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Team players in the pathogenesis of metabolic dysfunctionsassociated steatotic liver disease:The basis of development of pharmacotherapy

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World Journal of Gastrointestinal Pathophysiology 2024年第4期15卷 1-29页

作者： Shahid habib Department of Hepatology Liver Institute PLLCTucsonAZ 85712United States

Nutrient metabolism is regulated by several *** determinants of health with or without genetics are the primary regulator of metabolism,and an unhealthy lifestyle affects all modulators and mediators,leading to the adaptation and finally to the exhaustion of cellular *** steatosis is defined by presence of fat in more than 5%of *** hepatocytes,fat is stored as triglycerides in lipid *** steatosis results from a combination of multiple intracellular *** a healthy individual nutrient metabolism is regulated at several *** ranges from the selection of nutrients in a grocery store to the last step of consumption of ATP as an energy or as a building block of a cell as structural *** hormones,peptides,and genes have been described that participate in nutrient *** enzymes participate in each nutrient metabolism as described above from ingestion to generation of *** of now several publications have revealed very intricate regulation of nutrient metabolism,where most of the regulatory factors are tied to each other bidirectionally,making it difficult to comprehend chronological sequence of *** hormone is the primary regulator of all nutrients’metabolism both in prandial and fasting *** exerts its effects directly and indirectly on enzymes involved in the three main cellular function processes;metabolic,inflammation and repair,and cell growth and *** regulators that control the enzymatic functions through stimulation or suppression of a cell are nuclear receptors in especially farnesoid X receptor and peroxisome proliferator-activated receptor/RXR ligands,adiponectin,leptin,and *** hormone has direct effect on these final *** blood glucose level,serum lipids,incretin hormones,bile acids in conjunction with microbiota are intermediary modulators which are controlled by *** purpose of this review is to overvi

关键词： Metabolic dysfunctions-associated steatotic liver disease Visceral adiposity Obesity Farnesoid X receptor Peroxisome proliferator-activated receptor Insulin Adiponectin Glucagon-like peptide-1 Genetics PNPLA3 TM6SF2 Diabetes Dyslipidemia Pathogenesis

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Posture Detection of Heart Disease Using Multi-Head Attention Vision Hybrid(MHAVH)Model

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Computers, Materials & Continua 2024年第5期79卷 2673-2696页

作者： Hina Naz Zuping Zhang Mohammed Al-habib Fuad A.Awwad Emad A.A.Ismail Zaid Ali Khan School of Computer Science and Engineering Central South UniversityChangsha410003China Department of Quantitative analysis College of Business AdministrationKing Saud UniversityP.O.Box 71115Riyadh11587Saudi Arabia Electrical and Computer Engineering University of VictoriaVictoriaV9A1B8Canada

Cardiovascular disease is the leading cause of death *** disease causes loss of heart muscles and is also responsible for the death of heart cells,sometimes damaging their functionality.A person’s life may depend on receiving timely assistance as soon as ***,minimizing the death ratio can be achieved by early detection of heart attack(HA)*** the United States alone,an estimated 610,000 people die fromheart attacks each year,accounting for one in every four ***,by identifying and reporting heart attack symptoms early on,it is possible to reduce damage and save many lives *** objective is to devise an algorithm aimed at helping individuals,particularly elderly individuals living independently,to safeguard their *** address these challenges,we employ deep learning *** have utilized a vision transformer(ViT)to address this ***,it has a significant overhead cost due to its memory consumption and computational complexity because of scaling dot-product ***,since transformer performance typically relies on large-scale or adequate data,adapting ViT for smaller datasets is more *** response,we propose a three-in-one steam model,theMulti-Head Attention Vision Hybrid(MHAVH).Thismodel integrates a real-time posture recognition framework to identify chest pain postures indicative of heart attacks using transfer learning techniques,such as ResNet-50 and VGG-16,renowned for their robust feature extraction *** incorporatingmultiple heads into the vision transformer to generate additional metrics and enhance heart-detection capabilities,we leverage a 2019 posture-based dataset comprising RGB images,a novel creation by the author that marks the first dataset tailored for posture-based heart attack *** the limited online data availability,we segmented this dataset into gender categories(male and female)and conducted testing on both segmented and original dat

关键词： Image analysis posture of heart attack(PHA)detection hybrid features VGG-16 ResNet-50 vision transformer advance multi-head attention layer

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Metabolic dysfunction-associated steatotic liver disease heterogeneity: Need of subtyping

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World Journal of Gastrointestinal Pathophysiology 2024年第2期15卷 1-14页

作者： Shahid habib Department of Hepatology Liver Institute PLLCTucsonAZ 85716United States

Metabolic dysfunction-associated steatotic liver disease(MASLD)is a widespread global disease with significant health *** lifestyle,obesity,diabetes mellitus(DM),insulin resistance,and genetics have been implicated in the pathogenesis of MASLD.A significant degree of heterogeneity exists among each of above-mentioned risk *** of these risk factors translates into the heterogeneity of *** the other hand,MASLD can itself lead to insulin resistance and *** heterogeneity makes it difficult to assess the natural course of an individual with MASLD in clinical *** present MASLD is considered as one disease despite the variability of etiopathogenic processes,and we lack the consensus definitions of unique subtypes of *** this review,pathogenic processes of MASLD are discussed and a need of subtyping is recommended.

关键词： Metabolic dysfunctions-associated steatotic liver disease Visceral obesity Genetics Diabetes Insulin resistance

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Efficient and Cost-Effective Vehicle Detection in FoggyWeather for Edge/Fog-Enabled Traffic Surveillance and Collision Avoidance Systems

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Computers, Materials and Continua 2024年第1期81卷 911-931页

作者： Raza, Naeem habib, Muhammad Asif Ahmad, Mudassar Abbas, Qaisar Aldajani, Mutlaq B. Latif, Muhammad Ahsan Department of Computer Science National Textile University Faisalabad 37610 Pakistan College of Computer and Information Sciences Imam Mohammad Ibn Saud Islamic University (IMSIU) Riyadh 11432 Saudi Arabia Department of Computer Science University of Agriculture Faisalabad 38000 Pakistan

Vision-based vehicle detection in adverse weather conditions such as fog, haze, and mist is a challenging research area in the fields of autonomous vehicles, collision avoidance, and Internet of Things (IoT)-enabled edge/fog computing traffic surveillance and monitoring systems. Efficient and cost-effective vehicle detection at high accuracy and speed in foggy weather is essential to avoiding road traffic collisions in real-time. To evaluate vision-based vehicle detection performance in foggy weather conditions, state-of-the-art Vehicle Detection in Adverse Weather Nature (DAWN) and Foggy Driving (FD) datasets are self-annotated using the YOLO LABEL tool and customized to four vehicle detection classes: cars, buses, motorcycles, and trucks. The state-of-the-art single-stage deep learning algorithms YOLO-V5, and YOLO-V8 are considered for the task of vehicle detection. Furthermore, YOLO-V5s is enhanced by introducing attention modules Convolutional Block Attention Module (CBAM), Normalized-based Attention Module (NAM), and Simple Attention Module (SimAM) after the SPPF module as well as YOLO-V5l with BiFPN. Their vehicle detection accuracy parameters and running speed is validated on cloud (Google Colab) and edge (local) systems. The mAP50 score of YOLO-V5n is 72.60%, YOLOV5s is 75.20%, YOLO-V5m is 73.40%, and YOLO-V5l is 77.30%; and YOLO-V8n is 60.20%, YOLO-V8s is 73.50%, YOLO-V8m is 73.80%, and YOLO-V8l is 72.60% on DAWN dataset. The mAP50 score of YOLO-V5n is 43.90%, YOLO-V5s is 40.10%, YOLO-V5m is 49.70%, and YOLO-V5l is 57.30%; and YOLO-V8n is 41.60%, YOLO-V8s is 46.90%, YOLO-V8m is 42.90%, and YOLO-V8l is 44.80% on FD dataset. The vehicle detection speed of YOLOV5n is 59 Frame Per Seconds (FPS), YOLO-V5s is 47 FPS, YOLO-V5m is 38 FPS, and YOLO-V5l is 30 FPS; and YOLO-V8n is 185 FPS, YOLO-V8s is 109 FPS, YOLO-V8m is 72 FPS, and YOLO-V8l is 63 FPS on DAWNdataset. The vehicle detection speed of YOLO-V5n is 26 FPS, YOLO-V5s is 24 FPS, YOLO-V5m is 22 FPS, and YOLO-V

关键词： Fog computing

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Xinjiang Blossoming Under Rule of Law

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Beijing Review 2024年第37期67卷 20-21页

作者： Yasir habib Khan Pakistan's Institute of International Relations and Media Research

Contrary to the West's false and misleading information regarding repression of Uygur Muslims in Xinjiang Uygur Autonomous Region,Islam is blossoming with all its religious colors and traditional fashion under the *** is an eye-witness observation of a nine-member Pakistani media delegation that visited Urumqi and Yining cities from August 19 to *** delegation visited the Xinjiang Counter-Terrorism and Counter-Extremism Exhibition,Xinjiang Islamic Institute(XII),Xinjiang Art Theater Muqam Art Troupe,Xinjiang International Grand Bazaar,Shaanxi Mosque and other places.

关键词： Xinjiang delegation religious

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MicroRNAs modulation in lung cancer: exploring dual mechanisms and clinical prospects

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BIOCELL 2024年第3期48卷 403-413页

作者： SHAHID HUSSAIN habib BOKHARI XINGXING FAN SHAUKAT IQBAL MALIK SUNDAS IJAZ MUHAMMAD ADNAN SHEREEN AIMAN FATIMA Department of Biotechnology Kohsar University MurreeMurreePakistan Macao University of Science and Technology State Key Laboratory of Quality Research in Chinese Medicines TaipaMacao Department of Bioinformatics and Biosciences Capital University of Science and TechnologyIslamabadPakistan Department of Microbiology Kohsar University MurreeMurreePakistan

The global incidence of lung cancer is marked by a considerably elevated mortality ***(miRNAs)exert pivotal inﬂuence in the intricate orchestration of gene regulation,and their dysregulation can precipitate dire consequences,notably *** this context,miRNAs encapsulated in exosomes manifest a diversiﬁed impact on the landscape of lung cancer,wherein their actions may either foster angiogenesis,cell proliferation,and metastasis,or counteract these *** comprehensive review article discerns potential targets for the prospective development of therapeutic agents tailored for lung ***-suppressive miRNAs,such as miR-204,miR-192,miR-30a,miR-34a,miR-34b,miR-203,and miR-212,exhibit heightened expression and demonstrate the capacity to inhibit cellular proliferation and ***,the deleterious effects of tumor-promoting miRNAs like miR-21,miR-106a,miR-155,miR-205,and miR-210 can be attenuated through the application of their respective *** miRNAs selectively target various oncogenes,including NUAK Family Kinase 1(NUAK1),Snail Family Transcriptional Repressor 1(Snai1),Astrocyte elevated gene-1(AEG-1),Vimentin,Proliferation and apoptosis adaptor protein 15(PEA-15/PED),Hypoxia-inducible factor 1-alpha(HIF1),as well as tumor suppressor genes such as phosphatase and tensin homolog(PTEN),Suppressor of cytokine signaling 1(SOCS1),Tumor protein P53 binding protein 1(TP53BP1),and PH Domain and Leucine Rich Repeat Protein Phosphatase 2(PHLP22).This investigative approach proves invaluable in elucidating the speciﬁc miRNAs implicated in the deregulation of crucial genes pivotal to the pathogenesis of cancer.

关键词： miRNAs Oncogenes Tumor suppressive genes Lung cancer therapy

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Heavy metal contamination and health risk assessment of road dust from landfills in Dhaka-Narayanganj, Bangladesh

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Emerging Contaminants 2024年第1期10卷 117-125页

作者： Mrittika Chakraborty Md Masudur Rahman Rahat Tasrina Rabia Choudhury Refayat Nigar Guorui Liu Ahsan habib Department of Chemistry University of DhakaDhaka1000Bangladesh Analytical Chemistry Laboratory Chemistry DivisionAtomic Energy Centre Dhaka Bangladesh Atomic Energy CommissionDhaka1000Bangladesh State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental ScienecsChinese Academy of SciencesBeijing100085China

In the recent years,air pollution has become an alarming issue for human health in many rapidly growing megacities including Dhaka and ***,pollution status and health risk have been assessed by the road dusts collected from landfills in Dhaka and Narayanganj through determination of heavy metals including Pb,Cd,Cr,As,Cu,Ni,Zn and Mn using atomic absorption *** collected dust samples have been grouped into three sizes,for example,150,75 and<75μm,to assess the degree of heavy metal accumulation in the dust *** dust particles were accumulated with high concentrations of Pb and As at Matuail landfills,whereas Cd,Cr,Zn,and Mn concentrations were highest at Narayanganj *** finer particles,for example 75μm,accumulated substantial concentrations of heavy *** index and pollution load index(PLI)results revealed that all of the sites were deteriorated by Pb,Cd,Cu,Zn and *** results exhibited that the quality of the Matuail landfill area was severely *** terms of non-carcinogenic health risk,the values of hazard quotient for ingestion were greater than those for inhalation and dermal *** adult groups,hazard index values for the Matuail landfills and medical waste incineration sites were greater than 1,while for the children groups,the values for the same areas,including the Narayanganj landfills,were also larger than *** values were at least one order of magnitude higher for the children groups than for the adult *** the results,it would be reasonable to draw the conclusion that non-carcinogenic health risks for children may be more prevalent in the relevant areas.

关键词： Road dusts Heavy metals Landfills Bangladesh Degree of accumulation Health risk assessment

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Screening legacy and emerging organic pollutants in the contaminated soil of Dhaka,Bangladesh

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Emerging Contaminants 2024年第3期10卷 343-353页

作者： Refayat Nigar Shizhen Zhao Xin Liu Huanfang Huang Lele Tian Yuwei Xiao Ahsan habib Gan Zhang State Key Laboratory of Organic Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou510640China Guangdong-Hong Kong-Macao Joint Laboratory for Environmental Pollution and Control and Guangdong Provincial Key Laboratory of Environmental Protection and Resources Utilization Guangzhou510640China Anti-Drug Technology Center of Guangdong Province and National Anti-Drug Laboratory Guangdong Regional Center Guangzhou510230China State Environmental Protection Key Laboratory of Water Environmental Simulation and Pollution Control South China Institute of Environmental SciencesMinistry of Ecology and EnvironmentGuangzhou510530China Department of Chemistry University of DhakaDhaka1000Bangladesh University of Chinese Academy of Sciences Beijing100049China

The current understanding of the legacy and emerging organic pollutants in the soil of Bangladesh remains *** disposal practices,particularly in e-waste,landfills,and industrial operations,may lead to the pervasive presence of persistent organic pollutants(POPs)and polycyclic aromatic hydrocarbons(PAHs)in the *** study aimed to systematically investigate the concentrations,sources,and risk assessment of halogenated flame retardants(HFRs),polychlorinated biphenyls(PCBs),polychlorinated naphthalenes(PCNs),organochlorine pesticides(OCPs),chlorinated paraffins(CPs),and PAHs in the contaminated soil of Dhaka's dumpsites,e-waste,and industrial areas collected in *** total concentration of investigated pollutants averaged at 4790±4040 ng g^(-1)dw,with the following order:P44CPs(4110±4140 ng g^(-1)dw)>P16PAHs(422±491 ng g^(-1)dw)>P16HFRs(190±538 ng g^(-1)dw)>P209PCBs(43.5±73.5 ng g^(-1)dw)>P50PCNs(17.7±21.0 ng g^(-1)dw)>P27OCPs(9.41±9.61 ng g^(-1)dw).The e-waste site exhibited the highest total concentration of the target pollutants,reaching 12,700 ng g1 *** were the predominant contributors,accounting for averages of 81.8%,70.5%,and 68.5%to waste landfills,e-waste,and industrial sites,respectively.A comprehensive analysis of 209 PCB congeners revealed their primary origin from Aroclor PCBs,with minor contributions from unintentionally produced *** highest incremental lifetime carcinogenic risk(ILCR)occurred in e-waste sites,contributed by dioxin-like PCBs,with a maximum value of 5.9×10^(-5)for adults,exceeding the limit 1.0×10^(-6)set by the *** non-carcinogenic hazard quotients(HQs)were much lower,suggesting no significant risk from the investigated *** findings highlight the importance of proper waste management and regulated e-waste recycling to mitigate potential hazardous risks to the Bangladeshi population.

关键词： Persistent organic pollutants Polycyclic aromatic hydrocarbons Chlorinated paraffins Polychlorinated biphenyls Risk assessment Contaminated soil Bangladesh

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Predictive modelling of volumetric and Marshall properties of asphalt mixtures modified with waste tire-derived char:A statistical neural network approach

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Journal of Road Engineering 2024年第3期4卷 318-333页

作者： Nura Shehu Aliyu Yaro Muslich Hartadi Sutanto Noor Zainab habib Aliyu Usman Abiola Adebanjo Surajo Abubakar Wada Ahmad Hussaini Jagaba Department of Civil and Environmental Engineering Universiti Teknologi PETRONASSeri Iskandar 32610Malaysia Department of Civil Engineering Ahmadu Bello UniversityZaria 810107Nigeria Institute of Infrastructure and Environment Heriot-Watt UniversityDubai 294345United Arab Emirates School of Civil Engineering Central South UniversityChangsha 410075China Interdisciplinary Research Centre for Membranes and Water Security King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia

The goals of this study are to assess the viability of waste tire-derived char(WTDC)as a sustainable,low-cost fine aggregate surrogate material for asphalt mixtures and to develop the statistically coupled neural network(SCNN)model for predicting volumetric and Marshall properties of asphalt mixtures modified with *** study is based on experimental data acquired from laboratory volumetric and Marshall properties testing on WTDCmodified asphalt mixtures(WTDC-MAM).The input variables comprised waste tire char content and asphalt binder *** output variables comprised mixture unit weight,total voids,voids filled with asphalt,Marshall stability,and *** coupled neural networks were utilized to predict the volumetric and Marshall properties of asphalt *** predictive modeling,the SCNN model is employed,incorporating a three-layer neural network and preprocessing techniques to enhance accuracy and *** optimal network architecture,using the collected dataset,was a 2:6:5 structure,and the neural network was trained with 60%of the data,whereas the other 20%was used for cross-validation and testing *** network employed a hyperbolic tangent(tanh)activation function and a feed-forward *** to the results,the network model could accurately predict the volumetric and Marshall *** predicted accuracy of SCNN was found to be as high value>98%and low prediction errors for both volumetric and Marshall *** study demonstrates WTDC's potential as a low-cost,sustainable aggregate *** SCNN-based predictive model proves its efficiency and versatility and promotes sustainable practices.

关键词： Waste tire Neural network Sustainable practices Asphalt mixtures Predictive model

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Analysis of the Impact of the Blazhko Effect Both on the Van Hoof Effect and Radial Velocity Amplitude in the Star RR Lyr

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Research in Astronomy and Astrophysics 2024年第6期24卷 253-272页

作者： Y.El jariri F.L.Sefyani A.Benhida Z.Benkhaldoun K.Kolenberg K.Chafouai A.habib M.Sabil Observatoire de l'Oukaimeden LPHEAFSSMUniversitéCadi AyyadMarrakech2390Morocco Observatoire de l'Oukaimeden LPHEAFSTGUniversitéCadi AyyadMarrakech549Morocco Département de physique Universitéd'Anvers Avenue Groenenborger 171Anvers2020Belgium LICPM ENSA-BMUniversitéSultan Moulay SlimaneBeni-Mellal23020Morocco

The Van Hoof effect is a phase shift existing between the radial velocity curves of hydrogen and metallic lines within the atmosphere of pulsating *** this article,we present a study of this phenomenon through the spectra of the brightest pulsating star RR Lyr of RR Lyrae stars recorded for 22 *** based ourselves,on the one hand,on 1268 spectra(41 nights of observation)recorded between the years 1994 and 1997 at the Observatory of Haute Provence(OHP,France)previously observed by Chadid and Gillet,and on the other hand on 1569 spectra(46nights of observation)recorded at our Oukaimeden Observatory(Morocco)between 2015 and *** this study,we have detected information on atmospheric dynamics that had not previously been ***,the Van Hoof effect which results in a clear correlation between the radial velocities of hydrogen and those of the metallic lines has been observed and analyzed at different Blazhko phases.A correlation between the radial velocities of different metallic lines located in the lower atmosphere has been observed as *** the first time,we were able to show that the amplitude of the radial velocity curves deduced from the lines of hydrogen and that of FeⅡ(λ4923.921?)increases toward the minimum of the Blazhko cycle and decreases toward the maximum of the same Blazhko ***,we found that the Van Hoof effect is also modulated by the Blazhko ***,toward the minimum of the Blazhko cycle the Van Hoof effect is more visible and at the maximum of the Blazhko cycle,this effect is *** also observed the temporal evolution of the amplitudes of the radial velocities of the lower and upper *** observed over a long time,we can interpret it as a function of the Blazhko phases.

关键词： stars:atmospheres stars:variables:RR Lyrae shock waves techniques:spectroscopic techniques:radial velocities stars:individual(RR Lyr)

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