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Oral cyclophosphamide-induced posterior reversible encephalopathy syndrome in a patient with ANCA-associated vasculitis:A case report

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World Journal of Clinical Cases 2021年第21期9卷 6130-6137页

作者： Yire Kim Jihye Kwak Sehyun Jung Seunghye Lee ha nee jang Hyun Seop Cho Se-Ho Chang Hyun-Jung Kim Internal Medicine Gyeongsang National University HospitalJinju 52727South Korea Institute of Health Sciences Gyeongsang National UniversityJinju 52727South Korea Internal Medicine College of MedicineGyeongsang National UniversityJinju 52727South Korea

BACKGROUND Posterior reversible encephalopathy syndrome(PRES)manifests many neurological symptoms with typical features on neuroimaging studies and has various risk *** is one of the therapeutic agents for antineutrophil cytoplasmic antibody(ANCA)-associated *** as the sole cause of PRES has been reported in only a few ***,we report a unique case of early-onset oral cyclophosphamide-induced PRES in a patient with ANCA-associated *** SUMMARY A 73-year-old man was transferred to our hospital for sepsis due to acute *** had already received hemodialysis for two weeks due to septic acute kidney *** azotemia was not improved after sepsis resolved and perinuclear-ANCA was *** biopsy showed crescentic *** hemorrhage was observed on *** was initially treated with intravenous methylprednisolone and plasma exchange for one *** then,two days after adding oral cyclophosphamide,the patient developed generalized tonic-clonic *** diagnosed PRES by Brain magnetic resonance imaging(MRI)and *** were controlled with fosphenytoin 750 *** was suspected to be the cause of PRES and *** mentality was recovered after seven days and brain MRI showed normal state after two *** The present case shows the possibility of PRES induction due to short-term use of oral cyclophosphamide *** should carefully monitor neurologic symptoms after oral cyclophosphamide administration in elderly patients with underlying diseases like sepsis,renal failure and ANCA-associated vasculitis.

关键词： Cyclophosphamide Posterior reversible encephalopathy syndrome Antineutrophil cytoplasmic antibody-associated vasculitis Renal failure Case report

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Acoustofluidic separation of prolate and spherical micro-objects

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Microsystems & Nanoengineering 2024年第1期10卷 217-230页

作者： Muhammad Soban Khan Mushtaq Ali Song ha Lee Keun Young jang Seong Jae Lee Jinsoo Park Department of Mechanical Engineering Chonnam National University77 Yongbong-roBuk-guGwangju 61186Republic of Korea Department of Polymer Engineering The University of Suwon17 Wauan-gilBongdam-eupHwaseongGyeonggi 18323Republic of Korea

Most microfluidic separation techniques rely largely on object size as a separation *** ability to separate micro-objects based on their shape is crucial in various biomedical and chemical ***,we develop an ondemand,label-free acoustofluidic method to separate prolate ellipsoids from spherical microparticles based on traveling surface acoustic wave-induced acoustic radiation force and *** freely rotating non-spherical microobjects were aligned under the progressive acoustic field by the counterrotating radiation torque,and the major axis of the prolate ellipsoids was parallel to the progressive wave *** specific alignment of the ellipsoidal particles resulted in a reduction in the cross-sectional area perpendicular to the wave *** a consequence,the acoustic backscattering decreased,resulting in a decreased magnitude of the radiation *** the variation in radiation force,which depended on the micro-object morphology enabled the acoustofluidic shape-based *** conducted numerical simulations for the wave scattering of spherical and prolate objects to elucidate the working mechanism underlying the proposed method.A series of experiments with polystyrene microspheres,prolate ellipsoids,and peanut-shaped microparticles were performed for *** quantitative analysis of the separation efficiency,we confirmed the high purity and high recovery rate of the proposed acoustofluidic shapebased separation of *** a bioparticle,we utilize Thalassiosira eccentrica to perform shape-based separation,as the species has a variety of potential applications in drug delivery,biosensing,nanofabrication,bioencapsulation and immunoisolation.

关键词： separation spherical rotating

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Crystal reconstruction of V2O3/carbon heterointerfaces via anodic hydration for ultrafast and reversible Mg-ion battery cathodes

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InfoMat 2024年第3期6卷 95-107页

作者： Gun jang Yun Sang Joe Sang Joon Lee Hyun Gyu Cho Sang ha Baek Peixun Xiong Kang Ho Shin Jeong Seok Yeon Min Su Kang Si Hyoung Oh Ho Seok Park School of Chemical Engineering Sungkyunkwan University(SKKU)SuwonRepublic of Korea Advanced Batteries Research Center Korea Electronics Technology InstituteSeongnamRepublic of Korea Korea Institute of Science and Technology SeoulRepublic of Korea SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan UniversitySuwonRepublic of Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan UniversitySuwonRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwonRepublic of Korea

Magnesium-ion batteries(MIBs)have promising applications because of their high theoretical capacity and the natural abundance of magnesium ***,the kinetic performance and cyclic stability of cathode materials are limited by the strong interactions between Mg ions and the crystal ***,we demonstrate the unique Mg^(2+)-ion storage mechanism of a hierarchical accordion-like vanadium oxide/carbon heterointerface(V2O3@C),where the V2O3 crystalline structure is reconstructed into a MgV_(3)O_(7)·H_(2)O phase through an anodic hydration reaction upon first cycle,for the improved kinetic and cyclic *** verified by in situ/ex situ spectroscopic and electrochemical analyses,the fast charge transfer kinetics of the V2O3@C cathode were due to the crystal-reconstruction and chemically coupled *** V2O3@C demonstrated an ultrahigh rate capacity of 130.4 mAh g^(-1)at 50000 mA g^(-1)and 1000 cycles,achieving a Coulombic efficiency of 99.6%.The high capacity of 381.0 mA h g^(-1)can be attributed to the reversible Mg^(2+)-ion intercalation mechanism observed in the MgV_(3)O_(7)·H_(2)O phase using a 0.3 M Mg(TFSI)2/ACN(H_(2)O)***,within the voltage range of 2.25 V versus Mg/Mg^(2+),the V2O3@C exhibited a capacity of 245.1 mAh g^(-1)when evaluated with magnesium metal in a 0.3 M Mg(TFSI)^(2+)0.25 M MgCl_(2)/DME *** research findings have important implications for understanding the relationship between the Mg-ion storage mechanism and reconstructed crystal phase of vanadium oxides as well as the heterointerface reconstruction for the rational design of MIB cathode materials.

关键词： anodic hydration reaction magnesium ion battery nano crystal vanadium oxide

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KoNA:Korean Nucleotide Archive as A New Data Repository for Nucleotide Sequence Data

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 161-167页

作者： Gunhwan Ko Jae Ho Lee Young Mi Sim Wangho Song Byung-ha Yoon Iksu Byeon Bang Hyuck Lee Sang-Ok Kim Jinhyuk Choi Insoo jang Hyerin Kim Jin Ok Yang Kiwon jang Sora Kim Jong-Hwan Kim Jongbum Jeon Jaeeun Jung Seungwoo Hwang Ji-Hwan Park Pan-Gyu Kim Seon-Young Kim Byungwook Lee Korea Bioinformation Center Korea Research Institute of Bioscience&BiotechnologyDaejeon 34141Republic of Korea

During the last decade,the generation and accumulation of petabase-scale high-throughput sequencing data have resulted in great challenges,including access to human data,as well as transfer,storage,and sharing of enormous amounts of *** promote data-driven biological research,the Korean government announced that all biological data generated from government-funded research projects should be deposited at the Korea BioData Station(K-BDS),which consists of multiple databases for individual data ***,we introduce the Korean Nucleotide Archive(KoNA),a repository of nucleotide sequence *** of July 2022,the Korean Read Archive in KoNA has collected over 477 TB of raw next-generation sequencing data from national genome *** ensure data quality and prepare for international alignment,a standard operating procedure was adopted,which is similar to that of the International Nucleotide Sequence Database *** standard operating procedure includes quality control processes for submitted data and metadata using an automated pipeline,followed by manual *** ensure fast and stable data transfer,a high-speed transmission system called GBox is used in ***,the data uploaded to or downloaded from KoNA through GBox can be readily processed using a cloud computing service called *** seamless coupling of KoNA,GBox,and Bio-Express enhances the data experience,including submission,access,and analysis of raw nucleotide *** not only satisfies the unmet needs for a national sequence repository in Korea but also provides datasets to researchers globally and contributes to advances in *** KoNA is available at https://***/kona/.

关键词： Korea BioData Station Nucleotide sequence Next-generation sequencing repository Genomics Deposition and access of big data

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Generation of double knockout cattle via CRISPR-Cas9 ribonucleoprotein(RNP)electroporation

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Journal of Animal Science and Biotechnology 2024年第1期15卷 456-462页

作者： Gyeong-Min Gim Kyeong-Hyeon Eom Dong-Hyeok Kwon Dae-Jin Jung Dae-Hyun Kim Jun-Koo Yi Jae-Jung ha Ji-Hyun Lee Seong-Beom Lee Woo-Jae Son Soo-Young Yum Won-Wu Lee Goo jang Laboratory of Theriogenology and Biotechnology Department of Veterinary Clinical ScienceCollege of Veterinary Medicine and the Research Institute of Veterinary ScienceSeoul National UniversitySeoulRepublic of Korea LARTBio Co. Ltd.SeoulRepublic of Korea Gyeongsangbukdo Livestock Research Institute YeongjuRepublic of Korea Comparative Medicine Disease Research Center Seoul National UniversitySeoulRepublic of Korea

Background Genome editing has been considered as powerful tool in agricultural ***,genome editing progress in cattle has not been fast as in other mammal species,for some disadvantages including long gestational periods,single pregnancy,and high raising ***,technically demanding methods such as microinjection and somatic cell nuclear transfer(SCNT)are needed for gene editing in *** this point of view,electroporation in embryos has been risen as an *** First,editing efficiency of our electroporation methods were tested for *** of mutation on embryo was confirmed by T7E1 *** first combination,mutation rates for MSTN and PRNP were 57.6%±13.7%and 54.6%±13.5%,*** case of MSTN/BLG,mutation rates were 83.9%±23.6%for MSTN,84.5%±18.0%for ***,the double-KO embryos were transferred to surrogates and mutation rate was identified in resultant calves by targeted deep *** recipients were transferred for MSTN/PRNP,4 calves were delivered,and one calf underwent an induction for double *** surrogates were given double-KO embryos for MSTN/BLG,and four of the six calves that were born had mutations in both *** These data demonstrated that production of genome edited cattle via electroporation of RNP could be effectively ***,MSTN and PRNP from beef cattle and MSTN and BLG from dairy cattle have been born and they will be valuable resources for future precision breeding.

关键词： Beta-lactoglobulin Cattle CRISPR-Cas9 Electroporation Knockout MSTN PRNP

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High Na-ion conductivity andmechanical integrity of anion-exchanged polymeric hydrogel electrolytes for flexible sodium ion hybrid energy storage

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SusMat 2024年第1期4卷 140-153页

作者： JungWoo Hong harpalsinh H.Rana Jeong Hee Park Jun Su Kim Sang Joon Lee Gun jang Tae Hoon Kang Kang Ho Shin Sang ha Baek Wooseok Yang Kwang Ho Kim Ju-Hyuk Lee Ho Seok Park School of Chemical Engineering Sungkyunkwan UniversitySuwonRepublic of Korea Clean Energy Research Center Korea Institute of Science and Technology(KIST)SeoulRepublic of Korea KIST-SKKU Carbon-Neutral Research Center Sungkyunkwan University(SKKU)SuwonRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwonRepublic of Korea COSMOS LAB/92 Jomaru-ro 385beon-gilBucheon-siRepublic of Korea SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan UniversitySuwonRepublic of Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan UniversitySuwonRepublic of Korea

The polymeric gel electrolytes are attractive owing to their higher ionic conductivities than those of dry polymer electrolytes and lowered water activity for enlarged potential ***,the ionic conductivity and mechanical strength of the Na-ion conducting polymeric gel electrolytes are limited by below 20 mS cm−1 and 2.2 ***,we demonstrate Na-ion conducting and flexible polymeric hydrogel electrolytes of the chemically coupled poly(diallyldimethylammonium chloride)-dextrin-N,N′-methylene-bisacrylamide film immersed in NaClO_(4) solution(ex-DDA-Dex+NaClO_(4))for flexible sodium-ion hybrid capacitors(f-NIHC).In particular,the anion exchange reaction and synergistic interaction of ex-DDA-Dex with the optimum ClO_(4)−enable to greatly improve the ionic conductivity up to 27.63 mS cm−1 at 25◦C and electrochemical stability window up to 2.6 V,whereas the double networking structure leads to achieve both the mechanical strength(7.48 MPa)and softness of hydrogel ***,the f-NIHCs with the ex-DDA-Dex+NaClO_(4) achieved high specific and high-rate capacities of 192.04 F g^(−1)at 500 mA g^(−1)and 116.06 F g^(−1)at 10000 mA g^(−1),respectively,delivering a large energy density of 120.03Wh kg^(−1)at 906Wkg^(−1)and long cyclability of 70%over 500 cycles as well as demonstrating functional operation under mechanical stresses.

关键词： anion exchange chemistry flexible energy storage hybrid energy storage hydrogel electrolytes renewable electrolytes sodium storage

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Pendulation reduction on ship-mounted container crane via T-S fuzzy model

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Journal of Central South University 2012年第1期19卷 163-167页

作者： jang Jae Hoon KWON Sung-ha JEUNG Eun Tae Department of Control and Instrumentation Changwon National UniversityChangwon 641-773Korea

Ship-mounted container cranes are challenging industrial applications of nonlinear pendulum-like systems with oscillating disturbance which can cause them *** wave-induced ship motion causes the hoisted container to swing during the transfer operation,the swing motion may be dangerously large and the operation must be *** order to reduce payload pendulation of ship-mounted crane,nonlinear dynamics of ship-mounted crane is derived and a control method using T-S fuzzy model is *** results are given to illustrate the validity of the proposed design method and pendulation of ship-mounted crane is reduced significantly.

关键词： ship-mounted crane disturbance pendulation control T-S fuzzy model

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High-performance colorful semitransparent perovskite solar cells with phase-compensated microcavities

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Nano Research 2018年第5期11卷 2553-2561页

作者： Kyu-Tae Lee Ji-Yun jang Na Young ha Soonil Lee Hui Joon Park Department of Materials Science and Engineering University of Illinois Urbana Illinois 61801 USA Department of EnergySystems Research Ajou University Suwon 16499 Republic of Korea Department of Electrical and Computer Engineering Ajou University Suwon 16499 Republic of Korea

We demonstrate highly efficient multi-colored semitransparent perovskite solar cells that can create high angular tolerant controllable transmissive colors up to 60~, based on phase-compensated microcavities. The efficiency of the semitransparent colors was improved by impedance matching, which was enabled by placing a dielectric functional layer on top of traditional optical microcavities, with negligible influence on color pureness. The vast majority of the visible part of solar radiation is efficiently utilized for solar energy harvesting, achieving 10.47%, 10.66%, and 11.18% of efficiency for red, green, and blue （RGB） colored solar cells, respective136 while a very small proportion of the visible solar spectrum is used for structural coloration that can be readily tuned by altering the cavity medium thickness. The approach described herein can be suitable for a variety of applications such as display systems with ultra-low power consumption, highly efficient colorful solar panels, low-power wearable electronics, and energy-efficient optoelectronics.

关键词： perovskite solar cells semitransparency color filters optical cavities

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Design of 512-bit logic process-based single poly EEPROM IP

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Journal of Central South University 2011年第6期18卷 2036-2044页

作者：金丽妍 jang Ji-Hye 余忆宁 ha Pan-Bong KIM Young-Hee Department of Electronic Engineering Changwon National University

A single poly EEPROM cell circuit sharing the deep N-well of a cell array was designed using the logic process. The proposed cell is written by the FN tunneling scheme and the cell size is 41.26 μm2, about 37% smaller than the conventional cell. Also, a small-area and low-power 512-bit EEPROM IP was designed using the proposed cells which was used for a 900 MHz passive UHF RFID tag chip. To secure the operation of the cell proposed with 3.3 V devices and the reliability of the used devices, an EEPROM core circuit and a DC-DC converter were proposed. Simulation results for the designed EEPROM IP based on the 0.18μm logic process show that the power consumptions in read mode, program mode and erase mode are 11.82, 25.15, and 24.08 ~tW, respectively, and the EEPROM size is 0.12 mm2.

关键词： single poly EEPROM cell Fowler-Nordheim tunneling logic process radio frequency identification small area

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Fragmentation stability and retention time-shift obtained by LC-MS/MS to distinguish sialylated N-glycan linkage isomers in therapeutic glycoproteins

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Journal of Pharmaceutical Analysis 2023年第3期13卷 305-314页

作者： Chi Soo Park Minju Kang Ahyeon Kim Chulmin Moon Mirae Kim Jieun Kim Subin Yang Leeseul jang Ji Yeon jang ha Hyung Kim Department of Global Innovative Drugs Graduate School of Chung-Ang UniversitySeoul06974Republic of Korea

Sialylated N-glycan isomers withα2-3 orα2-6 linkage(s)have distinctive roles in glycoproteins,but are difficult to ***-type(WT)and glycoengineered(mutant)therapeutic glycoproteins,cytotoxic T lymphocyte-associated antigen-4-immunoglobulin(CTLA4-Ig),were produced in Chinese hamster ovary cell lines;however,their linkage isomers have not been *** this study,N-glycans of CTLA4-Igs were released,labeled with procainamide,and analyzed by liquid chromatography-tandem mass spectrometry(MS/MS)to identify and quantify sialylated N-glycan linkage *** linkage isomers were distinguished by comparison of 1)intensity of the N-acetylglucosamine ion to the sialic acid ion(Ln/Nn)using different fragmentation stability in MS/MS spectra and 2)retention time-shift for a selective m/z value in the extracted ion *** isomer was distinctively identified,and each quantity(>0.1%)was obtained relative to the total N-glycans(100%)for all observed ionization *** sialylated N-glycan isomers with onlyα2-3 linkage(s)in WT were identified,and each isomer's sum of quantities was 50.4%.Furthermore,39 sialylated N-glycan isomers(58.8%)in mono-(3 N-glycans;0.9%),bi-(18;48.3%),tri-(14;8.9%),and tetra-(4;0.7%)antennary structures of mutant were obtained,which comprised mono-(15 N-glycans;25.4%),di-(15;28.4%),tri-(8;4.8%),and tetra-(1;0.2%)sialylation,respectively,with onlyα2-3(10 N-glycans;4.8%),bothα2-3 andα2-6(14;18.4%),and onlyα2-6(15;35.6%)linkage(s).These results are consistent with those forα2-3 neuraminidase-treated *** study generated a novel plot of Ln/Nn versus retention time to distinguish sialylated N-glycan linkage isomers in glycoprotein.

关键词： Therapeutic glycoprotein Sialylation Linkage isomer LC-MS/MS

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