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Induced Deactivation of Genes Encoding Chlorophyll Biosynthesis Enzymes Disentangles Tetrapyrrole- Mediated Retrograde Signaling

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Molecular Plant 2014年第7期7卷 1211-1227页

作者： hagen schlicke Annabel Salinas Hartwig Vivien Firtzlaff Andreas S. Richter , Christine Glasser Klaus Maier Iris Finkemeier Bernhard Grimm Institute of Biology/Plant Physiology Humboldt University Berlin Philippstr. 13 Building 12 D 10115 Berlin Germany Helmholtz Zentrum Monchen Deutsches Forschungszentrum for Gesundheit und Umwelt (GmbH) Ingolstadter Landstr. 1 85764 Neuherberg Germany Max-Planck-lnstitute for Plant Breeding Research. Plant Proteomics and Mass Spectrometry Group Carl-von-Linne Weg 10 50829 Cologne Germany

In photosynthetic organisms, tetrapyrrole-mediated retrograde signals are proposed to contribute to a bal- anced nuclear gene expression （NGE） in response to metabolic activity in chloroplasts. We followed an experimental short- term approach that allowed the assessment of modified NGE during the first hours of specifically modified enzymatic steps of the Mg branch of tetrapyrrole biosynthesis, when pleiotropic effects of other signals can be avoided. In response to 24-h-induced silencing of CHLH, CHLM, and CHL27 encoding the CHLH subunit of Mg chelatase, the Mg protoporphyrin methyltransferase and Mg protoporphyrin monomethylester cyclase, respectively, deactivated gene expression rapidly led to reduced activity of the corresponding enzymes and altered Mg porphyrin levels. But NGE was not substantially altered. When these three genes were continuously inactivated for up to 4 d, changes of transcript levels of nuclear genes were determined. CHL27 silencing for more than 24h results in necrotic leaf lesions and modulated transcript levels of oxidative stress-responsive and photosynthesis-associated nuclear genes （PhANGs）. The prolonged deactivation of CHLH and CHLM results in slightly elevated transcript levels of PhANGs and tetrapyrrole-associated genes. These time-resolved studies indicate a complex scenario for the contribution of tetrapyrrole biosynthesis on NGE mediated by IO2-induced signaling and feedback-regulated ALA synthesis.

关键词： plastid signal transcription analysis retrograde signal tetrapyrrole metabolism Mg protoporphyrin.

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Identification of Early Nuclear Target Genes of Plastidial Redox Signals that Trigger the Long- Term Response of Arabidopsis to Light Quality Sh∽ts

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Molecular Plant 2015年第8期8卷 1237-1252页

作者： Lars Dietzel Christine Glaeer Monique Liebers Stefan Hiekel Florence Courtois Olaf Czarneckit hagen schlicke Yan Zubo Thomas Borner Klaus Mayer Bernhard Grimm Thomas Pfannschmidt Department of Plant Physiology Institute of General Botany and Plant Physiology Friedrich-Schiller-University of Jena Domburger Strasse 159 07743 JenaGermany MIPS/IBI Helmholtz Zentrum MGnchen German Research Center for Environmental Health (GmbH) Ingolst~dter Landstrasse 1 85764 Neuherberg Germany Institute of Biology/Plant Physiology Humboldt-University Berlin Philippstrasse 13 Building 12 10115 Berlin Germany Institute of Biology Genetics Humboldt-University Berlin Chausseestrasse 117 10115 Berlin Germany present address: Institut fer Molekulare Biowissenschaften Pflanzliche Zellphysiologie Max-von-Laue-Strasse 9 Biozentrum Goethe-Universit~t Frankfurt 60438Frankfurt am Main Germany Present address: Zentrum fur Molekulare Biologie an der Universitat zu Heidelberg (ZMBH) Im Neuenheimer Feld 282 69120 Heidelberg Germany present address: Universite Grenoble-Alpes F-38000 Grenoble France Present address: CNRS UMR5168 F-38054 Grenoble France present address: CEA iRTSV Laboratoire de Physiologie Cellulaire & Vgetale F-38054 Grenoble France Present address: INRA USC1359 F-38054 Grenoble France Present address: Plant Reproductive Biology Group Department of Physiology and Ceil-Biology Leibniz Institute of Rant Genetics and Crop Plant Research (IPK)OT Gatersleben Corrensstrasse 3 D-06466 Stadt Seeland Germany present address: KWS Saat AG Grimsehlstrasse 31 37555 Einbeck Germany present address: Dartmouth College Department of Biological Sciences Ufe Sciences Center 78 College Street Hanover NH 03755 USA

Natural illumination conditions are highly variable and because of their sessile life style, plants are forced to acclimate to them at the cellular and molecular level. Changes in light intensity or quality induce changes in the reduction/oxidation （redox） state of the photosynthetic electron chain that acts as a trigger for compen- satory acclimation responses comprising functional and structural adjustments of photosynthesis and metabolism. Such responses include redox-controlled changes in plant gene expression in the nucleus and organelles. Here we describe a strategy for the identification of early redox-regulated genes （ERGs） in the nucleus of the model organism Arabidopsis thaliana that respond significantly 30 or 60 min after the generation of a reduction signal in the photosynthetic electron transport chain. By comparing the response of wild-type plants with that of the acclimation mutant stn7, we could specifically identify ERGs. The results reveal a significant impact of chloroplast redox signals on distinct nuclear gene groups including genes for the mitochondrial electron transport chain, tetrapyrrole biosynthesis, carbohydrate metabolism, and signaling lipid synthesis. These expression profiles are clearly different from those observed in response to the reduction of photosynthetic electron transport by high light treatments. Thus, the ERGs identified are unique to redox imbalances in photosynthetic electron transport and were then used for analyzing potential redox-responsive cis-elements, trans-factors, and chromosomal regulatory hot spots. The data identify a novel redox-responsive element and indicate extensive redox control at transcriptional and chromosomal levels that point to an unprecedented impact of redox signals on epigenetic processes.

关键词： plastidial redox signaling,early redox-regulated gene Arabidopsis thaliana Molecular Plant

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Aggresome-aggrephagy transition process: geting closer to the functional roles of HDAC6 and BAG3

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Neural Regeneration Research 2024年第6期 1181-1182页

作者： hagen K?rschgen Christian Behl The Autophagy Lab Institute of Pathobiochemistry University Medical Center of the Johannes Gutenberg University Mainz

Misfolding of proteins as well as their aggregation is a major driver of age-related neurodegenerative diseases. Hence, cells have evolved sophisticated protein quality control mechanisms. Mainly the ubiquitin-proteasome-system(UPS) and the autophagosome-lysosome-system, specifically a macroautophagy pathway called “aggrephagy”, govern the disposal of aggregates. However,

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External Factors Influencing the Motion of Tectonic Plates

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Open Journal of Earthquake Research 2024年第3期13卷 150-169页

作者： Marilia hagen Anibal Azevedo Instituto de Fsica Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Faculdade de Cincias Aplicadas da Unicamp Limeira Brazil

The investigation aims to understand how external forces influence tectonic plate movement, causing earthquakes and volcanic eruptions. Our emphasis was on calculating perigee forces at various moon-Earth distances. Our initial concern is the fluctuating perigee distance between the Moon and Earth. Later, we will cover Earth’s mass fluctuations caused by crustal inhomogeneity. Gravitational force depends on distance and Earth’s mass variations. Wobbling’s Earth and translation around Sun are additional factors. Tidal variations from the Moon trigger subduction zone earthquakes. Volcanoes in the Ring of Fire are influenced by plate movement on fractures and faults.

关键词： Sun Moon-Earth Forces Tectonic Plate Motion Seismic Activity Volcanoes

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Investigation of Potential Factors on South Atlantic Magnetic Anomaly

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Open Journal of Earthquake Research 2024年第1期13卷 1-26页

作者： Marilia hagen Anibal Azevedo Instituto de Física Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Faculdade de Ciencias Aplicadas da Unicamp Limeira Brazil

The first part of this investigation analyzes the deep earthquake occurrences in Nazca subducting under South America. The depth taken is to get information about possible influences from the unknown materials and formations under the crust. The results revealed the presence of malleable material, which is unbreakable and, therefore, unable to trigger earthquakes. The structure of those elements is diamagnetic, attracting ionized particles from the Van Allen belt region in the ionosphere. The charged particles travel towards Earth’s surface, enhanced during the geomagnetic storms. The South Atlantic Magnetic Anomaly (SAMA) found that the deformation suffered by the anomaly moving from South Africa to South America is, possibly due to a bulge of unknown flexible material buried underneath the oceanic and continental crust. The continental part is strengthening in weakness because the background also has a high amount of diamagnetic material in this region, and it would not happen over the Atlantic Ocean, where part of the deformation is placed.

关键词： Ultra-Deep Earthquakes (UDQ) Diamagnetism South Atlantic Magnetic Anomaly (SAMA)

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El Niño-Southern Oscillation (ENSO) Variations and Climate Changes Worldwide

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Atmospheric and Climate Sciences 2024年第2期14卷 233-249页

作者： Marilia hagen Anibal Azevedo (Retired) Instituto de Fí sica Universidade do Estado do Rio de Janeiro Rio de Janeiro Brazil Faculdade de Ciê ncias Aplicadas da Unicamp Limeira Brazil

This investigation aims to study the El-Niño-Southern Oscillation (ENSO) events in these three phases: El Niño, La Niña, and neutral. Warm and cold events relate to the Spring/Summer seasons. This paper will search for connections between the ENSO events and climate anomalies worldwide. There is some speculation that those events would be necessary for the climate anomalies observed worldwide. After analyzing the data from the reports to the ENSO, it shows almost periodicity from 1950-2023. We emphasized the occurrence of El Niño two years, when it was most prominent, and the climate anomalies (following NOAA maps), 2015 and 2023. The results indicated that the observed climate anomalies couldn’t be linked to the abnormal events observed. The worldwide temperatures in those years enhanced mostly in 2023. It shows an abnormal behavior compared with all the years scrutinized and analyzed since the records began. Therefore, there must be unknown factors beyond ENSO that rule the worldwide temperatures and the climate anomalies observed.

关键词： ENSO Southern Oscillation El Niño Climate Anomalies

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Public Perceptions and Support of Renewable Energy in North America in the Context of Global Climate Change

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International Journal of Disaster Risk Science 2015年第4期6卷 385-398页

作者： Bjoern hagen David Pijawka School of Geographical Sciences and Urban Planning Arizona State University

There is substantial interest in developing a coherent and effective North American renewable energy policy as a way to secure energy but also to mitigate global climate change. Based on surveys of the public in Canada,Mexico, and the United States, the article shows the levels of concern over climate change threats, perceived risk,knowledge of climate change policies, levels of uncertainty, and other perception factors to help understand the relationships between public perceptions and policy preferences for renewable energy. Results show national differences between the three countries in nearly all climate change perceptions, with Mexico reflecting the highest levels of concern and the United States the lowest. Mexico also shows the greatest support for renewable energy sources. However, the results show very high levels of uncertainty about climate change dimensions concerning risk, science, and knowledge and the effectiveness of policy approaches. The data demonstrate strong statistical correlations between risk perception factors and preferences for mitigation policies in the form of renewable energy policies.

关键词： Climate change Cross-national comparison Environmental policy North America Public perceptions Renewable energy

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Molecular diagnostic approaches for enteric parasites: an issue of relevance for deployed soldiers?

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Military Medical Research 2023年第3期10卷 415-417页

作者： hagen Frickmann Department of Microbiology and Hospital Hygiene Bundeswehr Hospital Hamburg22529 HamburgGermany Institute for Microbiology Virology and HygieneUniversity Medicine Rostock18057 RostockGermany

Dear Editor,Recently, Lindrose et al.[1] have conducted a retrospective assessment over 6 years on enteric helminth infections in United States(US)soldiers and their relatives to provide epidemiological insights into ... 详细信息

关键词： enteric neglected

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Infectious diseases during the European Union training mission Mali(EUTM MLI)–a four-year experience

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Military Medical Research 2018年第4期5卷 293-303页

作者： hagen Frickmann Ralf Matthias hagen Florian Geiselbrechtinger Nagpal Hoysal Department of Microbiology and Hospital Hygiene Bundeswehr Hospital Hamburg Institute for Medical Microbiology Virology and Hygiene University Medicine Rostock Department of Preventive Medicine Bundeswehr Medical Academy NATO Center of Excellence for Military Medicine (MilMedCOE) Deployment Health Surveillance Capability (DHSC) Institute of Medical Information Processing Biometry and Epidemiology

Background: The European Union Training Mission Mali(EUTM MLI) is a multinational military training deployment to the Western African tropical nation of Mali. Based on routinely collected disease and non-battle injury surveillance data, this study quantifies the true impact of infectious diseases for this tropical mission and potential seasonal variations in infectious disease ***: Categorized health events during the EUTM MLI mission and associated lost working days were reported using the EpiNATO-2 report. Infection-related health events were descriptively analyzed for a 4-year period from the 12 th week in 2013 to the 13 th week in 2017. Aggregated EpiNATO-2 data collected from all missions other than EUTM MLI were used as a ***: Among the infectious diseases reported by EUTM MLI, non-severe upper respiratory infections and gastrointestinal diseases dominated quantitatively, accounting for 1.65 and 1.42 consultations per 100 person-weeks, respectively. The number of recorded infectious disease-associated lost working days during the whole study interval was 723. Seasonal changes in disease frequency were detectable. More gastrointestinal infections were seen in the rainy season, and more respiratory infections occurred in the dry season; these were associated with peaks of more than 2.5 consultations per 100 person-weeks for both ***: Despite initial concerns focused on tropical infectious diseases during this mission in tropical Mali, upper respiratory tract and gastrointestinal infections predominate. The relatively low number of reported lost working days may indicate that these infections are at the milder end of the spectrum of infectious diseases despite a likely reporting bias.

关键词： Tropical deployment Infectious diseases Tropical medicine Gastrointestinal infections Upper respiratory tract infections Mali

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Growth performance,nutrient digestibility,intestinal morphology,cecal mucosal cytokines and serum antioxidant responses of broiler chickens to dietary enzymatically treated yeast and coccidia challenge

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1438-1450页

作者： Emmanuel Oluwabukunmi Alagbe hagen Schulze Olayiwola Adeola Department of Animal Sciences Purdue UniversityWest LafayetteIN 47907USA Livalta PeterboroughCambridgeshire PE26FLUK

Background There is a growing search for natural feed additives to alleviate the deleterious effects of coccidia infection in poultry *** study aimed to investigate the effect of enzymatically treated yeast(ETY) on the growth performance,nutrient digestibility,intestinal morphology,antioxidative status,and cecal mucosa cytokines of coccidia-challenged broiler *** From d 1 to 14 post hatching,480 broiler chickens were allocated to 3 corn-soybean meal-based experimental diets with increasing concentrations of ETY(0,1,or 2 g/kg).The experiment was designed as a randomized complete block design with body weight(BW) used as a blocking *** d 14 post hatching,the birds were re-randomized within each of the 3 experimental *** of the 3 diet groups was split into a challenge or no-challenge *** resulted in a 3 × 2 factorial arrangement of *** coccidia challenge was administered on d 15 by an oral *** Dietary ETY improved(P < 0.05) the G:F of birds on d 21 regardless of the challenge state and linearly increased(P < 0.01) the apparent ileal digestibility of dry matter(DM),nitrogen,and gross energy(GE).The coccidia challenge decreased(P < 0.05) BW gain and feed intake of broiler chickens and reduced(P < 0.01) the total tract retention of DM,GE,and *** coccidia challenge increased(P < 0.01) the mRNA gene expression of TNFα,IL-1β,IL-10,and IL-6 in the cecal *** was a tendency(P ne = 0.08) for ETY to linearly reduce IL-1β ***,ETY supplementation increased(P < 0.05) the geexpression of *** catalase increased(P < 0.05) with dietary ETY in broiler chickens on d *** ETY linearly increased(P < 0.05) the ileal villus height to crypt depth ratio,and ileal goblet cell density in broiler *** ileal and excreta oocyst counts decreased(P < 0.01) with increasing supplementation of dietary ETY in coccidia-challenged broiler chickens on d *** Dietary ETY enha

关键词： Broiler chickens Coccidia Goblet cells Growth performance Health Oocyst Peptides Postbiotics Yeast

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