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Regulatory T cells as targets of immune intervention in lupus

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Regulatory T cells as targets of immune intervention in lupu...

Opposing intraspecific *** diversity effects on herbivory and growth in subtropical experimental tree assemblages

The 8th International Congress on SLE

作者： Antonio La Cava Bevra H hahn University of California Los Angeles Los AngelesCaliforniaUSA University of California Los Angeles Los AngelesCaliforniaUSA

＜正＞Purpose:Our group and others have shown that immunoregulatory CD4+CD25+Foxp3+T（Treg）cells can suppress the aberrant production of autoantibodies,including pathogenic anti-DNA Ab,in murine *** have also recently shown that one important role of the hormone cytokine leptin is to influence the number and activity of Treg *** this study,we tested the possibility that Treg

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Journal of Plant Ecology 2017年第1期10卷 242-251页

作者： Christoph Z.hahn Pascal A.Niklaus Helge Bruelheide Stefan G.Michalski Miaomiao Shi Xuefei Yang Xueqin Zeng Markus Fischer Walter Durka Helmholtz Centre for Environmental Research—UFZ Department of Community Ecology(BZF)Theodor-Lieser-Straße 4D-06120 HalleGermany Department of Evolutionary Biology and Environmental Studies University of ZürichWinterthurerstrasse 190CH-8057 ZürichSwitzerland Institute of Biology Martin Luther University Halle-WittenbergAm Kirchtor 106108 HalleGermany German Centre for Integrative Biodiversity Research(iDiv)Halle-Jena-Leipzig Deutscher Platz 5e04103 LeipzigGermany South China Botanical Garden 723 Xingke RoadGuangzhou 510650China Key Laboratory of Biodiversity and Biogeography Kunming Institute of BotanyChinese Academy of Sciences132 Lanhei RoadKunming 650204China Kadoorie Farm and Botanic Garden Lam Kam RoadTai PoNew TerritoriesHong Kong Institute of Plant Sciences University of BernAltenbergrain 21CH-3013 BernSwitzerland

Aims Positive plant diversity-ecosystem function relations are ultimately driven by variation in functional traits among individuals that form a *** date,research has largely focused on the role of species diversity for ecosystem ***,substantial intraspecific trait variation is common and a significant part of this variation caused by genetic differences among ***,we studied the relative importance of species diversity and seed family(SF)diversity within species for growth and herbivory in experimental subtropical tree *** In 2010,we set up a field experiment in subtropical China,using four species from the local species *** were raised from seeds,with seeds from the same mother tree forming an *** established 23 plots containing one or four species(species diversity treatment)and one or four SFs per species(SF diversity treatment).Tree growth(stem diameter,plant height and crown expansion)and herbivory(percentage leaf loss due to leaf chewers)were monitored annually from 2011 to *** findings Tree species richness promoted growth but had no effect on *** contrast,SF diversity reduced growth and increased herbivory but only so in species *** of the observed effects were time dependent,with the largest effect found in *** results suggest that biodiversity can affect plant performance directly via tree species-species interactions,or context dependent,via potential effects on inter-trophic *** important conclusions should be drawn from our ***,in future studies regarding biodiversity and ecosystem functioning(BEF)relationships,intraspecific genetic diversity should be given similar weight as species diversity as it has often been neglected and its effects are not well ***,we demonstrate opposite effects of biodiversity among and within species,stressing the importance to consider the effects of multiple levels of biodiversity simul

关键词： BEF-China species diversity genetic diversity growth herbivory

平面应变状态下不可压缩幂硬化蠕变材料中刚性片状夹杂的奇异场和局部解

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应用力学学报 1992年第3期9卷 28-35页

作者：陈宜亨 Hans G.hahn 西安交通大学德国Kaiserslautern大学

本文采用Williams特征展开方法结合Lee伪应力函数方法得到了平面应变状态下不可压缩幂硬化蠕变材料中刚性片状夹杂物的奇异场和局部解.研究发现,夹杂物尖端的应力奇性为r^(-m/2),与幂硬化指数m有关;而应变奇性为r^(-1/2),与幂硬化指数无... 详细信息

本文采用Williams特征展开方法结合Lee伪应力函数方法得到了平面应变状态下不可压缩幂硬化蠕变材料中刚性片状夹杂物的奇异场和局部解.研究发现,夹杂物尖端的应力奇性为r^(-m/2),与幂硬化指数m有关;而应变奇性为r^(-1/2),与幂硬化指数无关.本文通过选择积分路径给出了近尖的局部解,并用显函数的形式给出了近尖应力和位移的角变化.

关键词：材料力学平面应变蠕变刚性夹杂

Establishment of Withania somnifera Hairy Root Cultures for the Production of Withanolide A

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Journal of Integrative Plant Biology 2008年第8期50卷 975-981页

作者： Hosakatte N. Murthy Camelia Dijkstra Paul Anthony Daniel A. White Mike R. Davey J. Brian Power Eun J. hahn Kee Y. Paek Plant Sciences Division School of Biosciences University of Nottingham Sutton Bonington Campus Loughborough LE12 5RD UK Department of Botany Karnatak University Dharwad 580 003 India Research Center for the Development of Advanced Horticultural Technology Chungbuk National University Cheongju 361-763 Korea Department of Botany Karnatak University Dharwad 580 003 India Food Sciences Division School of Biosciences University of Nottingham Sutton Bonington Campus Loughborough LE12 5RD UK Research Center for the Development of Advanced Horticultural Technology Chungbuk National University Cheongju 361-763 Korea

Withania sominifera （Indian ginseng） was transformed by Agrobacterium rhizogenes. Explants from seedling roots, stems, hypocotyls, cotyledonary nodal segments, cotyledons and young leaves were inoculated with A. rhizogenes strain R1601. Hairy （transformed） roots were induced from cotyledons and leaf explants. The transgenic status of hairy roots was confirmed by polymerase chain reaction using nptll and rolB specific primers and, subsequently, by Southern analysis for the presence of nptll and rolB genes in the genomes of transformed roots. Four clones of hairy roots were established; these differed in their morphology. The doubling time of faster growing cultures was 8-14 d with a fivefold increase in biomass after 28 d compared with cultured, non-transformed seedling roots. MS-based liquid medium was superior for the growth of transformed roots compared with other culture media evaluated （SH, LS and N6）, with MS-based medium supplemented with 40 g/L sucrose being optimal for biomass production. Cultured hairy roots synthesized withanolide A, a steroidal lactone of medicinal and therapeutic value. The concentration of withanolide A in transformed roots （157.4 μg/g dry weight） was 2.7-fold more than in non-transformed cultured roots （57.9 μg/g dry weight）.

关键词： Agrobacterium rhizogenes hairy (transformed) roots Indian ginseng transformation withanolide A

Effect of Pneumatic Boxing Gloves on Impact Kinematics and Their Relationship to Impact Forces

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World Journal of Engineering and Technology 2019年第3期7卷 472-512页

作者： Paul Perkins Alex Jamieson Wayne Spratford Allan hahn University of Canberra Research Institute for Sport & Exercise Canberra Australia Boxing Australia Limited Canberra Australia Queensland Academy of Sport Brisbane Australia Griffith University Brisbane Australia

This study was aimed at improved understanding of the mechanisms of previously reported protective effects of a pneumatic boxing glove. A Motion Capture System was used to obtain velocity data from four different boxing gloves dropped on to a force plate from nine heights ranging from 1 to 5 metres. Two gloves were of the conventional type but differed in mass. The other two were prototype pneumatic gloves. One of these (SBLI) had a sealed bladder while the other (ARLI) incorporated a port allowing air exchange with the external environment. The pneumatic gloves decelerated more slowly than the conventional gloves following impact and compressed through a greater absolute distance. Consequently, they took longer to reach zero velocity. As drop height increased, these trends became more pronounced for the ARLI glove than the SBLI glove. Increase in velocity during rebound was also slower for the pneumatic gloves. The ARLI glove had a lower coefficient of restitution than any of the other gloves at low to moderate drop heights but not at high drop heights. The SBLI glove had a higher coefficient of restitution than the other gloves at all drop heights from 2 metres upwards. This indicated that, overall, the ARLI glove was the most effective, and the SBLI glove the least effective, in dissipating the kinetic energy of impact through conversion to other energy forms. For all gloves at all drop heights, peak positive acceleration at the beginning of rebound was of lower absolute magnitude than peak negative acceleration at the end of compression. The influence of drop height on an index characterising this relationship differed between the conventional and pneumatic gloves, possibly reflecting structural changes to gloves as impact energy increased. The conventional and pneumatic gloves differed regarding temporal alignment between key kinematic and kinetic events, and there were some differences between the two pneumatic gloves in this respect. Nevertheless, peak glove

关键词： Pneumatic Boxing Gloves Boxing Safety Modified Boxing Sport Safety Sport Technology Sports Equipment Design Coefficient of Restitution Elas-tic-Plastic Impacts

Entacapone promotes hippocampal neurogenesis in mice

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Neural Regeneration Research 2021年第6期16卷 1005-1010页

作者： Dae Young Yoo Hyo Young Jung Woosuk Kim Kyu Ri hahn Hyun Jung Kwon Sung Min Nam Jin Young Chung Yeo Sung Yoon Dae Won Kim In Koo Hwang Department of Anatomy and Cell Biology College of Veterinary Medicineand Research Institute for Veterinary ScienceSeoul National UniversitySeoulSouth Korea Department of Anatomy College of MedicineSoonchunhyang UniversityCheonanSouth Korea Department of Biomedical Sciences and Research Institute for Bioscience and BiotechnologyHallym UniversityChuncheonSouth Korea Department of Biochemistry and Molecular Biology Research Institute of Oral SciencesCollege of DentistryGangneung-Wonju National UniversityGangneungSouth Korea Department of Anatomy College of Veterinary MedicineKonkuk UniversitySeoulSouth Korea Department of Veterinary Internal Medicine and Geriatrics College of Veterinary MedicineKangwon National UniversityChuncheonSouth Korea

Entacapone,a catechol-O-methyltransferase inhibitor,can strengthen the therapeutic effects of levodopa on the treatment of Parkinson’s ***,few studies are reported on whether entacapone can affect hippocampal neurogenesis in *** investigate the effects of entacapone,a modulator of dopamine,on proliferating cells and immature neurons in the mouse hippocampal dentate gyrus,60 mice(7 weeks old)were randomly divided into a vehicle-treated group and the groups treated with 10,50,or 200 mg/kg *** results showed that 50 and 200 mg/kg entacapone increased the exploration time for novel object *** staining results revealed that after entacapone treatment,the numbers of Ki67-positive proliferating cells,doublecortin-positive immature neurons,and phosphorylated cAMP response element-binding protein(pCREB)-positive cells were significantly *** blot analysis results revealed that treatment with tyrosine kinase receptor B(TrkB)receptor antagonist significantly decreased the exploration time for novel object recognition and inhibited the expression of phosphorylated TrkB and brain-derived neurotrophic factor(BDNF).Entacapone treatment antagonized the effects of TrkB receptor *** results suggest that entacapone treatment promoted hippocampal neurogenesis and improved memory function through activating the BDNF-TrkB-pCREB *** study was approved by the Institutional Animal Care and Use Committee of Seoul National University(approval ***-130730-1)on February 24,2014.

关键词： brain-derived neurotrophic factor entacapone hippocampus neurogenesis neurotrophic factor phosphorylated cAMP response element-binding protein tyrosine kinase receptor B receptor

Evaluation of Ability of Two Different Pneumatic Boxing Gloves to Reduce Delivered Impact Forces and Improve Safety

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World Journal of Engineering and Technology 2018年第2期6卷 457-491页

作者： Paul Perkins Alex Jamieson Wayne Spratford Allan hahn University of Canberra Research Institute for Sport and Exercise Canberra Australia Boxing Australia Limited Canberra Australia Queensland Academy of Sport Brisbane Australia Griffith University School of Engineering Brisbane Australia Australian Institute of Sport Canberra Australia

Two prototype pneumatic boxing gloves of different design were compared against conventional 10?oz (Std 10?oz) and 16?oz (Std 16?oz) gloves in terms of ability to reduce impact forces delivered to a target. One of the pneumatic gloves (SBLI) contained a sealed air bladder inflated to a pressure of 2?kPa. The other (ARLI) incorporated a bladder that allowed release of air to the external environment upon contact with a target, followed by rapid air reuptake. Each glove was placed on to a mechanical fist and dropped 10 times on to an in-floor force plate from each of nine heights ranging from 1.0 to 5.0 metres, with the 5-metre drop generating a peak pre-impact glove velocity close to the reported maximum for elite boxers. Compared to the conventional gloves, the ARLI glove substantially reduced peak impact forces at all drop heights, with the reduction exceeding 30% even at the 5-metre level. The SBLI glove was as effective as the ARLI glove in reducing peak impact forces at drop heights of up to 2.5 metres, but its performance then progressively diminished, and at drop heights of 4.0, 4.5 and 5.0 metres it produced peak force readings similar to those recorded for the Std 10?oz and Std 16?oz gloves. The superiority of the ARLI glove was even more evident in relation to peak rate of force development, with reductions relative to the Std 10?oz glove being ~60% at drop heights up to 3.5 metres and still ~47% at 5 metres. Peak rate of force development for the SBLI glove exceeded that for the ARLI glove for all drop heights of 2.0 metres and above, and at 4.0, 4.5 and 5.0 metres it was higher than the readings for the Std 10 oz and 16?oz gloves. The protective effect of the ARLI glove was?associated with an increase in impact compliance and prolongation of contact time between glove and target. It is concluded that a pneumatic boxing glove that provides for air exchange with the external environment can greatly reduce impact magnitudes across the whole range of pre-impa

关键词： Boxing Boxing Safety Box’Tag Modifed Boxing ModBox Pneumatic Box-ing Glove Sport Technology

Three-dimensional problem of transient contact dynamics

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Science China Mathematics 1996年第10期39卷 1096-1105页

作者：范天佑 H.G.hahn A.Voigt Beijing Institute of Technology Beijing 100081 China University of Kaiserslautern D -67663 Kaiserslautern Germany

An analytic solution to three-dimensional problem of transient contact dynamics is developed, and a generalized Galin’s theorem is proved. Based on the theorem, contact displacements can be determined analytically when the given contact stresses are some quite general functions; in contrast to this, one can readily evaluate the corresponding contact stresses in analytic version when some quite general displacements are prescribed. The quite general form mentioned above means the prescribed quantities are any polynomials of x and y and any transient function of time. Numerical results for the contact displacements-time variation dearly demonstrate the effect of inertia induced by the dynamic stress.

关键词： transient dynamic contact three-dimensional problem generalized Galin’s theorem.

Pneumatic Boxing Glove Reduces Upward Drift in Peak Force and Loading Rate over a Long Series of Impacts

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World Journal of Engineering and Technology 2019年第1期7卷 18-53页

作者： Paul Perkins Alex Jamieson Wayne Spratford Allan hahn University of Canberra Canberra Australia Boxing Australia Limited Canberra Australia Queensland Academy of Sport Brisbane Australia Griffith University Brisbane Australia

A conventional boxing glove and a prototype pneumatic glove were each fitted to a mechanical fist and dropped 253 times from a height of 3 metres on to a force plate covered by an ethylene vinyl acetate (EVA) mat. Impact dynamics were measured and modelled. From the outset, peak impact force and peak rate of force development (loading rate) were lower for the pneumatic glove. For both gloves, these variables displayed upward drift during the drop series, but the drift was smaller for the pneumatic glove. Consequently, the magnitude of the protective effect provided by the pneumatic glove increased with the number of impacts. For the conventional glove, change in peak force showed a close inverse relationship to force plate contact time (R2?>?0.96) and the time from first contact of the glove with the force plate to attainment of peak force (R2?=?0.85). These relationships were much weaker for the pneumatic glove (R2?=?0.09 and 0.59 respectively), suggesting the possibility of a more complex impact damping mechanism. Following the 253 drops of the pneumatic glove, the EVA mat covering the force plate was replaced, and another 10 drops then performed. Peak force readings were immediately reduced to an extent suggesting that 26%?-?34% of the increase that had occurred over the 253 drops was attributable to impact-induced change in mat properties. This has implications for future experimental designs. Overall, the findings provided further evidence of the potential of pneumatic gloves to enable safer boxing.

关键词： Boxing Safety Low-Impact Boxing Gloves Modified Boxing Pneumatic Boxing Gloves Protective Equipment for Boxing Sport Technology Sport Safety