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Chinese Chemical Letters 2000年第8期11卷 665-666页

作者： Xu, L Zheng, GR Xia, m Cai, JC Chinese Acad Sci Shanghai Inst Mat Med Shanghai 200031 Peoples R China

2-methoxy-6-oxo-1, 4, 2-diazaphosphorinane-2-oxide 8, phosphorus counterpart of 2, 6-dioxopiperazine, was synthesized as antitumor agent. The new phosphorus heterocycle compound 8 is the key intermediate in the synthe... 详细信息

关键词： antitumor activity phosphorus heterocycle compound 2,6-dioxopiperazine

New Alkaloids from the Rhizomes of Goniotha.a.us Griffithii

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Chinese Chemical Letters 1998年第11期9卷 0-0,0-0页

作者： Zhang, YJ Kong, m Chen, RY Yu, DQ Chinese Acad med Sci Inst Mat Med Beijing 100050 Peoples R China Peking Union med Coll Beijing 100050 Peoples R China

Three new alkaloids, griffithdionc 1, griffiazanone A 2 and griffiazanone B 3 were isolated from the rhizomes of Goniotha.a.us griffithii Hook. F. el. Thoms. Their structures were elucidated by analysis the spectral data (IR, UV, mS, 1 H and 13C NmR, HmBC, NOE experiment).The absolute configuration of griffitha.a.one A 2 was determined by mosher's methods.

关键词： Goniotha.a.us griffithii phenanthrene lactam alkaloids griffithdione griffiazadioneA and griffiazadione B

Pathological and biochemical alterations of astrocytes in ovariectomized rats injected with D-galactose: A potential contribution to Alzheimer's disease processes

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南京医科大学学报(自然科学版) 2008年第5期 574-574页

作者： Hua, X. D. Lei, m. Ding, H. han, Q. Y. Hu, G. Xiao, m. Nanjing med Univ, Dept Anat Histol & Pharmacol, Jiangsu Prov Key Lab Neurodegenerat, Nanjing 210029, Peoples R China

Astrocytes are implicated in the pathological changes of Alzheimer's disease. Our previous studies have demonstratedthat estrogen deprivation and oxidative stress act synergistically to accelerate0 the progress of Alzheimer's disease. Long-term D-galac-tose injection combined with ovariectomy may serve as a rodent model for Alzheimer's disease. To address the potential contributionof astroglia to the Alzheimer's disease pathogenesis, we investigated pathological and biochemical alterations of astrocytes under thisanimal model. Ovadectomized rats injected with D-galactose for 2 weeks showed extensive localization of glial fibrillary acidic proteinimmunoreactive astrocytes and slightly elevated glutathione levels in the hippocampus without significant impairments in the watermaze test and deficits of the cholinergic analyses, compared to the saline-injected rats. Ovariectomized rats injected with D-galactosefor 6 weeks, however, exhibited degeneration of astrocytes and decreased glutathione levels in the hippocampus, accompanied withsevere dysfunction of behavioral test and deficiency of cholinergic terminals. Electron microscopy further confirmed the pathologicalchanges of astrocytes, especially in the aggregated area of synapse and brain microvessels. Consistent with degeneration of perivascu-lar astrocytic endfeet, analysis of the horseradish peroxidase demonstrated an impairment of the blood-brain barrier *** findings indicate that biochemical and pathological alterations of astrocytes may partially contribute to exacerbating neuronaldeficits in the course of Alzheimer's disease. Restoring neuroprotective potential of astrocytes may be a useful therapeutic target forAlzheimer's disease and other neurodegenerative diseases.

关键词： Alzheimer’s disease astrocytes estrogen deprivation oxidative stress rats blood-brain-barrier senile plaques estrogen mice neuroprotection expression cortex acetylcholinesterase neurodegeneration innervation

SOmE CORRESPONDENCES BETWEEN RINGS AND mODULES

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苏州大学学报（自然科学版） 1994年第2期10卷 81-86页

作者：周士藩吴志祥 math. Dept. of Suzhou Univ math. Deft of Suzhou Med. Co.

in this paper, we define some maps which are similar to the maps in [1,3]. We use these maps to prob the relative properties in a more general situation. In this case TmA ,TNB are two bimodules and m^* = Homr (m, N).

关键词：环论模块图论幂子环

Pathological and biochemical alterations of astrocytes in ovariectomized rats injected with D-galactose:A potential contribution to Alzheimer's disease processes

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南京医科大学学报（自然科学版） 2008年第6期28卷 803-803页

作者： Hua, X. D. Lei, m. Ding, H. han, Q. Y. Hu, G. Xiao, m. Nanjing med Univ,Dept Anat Histol & Pharmacol,Jiangsu Prov Key Lab Neurodegenerat,Nanjing 210029,Peoples R China.

Astrocytes are implicated in the pathological changes of Alzheimer's disease. Our previous studies have demonstrated that estrogen deprivation and oxidative stress act synergistically to accelerate the progress of Alzheimer's disease. Long-term D-galactose injection combined with ovariectomy may serve as a rodent model for Alzheimer's disease. To address the potential contribution of astroglia to the Alzheimer's disease pathogenesis, we investigated pathological and biochemical alterations of astrocytes under this animal model. Ovadectomized rats injected with D-galactose for 2 weeks showed extensive localization of glial fibrillary acidic protein immunoreactive astrocytes and slightly elevated glutathione levels in the hippocampus without significant impairments in the water maze test and deficits of the cholinergic analyses, compared to the saline-injected rats. Ovariectomized rats injected with D-galactose for 6 weeks, however, exhibited degeneration of astrocytes and decreased glutathione levels in the hippocampus, accompanied with severe dysfunction of behavioral test and deficiency of cholinergic terminals. Electron microscopy further confirmed the pathological changes of astrocytes, especially in the aggregated area of synapse and brain microvessels. Consistent with degeneration of perivascular astrocytic endfeet, analysis of the horseradish peroxidase demonstrated an impairment of the blood-brain barrier permeability. These findings indicate that biochemical and pathological alterations of astrocytes may partially contribute to exacerbating neuronal deficits in the course of Alzheimer's disease. Restoring neuroprotective potential of astrocytes may be a useful therapeutic target for Alzheimer's disease and other neurodegenerative diseases.

关键词：老年痴呆生物化学技术星形胶质细胞半乳糖

Structural and optical properties of nano-spin coated sol-gel porous TiO_2 films

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Transactions of Nonferrous metals Society of China 2012年第12期22卷 3003-3011页

作者： m.m.El-NAhaSS m.H.ALI A.El-DENGLAWEY Physics Department Faculty of Education Ain Shams University Roxy Cairo 11757 Egypt Physics Department Faculty of Science Ain Shams University Cairo Egypt Physics Department Faculty of Science South Valley University Qena 83523 Egypt Phys Dep Fac of Appl Med Sci Turabah 21995 Taif University KSA

Three thicknesses of TiO2 films, 174, 195, and 229 nm, were deposited onto quartz substrates by sol–gel spin coating method. The as-deposited thin films were cha.a.terized by nano-crystallite with different sizes (19–46 nm) and relatively high porous structure. Optical constants were determined and showed the lowest refractive index of 1.66 for the as-prepared films that ever reported till now. Obtained results were discussed through current theoretical ideas.

关键词： TiO2 films optical properties nanostructure electron microscopy thin films spin coating technique

Sympathetic activity in breast cancer and metastasis:partners in crime

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Bone Research 2021年第1期9卷 26-36页

作者： Francisco Conceição Daniela m.Sousa Joana Paredes meriem Lamghari I 3S-Instituto de Investigação e Inovação em Saúde Universidade do Porto4200-135 PortoPortugal INEB-Instituto Nacional de Engenharia Biomédica Universidade do Porto4200-135 PortoPortugal ICBAS-Instituto de Ciências Biomédicas Abel Salazar Universidade do Porto4050-313 PortoPortugal IPATImUP-Instituto de Patologia e Imunologia molecular da Universidade do Porto 4200-135 PortoPortugal FmUP-Faculdade de medicina da Universidade do Porto 4200-319 PortoPortugal

The vast majority of patients with advanced breast cancer present skeletal complications that severely compromise their quality of *** cancer cells are cha.a.terized by a strong tropism to the bone *** engraftment and colonization of bone,breast cancer cells interact with native bone cells to hinder the normal bone remodeling process and establish an osteolytic“metastatic vicious cycle”.The sympathetic nervous system has emerged in recent years as an important modulator of breast cancer progression and metastasis,potentiating and accelerating the onset of the vicious cycle and leading to extensive bone ***,sympathetic neurotransmitters and their cognate receptors have been shown to promote several hallmarks of breast cancer,such as proliferation,angiogenesis,immune escape,and invasion of the extracellular *** this review,we assembled the current knowledge concerning the complex interactions that take place in the tumor microenvironment,with a special emphasis on sympathetic modulation of breast cancer cells and stromal ***,the differential action of epinephrine and norepinephrine,through eitherα-orβ-adrenergic receptors,on breast cancer progression prompts careful consideration when designing new therapeutic *** addition,the contribution of sympathetic innervation to the formation of bone metastatic foci is *** particular,we address the remarkable ability of adrenergic signaling to condition the native bone remodeling process and modulate the bone vasculature,driving breast cancer cell engraftment in the bone ***,clinical perspectives and developments on the use ofβ-adrenergic receptor inhibitors for breast cancer management and treatment are discussed.

关键词： breast metastasis invasion

The proteome of distal nerves: implication in delayed repair and poor functional recovery

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Neural Regeneration Research 2022年第9期17卷 1998-2006页

作者： Song Guo Raymond m.moore m.Cristine Charlesworth Kenneth L.Johnson Robert J.Spinner Anthony J.Windebank Huan Wang Department of Neurologic Surgery Mayo ClinicRochesterMNUSA Biomedical Statistics and Informatics Mayo ClinicRochesterMNUSA Proteomics Core Mayo ClinicRochesterMNUSA Department of Neurology Mayo ClinicRochesterMNUSA

Chronic denervation is one of the key factors that affect nerve *** axotomy deteriorates the distal nerve stump,causes protein changes,and renders the microenvironment less permissive for *** of these factors/proteins have been individually *** better delineate the comprehensive protein expression profiles and identify proteins that contribute to or are associated with this detrimental effect,we carried out a proteomic analysis of the distal nerve using an established delayed rat sciatic nerve repair *** rats that received immediate repair after sciatic nerve transection served as control,whereas four rats in the experimental group(chronic denervation)had their sciatic nerve repaired after a 12-week *** the rats were sacrificed after 16 weeks to harvest the distal nerves for extracting ***-five micrograms of protein from each sample were fractionated in SDS-PAGE ***-mS/mS analysis was applied to the *** expression levels of nerves on the surgery side were compared to those on the contralateral *** protein with a P value of less than 0.05 and a fold change of 4 or higher was deemed differentially *** the differentially expressed proteins in both groups were further stratified according to the biological processes.A Pubmed search was also conducted to identify the differentially expressed proteins that have been reported to be either beneficial or detrimental to nerve *** Pathway Analysis(IPA)software was used for pathway *** results showed that 709 differentially expressed proteins were identified in the delayed repair group,with a bigger proportion of immune and inflammatory process-related proteins and a smaller proportion of proteins related to axon regeneration and lipid metabolism in comparison to the control group where 478 differentially expressed proteins were *** experimental group also had more beneficial proteins that were d

关键词： chronic axotomy chronic denervation delayed repair distal nerve functional recovery nerve regeneration peripheral nerve prolonged denervation proteome sciatic nerve sciatic nerve transection

male Breast Cancer:10-Year Experience at mansoura University Hospital in Egypt

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Clinical oncology and cancer researeh 2012年第1期9卷 23-28页

作者： Wafaa El-Beshbeshi Engy m Abo-Elnaga Department of Clinical Oncology and Nuclear medicine Faculty of MedicineMansoura University

Objective male breast cancer （mBC） is a rare disease representing less than 1% of all malignancies. The objective of the study is to report clinicopathological cha.a.teristics, treatment patterns, and outcomes of mBC in mansoura University Hospital, Egypt. methods This retrospective study focused on male breast cancer patients during 10 years （2000-2009）. The studied variables were data regarding general cha.a.teristics of patients, treatment modalities and survival. Results The series included 37 patients （0.8% of all breast cancer）. The median age was 57.7 years （range： 26-86 years）. The main clinical complaint was a mass beneath the areola ill 94.5% of the cases. most patients had a locally advanced disease. 94.5% of tumors were invasive duct carcinomas. The treatment was essentially surgery in 91.8%, followed by adjuvant radiotherapy （in 89.2%）, hormonal therapy （in 56.7%） and chemotherapy （in 91.8%）. Follow-up period ranged from 6-115 months. Local recurrence occurred in 4 cases and metastasis in 11 cases. The 2-year and 5-year overall survival （OS） rates were 81.6% and 60.5%, respectively. The 2-year and 5-year disease-free survival （DFS） rates were 68.4%, and 52.6%, respectively. OS was not significantly affected by any of the studied parameters. Factors influencing DFS were： T stage （P=0.05）, positive lymph nodes （P=0.043）, metastasis （P=0.004）, and chemotherapy （1＇=0.046）. Conclusions mBC is a rare disease and often diagnosed at a locally advanced stage. The management of male and female breast carcinoma is identical. Future research for better understanding of this disease is needed to improve the management and prognosis of male breast cancer patients.

关键词： breast neoplasms male therapeutics Egypt

A NEW BICOUmARIN FROm PLEUROSPERmUm RIVULORUm (DIELS)

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Chinese Chemical Letters 1995年第5期6卷 385-386页

作者： Xiao, YQ Liu, XH Baba, K Taniguchi, m Chinese Acad Tradit Chinese med Inst Chinese Meteria Med Beijing 100700 Peoples R China Osaka Univ Pharmaceut Sci Osaka 580 Japan

From the BtOAc extract of the underground parts of Pleurospermum rivulorum (Diels), a new bicoumarin, rivulobirin was isolated along with eight known furocoumarins.

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