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An Atypical Ovarian and Peritoneal Pelvic Tuberculosis Complicated by Toxidermia

Case Reports in Clinical Medicine 2023年第8期12卷 261-269页

作者： Ndeye Amy Sarr Daouda Thioub Agbogbenkou Tevi Déla Lawson Khalifa Ababacar Mansour Fall haby dione Kane Sylvie Audrey Diop Service des Maladies infectieuses et tropicales de l’hô pital Abdoul Aziz Sy Dabakh de Tivaouane Tivaouane Sénégal Service gynécologie et obstétrique de l’hô pital Abdoul Aziz sy Dabakh de Tivaouane Tivaouane Sénégal Service dermatologie de l’hô pital Abdoul Aziz sy Dabakh de Tivaouane Tivaouane Sénégal

Background: Ovarian tuberculosis is a rare form of tuberculosis. Its clinical presentation mimics an ovarian tumor, leading to misdiagnosis. Proper treatment with anti-tuberculosis drugs can lead to a cure for the disease but can sometimes cause adverse effects that compromise therapeutic management. Observation: We report a 71-year-old female Senegalese patient who presented with a chronic abdominopelvic mass with an elevated Cancer Antigen 125 (CA125) level, raising the suspicion of an ovarian tumor. She underwent an exploratory laparotomy and the anatomopathological study confirmed the diagnosis of ovarian and peritoneal tuberculosis. After starting treatment with anti-tuberculosis drugs, she developed toxidermia in the form of generalized urticaria. Discontinuation of the four-drug therapy and separate reintroduction of anti-tuberculosis drugs led to the incrimination of rifampicin. Progress was then favorable on Isoniazid (H) pyrazinamide (Z) and Ethambutol (E). Conclusion: Ovarian tuberculosis should be suspected in the presence of an abdominopelvic mass in a woman living in an endemic area. The occurrence of adverse reactions to anti-tuberculosis treatment is not uncommon, hence the importance of regular monitoring.

关键词： Ovarian Peritoneal Tuberculosis Toxidermia Senegalese

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Evaluation of Early Warning Indicators of ARV Resistance to HIV in the Hospital of Tivaouane from 2008 to 2016

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Advances in Infectious Diseases 2018年第2期8卷 54-63页

作者： Agbogbenkou Tévi Déla-dem Lawson Ndeye Astou Lakhe haby dione Papa Souleymane Toure Mamadou Ba Ndeye Biram Niang Bernard Marcel Diop Sylvie Audrey Diop-Nyafouna Department of Health Thies University Thies Senegal Infectious and Tropical Diseases Department Fann Teaching University Hospital Dakar Senegal

Introduction: HIV resistance to antiretroviral is currently a global concern, and requires increased surveillance in a context of widespread ARV treatment. Objective: To evaluate early warning indicators of HIV resistance to ARVs in the Hospital of Tivaouane (Senegal) where viral load was not routinely available. Methods: This is a cross-sectional retrospective study from 2008-2016. The etraction tool (May 2010 version) was used to analyze the EWI. Results: We collected 360 HIV positive patients followed on average for 3.57 years ± 3.02. 2009, 2010 and 2012 recorded 100% ARV prescribing rates. Throughout the study period, the percentage of patients lost to follow-up during the first 12 months of treatment was less than 20%. Virtually, all patients were still under primary ARVT over 12-month treatment. All patients (100%) withdrew their ARV drugs on time. No stock storage regarding various classes of ARVs was noted during the study period. Conclusion: At the end of this study we recommend to maintain regular follow-up of EWI, and combine it with the achievement of viral load.

关键词： HIV Resistance EWI Tivaouane

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