, reducing the expression of apoptotic proteins and/or amplifying survival signals through increased production of antiapoptotic molecule. This review describes associations between heat shock proteins （HSPs） and the human androgen receptor （AR）, the role of HSPs and other stress-induced proteins in PCa development and emerging strategies in targeting these protective proteins to treat PCa.

关键词： apatorsen apoptosis bcl-2 homologous antagonist-killer protein clusterin custirsen ganetespib heat-shock proteins prostatic neoplasms

Ultralong persistent luminescence from carbon dots

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Light(Science & Applications) 2022年第6期11卷 1019-1020页

作者： Seunghyup Yoo Youngjin Song Sangin hahn School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea

Hour-level persistent luminescence is realized with carbon dots embedded in cyanuric acid,the composition of which is easily obtained by the microwave-assisted heating of carbon dots and *** forming donor-acceptor blends,the proposed composition yields intermediate states with long lifetimes,providing a rare-earth-metal-free route to ultralong persistent luminescence.

关键词： luminescence donor microwave

Understanding your health / 6th ed.

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A Fast Augmented Lagrangian Method for Euler’s Elastica Models

2000年

作者： Wayne A. Payne Dale B. hahn.

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Numerical Mathematics(Theory,Methods and Applications) 2013年第1期6卷 47-71页

作者： Yuping Duan Yu Wang Jooyoung hahn Institute for Infocomm Research Singapore Computer Science Department TechnionHaifa 32000Israel Institute for Mathematics and Scientific Computing University of GrazAustria

In this paper,a fast algorithm for Euler’s elastica functional is proposed,in which the Euler’s elastica functional is reformulated as a constrained minimization *** the augmented Lagrangian method and operator splitting techniques,the resulting saddle-point problem is solved by a serial of *** tackle the nonlinear constraints arising in the model,a novel fixed-point-based approach is proposed so that all the subproblems either is a linear problem or has a closed-form *** show the good performance of our approach in terms of speed and reliability using numerous numerical examples on synthetic,real-world and medical images for image denoising,image inpainting and image zooming problems.

关键词： Euler’s elastica augmented Lagrangian method image denoising image inpainting image zooming

Oncogenic Signaling Adaptor Proteins

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Journal of Genetics and Genomics 2015年第10期42卷 521-529页

作者： Leo Y.Luo William C.hahn Health Sciences and Technology Program Harvard Medical School Department of Medical Oncology Dana-Farber Cancer Institute Broad Institute of Harvard and Massachusetts Institute of Technology Center for Cancer Genome Discovery Dana-Farber Cancer Institute Department of Medicine Brigham and Women's Hospital

Signal transduction pathways activated by receptor tyrosine kinases （RTK） play a critical role in many aspects of cell function. Adaptor proteins serve an important scaffolding function that facilitates key signaling transduction events downstream of RTKs. Recent work integrating both structural and functional genomic approaches has identified several adaptor proteins as new oncogenes. In this review, we locus on the discovery, structure and function, and therapeutic implication of three of these adaptor oncogenes. CRKL. GAB2, and FRS2. Each of the three genes is recurrently amplified in lung adenocarcinoma or ovarian cancer, and is essential to cancer cell lines that harbor such amplification. Overexpression of each gene is able to transform immortalized human cell lines in in vitro or in vivo models. These observations identify adaptor protein as a distinct class of oncogenes and potential therapeutic targets.

关键词： Adaptor protein Cancer: Oncogene

Controlled afterglow luminescent particles for photochemical tissue bonding

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Light(Science & Applications) 2022年第11期11卷 2755-2765页

作者： Seong-Jong Kim Minji Choi Guosong Hong Sei Kwang hahn Department of Materials Science and Engineering Pohang University of Science and Technology(POSTECH)77 Cheongam-roNam-guPohangGyeongbuk 37673Korea Department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA

Upconversion materials(UCMs)have been developed to convert tissue-penetrating near-infrared(NIR)light into visible ***,the low energy conversion effciency of UCMs has limited their further biophotonic ***,we developed controlled afterglow luminescent particles(ALPs)of ZnS:Ag,Co with strong and persistent green luminescence for photochemical tissue bonding(PTB).The co-doping of Ag^(+) and Co^(2+) ions into ZnS:Ag,Co particles with the proper vacancy formation of host ions resulted in high luminescence intensity and long-term *** addition,the ALPs of ZnS:Ag,Co could be recharged rapidly under short ultraviolet(UV)irradiation,which effectively activated rose bengal(RB)in hyaluronate-RB(HA-RB)conjugates for the crosslinking of dissected collagen layers without additional light *** remarkable PTB of ZnS:Ag,Co particles with HA-RB conjugates was confirmed by in vitro collagen fibrillogenesis assay,in vivo animal wound closure rate analysis,and in vivo tensile strength evaluation of incised skin *** together,we could confirm the feasibility of controlled ALPs for various biophotonic applications.

关键词： bonding fir closure

Closed-loop hydrometallurgical treatment of end-of-life lithium ion batteries: Towards zero-waste process and metal recycling in advanced batteries

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Journal of Energy Chemistry 2019年第8期28卷 220-227,I0008页

作者： Thomas Abo Atia Giuseppe Elia Robert hahn Pietro Altimari Francesca Pagnanelli Department of Chemistry Sapienza University of RomeRome 00185 Italy Waste Recycling Technologies Flemish Institute for Technological ResearchMol 2400 Belgium Technische Universitat Berlin Research Center of Microperipheric TechnologiesBerlin D-13355 Germany Fraunhofer-Institut für Zuverlassigkeit und Mikrointegration Berlin D-13355 Germany

This work presents an enhanced hydrometallurgical process for recycling lithium ion batteries. First, endof-life batteries were processed in a physical pre-treatment plant to obtain a representative electrode material. The resulting leachate was purified forth by iron-precipitation, liquid–liquid extractions, and an innovative Li–Na separation, in order to obtain valuable products. These products include high-grade graphite, cobalt oxide(Co3O4, purity 83%), cobalt oxalate(CoC2O4, purity 96%), nickel oxide(Ni O, purity89%), and lithium carbonate(Li2CO3, purity 99.8%). The recovery rate was quantitative for graphite, between 80% and 85% for cobalt depending on the nature of the recovery method, 90% for nickel, and 72%for lithium. Secondary streams were also valorized to obtain sodium sulfate(Na2SO4, purity 96%), and MnCoFe2O4 magnetic nano-sorbents according to the zero-waste concept. In order to close the loop, recycled Co3O4 and NiO were used as conversion-type anode materials for advanced lithium ion batteries showing promising performances.

关键词： LIB recycling Graphite Cobalt Nickel Lithium Advanced LIB