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Natural Convection of a Power-Law Nanofluid in a Square Cavity with a Vertical Fin

Fluid Dynamics & materials Processing 2024年第9期20卷 2091-2108页

作者： Amira m’hadbi mohammed El Ganaoui haïkel Ben hamed Amenallah Guizani Khalid Chtaibi LERmAB Department of Transition and Energy Efficiency ProfessionsIUT H Poincaréde LongwyUniversity of LorraineLongwy54400France LPT Center for Energy Research and Technologies(Borj Cedria2084)University of Tunis El ManarTunis1068Tunisia LTI Department of Mechanical Engineering and ProductionIUTUniversity of Picardie Jules-VerneAmiens80025France

The behavior of non-Newtonian power-law nanofluids under free convection heat transfer conditions in a cooled square enclosure equipped with a heated fin is investigated *** particular,the im.a.t of nanofluids,composed of water and Al_(2)O_(3),TiO_(2),and Cu nanoparticles,on heat transfer enhancement is *** aim of this research is also to analyze the influence of different parameters,including the Rayleigh number(Ra=10^(4)-10^(6)),nanoparticle volume fraction(φ=0%-20%),non-Newtonian power-law indexes(n=0.6-1.4),and fin dimensions(Ar=0.3,0.5,and 0.7).Streamlines and isotherms are used to depict flow and related heat transfer *** indicate that thermal performance improves with increasing Rayleigh number,regardless of the nanoparticle type or nanofluid rheological *** suggests that the buoyancy force has a significant im.a.t on heat transfer,particularly near the heat *** Nusselt number is more sensitive to variations in Cu nanoparticle volume fractions com.a.ed to Al₂O₃and TiO₂.moreover,the average Nusselt numbers for power-law nanofluids with n1)are greater(smaller)than for Newtonian fluids due to the decrease(increase)in viscosity with increasing(decreasing)shear rate,at the same values of Rayleigh number Ra owing to the amplification(attenuation)of the convective ***,the most substantial enhancement is observed with Cu-water shear-thinning nanofluid,where the Nusselt number increases by 136%when changing from Newtonian to shear thinning behavior and by 154.9%when adding 16%nanoparticle volume ***,an even larger increase of 57%in the average Nusselt number is obtained on increasing the fin length from 0.3 to 0.7.

关键词： Heat transfer nanofluid non-Newtonian fluid natural convection

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A pipeline to cha.a.terize p53 effectors by integrative cistrome and transcriptome analysis in a genetically-defined organoid model

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Genes & Diseases 2024年第2期11卷 512-515页

作者： June-ha Shin Hwa-Ryeon Kim Jae-Seok Roe Department of Biochemistry College of Life Science and BiotechnologyYonsei UniversitySeoul 120-749Republic of Korea

Tumor-protein 53(p53)is a transcription factor(TF)encoded by TP53(Trp53 in mice)and is a master regulator of tumor-suppressive programs'.Importantly,TP53 is the most frequently mutated gene in human cancer,and its loss of function contributes to tumor development,exemplified by variable p53 mutations detected in 50%-75%of pancreatic cancers.2 From these perceptions,a number of targets transcribed by p53 that confer tumor suppression have been ***,our understanding of how p53 prevents normal cells from initiating tumorigenesis is still *** complement this limitation,herein,we established a new approach to identify underlying effectors transcribed by p53 in normal physiology.

关键词： incomplete initiating herein

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m1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3169-3183页

作者： ha Eun Shin Jun-Hyeok han Seungyong Shin Ga-Hyun Bae Boram Son Tae-Hyung Kim Hee Ho Park Chun Gwon Park Wooram Park Department of Integrative Biotechnology Sungkyunkwan University(SKKU)SuwonGyeonggi 16419Republic of Korea Deparment of Inteligent Precision Healthcare Convergence SKKUSuwonGyeonggi 16419Republic of Korea Department of metaBioHealth SKKU Institute for ConvergenceSKKUSuwonGyeonggi 16419Republic of Korea Department of Bioengineering Hanyang UniversitySeoul 04763Republic of Korea Department of Integrative Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Biomedical Engineering SKKUSuwonGyeonggi 16419Republic of Korea Korea Institute of Science and Technology(KIST) Seoul 02792Republic of Korea

Optimum genetic delivery for modulating target genes to diseased tissue is a major obstacle for profitable gene *** nanoparticles(LNPs),considered a prospective vehicle for nucleic acid delivery,have demonstrated efficacy in human use during the COVID-19 *** study introduces a novel biomaterial-based platform,m1-polarized macrophage-derived cellular nanovesicle-coated LNPs(m1-C-LNPs),specifically engineered for a combined gene-immunotherapy approach against solid *** dual-function system of m1-C-LNPs encapsulates Bcl2-targeting siRNA within LNPs and immune-modulating cytokines within m1 macrophage-derived cellular nanovesicles(m1-NVs),effectively facilitating apoptosis in cancer cells without im.a.ting T and NK cells,which activate the intratumoral immune response to promote granule-mediating killing for solid tumor *** retention within tumor was observed upon intratumoral administration of m1-C-LNPs,owing to the presence of adhesion molecules on m1-NVs,thereby contributing to superior tumor growth *** findings represent a promising strategy for the development of targeted and effective nanoparticle-based cancer genetic-immunotherapy,with significant implications for advancing biomaterial use in cancer therapeutics.

关键词： Genetic-immunotherapy m1 macrophage-derived cellular nanovesicles Lipid nanoparticles(LNPs) Gene therapy siRNA Cancer immunotherapy Solid tumor Tumor microenvironment(TmE)

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Elasto-inertial microfluidic separation of microspheres with submicron resolution at high-throughput

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microsystems & Nanoengineering 2024年第1期10卷 203-216页

作者： Hyunwoo Jeon Song ha Lee Jongho Shin Kicheol Song Nari Ahn Jinsoo Park Department of mechanical Engineering Chonnam National University77 Yongbong-ro Buk-guGwangju 61186Republic of Korea Analytical Engineering Team Samsung Display Co.Ltd.181 Samsung-roTangjeong-myeonAsan-siChungcheongnam-do 31454Republic of Korea

Elasto-inertial microfluidic separation offers many advantages including high throughput and separation *** though the separation efficiency highly depends on precise control of the flow conditions,no concrete guidelines have been reported yet in elasto-inertial ***,we propose a dimensionless analysis for precise estimation of the microsphere behaviors across the interface of Newtonian and viscoelastic *** number,modified Weissenberg number,and modified elastic number are used to investigate the balance between inertial and elastic lift *** on the findings,we introduce a new dimensionless number defined as the width of the Newtonian fluid stream divided by microsphere *** proposed dimensionless analysis allows us to predict whether the microspheres migrate across the co-flow *** theoretical estimation is found to be in good agreement with the experimental results using 2.1-and 3.2-μm-diameter polystyrene microspheres in a co-flow of water and polyethylene oxide *** on the theoretical estimation,we also realize submicron separation of the microspheres with 2.1 and 2.5μm in diameter at high throughput,high purity(>95%),and high recovery rate(>97%).The applicability of the proposed method was validated by separation of platelets from similar-sized Escherichia coli(***).

关键词： solution. separation estimation

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malignant triton tumor in the abdominal wall:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1467-1473页

作者： Ho Jik Yang Donghyun Kim Won Suk Lee Sang-ha Oh Department of Plastic and Reconstructive Surgery Chungnam National University Sejong HospitalSejong 30099South Korea Department of Plastic and Reconstructive Surgery Chungnam National University HospitalDaejeon 35015South Korea Department of Emergency Eulji University HospitalDaejeon 35233South Korea Department of Plastic and Reconstructive Surgery Chungnam National University College of MedicineDaejeon 35015South Korea

BACKGROUND malignant triton tumors(mTTs)comprise a subgroup of malignant peripheral nerve sheath tumors(mPNSTs)that exhibits rhabdomyosarcomatous differen-tiation and follow an aggressive *** are primarily located along peripheral *** of mTTs in the abdominal wall have not been *** has a poorer prognosis than classic mPNSTs,and accurate diagnosis necessitates a keen understanding of the clinical history and knowledge of its differential diagnosis *** for mTTs mirrors that for mPNSTs and is predominantly *** SUm.a.Y A 49-year-old woman presented with a subcutaneous mass in her lower abdo-minal wall and a pre-existing surgical scar that had grown slowly over 3-4 months before the *** had previously undergone radical hysterectomy and concurrent chemo-radiotherapy for cervical cancer approximately 5 years prior to the *** computed tomography(CT)showed a 1.3 cm midline mass in the lower abdomen with infiltration into the rectus abdominis *** was no sign of metastasis(T1N0m0).An incisional biopsy identified sporadic mTT of the lower abdomen.A comprehensive surgical excision with a 3 cm margin inclusive of the peritoneum was ***-quently,the general surgeon utilized an approach akin to the open peritoneal onlay mesh *** patient underwent additional treatment with an excision shaped as a mini-abdominoplasty for the skin *** complications arose,and annual follow-up CTs did not show signs of recurrence or *** An abdominal mTT was efficaciously treated with extensive excision and abdominal wall reconstruction,eliminating the need for postoperative radiotherapy.

关键词： malignant triton tumor Abdominal wall Surgical excision Reconstruction Case report

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PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflam.a.ion

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-ha Lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflam.a.ion has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflam.a.ion, both in deleterious and beneficial ways.

关键词： inflam.a.ion considerably

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Body-Shaping membrane to Regenerate Breast Fat by Elastic Structural Holding

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Research 2024年第1期2023卷 165-180页

作者： Hye-Seon Kim Jeongeun Park Hyun-Su ha Sewoom Baek Chan Hee Lee Kyubae Lee Suji Park Jueun Kim Se Won Yi hak-Joon Sung Department of medical Engineering Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoul 03722Republic of Korea TmD LAB Co.Ltd. 6th Floor31Gwangnaru-ro 8-gilSeongdong-guSeoul 04799Republic of Korea

Tissue regeneration requires structural holding and movement support using tissue-type-specific aids such as bone casts,skin bandages,and joint ***,an unmet need exists in aiding breast fat regeneration as the breast moves following continuous body motion by exposing the breast fat to dynamic ***,the concept of elastic structural holding is applied to develop a shape-fitting moldable membrane for breast fat regeneration(“adipoconductive”)after surgical defects are *** membrane has the following key cha.a.teristics:(a)It contains a panel of honeycomb structures,thereby efficiently handling motion stress through the entire membrane;(b)a strut is added into each honeycomb in a direction perpendicular to gravity,thereby suppressing the deformation and stress concentration upon lying and standing;and(c)thermo-responsive moldable elastomers are used to support structural holding by suppressing large deviations of movement that occur *** elastomer became moldable upon a temperature shift above T_(m).The structure can then be fixed as the temperature *** a result,the membrane promotes adipogenesis by activating mechanotransduction in a fat miniature model with pre-adipocyte spheroids under continuous shaking in vitro and in a subcutaneous implant placed on the motion-prone back areas of rodents in vivo.

关键词： thereby shaking Elastic

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Surface engineering of ZnO electrocatalyst by N doping towards electrochemical CO_(2) reduction

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Journal of Energy Chemistry 2024年第1期88卷 71-81,I0002页

作者： Rohini Subhash Kanase Getasew mulualem Zewdie maheswari Arunacha.a. Jyoti Badiger Suzan Abdelfattah Sayed Kwang-Soon Ahn Jun-Seok ha Uk Sim Hyeyoung Shin Soon Hyung Kang Department of Interdisciplinary Program for Photonic Engineering Chonnam National UniversityGwangju 61186Republic of Korea Graduate School of Energy Science and Technology(GEST) Chungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea Department of Chemistry Education and Optoelectronic Convergence Research Center Chonnam National UniversityGwangju 61186Republic of Korea Department of Advanced Chemicals and Engineering Chonnam National UniversityGwangju 61186Republic of Korea School of Chemical Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Energy Engineering Korea Institute of Energy Technology(KENTECH)Naju 58217Republic of Korea

The discovery of efficient,selective,and stable electrocatalysts can be a key point to produce the largescale chemical fuels via electrochemical CO_(2) reduction(ECR).In this study,an earth-abundant and nontoxic ZnO-based electrocatalyst was developed for use in gas-diffusion electrodes(GDE),and the effect of nitrogen(N)doping on the ECR activity of ZnO electrocatalysts was ***,a ZnO nanosheet was prepared via the hydrothermal method,and nitridation was performed at different times to control the N-doping *** an increase in the N-doping content,the morphological properties of the nanosheet changed significantly,namely,the 2D nanosheets transformed into irregularly shaped ***,the ECR performance of Zn O electrocatalysts with different N-doping content was assessed in 1.0 m KHCO_(3) electrolyte using a gas-diffusion electrode-based ECR *** the ECR activity increased after a small amount of N doping,it decreased for higher N doping *** them,the N:ZnO-1 h electrocatalysts showed the best CO selectivity,with a faradaic efficiency(FE_(CO))of 92.7%at-0.73 V *** hydrogen electrode(RHE),which was greater than that of an undoped Zn O electrocatalyst(FE_(CO)of 63.4%at-0.78 V_(RHE)).Also,the N:ZnO-1 h electrocatalyst exhibited outstanding durability for 16 h,with a partial current density of-92.1 mA cm^(-2).This improvement of N:ZnO-1 h electrocatalyst can be explained by density functional theory calculations,demonstrating that this improvement of N:ZnO-1 h electrocatalyst comes from(ⅰ)the optimized active sites lowering the free energy barrier for the rate-determining step(RDS),and(ⅱ)the modification of electronic structure enhancing the electron transfer rate by N doping.

关键词： ZnO N-doped ZnO Gas-diffusion electrode CO Selectivity Electrochemical CO_(2)reduction

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Preliminary results of lithological and palynological study of Svobodny,ancient man’s parking relic in Amur region,Russia

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Global Geology 2024年第3期27卷 121-131页

作者： Kovalenko S.V. Kezina T.V. Kryuchko E.I. mironov m.a. Center for the Preservation of Historical and Cultural Heritage of the Amur Region Blagoveshchensk 675000Russia Amur State University Blagoveshchensk 675027Russia

A single-layer monument Svobodny,ancient man's parking lot-1,discovered in 2021 as part of archaeological work to study the zone of economic development of the Amur region was investigated lithologically and *** on the results of geomorphological analysis of the territory,the study of artifacts,palynological data,as well as analogy with previously identified and sufficiently studied relics in the region,the existence of the Osinoozersk late Neolithic culture in this territory is *** time of its expansion in the Amur region is determined within the framework of the second half of theⅣmillennium BC to the first half of theⅡmillennium *** preliminary results of palynological analysis suggest the existence of a temperate climate here,was close to the modern one,which does not contradict the reconstructed paleoclimate and environments of the region during the Holocene period.

关键词： Osinoozersk culture palynological spectra Zeya River paleoclimate

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Dysprosium oxide,alumina,and graphene oxide reinforced polycaprolactone thin films:Thermal stability,morphology,and cell viability

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Journal of Rare Earths 2024年第7期42卷 1337-1343,I0005页

作者： mohamed Tharwat Elabbasy mohamed R.Atteya mai A.Samak mousa Abdelrahman Tahani Almahmoud m.a.El-morsy A.A.menazea m.F.H.Abd El-Kader Department of Public Health College of Public Health and Health InformaticsUniversity of Ha'ilHa'il2440Saudi Arabia Food Control Department Faculty of Veterinary MedicineZagazig UniversityZagazig44519Egypt Department of Physical Therapy College of Applied Medical SciencesUniversity of Ha'ilHa'ilSaudi Arabia Department of Histology and Cell Biology Faculty of MedicineZagazig UniversityZagazig44519Egypt College of Nursing University of Ha'ilHa'ilSaudi Arabia College of Science and Humanities in Al-Kharj Physics DepartmentPlasma Technology and Material Science UnitPrince Sattam Bin Abdulaziz UniversityAl-kharj11942Saudi Arabia Physics Department Faculty of ScienceUniversity of DamiettaNew Damietta34517Egypt Spectroscopy Department Physics Research InstituteNational Research CentreDokki12622GizaEgypt Biophysics Department Faculty of ScienceCairo UniversityGizaEgypt

Developing a biomaterial for wound healing applications is still a ***,dysprosium oxide(Dy_(2)O_(3)),aluminum oxide(Al_(2)O_(3)),and graphene oxide(GO)were embedded in cast films based on polycaprolactone(PCL)to be examined for wound dressing *** techniques were used to cha.a.terize the fabricated films including X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),Raman,and scanning electron microscopy(SEm),besides their biological *** thermogravimetric analysis(TGA)exhibits high thermal stability as the scaffold weight decreases slightly to 98.6%after raising the temperature from room temperature to 280℃.The cell viability was investigated and it is shown that the viable cells grow up to approximately 93%at 75μg/***,the cell attachment shows excellent behavior as the cells attach on most of the surface of the modified PCL which shows high biocom.a.ibility.

关键词： Wound healing Polycaprolactone Dy_(2)O_(3) Al_(2)O_(3) Biocom.a.ible Rare earths

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