A case of a patient infected with a hepatitis C virus genotype 3a multidrug resistant variant in Pakistan

作     者：Asad Zia Muhammad Ali Hafsa Aziz Muhammad Zia Zabta Khan Shinwari Abida Raza Zia Asad;Ali Muhammad;Aziz Hafsa;Zia Muhammad;Shinwari Zabta Khan;Raza Abida

作者机构：Department of BiotechnologyQuaid-i-Azam University IslamabadIslamabadPakistan Nuclear Oncology and Radiotherapy Institute(NORI)IslamabadPakistan National Institute of Lasers and Optronics(NILOP)Nanomedicine Research LabsIslamabadPakistan 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2018年第7卷第1期

页      面：123-128页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：AZ is supported by“Indigenous Ph.D.fellowship program”from the Higher Education Commission(HEC)of Pakistan 

主　　题：patient infected multidrug 

摘      要：Background:Approximately 10 million people in Pakistan are infected with the hepatitis C virus(HCV).Most patients develop chronic hepatitis,with rare cases of spontaneous ***,little is known about multidrug resistant viral variants in ***:This case study describes a 47-year-old male diagnosed with chronic HCV genotype 3a infection in *** an initial diagnosis of viral infection,the patient remained treatment naïve for 5 *** received two therapy cycles of interferon(IFN)plus ribavirin(RBV)in 2007 and 2010,however,he was non-responsive to the *** patient then received an additional two treatment cycles of pegylated IFNα-2b plus RBV(in 2011 and 2013);he was still *** 2016,the patient underwent sofosbuvir plus RBV combination therapy,however,the sustained virological response was still not *** host genetic factor was found to be heterozygous guanine and thymine(GT)and cytosine and thymine(CT)genotypes of rs8099917 and rs12979860 polymorphism of IL28B,*** analysis suggests that the resistant variant belong to an out-group and may require triple ***:This is the first case that reports on a HCV-infected individual who was a non-responder to multiple IFN therapies in *** studies are needed to understand multidrug-resistant HCV variants in the Pakistani population.