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Chronic hepatitis-C infection in COVID-19 patients is associated with in-hospital mortality

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World Journal of Clinical Cases 2021年第29期9卷 8749-8762页

作者： Diana Ronderos Alaa Mabrouk Salem Omar hafsa Abbas Jasbir Makker Ahmed Baiomi Haozhe Sun Nikhitha Mantri Yongsun Choi Ked Fortuzi Dongmin Shin Harish Patel Sridhar Chilimuri Department of Internal Medicine BronxCare Hospital CenterBronxNY 10457United States Department of Cardiology Mount Sinai Morning SideNew YorkNY 10023United States Division of Gastroenterology Department of MedicineBronxCare Health SystemBronxNY 10457United States

BACKGROUND There is little evidence about the association of pre-existing hepatitis C infection(HCV)with outcomes in patients with coronavirus disease 2019(COVID-19).AIM To assess the prevalence of history of HCV among patients with COVID-19 and to study the relationship of in-hospital mortality in relation with other predictors of poor outcomes in the presence or absence of COVID-19 induced acute liver *** In a retrospective single-center study design,1193 patients with COVID-19 infection were *** were then classified into those with and without a history of HCV,50(4.1%)and 1157(95.9%)*** Multivariate cox-regression models showed that age,HCV,D-Dimer,and ferritin were the only predictors of in-hospital *** liver injury and fibrosis score(Fib-4 score)were not different between both *** coxregression model for liver profile revealed that aspartate aminotransferase/alanine aminotransferase ratio,Fib-4 score,and HCV were predictors of inhospital *** propensity score matching HCV was the only predictor of mortality in the multivariate cox-regression model.A model including HCV was found to add predictive value to clinical and laboratory *** In patients with COVID-19,history of HCV infection leads to an accentuated severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virulence,irrespective of baseline comorbidities,admission laboratory variables,or COVID-19-induced liver injury,which may be related to extrahepatic effects of HCV leading to enhanced ACE-2/TMPRSS mechanisms of SARS-CoV-2 viral entry,baseline cytokine-mediated pro-inflammation,and endothelial dysfunction.

关键词： Hepatitis C Acute liver injury Seropositive COVID-19 Mortality

TiO_(2)在锂金属负极界面的修饰及应用

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电池 2022年第5期52卷 492-496页

作者：陈超张华知宋扬 hafsa Youssoufi 四川化工职业技术学院应用化工学院四川泸州646000 四川大学化学工程学院四川成都610020 巴黎萨克雷大学ICMMO实验室法国奥赛91400

锂金属电极因超高的容量密度和较低的氧化还原电位,被认为是有前景的高能量密度负极材料。在实际应用中,锂金属负极枝晶的生长,不仅缩短电池寿命,还极易引发安全问题。在锂金属表面机械喷涂TiO_(2)粉末,构建Li_(x) TiO_(2)固体电解质相... 详细信息

锂金属电极因超高的容量密度和较低的氧化还原电位,被认为是有前景的高能量密度负极材料。在实际应用中,锂金属负极枝晶的生长,不仅缩短电池寿命,还极易引发安全问题。在锂金属表面机械喷涂TiO_(2)粉末,构建Li_(x) TiO_(2)固体电解质相界面(SEI)膜,使锂与TiO_(2)之间发生均匀的固-固锂化反应。制备的Li_(x) TiO_(2)@Li电极锂沉积更为致密、均匀,未发现锂枝晶。Li_(x) TiO_(2)@Li负极与商用磷酸铁锂(约3 mAh/cm^(2))制备的全电池,以1 mA/cm^(2)的电流密度在2.0~3.8 V循环,寿命为150次,相比锂金属负极电池44次的循环寿命,Li_(x) TiO_(2)@Li负极表现出更好的电化学性能。

关键词： TiO_(2) 锂金属负极界面锂枝晶电池

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A case of a patient infected with a hepatitis C virus genotype 3a multidrug resistant variant in Pakistan

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Infectious Diseases of Poverty 2018年第1期7卷 123-128页

作者： Asad Zia Muhammad Ali hafsa Aziz Muhammad Zia Zabta Khan Shinwari Abida Raza Department of Biotechnology Quaid-i-Azam University IslamabadIslamabadPakistan Nuclear Oncology and Radiotherapy Institute(NORI) IslamabadPakistan National Institute of Lasers and Optronics(NILOP) Nanomedicine Research LabsIslamabadPakistan

Background:Approximately 10 million people in Pakistan are infected with the hepatitis C virus(HCV).Most patients develop chronic hepatitis,with rare cases of spontaneous ***,little is known about multidrug resistant viral variants in ***:This case study describes a 47-year-old male diagnosed with chronic HCV genotype 3a infection in *** an initial diagnosis of viral infection,the patient remained treatment naïve for 5 *** received two therapy cycles of interferon(IFN)plus ribavirin(RBV)in 2007 and 2010,however,he was non-responsive to the *** patient then received an additional two treatment cycles of pegylated IFNα-2b plus RBV(in 2011 and 2013);he was still *** 2016,the patient underwent sofosbuvir plus RBV combination therapy,however,the sustained virological response was still not *** host genetic factor was found to be heterozygous guanine and thymine(GT)and cytosine and thymine(CT)genotypes of rs8099917 and rs12979860 polymorphism of IL28B,*** analysis suggests that the resistant variant belong to an out-group and may require triple ***:This is the first case that reports on a HCV-infected individual who was a non-responder to multiple IFN therapies in *** studies are needed to understand multidrug-resistant HCV variants in the Pakistani population.

关键词： patient infected multidrug

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Hiatal Hernia by Rolling Revealed by Respiratory Symptoms: A Rare Condition and Atypical Presentation

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Case Reports in Clinical Medicine 2016年第9期5卷 330-334页

作者： Hind Serhane Othmane Ouardi hafsa Sajiai Selma Aitbatahar Lamyae Amro Department of Respiratory Medicine Laboratory PCIM Faculty of Medicine and Pharmacy Cadi Ayyad University Marrakesh Morocco

Hiatal hernia by rolling is a rare pathology estimated at 5% of all diaphragmatic hernias. It is usually asymptomatic. Sometimes, it can be accompanied by different symptoms, such as post prandial bloating, dysphagia, regurgitation, retro sternal pain, even respiratory symptoms. The aim of this article is to show that a hiatus hernia by rolling can cause a misleading clinical picture that may be taken wrongly for a heart or respiratory disease. We report the case of an 80-year-old patient whose presentation was suggestive of an acute heart condition, but the scan confirmed a rolling diaphragmatic hernia. Because of the rarity and the atypical presentation of this case, we have found it desirable to bring this new observation.

关键词： Hiatal Hernia Diaphragmatic Hernia Rolling Hernia Retrosternal Pain Respiratory Symptoms

Ataxia Telangiectasia Syndrome Revealed by Severe Pneumonia

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Case Reports in Clinical Medicine 2015年第5期4卷 184-188页

作者： Hind Serhane Nisserine Louhab hafsa Sajiai Selma Aitbatahar Lamyae Amro Department of Respiratory Medicine Laboratory PCIM Faculty of Medicine and Pharmacy Cadi Ayyad University Marrakesh Morocco Department of Neurological Medicine Faculty of Medicine and Pharmacy Cadi Ayyad University Marrakesh Morocco

Ataxia Telangiectasia (AT) is a rare autosomal recessive multisystem disease. The diagnosis is often made on a clinical triad that combines neurological signs dominated by a progressive cerebellar ataxia, oculocutaneous signs (telangiectasia, coffee stain milk), immunodeficiency (humoral and cellular) with sinopulmonary infections and elevated alphaphetoprotein. The diagnosis of AT is usually early, however, some forms may be revealed late. We reported a case of a 19-year-old patient, admitted for severe pneumonia with Klebsiella Pneumonia. In its history, it was found a notion of recurrent respiratory infections and bronchiectasis. In its clinical examination, it had been discovered cerebellar ataxia and occulocutaneous telangiectasia. The determination of plasmatic alphafoetoprotein was elevated, and the search of immunodeficiency showed a mixed deficit (humoral and cellular) suggesting the diagnosis of AT.

关键词： Ataxia Telangiectasia Cerebellar Ataxia Occulocutaneous Telangiectasia Alphaphotoprotein Immunodeficiency Autosomal Recessive Disease

A Review on Emerging Contaminants: Effects on Human Health and Cancer Risks

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Journal of Clinical and Nursing Research 2024年第10期8卷 57-73页

作者： Hamza Khaliq Faiza Shahzad Asad Ullah Muhammad Aziz Abid hafsa Gul College of Environment Hohai UniversityNanjing 210000Jiangsu ProvinceChina School of Chemical Engineering Tianjin UniversityTianjin 300350China Institute of Geology University of the PunjabLahore 54590Pakistan Department of Medical Laboratory Technology(MLT) Government College University FaisalabadFaisalabad 38000Pakistan

Emerging contaminants are growing health concerns that pose potential threats to the environment and human health *** originate from multiple sources,including rapid industrial processes,agriculture,households,and wastewater treatment *** efforts to reduce the levels of such pollutants,these harmful elements remain a serious problem for public health and the overall quality of *** to emerging contaminants can lead to various health problems,including cardiovascular diseases,brain and developmental disorders,and *** contaminants can harm aquatic life,disrupt ecosystems,and contaminate drinking water ***,a complex heterogeneous disease,can be triggered by multiple causes,including genetic and environmental *** rapid increase in emerging contaminants has contributed significantly to the development and proliferation of *** review highlights the dangerous effects of exposure to these contaminants and explores future directions in ***,it summarizes the emerging roles of inorganic contaminants,such as engineered nanoparticles,and biological contaminants,including pathogenic bacteria,antibiotic-resistant bacteria and resistance genes,viruses,protein contaminants,microplastics,and nanoplastics,in cancer progression and treatment.

关键词： Cancer Emerging contaminants Pollutants Nanomaterials

全视网膜光凝术改善PDR患者的视觉相关生活质量及日常视觉功能（英文）

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国际眼科杂志 2016年第12期16卷 2171-2175页

作者： Muhammad Imran Saleem Channar Muhammad Farhan Saleem hafsa Malik B.V.医院眼科巴基斯坦巴哈瓦尔布尔63100

目的:评估全视网膜光凝术(PRP)对糖尿病视网膜病变(PDR)患者在视觉相关生活质量及日常视觉功能的影响。方法:研究纳入30例(男13例,女17例)接受全视网膜光凝术治疗糖尿病视网膜病变患者。国家眼科研究所发布的视觉功能量表(VFQ-25)用来... 详细信息

目的:评估全视网膜光凝术(PRP)对糖尿病视网膜病变(PDR)患者在视觉相关生活质量及日常视觉功能的影响。方法:研究纳入30例(男13例,女17例)接受全视网膜光凝术治疗糖尿病视网膜病变患者。国家眼科研究所发布的视觉功能量表(VFQ-25)用来评估全视网膜光凝术治疗前后视觉相关生活质量及日常视觉功能。患者在接受全视网膜光凝术治疗前和治疗后6mo分别填写VFQ-25量表,比较视觉相关生活质量及日常视觉功能差异。运用配对t检验对治疗前后VFQ-25评分对比。结果:全视网膜光凝术治疗前平均VFQ-25综合评分为74.79±15.7,术后平均综合评分为74.08±19.1。术前与术后的平均VFQ-25综合评分无统计学意义(P=0.875)。结论:全视网膜光凝术(PRP)对糖尿病视网膜病变(PDR)患者在视觉相关生活质量及日常视觉功能无不利影响。

关键词：全视网膜光凝术糖尿病视网膜病变视觉功能量表

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Predictors of response to antiviral therapy in patients with chronic hepatitis C from Pakistani population

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Chinese Medical Journal 2011年第9期124卷 1333-1337页

作者： hafsa Aziz Muhammad Amin Athar Shahnaz Murtaza Javaid Irfan Yasir Waheed Iram Bilal Abida Raza Nuclear Medicine Oncology and Radiotherapy Institute Islamabad Punjab University Lahore Pakistan Institute of Biochemistry & Biotechnology Punjab University Lahore Pakistan NUST Center of Virology and Immunology National University of Sciences and Technology Islamabad Pakistan COMSATS Institute Islamabad Pakistan

Background Hepatitis C virus （HCV） constitutes a major public health issue around the world, especially in developing countries like Pakistan. In this study, we assessed outcome of interferon （INF） treatment in chronic hepatitis C patients categorized by gender, age, and viral *** In this study, 750 HCV positive patients with genotype 3 were selected, out of which 616 completed the entire treatment. Their personal history, pro-treatment HCV RNA and serum alanine transaminase （ALT） was *** were treated with combination therapy of INF-α 2b three million units （thrice a week） plus ribavirin （1000-1200mg per day） for 24 weeks. After 24 weeks their HCV RNA and serum ALT level was *** Out of the 616 patients, 391 （63.5%） responded to therapeutic regimen （INF-α 2b plus ribavirin）. Among the responders, 27.1% were men and 36.4% were women. Best treatment response was observed in patients having Iow viral load ＜8×105 IU/ml and age ≤40 years than patients having Iow viral load and age ＞40 years （73.2% vs. 60.3%, P=0.05）.Conclusions Better response to IFN-α 2b plus ribavirin was observed in patients with lower viral RNA and younger *** suggests that all patients considered for treatment should have quantification of serum HCV RNA level. The result can be used to counsel patients on the likelihood of response and may influence the patient＇s decision on treatment.

关键词： hepatitis C interferon ribavirin

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Chemical colitis caused by hydrogen peroxide vaginal douche: A case report

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World Journal of Gastrointestinal Endoscopy 2019年第9期11卷 486-490页

作者： Ahmed Baiomi Harish Patel hafsa Abbas Vamshidhar Vootla Jasbir Makker Department of Medicine Division of GastroenterologyBronx Care Health System1650 Selwyn AveBronxNY 10457United States Western Maryland Health System 12500 Willowbrook RdCumberlandMD 21502United States

BACKGROUND Hydrogen peroxide is one of the most common household disinfectants *** peroxide has been documented as a rare cause of chemical *** SUMMARY We present a case of 31 years old lady who presented to our hospital with rectal bleeding and abdominal pain after using hydrogen peroxide vaginal douche as an *** underwent colonoscopy which showed findings suggestive of chemical colitis and was managed *** peroxide can induce chemical injury in the *** presentation and endoscopic findings of chemical colitis are *** taking is an important tool in identifying the underlying *** of literature showed few case reports,mostly were managed with oral antibiotics and conservative *** Chemical colitis is usually managed *** including perforation,stricture and peritonitis may happen and need aggressive treatment accordingly.

关键词： Chemical colitis Hydrogen peroxide Colitis Vaginal douche Colonoscopy Case report