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Genes & Diseases 2024年第2期11卷 512-515页

作者： June-ha shin Hwa-Ryeon Kim Jae-seok Roe Department of Biochemistry College of Life Science and BiotechnologyYonsei UniversitySeoul 120-749Republic of Korea

Tumor-protein 53(p53)is a transcription factor(TF)encoded by TP53(Trp53 in mice)and is a master regulator of tumor-suppressive programs'.Importantly,TP53 is the most frequently mutated gene in human cancer,and its loss of function contributes to tumor development,exemplified by variable p53 mutations detected in 50%-75%of pancreatic cancers.2 From these perceptions,a number of targets transcribed by p53 that confer tumor suppression have been ***,our understanding of how p53 prevents normal cells from initiating tumorigenesis is still *** complement this limitation,herein,we established a new approach to identify underlying effectors transcribed by p53 in normal physiology.

关键词： incomplete initiating herein

natural Convection of a Power-Law nanofluid in a square Cavity with a Vertical Fin

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Fluid Dynamics & materials Processing 2024年第9期20卷 2091-2108页

作者： Amira m’hadbi mohammed El Ganaoui haïkel Ben hamed Amenallah Guizani Khalid Chtaibi LERmAB Department of Transition and Energy Efficiency ProfessionsIUT H Poincaréde LongwyUniversity of LorraineLongwy54400France LPT Center for Energy Research and Technologies(Borj Cedria2084)University of Tunis El ManarTunis1068Tunisia LTI Department of Mechanical Engineering and ProductionIUTUniversity of Picardie Jules-VerneAmiens80025France

The behavior of non-Newtonian power-law nanofluids under free convection heat transfer conditions in a cooled square enclosure equipped with a heated fin is investigated *** particular,the impact of nanofluids,composed of water and Al_(2)O_(3),TiO_(2),and Cu nanoparticles,on heat transfer enhancement is *** aim of this research is also to analyze the influence of different parameters,including the Rayleigh number(Ra=10^(4)-10^(6)),nanoparticle volume fraction(φ=0%-20%),non-Newtonian power-law indexes(n=0.6-1.4),and fin dimensions(Ar=0.3,0.5,and 0.7).streamlines and isotherms are used to depict flow and related heat transfer *** indicate that thermal performance improves with increasing Rayleigh number,regardless of the nanoparticle type or nanofluid rheological *** suggests that the buoyancy force has a significant impact on heat transfer,particularly near the heat *** Nusselt number is more sensitive to variations in Cu nanoparticle volume fractions compared to Al₂O₃and TiO₂.moreover,the average Nusselt numbers for power-law nanofluids with n1)are greater(smaller)than for Newtonian fluids due to the decrease(increase)in viscosity with increasing(decreasing)shear rate,at the same values of Rayleigh number Ra owing to the amplification(attenuation)of the convective ***,the most substantial enhancement is observed with Cu-water shear-thinning nanofluid,where the Nusselt number increases by 136%when changing from Newtonian to shear thinning behavior and by 154.9%when adding 16%nanoparticle volume ***,an even larger increase of 57%in the average Nusselt number is obtained on increasing the fin length from 0.3 to 0.7.

关键词： Heat transfer nanofluid non-Newtonian fluid natural convection

Elasto-inertial microfluidic separation of microspheres with submicron resolution at high-throughput

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microsystems & nanoengineering 2024年第1期10卷 203-216页

作者： Hyunwoo Jeon song ha Lee Jongho shin Kicheol song nari Ahn Jinsoo Park Department of mechanical Engineering Chonnam National University77 Yongbong-ro Buk-guGwangju 61186Republic of Korea Analytical Engineering Team Samsung Display Co.Ltd.181 Samsung-roTangjeong-myeonAsan-siChungcheongnam-do 31454Republic of Korea

Elasto-inertial microfluidic separation offers many advantages including high throughput and separation *** though the separation efficiency highly depends on precise control of the flow conditions,no concrete guidelines have been reported yet in elasto-inertial ***,we propose a dimensionless analysis for precise estimation of the microsphere behaviors across the interface of Newtonian and viscoelastic *** number,modified Weissenberg number,and modified elastic number are used to investigate the balance between inertial and elastic lift *** on the findings,we introduce a new dimensionless number defined as the width of the Newtonian fluid stream divided by microsphere *** proposed dimensionless analysis allows us to predict whether the microspheres migrate across the co-flow *** theoretical estimation is found to be in good agreement with the experimental results using 2.1-and 3.2-μm-diameter polystyrene microspheres in a co-flow of water and polyethylene oxide *** on the theoretical estimation,we also realize submicron separation of the microspheres with 2.1 and 2.5μm in diameter at high throughput,high purity(>95%),and high recovery rate(>97%).The applicability of the proposed method was validated by separation of platelets from similar-sized Escherichia coli(***).

关键词： solution. separation estimation

malignant triton tumor in the abdominal wall:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1467-1473页

作者： Ho Jik Yang Donghyun Kim Won suk Lee sang-ha Oh Department of Plastic and Reconstructive surgery Chungnam National University Sejong HospitalSejong 30099South Korea Department of Plastic and Reconstructive surgery Chungnam National University HospitalDaejeon 35015South Korea Department of Emergency Eulji University HospitalDaejeon 35233South Korea Department of Plastic and Reconstructive surgery Chungnam National University College of MedicineDaejeon 35015South Korea

BACKGROUND malignant triton tumors(mTTs)comprise a subgroup of malignant peripheral nerve sheath tumors(mPNsTs)that exhibits rhabdomyosarcomatous differen-tiation and follow an aggressive *** are primarily located along peripheral *** of mTTs in the abdominal wall have not been *** has a poorer prognosis than classic mPNsTs,and accurate diagnosis necessitates a keen understanding of the clinical history and knowledge of its differential diagnosis *** for mTTs mirrors that for mPNsTs and is predominantly *** sUmmARY A 49-year-old woman presented with a subcutaneous mass in her lower abdo-minal wall and a pre-existing surgical scar that had grown slowly over 3-4 months before the *** had previously undergone radical hysterectomy and concurrent chemo-radiotherapy for cervical cancer approximately 5 years prior to the *** computed tomography(CT)showed a 1.3 cm midline mass in the lower abdomen with infiltration into the rectus abdominis *** was no sign of metastasis(T1N0m0).An incisional biopsy identified sporadic mTT of the lower abdomen.A comprehensive surgical excision with a 3 cm margin inclusive of the peritoneum was ***-quently,the general surgeon utilized an approach akin to the open peritoneal onlay mesh *** patient underwent additional treatment with an excision shaped as a mini-abdominoplasty for the skin *** complications arose,and annual follow-up CTs did not show signs of recurrence or *** An abdominal mTT was efficaciously treated with extensive excision and abdominal wall reconstruction,eliminating the need for postoperative radiotherapy.

关键词： malignant triton tumor Abdominal wall surgical excision Reconstruction Case report

PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-ha Lee Kyoungho suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea school of Life sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

Body-shaping membrane to Regenerate Breast fat by Elastic structural Holding

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Research 2024年第1期2023卷 165-180页

作者： Hye-seon Kim Jeongeun Park Hyun-su ha sewoom Baek Chan Hee Lee Kyubae Lee suji Park Jueun Kim se Won Yi hak-Joon sung Department of medical Engineering Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoul 03722Republic of Korea TmD LAB Co.Ltd. 6th Floor31Gwangnaru-ro 8-gilSeongdong-guSeoul 04799Republic of Korea

Tissue regeneration requires structural holding and movement support using tissue-type-specific aids such as bone casts,skin bandages,and joint ***,an unmet need exists in aiding breast fat regeneration as the breast moves following continuous body motion by exposing the breast fat to dynamic ***,the concept of elastic structural holding is applied to develop a shape-fitting moldable membrane for breast fat regeneration(“adipoconductive”)after surgical defects are *** membrane has the following key characteristics:(a)It contains a panel of honeycomb structures,thereby efficiently handling motion stress through the entire membrane;(b)a strut is added into each honeycomb in a direction perpendicular to gravity,thereby suppressing the deformation and stress concentration upon lying and standing;and(c)thermo-responsive moldable elastomers are used to support structural holding by suppressing large deviations of movement that occur *** elastomer became moldable upon a temperature shift above T_(m).The structure can then be fixed as the temperature *** a result,the membrane promotes adipogenesis by activating mechanotransduction in a fat miniature model with pre-adipocyte spheroids under continuous shaking in vitro and in a subcutaneous implant placed on the motion-prone back areas of rodents in vivo.

关键词： thereby shaking Elastic

surface engineering of ZnO electrocatalyst by N doping towards electrochemical CO_(2) reduction

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Journal of Energy Chemistry 2024年第1期88卷 71-81,I0002页

作者： Rohini subhash Kanase Getasew mulualem Zewdie maheswari Arunachalam Jyoti Badiger suzan Abdelfattah sayed Kwang-soon Ahn Jun-seok ha Uk sim Hyeyoung shin soon Hyung Kang Department of Interdisciplinary Program for Photonic Engineering Chonnam National UniversityGwangju 61186Republic of Korea Graduate school of Energy science and Technology(GEsT) Chungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea Department of Chemistry Education and Optoelectronic Convergence Research Center Chonnam National UniversityGwangju 61186Republic of Korea Department of Advanced Chemicals and Engineering Chonnam National UniversityGwangju 61186Republic of Korea school of Chemical Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Energy Engineering Korea Institute of Energy Technology(KENTECH)Naju 58217Republic of Korea

The discovery of efficient,selective,and stable electrocatalysts can be a key point to produce the largescale chemical fuels via electrochemical CO_(2) reduction(ECR).In this study,an earth-abundant and nontoxic ZnO-based electrocatalyst was developed for use in gas-diffusion electrodes(GDE),and the effect of nitrogen(N)doping on the ECR activity of ZnO electrocatalysts was ***,a ZnO nanosheet was prepared via the hydrothermal method,and nitridation was performed at different times to control the N-doping *** an increase in the N-doping content,the morphological properties of the nanosheet changed significantly,namely,the 2D nanosheets transformed into irregularly shaped ***,the ECR performance of Zn O electrocatalysts with different N-doping content was assessed in 1.0 m KHCO_(3) electrolyte using a gas-diffusion electrode-based ECR *** the ECR activity increased after a small amount of N doping,it decreased for higher N doping *** them,the N:ZnO-1 h electrocatalysts showed the best CO selectivity,with a faradaic efficiency(FE_(CO))of 92.7%at-0.73 V *** hydrogen electrode(RHE),which was greater than that of an undoped Zn O electrocatalyst(FE_(CO)of 63.4%at-0.78 V_(RHE)).Also,the N:ZnO-1 h electrocatalyst exhibited outstanding durability for 16 h,with a partial current density of-92.1 mA cm^(-2).This improvement of N:ZnO-1 h electrocatalyst can be explained by density functional theory calculations,demonstrating that this improvement of N:ZnO-1 h electrocatalyst comes from(ⅰ)the optimized active sites lowering the free energy barrier for the rate-determining step(RDs),and(ⅱ)the modification of electronic structure enhancing the electron transfer rate by N doping.

关键词： ZnO N-doped ZnO Gas-diffusion electrode CO selectivity Electrochemical CO_(2)reduction

m1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy

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Acta Pharmaceutica sinica B 2024年第7期14卷 3169-3183页

作者： ha Eun shin Jun-Hyeok han seungyong shin Ga-Hyun Bae Boram son Tae-Hyung Kim Hee Ho Park Chun Gwon Park Wooram Park Department of Integrative Biotechnology Sungkyunkwan University(SKKU)SuwonGyeonggi 16419Republic of Korea Deparment of Inteligent Precision Healthcare Convergence SKKUSuwonGyeonggi 16419Republic of Korea Department of metaBioHealth SKKU Institute for ConvergenceSKKUSuwonGyeonggi 16419Republic of Korea Department of Bioengineering Hanyang UniversitySeoul 04763Republic of Korea Department of Integrative Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Biomedical Engineering SKKUSuwonGyeonggi 16419Republic of Korea Korea Institute of science and Technology(KIsT) Seoul 02792Republic of Korea

Optimum genetic delivery for modulating target genes to diseased tissue is a major obstacle for profitable gene *** nanoparticles(LNPs),considered a prospective vehicle for nucleic acid delivery,have demonstrated efficacy in human use during the COVID-19 *** study introduces a novel biomaterial-based platform,m1-polarized macrophage-derived cellular nanovesicle-coated LNPs(m1-C-LNPs),specifically engineered for a combined gene-immunotherapy approach against solid *** dual-function system of m1-C-LNPs encapsulates Bcl2-targeting siRna within LNPs and immune-modulating cytokines within m1 macrophage-derived cellular nanovesicles(m1-NVs),effectively facilitating apoptosis in cancer cells without impacting T and NK cells,which activate the intratumoral immune response to promote granule-mediating killing for solid tumor *** retention within tumor was observed upon intratumoral administration of m1-C-LNPs,owing to the presence of adhesion molecules on m1-NVs,thereby contributing to superior tumor growth *** findings represent a promising strategy for the development of targeted and effective nanoparticle-based cancer genetic-immunotherapy,with significant implications for advancing biomaterial use in cancer therapeutics.

关键词： Genetic-immunotherapy m1 macrophage-derived cellular nanovesicles Lipid nanoparticles(LNPs) Gene therapy siRna Cancer immunotherapy solid tumor Tumor microenvironment(TmE)

Crystal reconstruction of V2O3/carbon heterointerfaces via anodic hydration for ultrafast and reversible mg-ion battery cathodes

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Infomat 2024年第3期6卷 95-107页

作者： Gun Jang Yun sang Joe sang Joon Lee Hyun Gyu Cho sang ha Baek Peixun Xiong Kang Ho shin Jeong seok Yeon min su Kang si Hyoung Oh Ho seok Park school of Chemical Engineering Sungkyunkwan University(SKKU)SuwonRepublic of Korea Advanced Batteries Research Center Korea Electronics Technology InstituteSeongnamRepublic of Korea Korea Institute of science and Technology SeoulRepublic of Korea sKKU Advanced Institute of nano Technology(sAINT) Sungkyunkwan UniversitySuwonRepublic of Korea Department of Health sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan UniversitySuwonRepublic of Korea sKKU Institute of Energy science and Technology(sIEsT) Sungkyunkwan UniversitySuwonRepublic of Korea

magnesium-ion batteries(mIBs)have promising applications because of their high theoretical capacity and the natural abundance of magnesium ***,the kinetic performance and cyclic stability of cathode materials are limited by the strong interactions between mg ions and the crystal ***,we demonstrate the unique mg^(2+)-ion storage mechanism of a hierarchical accordion-like vanadium oxide/carbon heterointerface(V2O3@C),where the V2O3 crystalline structure is reconstructed into a mgV_(3)O_(7)·H_(2)O phase through an anodic hydration reaction upon first cycle,for the improved kinetic and cyclic *** verified by in situ/ex situ spectroscopic and electrochemical analyses,the fast charge transfer kinetics of the V2O3@C cathode were due to the crystal-reconstruction and chemically coupled *** V2O3@C demonstrated an ultrahigh rate capacity of 130.4 mAh g^(-1)at 50000 mA g^(-1)and 1000 cycles,achieving a Coulombic efficiency of 99.6%.The high capacity of 381.0 mA h g^(-1)can be attributed to the reversible mg^(2+)-ion intercalation mechanism observed in the mgV_(3)O_(7)·H_(2)O phase using a 0.3 m mg(TFsI)2/ACN(H_(2)O)***,within the voltage range of 2.25 V versus mg/mg^(2+),the V2O3@C exhibited a capacity of 245.1 mAh g^(-1)when evaluated with magnesium metal in a 0.3 m mg(TFsI)^(2+)0.25 m mgCl_(2)/DmE *** research findings have important implications for understanding the relationship between the mg-ion storage mechanism and reconstructed crystal phase of vanadium oxides as well as the heterointerface reconstruction for the rational design of mIB cathode materials.

关键词： anodic hydration reaction magnesium ion battery nano crystal vanadium oxide

Vertical plane depth-resolved surface potential and carrier separation characteristics in flexible CZTsse solar cells with over 12% efficiency

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Carbon Energy 2024年第3期6卷 36-52页

作者： Dae-Ho son ha Kyung Park Dae-Hwan Kim Jin-Kyu Kang shi-Joon sung Dae-Kue Hwang Jaebaek Lee Dong-Hwan Jeon Yunae Cho William Jo Taeseon Lee JunHo Kim sang-Hoon nam Kee-Jeong Yang Division of Energy Technology DGISTDaeguRepublic of Korea Research Center for Thin Film solar Cells DGISTDaeguRepublic of Korea Department of Physics Ewha Womans UniversitySeoulRepublic of Korea Department of Physics Incheon National UniversityIncheonRepublic of Korea Department of mechanical Engineering Massachusetts Institute of TechnologyCambridgeMassachusettsUSA

Cu2Znsn(s,se)4(CZTsse)solar cells have resource distribution and economic *** main cause of their low efficiency is carrier loss resulting from recombination of photo-generated electron and *** overcome this,it is important to understand their electron-hole behavior *** determine the carrier separation characteristics,we measured the surface potential and the local current in terms of the absorber *** elemental variation in the intragrains(IGs)and at the grain boundaries(GBs)caused a band edge shift and bandgap(Eg)*** the absorber surface and subsurface,an upward Ec and Ev band bending structure was observed at the GBs,and the carrier separation was *** the absorber center,both upward Ec and Ev and downward Ec-upward Ev band bending structures were observed at the GBs,and the carrier separation was *** improve the carrier separation and suppress carrier recombination,an upward Ec and Ev band bending structure at the GBs is desirable.

关键词： carrier separation CZTsse flexible solar cell local current surface potential