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Treatment and prognosis of hepatic epithelioid hemangioendothelioma based on SEER data analysis from 1973 to 2014

Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 29-35页

作者： O Kyu Noh Soon sun Kim Min Jae Yang sun Gyo Lim Jae Chul Hwang Hyo jung Cho Jae Youn Cheong sung Won Cho Department of Radiation Oncology Ajou University School of MedicineSuwonKorea Department of Biomedical Informatics Ajou University School of MedicineSuwonKorea Office of Biostatistics Ajou Research Institute for Innovative MedicineAjou University Medical CenterSuwonKorea Department of Gastroenterology Ajou University School of MedicineSuwonKorea

Background: Hepatic epithelioid hemangioendothelioma (HEH) is a rare tumor of vascular origin with an unknown etiology, a low incidence, and a variable natural course. We evaluated the management and prognosis of HEH from the Surveillance, Epidemiology and End Results (SEER) program and changes in treatment modalities of HEH over 30 years. Methods: From 1973 to 2014 in the SEER database, we selected patients diagnosed with HEH. We analyzed the clinical characteristics, patterns of management, and clinical outcomes of patients with HEH. Results: We identi ed 79 patients with HEH (median age: 54.0 years;male to female ratio: 1:2.6). The initial extent of disease was local in 22 (27.8%) patients, regional metastasis in 22 (27.8%), distant metas-tasis in 31 (39.2%) and unknown in 4 (5.1%). The median size of primary tumor was 3.85 cm (interquartile range, 2.50 7.93 cm). Among 74 patients with available management data, the most common manage-ment was no treatment (29/74, 39.2%), followed by chemotherapy only (22/74, 29.7%), liver resection-based (13/74, 17.6%), and transplantation-based therapy (6/74, 8.1%). The 5-year cancer-speci c survival rate was 57.8%. Patients who underwent surgical treatment had signi cantly higher survival than those who underwent non-surgical treatment (5-year survival;88% vs. 49%, P=0.019). Multivariate analysis revealed that surgical therapy was the only independent prognostic factor for survival (hazard ratio: 0.20, P=0.040). Conclusions: Resection or liver transplantation is worth considering for treatment of patients with HEH.

关键词： Hemangioendothelioma Epithelioid SEER program Liver transplantation Hepatectomy Liver neoplasms

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Study on the Amperometric Glucose Biosensor Based on Tin Oxide Electrode

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稀有金属材料与工程 2006年第A03期35卷 291-294页

作者： Cheng-Wei Liao jung-Chuan Chou Tai-Ping sun Shen-Kan Hsiung Jui-Hsiang Hsieh Institute of Biomedical Engineering Chung Yuan Christian University Chung-Li Taiwan 320 China Graduate School of Electronic Engineering National Yunlin University of Science and Technology Douliou Taiwan 640 China Department of Electrical Engineering National Chi Nan University Nantou Taiwan 545 China Institute of Electronic Engineering Chung Yuan Christian University Chung-Li Taiwan 320 China

An amperometric glucose biosensor based on a tin oxide (SnO_2) electrode has been *** SnO_2 electrode is prepared by depositing the SnO_2 thin film onto a carbon *** fabricate the SnO_2 amperometric glucose biosensor,the glucose oxidase and electron transfer mediator (ferrocenecarboxylic acid,FcA) are coimmobilized on the SnO_2 electrode using *** detection range is up to glucose concentration of 520mg/dl as the applied potential is set at 300mV. Moreover,the most merit for the SnO_2 electrode as the base electrode of the SnO_2 amperometric glucose biosensor is that it can be operated at 150mV constant applied *** interference reduction,detection range,sensitivity and linearity are improved as the SnO_2 thin film is deposited onto a carbon ***,due to the low cost substrate and simple fabrication characteristics,a disposable amperometric glucose biosensor based on the SnO_2 electrode has been realized in this study.

关键词： amperometric glucose oxidase tin oxide carbon mediator

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Associations between walking parameters and subsequent sleep difficulty in older adults: A 2-year follow-up study

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Journal of Sport and Health Science 2018年第1期7卷 95-101页

作者： Li-jung Chen Kenneth R.Fox Wen-jung sun Pei-Shu Tsai Po-Wen Ku Dachen Chu Department of Exercise Health Science Taiwan University of Sport Department of Epidemiology and Public Health University College London Centre for Exercise Nutrition and Health Sciences University of Bristol Family Medicine Department Taipei City Hospital Zhongxing Branch Graduate Institute of Translation and Interpretation Changhua University of Education Graduate Institute of Sports and Health Changhua University of Education Department of Neurosurgery Taipei City Hospital and Institute of Public Health and Community Medicine Research Center Yang-Ming University

Purpose: This 2-year follow-up study aimed to examine the associations between total volume, frequency, duration, and speed of walking with subsequent sleep difficulty in older ***: A total of 800 older adults aged 65 years and over participated in the first survey in 2012 and 511 of them were followed 2 years *** 5-item Athens Insomnia Scale(AIS-5) was used to measure sleep difficulty. Frequency, duration, and speed of outdoor walking were self-reported. Walking speed was assigned a metabolic equivalent value(MET) from 2.5 to 4.5. Total walking volume in MET-h/week was calculated as frequency × duration × speed. Negative binomial regressions were performed to examine the associations between volume and components of walking with subsequent sleep difficulty with covariates of age, sex, education, marital status, living arrangement, smoking, alcohol consumption, mental health, Charlson Index, exercise(excluding walking), and sleep difficulty at ***: Participants with low walking volume had a higher level of sleep difficulty 2 years later compared with those with high walking volume(incident rate ratios = 1.61, p = 0.004). When speed, frequency, and duration of walking were simultaneously entered into 1 model, only walking speed was significantly associated with subsequent sleep difficulty(after the model was adjusted for covariates and baseline sleep difficulty).Sensitivity analyses showed that walking duration emerged as a significant predictor among 3 walking parameters, with 2-year changes of sleep scores as dependent ***: Total amount of walking(especially faster walking and lasting for more than 20 min) is associated with less subsequent sleep difficulty after 2 years among older adults.

关键词： Disturbed sleep Exercise Insomnia Physical activity Prospective study Sleep disorder

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Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim So-Young Park Chulhwan Kwak Yoonji Lee Dae-Geun Song Jae Woo jung haesong Lee Eun-Ae Shin Yangie Pinanga Kyung-hee Pyo Eun hae Lee Wonsik Kim Soyeon Kim Chang-Duck Jun Jeanho Yun sun Choi Hyun-Woo Rhee Kwang-Hyeon Liu jung Weon Lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

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Kinematic analysis of a humanoid robot CHP-1 and selection of motors in consideration of cooperative motion

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Journal of Central South University 2012年第11期19卷 3094-3099页

作者： KIM Do-un HWANG Sang-wook KANG Hyo-jung HONG Dae sun School of Mechatronics Changwon National UniversityChangwon 641-773Korea

A lower-part humanoid robot CHP-1 with 12 degree-of-freedom of motion has been developed for cooperative motion,such as pushing or lifting an *** capability of the robot is mainly dependent on the performance of the motors,thus the motors need to be properly *** the purpose,the kinematics of the robot was analyzed,and a number of simulations for two kinds of cooperative motions were carried *** torques required at each motor of the robot under external forces were ***,the external forces were also estimated through simulation and literature *** the basis of the torques found,the selection of motors was finally suggested,and the motors are to be installed to the humanoid robot.

关键词： humanoid robot motor selection cooperative motion kinematics

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Purtscher-like retinopathy with macular ischemia as the initial presentation of Behcet's disease

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 520-522页

作者： Min Ho Shin Woong sun Yoo Ji sung jung In Young Chung Department of Ophthalmology Chosun University HospitalGwangju 61453Republic of Korea Department of Ophthalmology Gyeongsang National University HospitalJinju 52727Republic of Korea

Dear Editor,We would like to present a case report of Purtscher-like retinopathy (PLR) with macular ischemia as the initial presentation of Behcet’s disease (BD).

关键词： ischemia Behcet macular

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Adrenal lymphangioma masquerading as a pancreatic tail cyst

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World Journal of Gastroenterology 2014年第36期20卷 13195-13199页

作者： hae Il jung Taesung Ahn Myoung Won Son Zisun Kim Sang Ho Bae Moon Soo Lee Chang Ho Kim Hyon Doek Cho Department of Surgery Soonchunhyang University Cheonan Hospital Cheonan 330-721South Korea Department of Surgery Soonchunhyang Universit Bucheon Hospital Bucheon 420-767 South Korea Department of Pathology Soonchunhyang University Cheonan Hospital Cheonan 330-721 South Korea

Cystic lymphangiomas of the adrenal gland are rare. A 79-year-old female presented in the emergency room with epigastric discomfort, and an immovable mass was palpated in her abdomen upon physical examination. Imaging studies revealed a large cystic lesion in the pancreatic tail. The radiologic impression ruled out the possibility of a mucinous cystic neoplasm, or a pseudocyst in the pancreas. The operative findings demonstrated that the cystic mass originated in the left adrenal gland. A laparoscopic excision of the cystic mass was performed, and immunohistochemistry confirmed that this mass was a lymphangioma of the adrenal gland. Several prior reports have suggested that lymphangioma can mimic renal or splenic cysts. However, lymphangioma cases mimicking pancreatic cysts are very rare.

关键词： Lymphangioma Adrenal gland Pancreas Cyst Mucinous neoplasm

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Citizens’Mental Health Issues and Psychological Trauma Experience due to a Crowd-Crush Disaster in Korea

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International Journal of Mental Health Promotion 2024年第6期26卷 439-447页

作者： Yun-jung Choi Jae-Won Kwak hae-In Namgung Red Cross College of Nursing Chung-Ang UniversitySeoul06974South Korea Graduate School of Nursing and Professions Chung-Ang UniversitySeoul06974South Korea Nursing Department Graduate School of Chung-Ang UniversitySeoul06974South Korea

This study evaluated the state of anxiety, depression, post-traumatic stress disorder, general mental health, and mental well-beingamong citizens after a crowd-crush disaster in Korea. Individuals who experienced the crowd crush had significantly higheranxiety, depression, and post-traumatic stress disorder (PTSD) scores than those who did not (p < 0.001). Additionally,people who avoided the disaster area had significantly higher depression and PTSD scores than those who did not avoid thearea (p < 0.001). Those who directly witnessed the Seoul Halloween crowd crush had a significant difference in PTSD levels ineither group than those who experienced it indirectly (p = 0.005). There was a significant difference in PTSD scores in cases ofdirect damage or death of an acquaintance (p < 0.001). The Seoul Halloween crowd crush caused psychological damagethrough indiscriminate exposure to the public, and symptoms of PTSD appeared over a long period. It is crucial to provideessential resources for ongoing treatment and case management.

关键词： Anxiety avoidance depression disaster experience mental health PTSD psychological trauma

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Contrast-enhanced ultrasonography for the evaluation of liver fibrosis after biliary obstruction

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World Journal of Gastroenterology 2015年第9期21卷 2614-2621页

作者： Hyun Joo Shin Eun Young Chang Hye sun Lee jung Hwa Hong Gyuri Park Hyun Gi Kim Myung-Joon Kim Mi-jung Lee Department of Radiology and Research Institute of Radiological Science Severance Children’s HospitalYonsei University College of MedicineSeoul 120-752South Korea Department of Pediatric Surgery Severance Children’s HospitalYonsei University College of MedicineSeoul 120-752South Korea Biostatistics Collaboration Unit Yonsei University College of MedicineSeoul 120-752South Korea Department of Laboratory Animal Resources Avison Bio Medical Research CenterYonsei University College of MedicineSeoul 120-752South Korea

AIM:To investigate perfusion change in contrastenhanced ultrasonography(CEUS) to evaluate liver fibrosis based on biliary obstruction using an animal ***:New Zealand white rabbits(3-4 kg) underwent bile duct ligation to form a biliary obstruction *** performed liver CEUS and laboratory tests on the day before the operation(day 0) and every 7 postoperative days until the rabbits were *** CEUS,signal intensity of liver parenchyma with a time-intensity curve was *** parameters were automatically calculated from regionof-interests,including peak signal intensity,mean transit time,area under the curve and time to *** grades of liver fibrosis were assessed according to the Metavir score system immediately after *** estimating equations were used to analyze the association between liver fibrosis grades and perfusion parameters for statistical *** perfusion parameters were measured on the last day and the difference between day 0 and the last day were ***:From the nine rabbits,histological grades of liver fibrosis were grade 1 in one rabbit,grade 2 and 3 in three rabbits each,and grade 4 in two *** the four CEUS parameters,only the peak signal intensity measured on the last day demonstrated a significant association with liver fibrosis grades(OR =1.392,95%CI:1.114-1.741,P =0.004).The difference in peak signal intensity between day 0 and the last dayalso demonstrated an association with liver fibrosis(OR =1.191,95%CI:0.999-1.419,P =0.051).The other parameters tested,including mean transit time,area under the curve,and time to peak,showed no significant correlation with liver fibrosis ***:This animal study demonstrates that CEUS can be used to evaluate liver fibrosis from biliary obstruction using peak signal intensity as a parameter.

关键词： Ultrasonography Contrast enhanced ultrasound Liver

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Helicobacter pylori and interleukin-8 in gastric cancer

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World Journal of Gastroenterology 2013年第45期19卷 8192-8202页

作者： Ko Eun Lee Pham Ngoc Khoi Yong Xia jung sun Park Young Eun Joo Kyung Keun Kim Seok Yong Choi Young Do jung Research Institute of Medical Sciences Chonnam National University Medical School Gwangju 501-190 South Korea

Helicobacter pylori(***)is a major etiological factor in the development of gastric ***-scale epidemiological studies have confirmed the strong association between *** infection and both cancer development and ***-8(IL-8)is overexpressed in gastric mucosa exposed to *** expression of IL-8 directly correlates with a poor prognosis in gastric ***-8 is *** addition to its potent chemotactic activity,it can induce proliferation and migration of cancer *** this review,we focus on recent insights into the mechanisms of IL-8 signaling associated with gastric *** relationship between IL-8 and *** is *** also summarize the current therapeutics against IL-8 in gastric cancer.

关键词： Helicobacter pylori Interleukin-8 Signals Gastric cancer Therapeutics

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